Page last updated: 2024-12-10

levomepromazine maleate

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Description

6-hydroxysalvinolone: from Salvia chorassanica; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5282484
CHEMBL ID1725730
SCHEMBL ID218717
MeSH IDM0069018
PubMed CID10735190
CHEMBL ID488040
CHEMBL ID3806074
SCHEMBL ID17403056
MeSH IDM0069018

Synonyms (72)

Synonym
neurocil
veractil
tisercin
hirnamin
nozinan
milezin
minozinan
NCGC00016681-01
cas-7104-38-3
7104-38-3
hirnamin (tn)
D02248
levomepromazine maleate (jp17/usan)
levomepromazine maleate
levo mepromazine maleate
HMS1570O16
HMS2097O16
tox21_110559
dtxsid4045399 ,
dtxcid2025399
5kn5y9v01k ,
methoprazine
(2r)-3-(2-methoxy-10h-phenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine hydrogen (2z)-but-2-enedioate
10h-phenothiazine-10-propanamine, 2-methoxy-n,n,beta-trimethyl-, (betar)-, (2z)-2-butenedioate (1:1)
methotrimeprazine maleate
unii-5kn5y9v01k
levomepromazine maleate [usan:jan]
einecs 230-412-8
neuractil
CHEMBL1725730
levomepromazine hydrogen maleate
sofmin
SCHEMBL218717
CCG-220797
levomepromazinum [hpus]
10h-phenothiazine-10-propanamine, 2-methoxy-n,n,.beta.-trimethyl-, (.beta.r)-, (2z)-2-butenedioate (1:1)
levomepromazine maleate [mi]
levomepromazine maleate [mart.]
(2r)-3-(2-methoxy-10h-phenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine (2z)-but-2-enedioate
levomepromazine maleate [usan]
levomepromazine maleate [who-dd]
levomepromazine maleate [jan]
levomepromazine maleate [ep monograph]
levomepromazinmaleat
AKOS025116974
sr-01000872673
SR-01000872673-1
levomepromazine maleate 1.0 mg/ml in methanol (as free base)
HMS3714O16
(2r)-3-(2-methoxyphenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine maleate
Q27262488
but-2-enedioic acid;(2r)-3-(2-methoxyphenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine
(z)-but-2-enedioic acid;(2r)-3-(2-methoxyphenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine
(betar)-2-methoxy-n,n,beta-trimethyl-10h-phenothiazine-10-propanamine (2z)-2-butenedioate
CS-0455065
(r)-3-(2-methoxy-10h-phenothiazin-10-yl)-n,n,2-trimethylpropan-1-amine maleate
L0299
14-deoxycoleon u
CHEMBL488040
88664-09-9
(4bs)-4,9,10-trihydroxy-2-isopropyl-4b,8,8-trimethyl-6,7-dihydro-5h-phenanthren-3-one
CHEMBL3806074
SCHEMBL17403056
5,6,10-trihydroxy-7-isopropyl-1,1,4a-trimethyl-2,3,4,4a-tetrahydrophenanthren- 9(1h)-one
6-hydroxysalvinolone
5,6,10-trihydroxy-7-isopropyl-1,1,4a-trimethyl-2,3,4,4a- tetrahydrophenanthren-9(1h)-one
AKOS032962522
FS-9451
(4ar)-5,6,10-trihydroxy-1,1,4a-trimethyl-7-propan-2-yl-3,4-dihydro-2h-phenanthren-9-one
DTXSID801316595
CS-0017038
HY-N1493

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
TDP1 proteinHomo sapiens (human)Potency11.44980.000811.382244.6684AID686978; AID686979
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency1.61810.000214.376460.0339AID720691
pregnane X nuclear receptorHomo sapiens (human)Potency12.58930.005428.02631,258.9301AID1346985
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency8.91250.01789.637444.6684AID588834
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency10.12350.000323.4451159.6830AID743065; AID743067
Cellular tumor antigen p53Homo sapiens (human)Potency1.60450.002319.595674.0614AID651631
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (124)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (34)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (19)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (50)

Assay IDTitleYearJournalArticle
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID343573Antitumor activity against human A549 cells at 10'-5 mol/l by SRB assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Abietane diterpenoids from the bark of Cryptomeria fortunei.
AID1304624Selectivity index, ratio of IC50 for human HT-29 cells to IC50 for Leishmania amazonensis amastigotes2016Journal of natural products, Mar-25, Volume: 79, Issue:3
Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.
AID1090234Effect on ingestion in L6 larvae Spodoptera littoralis assessed as consumption compound injected orally relative to control2005Journal of agricultural and food chemistry, Jun-29, Volume: 53, Issue:13
Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.
AID1304621Antileishmanial activity against Leishmania donovani LV82 promastigotes expressing red fluorescent protein after 72 hrs by flow cytometric analysis2016Journal of natural products, Mar-25, Volume: 79, Issue:3
Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.
AID1304623Antileishmanial activity against transgenic Leishmania amazonensis amastigotes infected in CD-1 mouse peritoneal macrophages assessed as beta-lactamase activity after 72 hrs by nitrocefin dye-based spectrophotometric analysis2016Journal of natural products, Mar-25, Volume: 79, Issue:3
Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.
AID1207006Antibacterial activity against Staphylococcus epidermidis assessed as growth inhibition at 50 ug/disc after 24 hrs by disc diffusion method2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID343568Antitumor activity against human HL60 cells at 10'-5 mol/l by MTT assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Abietane diterpenoids from the bark of Cryptomeria fortunei.
AID1207013Antibacterial activity against Micrococcus luteus assessed as growth inhibition at 500 ug/disc after 24 hrs by disc diffusion method2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID343569Antitumor activity against human HL60 cells at 10'-6 mol/l by MTT assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Abietane diterpenoids from the bark of Cryptomeria fortunei.
AID1090232Effect on weight gain in L6 larvae Spodoptera littoralis assessed as biomass compound injected orally relative to control2005Journal of agricultural and food chemistry, Jun-29, Volume: 53, Issue:13
Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.
AID1090231Cytotoxicity in insect Spodoptera frugiperda pupal ovarian tissue sf9 cells measured after 48 hr by MTT assay2005Journal of agricultural and food chemistry, Jun-29, Volume: 53, Issue:13
Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.
AID1304620Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay2016Journal of natural products, Mar-25, Volume: 79, Issue:3
Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.
AID343572Antitumor activity against human A549 cells at 10'-4 mol/l by SRB assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Abietane diterpenoids from the bark of Cryptomeria fortunei.
AID343570Antitumor activity against human HL60 cells at 10'-7 mol/l by MTT assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Abietane diterpenoids from the bark of Cryptomeria fortunei.
AID343576Antitumor activity against human A549 cells at 10'-8 mol/l by SRB assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Abietane diterpenoids from the bark of Cryptomeria fortunei.
AID1058383Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID1058388Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID343574Antitumor activity against human A549 cells at 10'-6 mol/l by SRB assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Abietane diterpenoids from the bark of Cryptomeria fortunei.
AID1754207Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Structurally Diverse Diterpenoids from the Roots of
AID1207004Antibacterial activity against Staphylococcus aureus assessed as growth inhibition at 50 ug/disc after 24 hrs by disc diffusion method2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID1090233Antifeedant activity against L6 larvae Spodoptera littoralis compound injected orally relative to control2005Journal of agricultural and food chemistry, Jun-29, Volume: 53, Issue:13
Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.
AID343567Antitumor activity against human HL60 cells at 10'-4 mol/l by MTT assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Abietane diterpenoids from the bark of Cryptomeria fortunei.
AID1754212Cytotoxicity against human BEAS2B cells assessed as reduction in cell viability after 48 hrs by MTS assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Structurally Diverse Diterpenoids from the Roots of
AID1207010Antibacterial activity against Enterococcus faecalis assessed as growth inhibition at 500 ug/disc after 24 hrs by disc diffusion method2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID1304622Selectivity index, ratio of IC50 for human HT-29 cells to IC50 for Leishmania donovani LV82 promastigotes expressing red fluorescent protein2016Journal of natural products, Mar-25, Volume: 79, Issue:3
Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.
AID1754210Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Structurally Diverse Diterpenoids from the Roots of
AID1754208Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Structurally Diverse Diterpenoids from the Roots of
AID343571Antitumor activity against human HL60 cells at 10'-8 mol/l by MTT assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Abietane diterpenoids from the bark of Cryptomeria fortunei.
AID1058387Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID1207012Antibacterial activity against Micrococcus luteus assessed as growth inhibition at 50 ug/disc after 24 hrs by disc diffusion method2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID1207009Antibacterial activity against Enterococcus faecalis assessed as growth inhibition at 50 ug/disc after 24 hrs by disc diffusion method2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID1207007Antibacterial activity against Staphylococcus epidermidis assessed as growth inhibition at 500 ug/disc after 24 hrs by disc diffusion method2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID1754211Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Structurally Diverse Diterpenoids from the Roots of
AID1090230Cytotoxicity in insect Cricetulus griseus CHO (Chinese hamster ovary) cells measured after 48 hr by MTT assay2005Journal of agricultural and food chemistry, Jun-29, Volume: 53, Issue:13
Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.
AID1058384Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID1058386Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID1058385Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID1754209Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Structurally Diverse Diterpenoids from the Roots of
AID343575Antitumor activity against human A549 cells at 10'-7 mol/l by SRB assay2008Journal of natural products, Jul, Volume: 71, Issue:7
Abietane diterpenoids from the bark of Cryptomeria fortunei.
AID1207003Antibacterial activity against Staphylococcus aureus assessed as growth inhibition at 500 ug/disc after 24 hrs by disc diffusion method2015Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12
An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
AID1090236Antifeedant activity against adult Leptinotarsa decemlineata in host plant assessed as feeding inhibition2005Journal of agricultural and food chemistry, Jun-29, Volume: 53, Issue:13
Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.
AID1090235Mortality in adult Leptinotarsa decemlineata in host plant measured after 72 hr2005Journal of agricultural and food chemistry, Jun-29, Volume: 53, Issue:13
Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.
AID1058382Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.
AID1299560Antitrypanosomal activity against intracellular form of Trypanosoma cruzi2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (42)

TimeframeStudies, This Drug (%)All Drugs %
pre-199027 (64.29)18.7374
1990's0 (0.00)18.2507
2000's3 (7.14)29.6817
2010's9 (21.43)24.3611
2020's3 (7.14)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.80 (24.57)
Research Supply Index3.53 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index36.71 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other33 (100.00%)84.16%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]