fascia adherens
Definition
Target type: cellularcomponent
A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes. [GOC:aruk, GOC:bc, GOC:mtg_muscle, PMID:11732910]
Fascia adherens, also known as zonula adherens, is a type of cell-cell junction that plays a crucial role in maintaining tissue integrity and cell adhesion. It is characterized by a dense plaque-like structure located on the cytoplasmic side of the plasma membrane, where the actin cytoskeleton is anchored. This plaque is composed of a complex network of proteins, including:
* **Cadherins:** These transmembrane proteins are responsible for cell-cell adhesion. They bind to cadherins on adjacent cells in a calcium-dependent manner, forming strong intercellular connections. In fascia adherens, the primary cadherin is **E-cadherin**.
* **Catenins:** These proteins link cadherins to the actin cytoskeleton. Alpha-catenin directly interacts with cadherins and actin filaments, while beta-catenin connects alpha-catenin to cadherins.
* **Actin filaments:** These cytoskeletal filaments provide structural support and are involved in cell shape, motility, and signaling.
* **Other associated proteins:** Additional proteins, such as nectin, afadin, and p120 catenin, are also found in fascia adherens and contribute to its assembly, regulation, and stability.
The fascia adherens is closely associated with other cell junctions, such as tight junctions and desmosomes. This complex interplay of junctions ensures proper cell-cell adhesion, communication, and tissue organization.
Functionally, fascia adherens play several important roles:
* **Cell adhesion:** The strong adhesive properties of fascia adherens help to maintain tissue integrity and prevent cells from separating.
* **Cell signaling:** Fascia adherens are involved in cell signaling pathways, including those related to growth, differentiation, and development.
* **Regulation of cell behavior:** They influence cell shape, motility, and polarity, contributing to tissue morphogenesis and homeostasis.
The intricate structure and function of fascia adherens are essential for maintaining the integrity and organization of tissues, ensuring proper cell-cell communication, and supporting various cellular processes.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Catenin beta-1 | A catenin beta-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35222] | Homo sapiens (human) |
| Gap junction alpha-1 protein | A gap junction alpha-1 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17302] | Homo sapiens (human) |
Compounds (7)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| kanamycin a | kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components. Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components. | kanamycins | bacterial metabolite |
| salvin | salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae) | abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid | angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite |
| toxoflavin | toxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. toxoflavin: azapteridine antibiotic; structure | carbonyl compound; pyrimidotriazine | antibacterial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; toxin; virulence factor; Wnt signalling inhibitor |
| cercosporin | cercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora. cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants | ||
| LSM-42773 | aromatic ketone | ||
| etodolac, (-)-isomer | (R)-etodolac : The R-enantiomer of etodolac. It is inactive, in contrast to the enantiomer, (S)-etodolac, which is a preferential inhibitor of cyclo-oxygenase 2 and a non-steroidal anti-inflammatory. The racemate is commonly used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. | etodolac | |
| ucn 1028 c | calphostin C: structure given in first source; isolated from Cladosporium cladosporioides |