kanamycin a has been researched along with ethacrynic acid in 70 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (47.14) | 18.7374 |
| 1990's | 12 (17.14) | 18.2507 |
| 2000's | 13 (18.57) | 29.6817 |
| 2010's | 12 (17.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Guth, PS; Stockwell, M | 1 |
| Gnanapragasam, A | 1 |
| Iaroshevich, VI | 1 |
| Hybels, RL | 1 |
| Brown, RT; Brummett, RE; Himes, DL | 1 |
| Brummett, RE; Fox, KE; Russell, NJ | 1 |
| Asakuma, S; Beaugard, ME; Snow, JB | 2 |
| Nakai, Y | 1 |
| Moran, WB | 1 |
| Altschuler, RA; Raphael, Y | 1 |
| Altschuler, RA; Hartshorn, DO; Miller, JM | 1 |
| Bobbin, RP; Ceasar, G; Fallon, M | 1 |
| Miller, JM | 1 |
| Cannon, SC; Jyung, RW; Miller, JM | 1 |
| Hoffman, DW; Jones, KL; Rybak, LP; Whitworth, CA | 1 |
| Kawamoto, K; Kusakari, J; Ohyama, K | 1 |
| Sheffield, PA; Turner, JS | 1 |
| D'Arcy, PF; Harpur, ES | 2 |
| Farmer, JC; Hudson, WR; Kaku, Y | 1 |
| Paparella, MM | 1 |
| Crifò, S | 1 |
| Falk, SA | 1 |
| Jones, HC | 1 |
| Brummett, RE; Himes, DL; West, BA | 1 |
| Ernstson, S | 2 |
| Hamilton, CH; Johnson, AH | 1 |
| Matz, GJ; Naunton, RF | 1 |
| Humes, LE | 1 |
| Bleeker, JD; Wit, HP | 1 |
| Lietman, PS; Smith, CR | 1 |
| Webster, DB; Webster, M | 2 |
| Beaugard, ME | 1 |
| Clark, GM; Martin, RL; Matsushima, J; Shepherd, RK | 1 |
| Hartmann, R; Klinke, R; Pfennigdorff, T | 1 |
| Clark, GM; Shepherd, RK; Xu, SA | 1 |
| Chen, Y; Clark, GM; Shepherd, RK; Xu, SA | 1 |
| Altschuler, RA; Frey, K; Miller, JM; Schacht, J; Schwartz, DR | 1 |
| Martin, RL; Shepherd, RK | 1 |
| Butterfield, DA; Clerici, WJ; DiMartino, DL; Hensley, K | 1 |
| Haruta, A; Kato, E; Komune, S; Matsuda, K; Tono, T; Yamasaki, M | 1 |
| Collins, F; Hever, G; Keithley, E; Kuang, R; Louis, JC; Magal, E; Yan, Q; Zajic, G | 1 |
| Doi, T; Himeno, C; Izumikawa, M; Komeda, M; Kuriyama, H; Miller, JM; Takemura, K; Weiping, Y; Yagi, M; Yamashita, T | 1 |
| Kondo, K; Miyajima, C; Suzuki, M; Yamasoba, T | 1 |
| Abbas, PJ; Hu, N; Miller, CA; Nourski, KV | 1 |
| Abrashkin, KA; Brough, DE; Dolan, DF; Izumikawa, M; Kawamoto, K; Minoda, R; Raphael, Y; Swiderski, DL | 1 |
| Kondo, K; Yamasoba, T | 1 |
| Abrashkin, KA; Beyer, LA; Crumling, MA; Gong, TW; Izumikawa, M; Miyazawa, T; Raphael, Y; Swiderski, DL; Wang, CH | 1 |
| Asoh, S; Kashio, A; Ohta, S; Sakamoto, T; Suzukawa, K; Yamasoba, T | 1 |
| Abrashkin, KA; Humayun, N; Lee, VA; Raphael, Y; Rejali, D; Swiderski, DL | 1 |
| Izumikawa, M; Kim, YH; Osumi, Y; Raphael, Y | 1 |
| Altschuler, RA; Bitsche, M; Glueckert, R; Miller, JM; Prieskorn, DM; Schrott-Fischer, A; Zhu, Y | 1 |
| Brown, M; Fallon, JB; Irvine, DR; Shepherd, RK | 1 |
| Ding, DL; Jiang, HY; Liu, H; Salvi, R; Sun, H; Wu, XW | 1 |
| Hamanishi, S; Inaoka, T; Ito, J; Kawano, S; Nakagawa, T; Ogita, H; Sakamoto, T; Shintaku, H; Wada, H | 1 |
| Asoh, S; Kakigi, A; Kashio, A; Kondo, K; Ohta, S; Sakamoto, T; Sato, Y; Suzukawa, K; Suzuki, M; Yamasoba, T | 1 |
| Esser, KH; Gross, G; Hoffmann, A; Lenarz, T; Paasche, G; Reich, U; Sasse, S; Scheper, V; Stöver, T; Warnecke, A; Wenzel, GI; Wissel, K | 1 |
| Kng, W; Yin, Z | 1 |
| Allman, BL; Meredith, MA | 1 |
| Jang, JH; Lee, HS; Oh, SH; Park, MH | 1 |
4 review(s) available for kanamycin a and ethacrynic acid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Otorhinolaryngology.
Topics: Animals; Deafness; Ear Diseases; Electrodiagnosis; Ethacrynic Acid; Fibroma; Guinea Pigs; Humans; Kanamycin; Laryngeal Neoplasms; Laryngeal Nerves; Laryngostenosis | 1976 |
Non-sensory cells in the deafened organ of Corti: approaches for repair.
Topics: Animals; Anti-Bacterial Agents; Deafness; Epithelium; Ethacrynic Acid; Genetic Therapy; Hair Cells, Auditory; Kanamycin; Labyrinth Supporting Cells; Models, Biological; Neomycin; Organ of Corti; Regeneration | 2007 |
[Research progress of acute kanamycin sulfate-induced deafness in guinea pig].
Topics: Animals; Anti-Bacterial Agents; Cochlea; Deafness; Disease Models, Animal; Ethacrynic Acid; Guinea Pigs; Hair Cells, Auditory; Humans; Kanamycin; Neurons; Spiral Ganglion | 2012 |
1 trial(s) available for kanamycin a and ethacrynic acid
| Article | Year |
|---|---|
Effect of furosemide on aminoglycoside-induced nephrotoxicity and auditory toxicity in humans.
Topics: Aminoglycosides; Anti-Bacterial Agents; Drug Interactions; Ear; Ethacrynic Acid; Furosemide; Humans; Kanamycin; Kidney; Middle Aged | 1983 |
65 other study(ies) available for kanamycin a and ethacrynic acid
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Guanylate cyclase and cyclic guanosine monophosphate in the guinea-pig cochlea.
Topics: Animals; Cochlea; Cochlear Nerve; Cyclic AMP; Cyclic GMP; Deafness; Ethacrynic Acid; Guanylate Cyclase; Guinea Pigs; Kanamycin; Olivary Nucleus | 1977 |
Ototoxic therapeutic agents.
Topics: Animals; Anti-Bacterial Agents; Chloramphenicol; Deafness; Dihydrostreptomycin Sulfate; Ethacrynic Acid; Female; Humans; Infant, Newborn; Kanamycin; Neomycin; Pregnancy; Quinine; Salicylates; Streptomycin | 1975 |
[Ototoxicity of some drug agents].
Topics: Age Factors; Aminoglycosides; Bleomycin; Cochlea; Deafness; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Ear; Ethacrynic Acid; Furosemide; Hearing Disorders; Humans; Kanamycin; Neomycin; Streptomycin; Toxicology; Vestibule, Labyrinth; Viomycin | 1975 |
Drug toxicity of the inner ear.
Topics: Animals; Chloroquine; Dihydrostreptomycin Sulfate; Ethacrynic Acid; Furosemide; Gentamicins; Humans; Kanamycin; Labyrinth Diseases; Neomycin; Quinine; Salicylates; Streptomycin; Tobramycin | 1979 |
Quantitative relationships of the ototoxic interaction of kanamycin and ethacrynic acid.
Topics: Animals; Cochlea; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Ethacrynic Acid; Guinea Pigs; Hearing Loss, Sensorineural; Humans; Kanamycin; Organ of Corti; Sound | 1979 |
Ototoxic effects of the interaction between kanamycin and ethacrynic acid. Cochlear ultrastructure correlated with cochlear potentials and kanamycin levels.
Topics: Animals; Cochlea; Drug Synergism; Ethacrynic Acid; Evoked Potentials, Auditory; Guinea Pigs; Hair Cells, Auditory; Kanamycin; Organ of Corti; Stria Vascularis; Time Factors | 1979 |
Comparative ototoxicity of chloramphenicol and kanamycin with ethacrynic acid.
Topics: Acoustic Stimulation; Animals; Chloramphenicol; Drug Interactions; Ear; Ear, Middle; Ethacrynic Acid; Guinea Pigs; Kanamycin; Mucous Membrane; Reflex | 1979 |
Combined effect of 3', 4'-dideoxykanamycin B and potent diuretics on the cochlea. (A scanning and transmission electron microscopic evaluation).
Topics: Animals; Cochlea; Dibekacin; Drug Synergism; Ethacrynic Acid; Furosemide; Guinea Pigs; Hair Cells, Auditory; Hearing Disorders; Kanamycin; Mice; Microscopy, Electron; Microscopy, Electron, Scanning; Mitochondria; Organ of Corti | 1977 |
Scar formation after drug-induced cochlear insult.
Topics: Actin Cytoskeleton; Actins; Animals; Cicatrix; Cochlea; Ethacrynic Acid; Guinea Pigs; Hair Cells, Auditory; Histocytochemistry; Kanamycin; Keratins; Microscopy, Electron; Organ of Corti | 1991 |
Protective effect of electrical stimulation in the deafened guinea pig cochlea.
Topics: Animals; Auditory Threshold; Cell Nucleus; Cell Survival; Cytoplasm; Deafness; Electric Stimulation; Electrodes, Implanted; Ethacrynic Acid; Evoked Potentials, Auditory; Guinea Pigs; Hair Cells, Auditory; Kanamycin; Reaction Time; Scala Tympani; Spiral Ganglion | 1991 |
Potassium induced release of GABA and other substances from the guinea pig cochlea.
Topics: Animals; Cochlea; Ethacrynic Acid; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Guinea Pigs; Kanamycin; Male; Potassium; Taurine | 1990 |
Physiologic measures of electrically evoked auditory system responsiveness: effects of pathology and electrical stimulation.
Topics: Acoustic Stimulation; Anesthesia; Animals; Auditory Threshold; Cell Survival; Cochlea; Electric Stimulation; Ethacrynic Acid; Evoked Potentials, Auditory; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Kanamycin; Round Window, Ear; Scala Tympani; Spiral Ganglion; Tetrodotoxin | 1991 |
Evaluation of eighth nerve integrity by the electrically evoked middle latency response.
Topics: Animals; Auditory Threshold; Cell Count; Electric Stimulation; Ethacrynic Acid; Evoked Potentials, Auditory; Guinea Pigs; Kanamycin; Reaction Time; Spiral Ganglion; Vestibulocochlear Nerve | 1989 |
Nutritional status, glutathione levels, and ototoxicity of loop diuretics and aminoglycoside antibiotics.
Topics: Animals; Chinchilla; Cochlea; Deafness; Drug Synergism; Ethacrynic Acid; Evoked Potentials, Auditory; Food Deprivation; Glutathione; Hearing Loss; Inactivation, Metabolic; Kanamycin; Liver; Nutritional Status | 1987 |
Ultrasonic electrocochleography in guinea pig.
Topics: Animals; Asphyxia; Body Temperature; Cochlea; Cochlear Microphonic Potentials; Ethacrynic Acid; Guinea Pigs; Hearing; Kanamycin; Reaction Time; Ultrasonics | 1985 |
Ototoxic drugs: a review of clinical aspects, histopathologic changes and mechanisms of action.
Topics: Animals; Anti-Bacterial Agents; Antimalarials; Aspirin; Chloroquine; Cochlea; Dihydrostreptomycin Sulfate; Ear, Inner; Ethacrynic Acid; Female; Hearing Disorders; Humans; Kanamycin; Neomycin; Poisons; Pregnancy; Quinine; Streptomycin | 1971 |
Screening drugs for ototoxicity.
Topics: Animals; Deafness; Ethacrynic Acid; Injections, Intraperitoneal; Injections, Intravenous; Kanamycin; Mice; Mice, Inbred DBA | 1972 |
Ototoxic drug effects on cochlear histochemistry.
Topics: Adenosine Triphosphatases; Animals; Cochlea; Dihydrolipoamide Dehydrogenase; Ear, Middle; Ethacrynic Acid; Guinea Pigs; Histocytochemistry; Kanamycin; Organ of Corti; Succinate Dehydrogenase; Time Factors | 1973 |
The dizzy patient.
Topics: Diazepam; Drainage; Ear; Ear Neoplasms; Ethacrynic Acid; Gentamicins; Hearing Disorders; Humans; Inflammation; Kanamycin; Labyrinth Diseases; Meniere Disease; Neoplasm Metastasis; Posture; Streptomycin; Vertigo; Vestibular Function Tests; Vestibular Nerve; Viomycin | 1972 |
Identification of ototoxic drugs by guinea pig shiver audiometry.
Topics: Animals; Audiometry; Auditory Threshold; Avoidance Learning; Deafness; Disease Models, Animal; Drug Evaluation, Preclinical; Ear; Ear Diseases; Electroshock; Ethacrynic Acid; Female; Guinea Pigs; Kanamycin; Male; Organ of Corti; Shivering; Sodium; Sulfates | 1974 |
Combined effects of noise and ototoxic drugs.
Topics: Animals; Anti-Bacterial Agents; Cochlea; Diuretics; Environmental Exposure; Ethacrynic Acid; Furosemide; Guinea Pigs; Haplorhini; Hearing Disorders; Humans; Kanamycin; Microscopy, Electron; Neomycin; Noise; Occupational Diseases; Organ of Corti; Quinine; Salicylates; Sound; Streptomycin | 1972 |
Intrauterine ototoxicity. A case report and review of literature.
Topics: Abnormalities, Drug-Induced; Adult; Deafness; Ear; Ethacrynic Acid; Female; Fetus; Humans; Kanamycin; Maternal-Fetal Exchange; Pregnancy | 1973 |
Interaction of kanamycin and ethacrynic acid. Severe cochlear damage in guinea pigs.
Topics: Acoustic Stimulation; Action Potentials; Animals; Cochlea; Drug Interactions; Epithelial Cells; Epithelium; Ethacrynic Acid; Guinea Pigs; Hearing Disorders; Injections, Intravenous; Injections, Subcutaneous; Kanamycin; Methods; Sensory Receptor Cells; Time Factors | 1973 |
Laboratory testing for ototoxic effects of drugs.
Topics: Animals; Ear Diseases; Ethacrynic Acid; Furosemide; Hearing Disorders; Hearing Tests; Kanamycin; Mice; Mice, Inbred Strains; Reflex, Startle; Toxicology | 1973 |
Drug-induced deafness.
Topics: Adult; Anti-Bacterial Agents; Aspirin; Deafness; Drug-Related Side Effects and Adverse Reactions; Ethacrynic Acid; Gentamicins; Glycosides; Humans; Injections, Intravenous; Kanamycin; Male; Middle Aged; Neomycin; Paromomycin; Quinidine | 1973 |
Ethacrynic acid-induced hearing loss in guinea pigs.
Topics: Animals; Audiometry; Auditory Threshold; Deafness; Ethacrynic Acid; Guinea Pigs; Hearing Tests; Kanamycin | 1972 |
Kanamycin ototoxicity--possible potentiation by other drugs.
Topics: Adult; Deafness; Drug Synergism; Ethacrynic Acid; Female; Humans; Kanamycin; Male; Mannitol; Middle Aged; Neomycin; Streptomycin | 1970 |
[Hearing tests on ototoxic-treated guinea pigs].
Topics: Animals; Auditory Threshold; Ethacrynic Acid; Guinea Pigs; Kanamycin | 1971 |
Ototoxic drugs and poor renal function.
Topics: Animals; Audiometry; Cats; Cochlea; Ethacrynic Acid; Hearing Disorders; Humans; Kanamycin; Kidney; Kidney Diseases; Kidney Function Tests; Vestibular Function Tests | 1968 |
Noise-induced hearing loss as influenced by other agents and by some physical characteristics of the individual.
Topics: Acoustic Stimulation; Age Factors; Animals; Ethacrynic Acid; Eye Color; Furosemide; Hearing Loss, Noise-Induced; Hearing Loss, Sensorineural; Humans; Kanamycin; Melanins; Neomycin; Presbycusis; Risk; Salicylates; Vibration | 1984 |
A possible method to study transient effects of ototoxic agents on the vestibular system.
Topics: Animals; Cochlear Nerve; Columbidae; Ethacrynic Acid; Evoked Potentials, Auditory; Furosemide; Kanamycin; Vestibular Nerve; Vestibule, Labyrinth | 1983 |
Multipolar spiral ganglion neurons following organ of Corti loss.
Topics: Animals; Cochlea; Deafness; Denervation; Ethacrynic Acid; Guinea Pigs; Kanamycin; Nerve Regeneration; Neurons; Organ of Corti; Spiral Ganglion | 1982 |
Spiral ganglion neuron loss following organ of Corti loss: a quantitative study.
Topics: Animals; Auditory Pathways; Cell Count; Cochlea; Ethacrynic Acid; Guinea Pigs; Hair Cells, Auditory; Hearing Loss, Noise-Induced; Kanamycin; Neurons; Organ of Corti; Spiral Ganglion | 1981 |
Comparative ototoxicity of chloramphenicol and kanamycin with ethacrynic acid.
Topics: Animals; Chloramphenicol; Ethacrynic Acid; Guinea Pigs; Hearing Loss, Sensorineural; Kanamycin | 1981 |
Comparative ototoxicity of chloramphenicol and kanamycin with ethacrynic acid.
Topics: Animals; Auditory Threshold; Chloramphenicol; Cochlea; Drug Synergism; Ear; Ethacrynic Acid; Guinea Pigs; Kanamycin; Sodium Chloride | 1981 |
Cochlear pathology following chronic electrical stimulation of the auditory nerve: II. Deafened kittens.
Topics: Analysis of Variance; Animals; Bone Development; Cats; Cell Count; Cell Survival; Cochlea; Cochlear Implants; Electric Stimulation; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Hair Cells, Auditory; Hearing Loss, Sensorineural; Kanamycin; Organ of Corti; Scala Tympani; Spiral Ganglion; Vestibulocochlear Nerve | 1994 |
Evoked potentials from the auditory nerve following sinusoidal electrical stimulation of the cochlea: new possibilities for preoperative testing in cochlear-implant candidates?
Topics: Acoustic Stimulation; Action Potentials; Animals; Artifacts; Cats; Cochlea; Cochlear Implants; Deafness; Disease Models, Animal; Electric Stimulation; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Humans; Kanamycin; Neomycin; Vestibulocochlear Nerve | 1994 |
Partial hearing loss in the macaque following the co-administration of kanamycin and ethacrynic acid.
Topics: Animals; Auditory Threshold; Dose-Response Relationship, Drug; Drug Synergism; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Hearing Loss, Bilateral; Kanamycin; Macaca fascicularis; Renal Insufficiency | 1994 |
Profound hearing loss in the cat following the single co-administration of kanamycin and ethacrynic acid.
Topics: Animals; Cats; Cochlea; Deafness; Dendrites; Disease Models, Animal; Dose-Response Relationship, Drug; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Hair Cells, Auditory; Kanamycin; Kidney; Organ of Corti; Spiral Ganglion | 1993 |
Chronic electrical stimulation reverses deafness-related depression of electrically evoked 2-deoxyglucose activity in the guinea pig inferior colliculus.
Topics: Animals; Cochlea; Cochlear Implants; Deafness; Deoxyglucose; Electric Stimulation; Electrodes, Implanted; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Inferior Colliculi; Kanamycin | 1993 |
Onset of ototoxicity in the cat is related to onset of auditory function.
Topics: Aging; Animals; Anti-Bacterial Agents; Audiometry; Auditory Cortex; Auditory Threshold; Cats; Cochlea; Deafness; Diuretics; Drug Synergism; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Hearing Loss, High-Frequency; Kanamycin | 1995 |
Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cisplatin; Cochlea; Cyclic N-Oxides; Diuretics; Electron Spin Resonance Spectroscopy; Ethacrynic Acid; Female; Furosemide; Gentamicins; Guinea Pigs; Hydrogen Peroxide; Hydroxyl Radical; Kanamycin; Male; Perilymph; Quinine; Spin Labels; Trimethyltin Compounds | 1996 |
A role of glutamate in drug-induced ototoxicity: in vivo microdialysis study combined with on-line enzyme fluorometric detection of glutamate in the guinea pig cochlea.
Topics: Animals; Anti-Bacterial Agents; Diuretics; Ethacrynic Acid; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory, Inner; Hair Cells, Auditory, Outer; Kanamycin; Microdialysis; Perilymph; Stria Vascularis | 2000 |
Glial cell line-derived neurotrophic factor. Potential for otoprotection.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cells, Cultured; Cisplatin; Enzyme Inhibitors; Ethacrynic Acid; Glial Cell Line-Derived Neurotrophic Factor; Guinea Pigs; Hair Cells, Auditory, Outer; Humans; Kanamycin; Nerve Growth Factors; Nerve Tissue Proteins; Neuroprotective Agents; Rats; Rats, Long-Evans; Rats, Wistar; Scala Tympani | 1999 |
Intra-cochlear administration of dexamethasone attenuates aminoglycoside ototoxicity in the guinea pig.
Topics: Animals; Anti-Bacterial Agents; Cell Survival; Cochlea; Dexamethasone; Drug Delivery Systems; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Glucocorticoids; Guinea Pigs; Hair Cells, Auditory, Outer; Kanamycin; Male | 2002 |
Changes in cell proliferation in rat and guinea pig cochlea after aminoglycoside-induced damage.
Topics: Aminoglycosides; Animals; Cell Division; Cochlea; Deafness; Ethacrynic Acid; Guinea Pigs; Hair Cells, Auditory; Kanamycin; Rats; Species Specificity | 2003 |
Co-administration of kanamycin and ethacrynic acid as a deafening method for acute animal experiments.
Topics: Animals; Deafness; Disease Models, Animal; Drug Synergism; Ethacrynic Acid; Guinea Pigs; Kanamycin | 2004 |
Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals.
Topics: Adenoviridae; Animals; Cochlea; DNA-Binding Proteins; Ethacrynic Acid; Gene Expression Regulation, Developmental; Genetic Therapy; Guinea Pigs; Hair Cells, Auditory; Hearing Loss, Sensorineural; Helix-Loop-Helix Motifs; Kanamycin; Nerve Regeneration; Nerve Tissue Proteins; Transcription Factors | 2005 |
Supporting cell proliferation after hair cell injury in mature guinea pig cochlea in vivo.
Topics: Animals; Anti-Bacterial Agents; Bromodeoxyuridine; Cell Division; Cell Survival; Cochlea; Enzyme Inhibitors; Ethacrynic Acid; Guinea Pigs; Hair Cells, Auditory; Immunohistochemistry; Kanamycin; Labyrinth Supporting Cells; Time Factors | 2006 |
The fate of outer hair cells after acoustic or ototoxic insults.
Topics: Animals; Cell Death; Ethacrynic Acid; Female; Guinea Pigs; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Kanamycin; Male; Mice; Molecular Motor Proteins; Proteins; RNA, Messenger | 2006 |
A protein derived from the fusion of TAT peptide and FNK, a Bcl-x(L) derivative, prevents cochlear hair cell death from aminoglycoside ototoxicity in vivo.
Topics: Aminoglycosides; Analysis of Variance; Animals; bcl-X Protein; Cell Death; Cochlea; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Gene Products, tat; Guinea Pigs; Hair Cells, Auditory; Hearing Loss; Immunohistochemistry; Kanamycin; Male; Neuroprotective Agents; Peptide Fragments; Recombinant Fusion Proteins | 2007 |
Cochlear implants and ex vivo BDNF gene therapy protect spiral ganglion neurons.
Topics: Adenoviridae; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cochlear Implantation; Cochlear Implants; Deafness; Disease Models, Animal; Ethacrynic Acid; Feasibility Studies; Fibroblasts; Genetic Therapy; Genetic Vectors; Guinea Pigs; Kanamycin; Nerve Degeneration; Neurons; Prosthesis Design; Sepharose; Spiral Ganglion; Transduction, Genetic | 2007 |
Deafferentation-associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar brain-derived neurotrophic factor and acidic fibroblast growth factor.
Topics: Animals; Auditory Pathways; Brain-Derived Neurotrophic Factor; Cochlea; Deafness; Enzyme Inhibitors; Ethacrynic Acid; Female; Fibroblast Growth Factor 1; Guinea Pigs; Image Processing, Computer-Assisted; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Kanamycin; Male; Microscopy, Confocal; Microscopy, Electron, Transmission; Nerve Regeneration; Neurons; Neurons, Afferent; Neurons, Efferent; Parvalbumins; Protein Synthesis Inhibitors; Synaptophysin; Time | 2008 |
Effects of neonatal partial deafness and chronic intracochlear electrical stimulation on auditory and electrical response characteristics in primary auditory cortex.
Topics: Acoustic Stimulation; Age Factors; Aging; Animals; Animals, Newborn; Auditory Cortex; Auditory Perception; Auditory Threshold; Cats; Cochlear Implantation; Cochlear Implants; Disease Models, Animal; Electric Stimulation; Ethacrynic Acid; Evoked Potentials, Auditory; Hearing Loss, High-Frequency; Kanamycin; Neuronal Plasticity; Reaction Time; Time Factors | 2009 |
Ototoxic destruction by co-administration of kanamycin and ethacrynic acid in rats.
Topics: Animals; Anti-Bacterial Agents; Deafness; Ear, Inner; Ethacrynic Acid; Hearing Loss; Kanamycin; Rats; Rats, Sprague-Dawley; Stria Vascularis | 2011 |
Piezoelectric materials mimic the function of the cochlear sensory epithelium.
Topics: Acoustic Stimulation; Animals; Basilar Membrane; Cochlea; Electronics; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Female; Guinea Pigs; Kanamycin | 2011 |
Topical application of the antiapoptotic TAT-FNK protein prevents aminoglycoside-induced ototoxicity.
Topics: Administration, Topical; Aminoglycosides; Animals; Apoptosis; Caspase 9; Cochlea; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Gene Products, tat; Guinea Pigs; Hair Cells, Auditory; Kanamycin; Labyrinth Diseases; Neuroprotective Agents; Protein Serine-Threonine Kinases; Rats; Recombinant Fusion Proteins; Round Window, Ear; Tumor Suppressor Proteins | 2012 |
Stable release of BDNF from the fibroblast cell line NIH3T3 grown on silicone elastomers enhances survival of spiral ganglion cells in vitro and in vivo.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Adhesion; Cell Culture Techniques; Cell Proliferation; Cell Survival; Coculture Techniques; Deafness; Disease Models, Animal; Ethacrynic Acid; Female; Fibroblasts; Genetic Vectors; Green Fluorescent Proteins; Guinea Pigs; Humans; Kanamycin; Lentivirus; Male; Mice; Neurons; NIH 3T3 Cells; Paracrine Communication; Rats; Rats, Sprague-Dawley; Silicone Elastomers; Spiral Ganglion; Time Factors; Transfection | 2012 |
Early hearing-impairment results in crossmodal reorganization of ferret core auditory cortex.
Topics: Acoustic Stimulation; Animals; Anti-Bacterial Agents; Auditory Cortex; Auditory Threshold; Diuretics; Electrophysiological Phenomena; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Ferrets; Hearing Disorders; Kanamycin; Magnetoencephalography; Neuronal Plasticity; Neurons; Photic Stimulation; Physical Stimulation; Thalamus | 2012 |
Efficacy of the cat deafening method: Co-administration of ethacrynic acid and kanamycin.
Topics: Animals; Cats; Deafness; Disease Models, Animal; Ethacrynic Acid; Kanamycin; Organ of Corti | 2016 |