Klein Syndrome

Rare, autosomal dominant disease with variable penetrance and several known clinical types. Characteristics may include depigmentation of the hair and skin, congenital deafness, heterochromia iridis, medial eyebrow hyperplasia, hypertrophy of the nasal root, and especially dystopia canthorum. The underlying cause may be defective development of the neural crest (neurocristopathy). Waardenburg's syndrome may be closely related to piebaldism. Klein-Waardenburg Syndrome refers to a disorder that also includes upper limb abnormalities.

Synonym
Waardenburg Syndrome, Type 1
Waardenburg Syndrome with Upper Limb Anomalies
White Forelock (Poliosis) Syndrome with Multiple Congenital Malformations
Waardenburg-Klein Syndrome
Klein's Syndrome
Waardenburg Syndrome
Waardenburg Syndrome Type 3
Klein-Waardenburg Syndrome
Waardenburg's Syndrome Type 1
Waardenburg Syndrome Type 1
Waardenburg Syndrome, Type 3
Waardenburg's Syndrome
Klein Syndrome
Waardenburg Syndrome with Dystopia Canthorum
Waardenburg Syndrome, Type III

Excerpt	Reference
"Waardenburg-Klein syndrome is an "Oculo-dermato-auditif" dysplasia described in 1947 by Waardenburg and by Klein in 1950."	( Babagbeto, M; Bassabi, SK; Doutetien, C; Hounkpe, YY; Latoundji, S; Medji, AP; Oussa, G; Vodouhe, SJ, 1997)
"Waardenburg syndrome is a rare genetic disorder characterized by varying degree of deafness associated with pigmentary anomaly and defects of neural crest cell derived structures."	( Bansal, Y; Goyal, G; Jain, P; Mishra, C; Singh, M, 2013)
"The Waardenburg syndrome is a group of rare genetic diseases, which clinical manifestations include neurosensory hearing loss, diminished pigmentation of forelock in the frontal region, iris heterochromia, medial canthus dystopia, and the presence of such changes in first-line relatives."	( Astakhov, SY; Astakhov, YS; Lisochkina, AB; Shakhnazarova, AA; Takhtaev, YV; Tultseva, SN, 2019)
"Waardenburg syndrome is an autosomal dominant disorder with varying degrees of sensorineural hearing loss as well as abnormal pigmentation in hair, skin, and iris."	( Wan, Y; Wang, N; Zhang, L, 2022)
"Waardenburg syndrome is a rare genetic condition with an incidence of 1 in 212 000."	( George, FSA; Sam, LE; Tanwar, M; Wall, L, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	38 (42.22)	23.3326
1990's	14 (15.56)	12.5806
2000's	8 (8.89)	18.1394
2010's	23 (25.56)	28.8240
2020's	7 (7.78)	9.53

Drug	Relationship Strength	Studies
cytosine	low	1
iodine	low	1
thymine	low	1
uric acid	low	1
gentamicin	low	1
guanethidine	low	1
2-propanol	low	40
midazolam	low	1
thalidomide	low	1
serine	low	1
glutamine	low	1
physostigmine	low	1
kanamycin a	low	1
leucine	low	1
methionine	low	1
histidine	low	1
valine	low	1
arginine	low	2
ethylnitrosourea	low	3
streptomycin	low	1
etoposide	low	1
propiconazole	low	1
nsc-172755	low	1
proline	low	1
atropine	low	1
carboplatin	low	1
cocaine	low	1
isomethyleugenol	low	1
zinc oxide	low	1
quinine	low	1
phenylephrine hydrochloride	low	15
eye	low	14

Protein Targets (385)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	9	0	0	9
GLI family zinc finger 3	10	0	0	10
AR protein	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	5	0	0	5
retinoid X nuclear receptor alpha	6	0	0	6
estrogen nuclear receptor alpha	9	0	0	9
peroxisome proliferator-activated receptor delta	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Histone H2A.x	2	0	0	2
thyroid hormone receptor beta isoform a	3	0	0	3
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
lamin isoform A-delta10	6	0	0	6
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Glutamate receptor 2	4	0	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	4	0	0	4
phosphopantetheinyl transferase	5	0	0	5
NFKB1 protein, partial	1	0	0	1
GLS protein	3	0	0	3
thyroid stimulating hormone receptor	1	0	0	1
alpha-galactosidase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
cytochrome P450 2C19 precursor	1	0	0	1
chromobox protein homolog 1	4	0	0	4
flap endonuclease 1	3	0	0	3
DNA polymerase iota isoform a (long)	3	0	0	3
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	4	0	0	4
Cytochrome P450 3A4	0	3	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	4
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
glucocorticoid receptor [Homo sapiens]	6	0	0	6
pregnane X nuclear receptor	5	0	0	5
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	1	0	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	4	0	4
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
5-hydroxytryptamine receptor 4	0	2	0	2
Bile salt export pump	0	9	0	9
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M2	0	3	1	7
Muscarinic acetylcholine receptor M1	0	2	1	6
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	2	1	5
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	1	0	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	5	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, Cruzipain	1	0	0	1
USP1 protein, partial	2	0	0	2
Microtubule-associated protein tau	1	0	0	1
vitamin D3 receptor isoform VDRA	4	0	0	4
DNA polymerase kappa isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Solute carrier organic anion transporter family member 1B1	0	2	0	3
acetylcholinesterase	3	0	0	3
estrogen receptor 2 (ER beta)	2	0	0	2
G	1	0	0	1
cytochrome P450 2D6	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	3
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	4
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	3
Glutamate receptor ionotropic, NMDA 2B	0	1	0	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	3
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	3
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	3
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	2	0	2
IDH1	3	0	0	3
geminin	6	0	0	6
Deoxycytidine kinase	0	0	0	1
interleukin 8	1	0	0	1
pregnane X receptor	2	0	0	2
progesterone receptor	4	0	0	4
glp-1 receptor, partial	3	0	0	3
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
TDP1 protein	6	0	0	6
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen-related nuclear receptor alpha	6	0	0	6
67.9K protein	1	0	0	1
peroxisome proliferator activated receptor gamma	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
caspase-3	1	0	0	1
LMP1 [Human herpesvirus 4]	0	0	0	1
thyroid stimulating hormone receptor	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
thyroid hormone receptor beta isoform 2	3	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
Cellular tumor antigen p53	3	0	0	3
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	5	0	7
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
Cytochrome P450 2C9	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Serum paraoxonase/arylesterase 1	0	1	0	1
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
arylsulfatase A	3	0	0	3
Bloom syndrome protein isoform 1	4	0	0	4
peripheral myelin protein 22 isoform 1	1	0	0	1
Carbonic anhydrase 1	0	0	0	3
Carbonic anhydrase 2	0	0	0	3
Neutral amino acid transporter A	0	3	0	3
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	2
Amino acid transporter	0	3	0	3
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
ATAD5 protein, partial	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	1	0	2
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	1	1	0	2
Gamma-aminobutyric acid receptor subunit delta	1	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	1	1	0	2
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	1	1	0	2
Adenosine receptor A1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	1	1	0	2
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	1	1	0	2
Gamma-aminobutyric acid receptor subunit beta-2	1	1	0	2
Large neutral amino acids transporter small subunit 1	0	4	0	4
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
GABA theta subunit	1	1	0	2
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	1	0	2
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Luciferase	1	0	0	1
aryl hydrocarbon receptor	4	0	0	4
histone deacetylase 9 isoform 3	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Spike glycoprotein	2	0	0	2
Acyl-protein thioesterase 1	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Proton-coupled amino acid transporter 1	0	3	0	4
Phospholipase A-2-activating protein	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
peripheral myelin protein 22	3	0	0	3
Translocator protein	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
GALC protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
nonstructural protein 1	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Acetylcholinesterase	0	3	0	4
Bile salt export pump	0	2	0	2
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	2	0	2
Cytochrome P450 2D6	0	3	0	3
Alpha-1B adrenergic receptor	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	2
Acetylcholinesterase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Cholinesterase	0	3	0	4
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain A, Beta-lactamase	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
farnesoid X nuclear receptor	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
heat shock protein 90, putative	0	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Albumin	0	0	1	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Cytochrome P450 2D4	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Pyruvate kinase PKM	0	0	1	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Protein-arginine deiminase type-4	0	2	0	2
Cereblon isoform 4	0	2	0	2
EWS/FLI fusion protein	1	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Thymidine phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Chain A, Arginase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(15)

Research Excerpts

Overview

Research

Studies (90)

Protein Targets (385)

Klein Syndrome

Synonyms(15)

Research Excerpts

Overview

Research

Studies (90)

Drugs Studied (39)

Protein Targets (385)