| Assay ID | Title | Year | Journal | Article |
|---|
| AID704059 | Competitive inhibition of tetrahymena telomerase using 3'-ACT TCG TAG AGC AGA TTG-5' as substrate assessed as ratio of IC50 at saturated substrate concentration to IC50 at Km by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID704062 | Mixed type inhibition of telomerase in human HeLa cells using dNTP as substrate assessed as ratio of IC50 at saturated substrate concentration to IC50 at Km by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID1617940 | Antibacterial activity against Staphylococcus aureus ATCC 6538 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID1617947 | Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID1617943 | Antibacterial activity against Mycobacterium aurum ATCC 23366 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID704066 | Selectivity ratio of IC50 for telomerase in human HeLa cells to IC50 for tetrahymena telomerase by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID1617941 | Antibacterial activity against Micrococcus luteus ATCC 15307 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID704067 | Inhibition of tetrahymena telomerase using 3'-ACT TCG TAG AGC AGA TTG-5' as substrate at 1 uM incubated for 10 mins prior to extension reaction by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID704073 | Inhibition of telomerase in human K562 cells by modified telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID704057 | Noncompetitive inhibition of tetrahymena telomerase using dNTP as substrate assessed as ratio of IC50 at saturated substrate concentration to IC50 at Km by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID1617944 | Antibacterial activity against Escherichia coli ATCC 12435 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID704068 | Inhibition of tetrahymena telomerase using 3'-ACT TCG TAG AGC AGA TTG-5' as substrate incubated for 10 mins prior to extension reaction by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID704064 | Mixed type inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate assessed as ratio of IC50 at saturated substrate concentration to IC50 at Km by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID704077 | Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction followed by compound washout by spin-telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID1617946 | Antifungal activity against Saccharomyces cerevisiae ATCC 204508 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID1065399 | Inhibition of human telomerase activity by TRAP assay | 2014 | Journal of medicinal chemistry, Feb-13, Volume: 57, Issue:3
| Telomere maintenance as a target for drug discovery. |
| AID704076 | Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID704069 | Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate at 1 uM incubated for 15 mins prior to extension reaction by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID1617948 | Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID704055 | Inhibition of Thermus aquaticus DNA polymerase using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate after 15 mins by telomeric repeat amplification protocol | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID704070 | Binding affinity to Stenotrophomonas sp. TSG4 5'-(GGGATT)3GGGTT-3' DNA assessed as G-quadruplex stabilization at 2 uM by thermal melt analysis | 2012 | Journal of medicinal chemistry, Apr-26, Volume: 55, Issue:8
| A new strategy for detection and development of tractable telomerase inhibitors. |
| AID1617945 | Antibacterial activity against Salmonella enterica ATCC 10708 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| AID1617942 | Antibacterial activity against Bacillus subtilis ATCC 6633 after 16 to 48 hrs | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12
| Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |