thiazoles has been researched along with Chagas Disease in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.38) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (15.63) | 29.6817 |
| 2010's | 15 (46.88) | 24.3611 |
| 2020's | 9 (28.13) | 2.80 |
| Authors | Studies |
|---|---|
| Accioly Brelaz de Castro, MC; Bezerra de Oliveira Filho, G; Cox Holanda de Barros Dias, M; Cristovão Silva, AC; da Silva Santos, AC; de Freitas E Silva, R; Gomes Rebello Ferreira, LF; Lima Leite, AC; Maria Nascimento Moura, D; Rêgo Alves Pereira, V; Souza Barbalho, M; Veríssimo de Oliveira Cardoso, M; Zaldini Hernandes, M | 1 |
| Crispim, M; Cuevas-Hernández, RI; Elias, MC; Girard, RMBM; Martínez-Cerón, S; Santos da Silva, M; Silber, AM; Trujillo-Ferrara, JG | 1 |
| Miller Conrad, LC; Nguyen, TH; Sass, G; Stevens, DA | 1 |
| Bahia, MT; Caldas, IS; Diniz, LF; Machado, YA; Marques, MJ; Martins-Filho, OA; Mazzeti, AL; Novaes, RD; Santos, LJS; Vilas Boas, BR | 1 |
| Au, HYA; Bhattacharyya, T; Chatelain, E; Franco, CH; Freitas-Junior, LH; Giardini, MA; Le, H; Madeira, RP; Miles, MA; Moraes, CB; Pascoalino, BS; Romera, LMD; Schenkman, S; Torrecilhas, AC; Warhurst, DC | 1 |
| Duchowicz, PR; Gómez Castaño, JA; Nossa González, DL; Rozo Núñez, WE | 1 |
| Hata, K | 1 |
| Cuevas-Hernández, RI; Gutiérrez-Nágera, NA; Martínez-Cerón, S; Mirzaeicheshmeh, E; Trujillo-Ferrara, JG | 1 |
| Bahia, MT; de Castro, KCMP; Mazzeti, AL; Mendes, PF; Mosqueira, VCF; Spósito, PÁ; Urbina, JA | 1 |
| Anderson, RF; Blaser, A; Chatelain, E; Denny, WA; Franzblau, SG; Launay, D; Ma, Z; Maes, L; Palmer, BD; Shinde, SS; Thompson, AM; Wan, B; Wang, Y | 1 |
| Anjos, PSD; Cardoso, MVO; Coelho, PL; de Oliveira Filho, GB; Espíndola, JWP; Ferreira, RS; Leite, ACL; Meira, CS; Moreira, DRM; Oliveira E Silva, DA; Santos, ES; Soares, MBP | 1 |
| Almeida, IC; Alonso-Vega, C; Alves, F; Gascon, J; Ortiz, L; Pinazo, MJ; Ribeiro, I; Schijman, A; Strub-Wourgaft, N; Torrico, F | 1 |
| Chung, MC; Dos Santos, JL; Ferreira, CMR; Jornada, DH; Machado, MGM; Scarim, CB | 1 |
| Erath, J; Ferrins, L; Gillingwater, K; Leed, SE; Mehta, N; Mensa-Wilmot, K; Pollastri, MP; Rodriguez, A; Sciotti, RJ; Sharma, A; Tanghe, S; Thomas, SM | 1 |
| Alonso-Vega, C; Alves, F; de la Barra, A; Flevaud, L; Garcia, L; Gascon, J; Illanes, D; Juiz, N; Ortiz, L; Parrado, R; Ramirez, JC; Ribeiro, I; Schijman, AG; Torrico, F | 1 |
| Aiub, CA; Araújo, JS; Batista, Dda G; Batista, MM; Britto, C; da Silva, CF; da Silva, PB; de Souza, EM; Hargrove, TY; Kim, K; Lepesheva, GI; Lionel, J; Pavão, BP; Soeiro, Mde N; Sulikowski, G; Waterman, MR | 1 |
| Alexander, PW; Chaplin, JH; Charman, SA; Chatelain, E; Hargrove, TY; Keenan, M; Lepesheva, GI; Perez, CJ; Waterman, MR; Wawrzak, Z | 1 |
| Álvarez, G; Cerecetto, H; Cruces, E; Escobar, P; Fernández, M; Figueredo Thiel, SJ; Gabay, M; González, M; Leal, SM; Sanabria, L; Serna, E; Torres, S; Varela, J; Vera de Bilbao, NI; Yaluff, G | 1 |
| Asada, M | 1 |
| Bloomer, WD; Kaiser, M; Papadopoulou, MV; Rosenzweig, HS; Szular, J; Wilkinson, SR | 1 |
| Delgado-Enciso, I; Dobrovinskaya, O; Espinoza-Gómez, F; López-Lemus, UA; Melnikov, V; Pimientel-Rodrigez, V; Rodriguez-Hernández, A; Rueda-Valdovinos, G; Valle-Reyes, JS; Wookee-Zea, C | 1 |
| Cardoso, MV; da Silva Mendes, CH; da Silva, AC; da Silva, EB; de Castro, MC; de Simone, CA; Dos Santos, TA; Ferreira, RS; Leite, AC; Moreira, DR; Oliveira E Silva, DA; Oliveira, AR; Pereira, VR | 1 |
| Moloney, A | 1 |
| do Prado, JC; Kuehn, CC; Oliveira, LG; Santos, CD; Toldo, MP | 1 |
| Bahia, MT; Caldas, IS; Carneiro, CM; Crepalde, G; de Lana, M; Diniz, Lde F; Guedes, PM; Talvani, A; Urbina, JA | 1 |
| Lira, R; Payares, G; Romanha, AJ; Sanoja, C; Urbina, JA | 1 |
| Cunha, FQ; Michelin, MA; Silva, JS | 1 |
| Abdalla, GK; Castro, EC; Faria, GE; Michelin, MA; Reis, MA; Silva, KT | 1 |
| Campbell-Lendrum, D; Castillo-Riquelme, M; Chalabi, Z; Davies, C; Fox-Rushby, J; Guhl, F; Lord, J | 1 |
| Neville, MC; Verge, JP | 1 |
| Roffey, P; Verge, JP | 1 |
| Velásquez Antich, A | 1 |
1 review(s) available for thiazoles and Chagas Disease
| Article | Year |
|---|---|
Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria.
Topics: Animals; Chagas Disease; Drug Design; Humans; Leishmaniasis; Malaria; Protozoan Infections; Semicarbazones; Thiazoles; Thiosemicarbazones; Trypanosomiasis, African | 2019 |
2 trial(s) available for thiazoles and Chagas Disease
| Article | Year |
|---|---|
Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Bolivia; Chagas Disease; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Incidence; Male; Middle Aged; Nitroimidazoles; Parasite Load; Placebos; Polymerase Chain Reaction; Prospective Studies; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2018 |
Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease.
Topics: Adolescent; Adult; Chagas Disease; DNA, Protozoan; Humans; Middle Aged; Monitoring, Physiologic; Nitroimidazoles; Parasite Load; Placebos; Real-Time Polymerase Chain Reaction; Thiazoles; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult | 2019 |
29 other study(ies) available for thiazoles and Chagas Disease
| Article | Year |
|---|---|
1,3-Thiazole derivatives as privileged structures for anti-Trypanosoma cruzi activity: Rational design, synthesis, in silico and in vitro studies.
Topics: Chagas Disease; Drug Design; Humans; Molecular Docking Simulation; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
A Fluorinated Phenylbenzothiazole Arrests the Trypanosoma cruzi Cell Cycle and Diminishes the Infection of Mammalian Host Cells.
Topics: Animals; Cell Cycle; Chagas Disease; CHO Cells; Cricetulus; Halogenation; Humans; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
The Pseudomonas aeruginosa product pyochelin interferes with Trypanosoma cruzi infection and multiplication in vitro.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Phenols; Pseudomonas aeruginosa; Thiazoles; Trypanosoma cruzi; Vero Cells | 2020 |
Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection.
Topics: Amlodipine; Animals; Chagas Disease; Mice; Nitroimidazoles; Parasitemia; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity.
Topics: 14-alpha Demethylase Inhibitors; Animals; Cell Line; Chagas Disease; Drug Resistance, Multiple; Genes, Protozoan; Mutation; Nitroimidazoles; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Antiprotozoal QSAR modelling for trypanosomiasis (Chagas disease) based on thiosemicarbazone and thiazole derivatives.
Topics: Chagas Disease; Humans; Quantitative Structure-Activity Relationship; Thiazoles; Thiosemicarbazones; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Development of E1224 by leveraging a strategic partnership for the medicines creation against neglected tropical diseases.
Topics: Chagas Disease; Global Health; Neglected Diseases; Thiazoles; Triazoles; Tropical Medicine; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Phenylbenzothiazole derivatives: effects against a Trypanosoma cruzi infection and toxicological profiles.
Topics: Animals; Chagas Disease; Mice; Nitroimidazoles; Thiazoles; Toxicity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Higher oral efficacy of ravuconazole in self-nanoemulsifying systems in shorter treatment in experimental chagas disease.
Topics: Animals; Chagas Disease; Emulsions; Female; Hep G2 Cells; Humans; Inhibitory Concentration 50; Mice; Myocytes, Cardiac; Nanostructures; Rats; Thiazoles; Triazoles; Trypanosoma cruzi | 2021 |
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.
Topics: Animals; Antitubercular Agents; Chagas Disease; Disease Models, Animal; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Structure-Activity Relationship; Thiazoles; Tuberculosis | 2017 |
Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Drug Design; Female; Mice; Mice, Inbred BALB C; Molecular Structure; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Anilinoquinoline based inhibitors of trypanosomatid proliferation.
Topics: Animals; Antiprotozoal Agents; Cell Proliferation; Chagas Disease; Female; Humans; Leishmania; Leishmaniasis; Mice; Thiazoles; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African | 2018 |
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.
Topics: 14-alpha Demethylase Inhibitors; Antiprotozoal Agents; Chagas Disease; Crystallography, X-Ray; Humans; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanosoma cruzi | 2013 |
Identification of a new amide-containing thiazole as a drug candidate for treatment of Chagas' disease.
Topics: Amides; Animals; Chagas Disease; Drug Discovery; Male; Mice; Mice, Inbred BALB C; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
[Development and Distribution of Drugs for NTDs: Efforts of One Pharmaceutical Company].
Topics: Animals; Antifungal Agents; Chagas Disease; Cost-Benefit Analysis; Drug Discovery; Drug Industry; Global Health; Humans; Intersectoral Collaboration; Mice; Neglected Diseases; Prodrugs; Thiazoles; Triazoles; Tropical Medicine | 2016 |
Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds.
Topics: Amides; Antiprotozoal Agents; Cell Line; Chagas Disease; Humans; Leishmania; Parasitic Sensitivity Tests; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma | 2016 |
Antiprotozoal drug nitazoxanide enhances parasitemia, tissue lesions and mortality caused by Trypanosoma cruzi in murine model.
Topics: Animals; Chagas Disease; Disease Models, Animal; Heart; Male; Mice, Inbred BALB C; Muscle, Striated; Myocardium; Nitro Compounds; Parasitemia; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Desing and synthesis of potent anti-Trypanosoma cruzi agents new thiazoles derivatives which induce apoptotic parasite death.
Topics: Apoptosis; Chagas Disease; Cysteine Endopeptidases; Drug Design; Parasitic Sensitivity Tests; Protozoan Proteins; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Trial renews interest in Chagas' disease.
Topics: Chagas Disease; Clinical Trials, Phase I as Topic; Drug Industry; Global Health; Humans; Latin America; Prodrugs; Research Support as Topic; Thiazoles; Triazoles | 2009 |
Enhanced protection by melatonin and meloxicam combination in experimental infection by Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Dinoprostone; Drug Synergism; Immunologic Factors; Interferon-gamma; Interleukin-2; Macrophages; Male; Melatonin; Meloxicam; Nitric Oxide; Rats; Rats, Wistar; Thiazines; Thiazoles; Trypanosoma cruzi | 2010 |
Effects of ravuconazole treatment on parasite load and immune response in dogs experimentally infected with Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Dogs; Enzyme-Linked Immunosorbent Assay; Immunoglobulin G; Interferon-gamma; Interleukin-10; Myocardium; Polymerase Chain Reaction; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Drug Resistance; Female; Mice; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2003 |
Inducible cyclooxygenase released prostaglandin mediates immunosuppression in acute phase of experimental Trypanosoma cruzi infection.
Topics: Acute Disease; Animals; Cells, Cultured; Chagas Disease; Concanavalin A; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Dinoprostone; Immune Tolerance; Lymphocyte Activation; Male; Meloxicam; Mice; Mice, Inbred BALB C; Parasitemia; Prostaglandin-Endoperoxide Synthases; Sodium Salicylate; Spleen; T-Lymphocytes; Thiazines; Thiazoles | 2005 |
Trypanosoma cruzi: the role of PGE2 in immune response during the acute phase of experimental infection.
Topics: Acute Disease; Animals; Cells, Cultured; Chagas Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Etoricoxib; Fibrosis; Male; Meloxicam; Mice; Mice, Inbred BALB C; Myocardium; Parasitemia; Prostaglandins; Pyridines; Spleen; Sulfones; Thiazines; Thiazoles; Trypanosoma cruzi | 2008 |
Modelling geographic variation in the cost-effectiveness of control policies for infectious vector diseases: the example of Chagas disease.
Topics: Chagas Disease; Communicable Diseases; Cost-Benefit Analysis; Geography; Health Policy; Infection Control; Models, Econometric; Nitro Compounds; Thiazoles | 2008 |
Antiprotozoal thiazoles. 2. 2-(5-Nitro-2-furyl-, thiazolyl-, and 1-methylimidazolyl-)thiazoles.
Topics: Animals; Chagas Disease; Mice; Thiazoles; Trypanocidal Agents | 1977 |
Antiprotozoal Thiazoles. 2-(5-Nitro-2-thienyl)thiazoles.
Topics: Administration, Oral; Animals; Chagas Disease; Injections, Intraperitoneal; Lethal Dose 50; Mice; Nitro Compounds; Thiazoles; Thiophenes; Trypanocidal Agents; Trypanosomiasis, African | 1975 |
Suppressive effect of 32'644-Ba "Ambilhar" 1-(5-nitro-2-thiazolyl-2-imidazolidinone) on experimental acute S. cruzi infection in mice.
Topics: Animals; Anthelmintics; Chagas Disease; Imidazoles; Mice; Thiazoles; Trypanosoma | 1969 |