| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. | 2.13 | 1 | 0 | aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole | analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic |
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components. | 2.15 | 1 | 0 | kanamycins | bacterial metabolite |
triptonide
triptonide: extracted from Tripterygium wilfordii; structure given in first source. triptonide : A diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii. | 2.25 | 1 | 0 | butenolide;
cyclic ketone;
diterpene triepoxide;
organic heteroheptacyclic compound | anti-inflammatory agent;
antineoplastic agent;
immunosuppressive agent |
nagilactone c
nagilactone C: norditerpene lactone isolated from leaves of Podocarpus; structure | 2.25 | 1 | 0 | | |
brusatol
brusatol: quassinoid from B. javanica; structure | 2.25 | 1 | 0 | triterpenoid | |
triptolide
[no description available] | 2.25 | 1 | 0 | diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound | antispermatogenic agent;
plant metabolite |
parthenolide
[no description available] | 2.25 | 1 | 0 | germacranolide | |
obacunone
obacunone: from bark of Chinese plant Phellodendron amurense; shortens sleeping time induced in mice by alpha-chloralose-urethane | 2.25 | 1 | 0 | limonoid | |
chlorolissoclimide
chlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson | 2.25 | 1 | 0 | | |
bruceine a
bruceine A: quassinoid which inhibits protein synthesis & DNA synthesis in cells; RN given refers to (11 beta,12 alpha,15 beta)-isomer; structure given in first source | 2.25 | 1 | 0 | quassinoid | |
bruceine b
bruceine B: quassinoid which inhibits protein synthesis & DNA synthesis in cells; structure in first source | 2.25 | 1 | 0 | triterpenoid | |
jolkinolide b
jolkinolide B: isolated from Euphorbia fischeriana | 3.33 | 6 | 0 | diterpene lactone | metabolite |
limonin
[no description available] | 2.25 | 1 | 0 | epoxide;
furans;
hexacyclic triterpenoid;
lactone;
limonoid;
organic heterohexacyclic compound | inhibitor;
metabolite;
volatile oil component |
tripdiolide
tripdiolide: structure | 2.25 | 1 | 0 | oxacycle | |
thapsigargin
Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.. thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. | 2.25 | 1 | 0 | butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone | calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor |
12-deoxyphorbol 13-acetate
[no description available] | 2.15 | 1 | 0 | phorbol ester | metabolite |
phorbol 13-monoacetate
phorbol 13-monoacetate: RN given refers to (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha)-isomer); RN for cpd without isomeric designation not in Chemlne 11/86 | 2.15 | 1 | 0 | phorbol ester | |
bruceantin
[no description available] | 2.25 | 1 | 0 | triterpenoid | |
andrographolide
[no description available] | 2.25 | 1 | 0 | carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol | anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite |
shihulimonin a
shihulimonin A: isolated from Evodia rutaecarpa; structure in first source | 2.25 | 1 | 0 | limonoid | |
dichapetalin a
dichapetalin A: isolated from Dichapetalum; structure in first source | 2.25 | 1 | 0 | | |
ginkgolide b
[no description available] | 2.25 | 1 | 0 | | |
17-hydroxyjolkinolide b
17-hydroxyjolkinolide B: isolated from Euphorbia fischeriana | 2.73 | 3 | 0 | diterpene lactone | metabolite |
bn 52020
[no description available] | 2.25 | 1 | 0 | | |
dichlorolissoclimide
dichlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson | 2.25 | 1 | 0 | | |
14-o-phosphonooxymethyltriptolide
14-O-phosphonooxymethyltriptolide disodium salt: pro-drug of triptolide; has antineoplastic activity | 2.25 | 1 | 0 | | |