Compounds > nybomycin
Page last updated: 2024-12-08

nybomycin

Description

nybomycin: antibiotic substance produced by Streptomyces A 717; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID169159
CHEMBL ID1999880
SCHEMBL ID4326654
MeSH IDM0046788

Synonyms (27)

Synonym
8,9-dihydro-4-(hydroxymethyl)-6,9-dimethyl-2,8-dioxopyrido(3,2-g)quinoline-1(2h)-carboxaldehyde
nybomycin
nsc613948
26326-47-6
nsc-613948
8-(hydroxymethyl)-6,11-dimethyl-4h-[1,3]oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11h)-dione
NCI60_004922
SCHEMBL4326654
unii-nlb430f005
nlb430f005 ,
30408-30-1
8-(hydroxymethyl)-6,11-dimethyl-4h-(1,3)oxazolo(5,4,3-ij)pyrido(3,2-g)quinoline-4,10(11h)-dione
nsc 613948
nybomycin [mi]
8-(hydroxymethyl)-6,11-dimethyl-2h,4h-oxazolo(5,4,3-ij)pyrido(3,2-g)quinoline-4,10(11h)-dione
CHEMBL1999880
8-(hydroxymethyl)-6,11-dimethyl-2h,4h-oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11h)-dione
J-017950
Q27284932
8-(hydroxymethyl)-6,11-dimethyl-2h,4h-[1,3]oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11h)-dione
DTXSID40949186
6-(hydroxymethyl)-3,10-dimethyl-15-oxa-3,13-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(16),2(7),5,8,10-pentaene-4,12-dione
6-(hydroxymethyl)-3,10-dimethyl-15-oxa-3,13-diazatetracyclo[7.6.1.0?,?.0??,??]hexadeca-1(16),2(7),5,8,10-pentaene-4,12-dione
HY-123635
CS-0084000
8-(hydroxymethyl)-6,11-dimethyl-4h-oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11h)-dione
AKOS040756181
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID1231585Antibacterial activity against Mycobacterium smegmatis MC2 155 assessed as induction of morphological changes at 1 ug/ml after 48 hrs by phase contrast/scanning electron microscopic analysis2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1617944Antibacterial activity against Escherichia coli ATCC 12435 after 16 to 48 hrs2019Journal of natural products, 12-27, Volume: 82, Issue:12
Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID1231597Inhibition of nybomycin probe (2) binding to pMV206 DNA (unknown origin) with cloned 700476 to 702854 bp of Mycobacterium bovis BCG genome overexpressed in Mycobacterium smegmatis ICHO1036 at 60 uM after 1 hr by agarose gel electrophoresis2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231579Antibacterial activity against Mycobacterium smegmatis MC2 155 under hypoxic condition after 96 hrs by MTT assay2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231590Antibacterial activity against Mycobacterium smegmatis ICHO1037 harboring pMV261 with cloned 4109204 to 4110235 bp of Mycobacterium bovis BCG genome at 2 ug/ml by agar plate method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231591Antibacterial activity against Mycobacterium smegmatis ICHO1034 harboring pMV206 with cloned 685769 to 689308 bp of Mycobacterium bovis BCG genome at 4 ug/ml by agar plate method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1617945Antibacterial activity against Salmonella enterica ATCC 10708 after 16 to 48 hrs2019Journal of natural products, 12-27, Volume: 82, Issue:12
Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID1231589Antibacterial activity against Mycobacterium smegmatis ICHO1035 harboring pMV206 with cloned 696695 to 700844 bp of Mycobacterium bovis BCG genome at 2 ug/ml by agar plate method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231596Antibacterial activity against Mycobacterium smegmatis ICHO2012 harboring pYUB415 with cloned 686465 to 716464 bp of Mycobacterium bovis BCG genome at 4 ug/ml by agar plate method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231594Antibacterial activity against Mycobacterium smegmatis ICHO1037 harboring pMV261 with cloned 4109204 to 4110235 bp of Mycobacterium bovis BCG genome at 4 ug/ml by agar plate method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1617942Antibacterial activity against Bacillus subtilis ATCC 6633 after 16 to 48 hrs2019Journal of natural products, 12-27, Volume: 82, Issue:12
Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID1231578Antibacterial activity against Mycobacterium smegmatis MC2 155 under aerobic condition after 36 hrs by MTT assay2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231588Antibacterial activity against Mycobacterium smegmatis ICHO2012 harboring pYUB415 with cloned 686465 to 716464 bp of Mycobacterium bovis BCG genome at 2 ug/ml by agar plate method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231586Antibacterial activity against Mycobacterium smegmatis ICHO1034 harboring pMV206 with cloned 685769 to 689308 bp of Mycobacterium bovis BCG genome at 2 ug/ml by agar plate method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231584Antibacterial activity against Mycobacterium tuberculosis T1538 under aerobic condition after 7 days by MTT assay2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231580Antibacterial activity against Mycobacterium bovis BCG under aerobic condition after 7 days by MTT assay2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231593Antibacterial activity against Mycobacterium smegmatis ICHO1036 harboring pMV206 with cloned 700476 to 702854 bp of Mycobacterium bovis BCG genome at 4 ug/ml by agar plate method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231587Antibacterial activity against Mycobacterium smegmatis ICHO1036 harboring pMV206 with cloned 700476 to 702854 bp of Mycobacterium bovis BCG genome at 2 ug/ml by agar plate method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1617941Antibacterial activity against Micrococcus luteus ATCC 15307 after 16 to 48 hrs2019Journal of natural products, 12-27, Volume: 82, Issue:12
Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID1231595Antibacterial activity against Mycobacterium smegmatis ICHO1038 harboring pMV261 with cloned 4126836 to 4129396 bp of Mycobacterium bovis BCG genome at 4 ug/ml by agar plate method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231583Antibacterial activity against Mycobacterium tuberculosis T1413 under aerobic condition after 7 days by MTT assay2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231592Antibacterial activity against Mycobacterium smegmatis ICHO1035 harboring pMV206 with cloned 696695 to 700844 bp of Mycobacterium bovis BCG genome at 4 ug/ml by agar plate method2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1617947Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay2019Journal of natural products, 12-27, Volume: 82, Issue:12
Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID1617940Antibacterial activity against Staphylococcus aureus ATCC 6538 after 16 to 48 hrs2019Journal of natural products, 12-27, Volume: 82, Issue:12
Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID1231581Antibacterial activity against Mycobacterium bovis BCG under hypoxic condition after 14 days by MTT assay2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1231582Antibacterial activity against Mycobacterium tuberculosis H37Rv under aerobic condition after 7 days by MTT assay2015Bioorganic & medicinal chemistry, Jul-01, Volume: 23, Issue:13
Anti-dormant mycobacterial activity and target analysis of nybomycin produced by a marine-derived Streptomyces sp.
AID1617946Antifungal activity against Saccharomyces cerevisiae ATCC 204508 after 16 to 48 hrs2019Journal of natural products, 12-27, Volume: 82, Issue:12
Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID1617948Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay2019Journal of natural products, 12-27, Volume: 82, Issue:12
Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
AID1617943Antibacterial activity against Mycobacterium aurum ATCC 23366 after 16 to 48 hrs2019Journal of natural products, 12-27, Volume: 82, Issue:12
Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (33.33)18.7374
1990's1 (8.33)18.2507
2000's0 (0.00)29.6817
2010's7 (58.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.23 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.16 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.1110carbohydrazideantitubercular agent;
drug allergen
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.		2.2110kanamycinsbacterial metabolite
carbostyril
Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.		3.86120monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
methicillin
Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.		2.0710penicillin allergen;
penicillin		antibacterial drug
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.2110beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0710glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
levofloxacin
Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.		2.11109-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;
fluoroquinolone antibiotic;
quinolone antibiotic		antibacterial drug;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor
deoxynyboquinone
deoxynyboquinone: structure in first source		2.2110
dactinomycin
Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)		2.2110actinomycinmutagen
apigenin
Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.		2.1110trihydroxyflavoneantineoplastic agent;
metabolite
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.2110antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
beta-rubromycin
beta-rubromycin: structure given in first source		2.2110
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.2110cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Lung
[description not available]		02.2110
Lung Neoplasms
Tumors or cancer of the LUNG.		02.2110
Infections, Staphylococcal
[description not available]		02.1110
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.1110
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