Compounds > glycyrin
Page last updated: 2024-11-08

glycyrin

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Description

glycyrin: has antibacterial, antiviral, and hypotensive activities; isolated from licorice [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

glycyrin : A member of the class of coumarins that is coumarin substituted by methoxy groups at positions 5 and 7, a prenyl group at position 6 and a 2,4-dihydroxyphenyl group at position 3. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
GlycyrrhizagenusA genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivative, CARBENOXOLONE.[MeSH]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]
Glycyrrhiza uralensisspeciesA plant species of the family FABACEAE.[MeSH]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]
Glycyrrhiza uralensisspeciesA plant species of the family FABACEAE.[MeSH]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

Cross-References

ID SourceID
PubMed CID480787
CHEMBL ID132535
CHEBI ID69086
SCHEMBL ID5327472
MeSH IDM000610881

Synonyms (20)

Synonym
3-(2,4-dihydroxy-phenyl)-5,7-dimethoxy-6-(3-methyl-but-2-enyl)-1-benzopyran-2-one
66056-18-6
glycyrin
3-(2,4-dihydroxyphenyl)-5,7-dimethoxy-6-(3-methylbut-2-enyl)chromen-2-one
chebi:69086 ,
CHEMBL132535
3-(2,4-dihydroxyphenyl)-5,7-dimethoxy-6-(3-methylbut-2-en-1-yl)-2h-chromen-2-one
3-(2,4-dihydroxyphenyl)-5,7-dimethoxy-6-prenylcoumarin
LMPK12160017
994bq9m3av ,
unii-994bq9m3av
3-(2',4'-dihydroxyphenyl)-5,7-dimethoxy-2-isopentenylcoumarin
3-(2,4-dihydroxyphenyl)-5,7-dimethoxy-6-(3-methyl-but-2-enyl)-1-benzopyran-2-one
SCHEMBL5327472
2h-1-benzopyran-2-one, 3-(2,4-dihydroxyphenyl)-5,7-dimethoxy-6-(3-methyl-2-buten-1-yl)-
DTXSID50216255
3-(2,4-dihydroxyphenyl)-5,7-dimethoxy-6-(3-methyl-2-butenyl)-2h-1-benzopyran-2-one, 9ci
AKOS032949083
Q27137426
FS-6891
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
coumarins
hydroxyisoflavansA member of the class of isoflavans in which one or more ring hydrogens are replaced by hydroxy groups.
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (30)

Assay IDTitleYearJournalArticle
AID547822Antiviral activity against KJ56-1 Porcine rotavirus G5P[7] in human RBC assessed as inhibition of virus-induced hemagglutinination after 1 hr2010Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21
In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.
AID109829Body weight of the non-fasted diabetic KK-Ay mice on day 7 was measured2003Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice.
AID1432494Inhibition of Escherichia coli N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 20 uM after 1 hr relative to control2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.
AID109805Blood glucose level of the diabetic KK-Ay mice on day 4 was measured2003Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice.
AID110560Average food intake of the diabetic KK-Ay mice was measured from total intake amount/days/number of mice2003Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice.
AID547828Antiviral activity against KJ56-1 Bovine rotavirus G8P[7] infected in african green monkey TF-104 cells assessed as inhibition of virus-induced cytopathic effect after 72 hrs2010Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21
In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.
AID547824Antiviral activity against KJ56-1 Bovine rotavirus G8P[7] infected in african green monkey TF-104 cells after 72 hrs by virucidal assay2010Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21
In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.
AID458821Inhibition of Spanish flu (A/Bervig_Mission/1/18) neuraminidase by noncompetitive inhibition assay2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.
AID634223Antibacterial activity against Streptococcus mutans ATCC 25175 assessed as growth inhibition at 1.25 to 10 ug/ml after 24 hrs by microplate dilution assay2011Journal of natural products, Dec-27, Volume: 74, Issue:12
Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification.
AID109827Body weight of the non-fasted diabetic KK-Ay mice on day 0 was measured2003Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice.
AID634229Antibacterial activity against Prevotella intermedia ATCC 25611 assessed as growth inhibition at 1.25 to 10 ug/ml after 24 hrs by microplate dilution assay2011Journal of natural products, Dec-27, Volume: 74, Issue:12
Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification.
AID547832Antiviral activity against KJ56-1 Bovine rotavirus G8P[7] in human RBC assessed as inhibition of virus-induced hemagglutinination after 1 hr2010Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21
In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.
AID1301449Activation of NRF2 transcription in human HepG2C8 cells at 10 uM after 6 hrs by luciferase reporter gene assay relative to control2016Journal of natural products, Feb-26, Volume: 79, Issue:2
Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.
AID1432498Uncompetitive inhibition of Bacillus subtilis N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) after 1 hr by Lineweaver-Burk plot analysis2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.
AID634224Antibacterial activity against Streptococcus sobrinus ATCC 33478 assessed as growth inhibition at 1.25 to 10 ug/ml after 24 hrs by microplate dilution assay2011Journal of natural products, Dec-27, Volume: 74, Issue:12
Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification.
AID1432491Inhibition of Bacillus subtilis N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 20 uM after 1 hr relative to control2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.
AID109824Body weight of the fasted diabetic KK-Ay mice on day 10 was measured2003Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice.
AID110711Average sample intake of the diabetic KK-Ay mice was measured as average food intake/average body weight of mice2003Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice.
AID1432492Inhibition of Bacillus subtilis N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 100 uM after 1 hr relative to control2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.
AID547823Cytotoxicity against african green monkey TF-104 cells after 72 hrs by MTT assay2010Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21
In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.
AID458822Inhibition of Spanish flu (A/Bervig_Mission/1/18) neuraminidase at 200 uM2010Bioorganic & medicinal chemistry letters, Feb-01, Volume: 20, Issue:3
Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.
AID1432497Inhibition of Bacillus subtilis N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) at 100 uM after 1 hr relative to control2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.
AID1432493Inhibition of Bacillus subtilis N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 200 uM after 1 hr relative to control2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.
AID1432499Inhibition of Bacillus subtilis N-terminal hexahistidine-tagged FtsZ V307R mutant GTPase activity expressed in Escherichia coli BL21 (DE3) after 1 hr relative to wild type protein2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.
AID1432495Inhibition of Escherichia coli N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 100 uM after 1 hr relative to control2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.
AID1432500Antibacterial activity against Bacillus subtilis NBRC 3134 after overnight incubation by MTT assay2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.
AID109804Blood glucose level of the diabetic KK-Ay mice on day 0 was measured2003Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice.
AID547825Selectivity index, ratio of CC50 for african green monkey TF-104 cells to EC50 for KJ56-1 Bovine rotavirus G8P[7] by virucidal assay2010Bioorganic & medicinal chemistry, Nov-01, Volume: 18, Issue:21
In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis.
AID109828Body weight of the non-fasted diabetic KK-Ay mice on day 4 was measured2003Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice.
AID1432496Inhibition of Escherichia coli N-terminal hexahistidine-tagged FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as residual activity at 200 uM after 1 hr relative to control2017Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's6 (75.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 61.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index61.18 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index195.48 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (61.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pioglitazone
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.. pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.		2.0110aromatic ether;
pyridines;
thiazolidinediones		antidepressant;
cardioprotective agent;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hypoglycemic agent;
insulin-sensitizing drug;
PPARgamma agonist;
xenobiotic
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.		2.0610penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.		2.1510kanamycinsbacterial metabolite
galantamine
Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.		2.1310benzazepine alkaloid fundamental parent;
benzazepine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound		antidote to curare poisoning;
cholinergic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite
glycyrrhizic acid
glycyrrhizinic acid : A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.		2.4520enone;
glucosiduronic acid;
pentacyclic triterpenoid;
tricarboxylic acid;
triterpenoid saponin		EC 3.4.21.5 (thrombin) inhibitor;
plant metabolite
2-tert-butylhydroquinone
2-tert-butylhydroquinone: an anticarcinogenic and chemopreventive agent. 2-tert-butylhydroquinone : A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.		2.1310hydroquinonesfood antioxidant
irinotecan
[no description available]		2.1310carbamate ester;
delta-lactone;
N-acylpiperidine;
pyranoindolizinoquinoline;
ring assembly;
tertiary alcohol;
tertiary amino compound		antineoplastic agent;
apoptosis inducer;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
prodrug
ursolic acid
[no description available]		2.1310hydroxy monocarboxylic acid;
pentacyclic triterpenoid		geroprotector;
plant metabolite
oseltamivir
Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.		2.0510acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
gliclazide
18alpha-glycyrrhetinic acid: a gap junction inhibitor		2.1310
tamiflu
[no description available]		2.1310phosphate salt
liquiritigenin
liquiritigenin: structure given in first source; isolated from Pterocarpus marsupium. 4',7-dihydroxyflavanone : A dihydroxyflavanone in which the two hydroxy substituents are located at positions 4' and 7.. liquiritigenin : A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta.		2.49204',7-dihydroxyflavanonehormone agonist;
plant metabolite
gu 7
GU 7: structure given in first source; isolated from Glycyrrhizae Radix		2.0510isoflavonoid;
organic hydroxy compound
glabridin
[no description available]		2.1310hydroxyisoflavansantiplasmodial drug
ononin
[no description available]		2.05104'-methoxyisoflavones;
7-hydroxyisoflavones 7-O-beta-D-glucoside;
monosaccharide derivative		plant metabolite
benzyloxycarbonylleucyl-leucyl-leucine aldehyde
benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor. N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.		2.1310amino aldehyde;
carbamate ester;
tripeptide		proteasome inhibitor
gancaonin I
gancaonin I : A member of the class of 1-benzofurans which consists of 1-benzofuran substituted by methoxy groups at positions 4 and 6, a prenyl group at position 5 and a 2,4-dihydroxyphenyl group at position 2. It has been isolated from Glycyrrhiza uralensis.		2.54201-benzofurans;
aromatic ether;
resorcinols		antibacterial agent;
plant metabolite
6,8-diprenylgenistein
6,8-diprenylgenistein: a lysoPAF acetyltransferase inhibitor isolated from licorice root; structure in first source. 5,7,4'-trihydroxy-6,8-diprenylisoflavone : A member of the class of 7-hydroxyisoflavones that is genistein substituted by prenyl groups at positions 6 and 8. It has been isolated from Derris scandens and Glycyrrhiza uralensis.		2.13107-hydroxyisoflavonesantibacterial agent;
plant metabolite
glyasperin D
glyasperin D : A member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4', methoxy groups at positions 5 and 7 and a prenyl group at position 6. It has been isolated from Glycyrrhiza uralensis.		2.9940aromatic ether;
hydroxyisoflavans;
methoxyisoflavan		plant metabolite
licoricidin
licoricidin: a lysoPAF acetyltransferase inhibitor isolated from licorice root; structure in first source. licoricidin : A member of the class of hydroxyisoflavans that is R-isoflavan with hydroxy groups at positions 7, 2' and 4', a methoxy group at position 5 and prenyl groups at positions 6 and 3'. Isolated from Glycyrrhiza uralensis, it exhibits antibacterial activity.		2.7430aromatic ether;
hydroxyisoflavans;
methoxyisoflavan		antibacterial agent;
plant metabolite
licocoumarone
licocoumarone: has anti-inflammatory activity; isolated from Glycyrrhiza uralensis; structure in first source. licocoumarone : A member of the class of 1-benzofurans which consists of 1-benzofuran substituted by a hydroxy group at position 6, a methoxy group at position 4, a prenyl group at position 5 and a 2,4-dihydroxyphenyl group at position 2. It has been isolated from Glycyrrhiza uralensis.		3401-benzofurans;
aromatic ether;
resorcinols		antibacterial agent;
apoptosis inducer;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite
likviriton
liquiritin: isoalted from Glycyrrhizae radix. liquiritin : A flavanone glycoside that is liquiritigenin attached to a beta-D-glucopyranosyl residue at position 4' via a glycosidic linkage.		2.0510beta-D-glucoside;
flavanone glycoside;
monohydroxyflavanone;
monosaccharide derivative		anti-inflammatory agent;
anticoronaviral agent;
plant metabolite
isoliquiritigenin
[no description available]		2.4920chalconesantineoplastic agent;
biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
GABA modulator;
geroprotector;
metabolite;
NMDA receptor antagonist
curcumin
Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.		2.1310aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
kaempferol
[no description available]		2.13107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
genistein
[no description available]		2.05107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
glycycoumarin
glycycoumarin: from the root of Glycyrrhizae Radix, acts as a potent antispasmodic through inhibition of phosphodiesterase 3; structure in first source. glycycoumarin : A member of the class of coumarins that is coumarin substituted by a hydroxy group at position 7, a methoxy group at position 5, a prenyl group at position 6 and a 2,4-dihydroxyphenyl group at position 3. Isolated from Glycyrrhiza uralensis, it exhibits antispasmodic activity.		2.830aromatic ether;
coumarins;
resorcinols		antispasmodic drug;
plant metabolite
Isolicoflavonol
[no description available]		2.5420flavones
Kumatakenin
[no description available]		2.0510ether;
flavonoids
Licoflavone A
[no description available]		2.1310flavones
3-deoxysappanchalcone
3-deoxysappanchalcone: Anti-allergic from the roots and heartwood of Caesalpinia sappan; structure in first source. 2'-O-methylisoliquiritigenin : A member of the class of chalcones that is isoliquiritigenin in which one of the hydroxy groups at position 2' is replaced by a methoxy group.		2.4620chalcones;
monomethoxybenzene;
phenols		metabolite
neoglycyrol
neoglycyrol: structure given in first source; from Glycyrrhiza uralensis Fisch. glycyrol : A member of the class of coumestans that is coumestan substituted by hydroxy groups at positions 1 and 9, a methoxy group at position 3 and a prenyl group at position 2 respectively.		2.9840aromatic ether;
coumestans;
delta-lactone;
polyphenol		antineoplastic agent;
plant metabolite
3-o-methylbutein
3-O-methylbutein: RN given refers to (E)-isomer; structure given in first source		2.1310chalcones
isoangustone a
isoangustone A: antioxidant isolated from Glycyrrhiza uralensis; structure in first source		2.1310isoflavanones
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.4420benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Diabetes Mellitus, Adult-Onset
[description not available]		02.0110
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.		02.0110
Infections, Respiratory
[description not available]		0210
Respiratory Tract Infections
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.		0210