beta-lapachone has been researched along with Chagas Disease in 7 studies
beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase
beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leishmania and cancer, reactions including copper-catalyzed azide-alkyne cycloaddition (click chemistry), palladium-catalysed cross couplings, C-H activation reactions, Ullmann couplings and heterocyclisations reported up to July 2019 will be discussed." | 2.61 | Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones. ( Ackermann, L; da Silva Júnior, EN; de Castro, SL; Dhawa, U; Jacob, C; Jardim, GAM, 2019) |
| "Chagas disease is caused by the hemoflagellate protozoa Trypanosoma cruzi and is one of the most important neglected tropical diseases, especially in Latin American countries, where there is an association between low-income populations and mortality." | 1.51 | Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of β-lapachone-derived naphthoimidazoles. ( Bombaça, ACS; da Silva Júnior, EN; Goulart, MOF; Guimarães, ACR; Menna-Barreto, RFS; Rodrigues, ABM; Santos, ACC; Silva, TL; Viana, PG, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Ferreira, SB | 1 |
| Salomão, K | 2 |
| de Carvalho da Silva, F | 1 |
| Pinto, AV | 2 |
| Kaiser, CR | 1 |
| Pinto, AC | 1 |
| Ferreira, VF | 2 |
| de Castro, SL | 4 |
| Cardoso, MFDC | 1 |
| Bombaça, AC | 1 |
| da Rocha, DR | 1 |
| da Silva, FC | 1 |
| Cavaleiro, JAS | 1 |
| da Silva Júnior, EN | 2 |
| Jardim, GAM | 1 |
| Jacob, C | 1 |
| Dhawa, U | 1 |
| Ackermann, L | 1 |
| Cascabulho, CM | 1 |
| Meuser-Batista, M | 1 |
| Moura, KCG | 1 |
| Pinto, MDC | 1 |
| Duque, TLA | 1 |
| Demarque, KC | 1 |
| Guimarães, ACR | 2 |
| Manso, PPA | 1 |
| Pelajo-Machado, M | 1 |
| Oliveira, GM | 1 |
| Castro, SL | 1 |
| Menna-Barreto, RF | 2 |
| Bombaça, ACS | 1 |
| Viana, PG | 1 |
| Santos, ACC | 1 |
| Silva, TL | 1 |
| Rodrigues, ABM | 1 |
| Goulart, MOF | 1 |
| Menna-Barreto, RFS | 1 |
| Brunoro, GV | 1 |
| Faça, VM | 1 |
| Caminha, MA | 1 |
| Ferreira, AT | 1 |
| Trugilho, M | 1 |
| de Moura, KC | 1 |
| Perales, J | 1 |
| Valente, RH | 1 |
2 reviews available for beta-lapachone and Chagas Disease
| Article | Year |
|---|---|
Synthesis of quinones with highlighted biological applications: A critical update on the strategies towards bioactive compounds with emphasis on lapachones.
Topics: Animals; Antineoplastic Agents; Antiprotozoal Agents; Cell Line, Tumor; Cell Proliferation; Chagas D | 2019 |
The trypanocidal activity of naphthoquinones: a review.
Topics: Animals; Chagas Disease; Humans; Naphthoquinones; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
5 other studies available for beta-lapachone and Chagas Disease
| Article | Year |
|---|---|
Synthesis and anti-Trypanosoma cruzi activity of β-lapachone analogues.
Topics: Animals; Blood Cells; Chagas Disease; Inhibitory Concentration 50; Life Cycle Stages; Mice; Naphthoq | 2011 |
Synthesis and anti-Trypanosoma cruzi activity of new 3-phenylthio-nor-β-lapachone derivatives.
Topics: Animals; Benzofurans; Cell Survival; Cells, Cultured; Chagas Disease; Embryo, Mammalian; Heart; Huma | 2015 |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chagas Disease; Disease Models, Animal; Electrocar | 2020 |
Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of β-lapachone-derived naphthoimidazoles.
Topics: Animals; Chagas Disease; Humans; Hydrogen Peroxide; Imidazoles; Membrane Potential, Mitochondrial; M | 2019 |
Differential Gel Electrophoresis (DIGE) Evaluation of Naphthoimidazoles Mode of Action: A Study in Trypanosoma cruzi Bloodstream Trypomastigotes.
Topics: Animals; Chagas Disease; Electrophoresis, Gel, Two-Dimensional; Mice; Naphthoquinones; Nifurtimox; N | 2016 |