Page last updated: 2024-09-28

Congenital Rubella Syndrome

Transplacental infection of the fetus with rubella usually in the first trimester of pregnancy, as a consequence of maternal infection, resulting in various developmental abnormalities in the newborn infant. They include cardiac and ocular lesions, deafness, microcephaly, mental retardation, and generalized growth retardation. (From Dorland, 27th ed)

Synonyms(3)

Synonym
Rubella Syndrome, Congenital
Syndrome, Congenital Rubella
Congenital Rubella Syndrome

Research Excerpts

Context

ExcerptReference
"However, congenital rubella syndrome has persisted with its associated health burden."( , 2008)

Research

Studies (45)

TimeframeStudies, This Condition (%)All Conditions %
pre-19906 (13.33)23.3326
1990's9 (20.00)12.5806
2000's5 (11.11)18.1394
2010's20 (44.44)28.8240
2020's5 (11.11)9.53
DrugIndicatedRelationship StrengthStudiesTrials
urea0low10
theophylline0low10
gentamicin0low10
2-propanol0low10
propofol0low10
thalidomide0low40
kanamycin a0low10
diethylamine0low10
trolamine salicylate0low30
alfentanil0low10
inositol 3-phosphate0low10
tretinoin0low10
retinol0low10
diethylstilbestrol0low20
morphine0low10
clove0low10
warfarin0low10
exudates0low30
trypan blue0low10
eye0low10

Protein Targets (441)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma9009
GLI family zinc finger 39009
AR protein7007
aldehyde dehydrogenase 1 family, member A18008
retinoic acid nuclear receptor alpha variant 1100010
retinoid X nuclear receptor alpha9009
estrogen nuclear receptor alpha110011
peroxisome proliferator-activated receptor delta5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x4004
thyroid hormone receptor beta isoform a6006
heat shock protein beta-15005
nuclear factor erythroid 2-related factor 2 isoform 17007
lamin isoform A-delta104004
Voltage-dependent calcium channel gamma-2 subunit3003
Glutamate receptor 23003
Bile salt export pump0909
ATP-dependent translocase ABCB10202
Mu-type opioid receptor0418
Kappa-type opioid receptor0303
Mu-type opioid receptor0303
Sigma non-opioid intracellular receptor 10303
interleukin 83003
estrogen-related nuclear receptor alpha9009
cellular tumor antigen p53 isoform a2002
Integrin beta-32002
Integrin alpha-IIb2002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, Ferritin light chain3003
Luciferase3003
acetylcholinesterase2002
glp-1 receptor, partial1001
15-lipoxygenase, partial2002
ATAD5 protein, partial1001
USP1 protein, partial5005
GLS protein4004
TDP1 protein5005
Microtubule-associated protein tau3003
Smad31001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
thyroid stimulating hormone receptor3003
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor3003
regulator of G-protein signaling 42002
cytochrome P450 family 3 subfamily A polypeptide 44004
glucocorticoid receptor [Homo sapiens]6006
farnesoid X nuclear receptor5005
pregnane X nuclear receptor7007
G3003
cytochrome P450 2D62002
67.9K protein1001
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
IDH12002
thyroid stimulating hormone receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
vitamin D3 receptor isoform VDRA3003
potassium voltage-gated channel subfamily H member 2 isoform d3003
thyroid hormone receptor beta isoform 26006
mitogen-activated protein kinase 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
serine/threonine-protein kinase PLK11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
nuclear receptor ROR-gamma isoform 13003
geminin6006
peripheral myelin protein 224004
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 14004
high affinity choline transporter 1 isoform a0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
lethal factor (plasmid)3003
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi4116
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
5-hydroxytryptamine receptor 40404
Nuclear receptor subfamily 1 group I member 20101
Carbonic anhydrase 10404
Carbonic anhydrase 20404
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 3003
Estrogen receptor0213
Glucocorticoid receptor0202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Cellular tumor antigen p536006
Tyrosine-protein kinase Fyn0101
Glycine receptor subunit alpha-10202
Aldo-keto reductase family 1 member B10505
Beta-1 adrenergic receptor0202
Alpha-2A adrenergic receptor0213
Polyunsaturated fatty acid 5-lipoxygenase0101
Adenosine receptor A30505
Muscarinic acetylcholine receptor M10202
Polyunsaturated fatty acid lipoxygenase ALOX150202
D(2) dopamine receptor0202
Androgen receptor0101
Gamma-aminobutyric acid receptor subunit beta-14116
Alpha-1B adrenergic receptor0404
Alpha-2B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta4116
Gamma-aminobutyric acid receptor subunit gamma-24116
Alpha-2C adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit alpha-54116
Gamma-aminobutyric acid receptor subunit alpha-34116
Muscarinic acetylcholine receptor M30202
Glycine receptor subunit beta0202
Substance-K receptor0202
D(1A) dopamine receptor0202
Acetylcholinesterase0202
Glycine receptor subunit alpha-20202
Prostaglandin G/H synthase 10303
Gamma-aminobutyric acid receptor subunit gamma-14116
Gamma-aminobutyric acid receptor subunit alpha-24116
Sodium-dependent noradrenaline transporter 0404
Glycine receptor subunit alpha-30202
Thromboxane-A synthase 0101
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0404
Gamma-aminobutyric acid receptor subunit alpha-44116
Gamma-aminobutyric acid receptor subunit gamma-34116
Adenosine receptor A2a0427
Gamma-aminobutyric acid receptor subunit alpha-64116
Adenosine receptor A10417
Sodium-dependent serotonin transporter0202
Mu-type opioid receptor0416
D(3) dopamine receptor0202
Vasopressin V1a receptor0202
Alpha-synuclein1203
Delta-type opioid receptor0416
Kappa-type opioid receptor0416
5-hydroxytryptamine receptor 2B0606
Alpha-1A adrenergic receptor0404
Histamine H2 receptor1001
5-hydroxytryptamine receptor 60202
Nuclear receptor ROR-gamma4116
Spike glycoprotein2002
Estrogen-related receptor gamma0011
Gamma-aminobutyric acid receptor subunit alpha-14116
Gamma-aminobutyric acid receptor subunit beta-34116
Gamma-aminobutyric acid receptor subunit beta-24116
Disintegrin and metalloproteinase domain-containing protein 172002
Inositol monophosphatase 12002
Sodium-dependent dopamine transporter 0202
Aldehyde oxidase0101
TAR DNA-binding protein 432002
UDP-glucose 4-epimerase0101
Mitogen-activated protein kinase 140101
GABA theta subunit4116
Inositol hexakisphosphate kinase 13003
Estrogen receptor beta0213
Gamma-aminobutyric acid receptor subunit epsilon4116
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Cysteinyl leukotriene receptor 10202
cytochrome P450 2C9, partial3003
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
3-oxoacyl-[acyl-carrier-protein] synthase 30101
Gap junction alpha-1 protein0101
Gap junction beta-2 protein0101
Acyl-protein thioesterase 10101
Canalicular multispecific organic anion transporter 10303
Opioid receptor, delta 1b 0101
Solute carrier family 22 member 1 0101
Acetylcholinesterase0101
Opioid receptor homologue0101
ATP-dependent translocase ABCB10101
Acyl-CoA desaturase 10101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Cytochrome P450 3A40123
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20101
Translocator protein0011
Histidine decarboxylase0011
ATP-dependent translocase ABCB10101
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0102
Delta-type opioid receptor0214
Kappa-type opioid receptor0214
Kappa-type opioid receptor0214
UDP-glucuronosyltransferase 1A30001
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Potassium voltage-gated channel subfamily H member 20101
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10101
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
caspase 7, apoptosis-related cysteine protease2002
caspase-32002
euchromatic histone-lysine N-methyltransferase 24004
Bloom syndrome protein isoform 13003
D(1A) dopamine receptor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
DNA polymerase iota isoform a (long)3003
muscarinic acetylcholine receptor M11001
Fatty-acid amide hydrolase 10101
UDP-glucuronosyltransferase 1A90002
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit alpha-50011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-40011
Fatty-acid amide hydrolase 10101
Gamma-aminobutyric acid receptor subunit alpha-60011
UDP-glucuronosyltransferase 1A80001
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Chain A, Cruzipain2002
thioredoxin reductase4004
pregnane X receptor3003
phosphopantetheinyl transferase3003
SMAD family member 21001
SMAD family member 31001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0202
Chain A, 2-oxoglutarate Oxygenase3003
chaperonin-containing TCP-1 beta subunit homolog1001
histone acetyltransferase KAT2A isoform 12002
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0202
Albumin0112
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Cereblon isoform 40202
EWS/FLI fusion protein3003
arylsulfatase A2002
Prostaglandin G/H synthase 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0303
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0303
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Chain A, Pyridoxal kinase0101
Chain A, Pyridoxal Kinase0101
bromodomain adjacent to zinc finger domain 2B2002
Phosphodiesterase 0202
transcriptional regulator ERG isoform 31001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Potassium channel subfamily K member 20011
Renin0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
5-hydroxytryptamine receptor 1A0101
Intestinal-type alkaline phosphatase0101
Replicase polyprotein 1ab0101
Replicase polyprotein 1ab0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Thyroid hormone receptor beta0101
D(3) dopamine receptor0101
Adenosine receptor A10203
Adenosine receptor A10202
Adenosine receptor A30101
Adenosine receptor A2b0102
Adenosine receptor A2b0102
Adenosine receptor A2a0103
Vasopressin V2 receptor0001
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
Adenosine receptor A10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Guanine nucleotide-binding protein G1001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Adenosine receptor A2b0001
Palmitoleoyl-protein carboxylesterase NOTUM0011
Endochitinase B10101
Phospholipase A-2-activating protein0101
ATP-dependent phosphofructokinase2002
Chain A, Nuclear Receptor ROR-beta0101
Chain A, Beta-lactamase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
thioredoxin glutathione reductase1001
nonstructural protein 11001
Parkin1001
aryl hydrocarbon receptor1001
thyrotropin-releasing hormone receptor1001
Caspase-71001
chromobox protein homolog 12002
nuclear factor erythroid 2-related factor 2 isoform 21001
caspase-31001
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
Ornithine decarboxylase0001
Cytochrome P450 1A20011
Ornithine decarboxylase0001
60 kDa chaperonin0101
Retinoic acid receptor alpha0227
Cytochrome P450 2D60011
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Cytochrome P450 2C9 0112
Retinoic acid receptor gamma 0227
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
5-hydroxytryptamine receptor 1A0101
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Alpha-1D adrenergic receptor0101
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2C190011
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Rap guanine nucleotide exchange factor 31001
Urease subunit alpha0101
Urease subunit beta0101
Olfactory receptor 51E20011
Cocaine esterase0101
Histone deacetylase 30202
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
PPM1D protein1001
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]