Target type: biologicalprocess
The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle. [GOC:mtg_heart]
Atrial ventricular junction (AVJ) remodeling is a complex process that involves structural and functional changes in the region where the atria and ventricles of the heart meet. This region is crucial for coordinating electrical impulses and ensuring proper heart rhythm. AVJ remodeling can occur in response to various stimuli, including:
* **Cardiac injury:** Conditions like myocardial infarction or heart failure can damage the AVJ, leading to changes in its electrical properties.
* **Hypertension:** High blood pressure can put stress on the heart, altering the structure and function of the AVJ.
* **Aging:** As we age, the heart undergoes natural changes, including structural modifications in the AVJ.
The remodeling process involves:
* **Electrophysiological changes:** The electrical conductivity and excitability of the AVJ can be altered. This can lead to slowed conduction, blockades, or even abnormal rhythms.
* **Structural changes:** The size, shape, and cellular composition of the AVJ can change. This can involve:
* **Fibrosis:** The formation of scar tissue, which can interfere with electrical conduction.
* **Hypertrophy:** An increase in the size of cells, which can affect electrical properties.
* **Inflammation:** An immune response that can contribute to damage and remodeling.
* **Cellular changes:** The types and number of cells in the AVJ can change. This can involve the proliferation of fibroblasts, which produce collagen and contribute to fibrosis.
These changes in the AVJ can have significant implications for heart function. They can contribute to:
* **Atrial fibrillation (AFib):** An irregular and often rapid heart rhythm, which can increase the risk of stroke and heart failure.
* **Atrioventricular block (AV block):** A condition in which the electrical signals from the atria are delayed or blocked from reaching the ventricles, resulting in slow heart rate.
* **Ventricular tachycardia (VT):** A fast heart rhythm originating from the ventricles, which can be life-threatening.
Understanding the process of AVJ remodeling is crucial for developing effective therapies to prevent and treat heart rhythm disorders.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Gap junction alpha-1 protein | A gap junction alpha-1 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:P17302] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| kanamycin a | kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components. Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components. | kanamycins | bacterial metabolite |