Compounds > gibbilimbol b
Page last updated: 2024-11-12

gibbilimbol b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

gibbilimbol B: isolated from Piper gibbilimbum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
PipergenusA plant genus of the family PIPERACEAE that includes species used for spicy and stimulating qualities.[MeSH]PiperaceaeA family of flowering plants in the order Piperales best known for the black pepper widely used in SPICES, and for KAVA and Betel used for neuroactive properties.[MeSH]

Cross-References

ID SourceID
PubMed CID10014185
CHEMBL ID443175
MeSH IDM0402892

Synonyms (5)

Synonym
4-[(e)-dec-3-enyl]phenol
CHEMBL443175
4-[(3'e)-decenyl]phenol
RQVUFITWWLNDGP-BQYQJAHWSA-N
gibbilimbol b
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID401716Antibacterial activity against Staphylococcus epidermidis at 60 ug/disk by paper disk diffusion technique1998Journal of natural products, Jul, Volume: 61, Issue:7
Gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols from Piper gibbilimbum.
AID401720Antibacterial activity against Bacillus cereus after 24 hrs by broth microdilution method1998Journal of natural products, Jul, Volume: 61, Issue:7
Gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols from Piper gibbilimbum.
AID1278157Antiparasitic activity against amastigote stage of Leishmania infantum chagasi MHOM/BR/1972/LD infected in BALB/c mouse peritoneal macrophages assessed as reduction of parasite burden after 120 hrs by Giemsa staining-based light microscopic analysis2016Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.
AID1278151Cytotoxicity against mouse NCTC-929 cells assessed as cell viability after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.
AID401715Cytotoxicity against human KB cells1998Journal of natural products, Jul, Volume: 61, Issue:7
Gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols from Piper gibbilimbum.
AID1278147Antiparasitic activity against trypomastigote stage of Trypanosoma cruzi Y assessed as parasite viability after 24 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.
AID401718Antibacterial activity against Pseudomonas aeruginosa at 60 ug/disk by paper disk diffusion technique1998Journal of natural products, Jul, Volume: 61, Issue:7
Gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols from Piper gibbilimbum.
AID401714Toxicity in Artemia salina1998Journal of natural products, Jul, Volume: 61, Issue:7
Gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols from Piper gibbilimbum.
AID401717Antibacterial activity against Bacillus cereus at 60 ug/disk by paper disk diffusion technique1998Journal of natural products, Jul, Volume: 61, Issue:7
Gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols from Piper gibbilimbum.
AID1278152Selectivity index, ratio of CC50 for mouse NCTC-292 cells to IC50 for Trypanosoma cruzi Y trypomastigotes2016Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.
AID1278159Selectivity index, ratio of CC50 for mouse NCTC-292 cells to IC50 for Leishmania infantum chagasi MHOM/BR/1972/LD amastigotes2016Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.
AID1278158Selectivity index, ratio of CC50 for mouse NCTC-292 cells to IC50 for Leishmania infantum chagasi MHOM/BR/1972/LD promastigotes2016Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.
AID1278156Antiparasitic activity against promastigote stage of Leishmania infantum chagasi MHOM/BR/1972/LD assessed as parasite viability after 24 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.
AID1278148Antiparasitic activity against amastigote stage of Trypanosoma cruzi Y2016Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4
Gibbilimbol analogues as antiparasitic agents--Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum.
AID401719Antibacterial activity against Staphylococcus epidermidis after 24 hrs by broth microdilution method1998Journal of natural products, Jul, Volume: 61, Issue:7
Gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols from Piper gibbilimbum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.84 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phenol
[no description available]		210phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		2.1310phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		1.9910C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
butylparaben
[no description available]		2.1310organic molecular entity
benzonidazole
benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.		2.1310C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
gibbilimbol a
gibbilimbol A: isoalted from Piper gibbilimbum; structure in first source		2.9340
ConditionIndicatedRelationship StrengthStudiesTrials
American Trypanosomiasis
[description not available]		02.5720
Chagas Disease
Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.		02.5720
Black Fever
[description not available]		02.0710
Leishmaniasis, Visceral
A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.		02.0710