d-glucaro-delta-lactam profile

D-glucaro-delta-lactam: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	451784
SCHEMBL ID	2792137
MeSH ID	M0042222

Synonym
d-glucaro-delta-lactam
SCHEMBL2792137

Excerpt	Relevance	Reference
" Protection was dosage related, and potentiated with increasing doses, but only when the two drugs were given simultaneously."	( Protective effect of D-glucaro-delta-lactam against amino-glycoside-induced nephrotoxicity in rats. Inouye, S; Koeda, T; Niida, T; Nizato, T; Tsuruoka, T, 1976)	0.26
"Intramuscular administration of glucarolactam in the form of aminoglycoside salt to guinea-pigs protected the experimental ototoxicity caused by high dosing of aminoglycoside antibiotics."	( Effect of glucarolactam on ototoxicity of aminoglycoside antibiotics in guinea-pigs. Inouye, S; Kitasato, I; Niizato, T; Yokota, M, 1989)	0.28

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (40.00)	18.7374
1990's	5 (50.00)	18.2507
2000's	1 (10.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gentamicin Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.	2.37	2
kanamycin a Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.	2.36	2	kanamycins	bacterial metabolite
glucaric acid Glucaric Acid: A sugar acid derived from D-glucose in which both the aldehydic carbon atom and the carbon atom bearing the primary hydroxyl group are oxidized to carboxylic acid groups.. D-glucaric acid : The D-enantiomer of glucaric acid.. glucaric acid : A hexaric acid derived by oxidation of sugar such as glucose with nitric acid.	3.68	10	glucaric acid	antineoplastic agent
ribostamycin Ribostamycin: A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus.. ribostamycin : An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-alpha-D-glucosyl residue attached at position 1 and a beta-D-ribosyl residue attached at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus).	1.96	1	amino cyclitol glycoside; aminoglycoside antibiotic	antibacterial drug; antimicrobial agent; metabolite
dibekacin Dibekacin: Analog of KANAMYCIN with antitubercular as well as broad-spectrum antimicrobial properties.. dibekacin : A kanamycin that is kanamycin B lacking the 3- and 4-hydroxy groups on the 2,6-diaminosugar ring.	1.97	1	kanamycins	antibacterial agent; protein synthesis inhibitor

Condition	Relationship Strength	Studies
Necrotizing Pyelonephritis [description not available]	1.96	1
Pyelonephritis Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA.	1.96	1
Experimental Hepatoma [description not available]	2.39	2
Cancer of Lung [description not available]	3.09	5
B16 Melanoma [description not available]	2.39	2
Experimental Mammary Neoplasms [description not available]	1.98	1
Invasiveness, Neoplasm [description not available]	2.91	4
Fibrosarcoma A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)	2.4	2
Lung Neoplasms Tumors or cancer of the LUNG.	3.09	5
Adenocarcinoma, Basal Cell [description not available]	1.98	1
Bladder Cancer [description not available]	1.98	1
Cancer of Ovary [description not available]	1.98	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	1.98	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	1.98	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	1.98	1
Carcinoma, Large Cell A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)	1.98	1
Metastase [description not available]	1.99	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	1.99	1
Adenocarcinoma Of Kidney [description not available]	2.4	2
Experimental Neoplasms [description not available]	1.99	1
Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.	2.4	2
Cancer of Colon [description not available]	2	1
Cancer of Head [description not available]	2	1
Cancer of Kidney [description not available]	2	1
Lymph Node Metastasis [description not available]	2	1
Malignant Melanoma [description not available]	2	1
Colonic Neoplasms Tumors or cancer of the COLON.	2	1
Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)	2	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	2	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2	1
Cancer of Liver [description not available]	2	1
Liver Neoplasms Tumors or cancer of the LIVER.	2	1
Dehydration The condition that results from excessive loss of water from a living organism.	2.36	2
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	2.65	3
Distorted Hearing [description not available]	1.97	1
Infections, Pseudomonas [description not available]	1.97	1
Pseudomonas Infections Infections with bacteria of the genus PSEUDOMONAS.	1.97	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.97	1

d-glucaro-delta-lactam

Description

Cross-References

Synonyms (2)

Research Excerpts

Dosage Studied

Research

Studies (10)

Study Types

d-glucaro-delta-lactam

Description

Cross-References

Synonyms (2)

Research Excerpts

Dosage Studied

Research

Studies (10)

Study Types

Related Drugs (5)

Related Conditions (39)