Page last updated: 2024-12-07
7-(n-(3-aminopropyl)amino)heptan-2-one
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
7-(N-(3-aminopropyl)amino)heptan-2-one: inhibits N(8)-acetylspermidine deacetylation in mice [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 129689 |
| CHEMBL ID | 173782 |
| CHEMBL ID | 2414008 |
| SCHEMBL ID | 12409526 |
| MeSH ID | M0167994 |
Synonyms (10)
| Synonym |
|---|
| CHEMBL173782 , |
| 7-(3-aminopropylamino)heptan-2-one |
| bdbm50405937 |
| chembl2414008 |
| 2-heptanone, 7-((3-aminopropyl)amino)- |
| 7-(n-(3-aminopropyl)amino)heptan-2-one |
| 122269-09-4 |
| SCHEMBL12409526 |
| DTXSID70153557 |
| 7-[n-(3-aminopropyl)amino]heptan-2-one |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) | Ki | 0.1800 | 0.1000 | 0.2767 | 0.5500 | AID144352 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (5)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| putrescine biosynthetic process | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| putrescine catabolic process | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| spermidine catabolic process | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| spermine catabolic process | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| positive regulation of spermidine biosynthetic process | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Molecular Functions (6)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| polyamine oxidase activity | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| spermine:oxygen oxidoreductase (spermidine-forming) activity | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Ceullar Components (2)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| peroxisomal matrix | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| cytosol | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Bioassays (1)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID144352 | Ability to inhibit the deacetylation of [acetyl-3H]-N8-Acetylspermidine deacetylase in rat liver. | 1989 | Journal of medicinal chemistry, May, Volume: 32, Issue:5 | Design and synthesis of inhibitors of N8-acetylspermidine deacetylase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.46
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.46) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||