Congenital Oculofacial Paralysis, Moebius

A syndrome of congenital facial paralysis, frequently associated with abducens palsy and other congenital abnormalities including lingual palsy, clubfeet, brachial disorders, cognitive deficits, and pectoral muscle defects. Pathologic findings are variable and include brain stem nuclear aplasia, facial nerve aplasia, and facial muscle aplasia, consistent with a multifactorial etiology. (Adams et al., Principles of Neurology, 6th ed, p1020)

Synonym
Moebius Spectrum
Moebius Syndrome
Moebius Congenital Oculofacial Paralysis
Mu00F6bius Sequence
Congenital Oculofacial Paralysis, Moebius
Congenital Ophthalmoplegia and Facial Paresis
Moebius Sequence
Mobius Syndrome

Excerpt	Reference
"Moebius syndrome is a congenital facial palsy associated with the impairment of ocular abduction."	( Di Blasio, C; Ferrario, VF; Gandolfini, M; Grandi, G; Pisoni, L; Sforza, C, 2009)
"Moebius syndrome is a rare disease characterized by congenital facial paralysis and abducens palsy."	( Araújo, AP; Freitas, ME; Gasparetto, EL; Pirmez, R, 2010)
"Moebius syndrome is a rare disorder found in approximately 1/100,000 neonates and the treatment of facial palsy is now well established worldwide and consists of free-muscle transplants reinnervated with motor nerves."	( Barbot, A; Bianchi, B; Brevi, B; Copelli, C; Di Blasio, A; Di Blasio, C; Ferri, A; Ferri, T; Sesenna, E, 2013)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	3 (5.77)	23.3326
1990's	0 (0.00)	12.5806
2000's	27 (51.92)	18.1394
2010's	19 (36.54)	28.8240
2020's	3 (5.77)	9.53

Drug	Relationship Strength	Studies
adenine	low	1
creatine	low	1
acetaminophen	low	1
cisapride	low	1
fentanyl	low	1
gentamicin	low	1
isoflurane	low	2
apnea	low	1
omeprazole	low	1
propofol	low	1
sevoflurane	low	1
thalidomide	low	5
zonisamide	low	1
glutamine	low	1
lysine	low	1
kanamycin a	low	1
arginine	low	1
ergotamine	low	1
isoxazoles	low	1
gold	low	1
trolamine salicylate	low	1
glutamic acid	low	1
desflurane	low	2
propiconazole	low	2
fomesafen	low	1
mifepristone	low	3
remifentanil	low	2
methotrexate	low	1
inositol 3-phosphate	low	9
rocuronium	low	1
vitamin k semiquinone radical	low	1
misoprostol	low	19
phenylephrine hydrochloride	low	2
jaw	low	2
piperidines	low	2
guanine	low	1
eye	low	1

Protein Targets (610)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	10	0	0	10
ATAD5 protein, partial	7	0	0	7
GLS protein	6	0	0	6
Microtubule-associated protein tau	5	0	0	5
Smad3	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
thyroid stimulating hormone receptor	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
progesterone receptor	8	0	0	8
EWS/FLI fusion protein	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
retinoid X nuclear receptor alpha	8	0	0	8
estrogen-related nuclear receptor alpha	12	0	0	12
estrogen nuclear receptor alpha	14	0	0	14
peroxisome proliferator activated receptor gamma	7	0	0	7
aryl hydrocarbon receptor	3	0	0	3
chromobox protein homolog 1	8	0	0	8
thyroid hormone receptor beta isoform 2	6	0	0	6
peripheral myelin protein 22	7	0	0	7
cytochrome P450 3A4 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	1	1	6
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	7
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	3	0	5
UDP-glucuronosyltransferase 1A9	0	0	0	2
Bile salt export pump	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Bile salt export pump	0	9	0	9
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	4	0	9
Carbonic anhydrase 2	0	4	2	11
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	0	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 3	0	3	0	4
Cytochrome P450 3A4	0	7	0	8
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	4	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	4	1	1	6
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	4	1	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	4	1	1	6
UDP-glucuronosyltransferase 1-6	0	1	0	2
Glutamate receptor 2	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-5	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	4	1	1	6
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Carbonic anhydrase 4	0	3	0	5
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	3	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-2	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	4	1	1	6
Gamma-aminobutyric acid receptor subunit gamma-3	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-6	4	1	1	6
Carbonic anhydrase 5A, mitochondrial	0	3	1	6
Prostaglandin G/H synthase 2	0	1	0	2
Carbonic anhydrase 7	0	3	0	5
Nuclear receptor ROR-gamma	1	0	0	1
Cytochrome P450 2J2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	4	1	1	6
Gamma-aminobutyric acid receptor subunit beta-3	4	1	1	6
Gamma-aminobutyric acid receptor subunit beta-2	4	1	1	6
Carbonic anhydrase 9	0	3	0	5
GABA theta subunit	4	1	1	6
Canalicular multispecific organic anion transporter 1	0	6	0	6
Carbonic anhydrase 15	0	2	0	3
Carbonic anhydrase 13	0	1	0	3
Gamma-aminobutyric acid receptor subunit epsilon	4	1	1	6
Carbonic anhydrase 14	0	3	0	5
Carbonic anhydrase 5B, mitochondrial	0	3	0	5
toxin B	0	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
TDP1 protein	12	0	0	12
AR protein	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
glucocorticoid receptor [Homo sapiens]	4	0	0	4
pregnane X nuclear receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
heat shock protein beta-1	4	0	0	4
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
lamin isoform A-delta10	8	0	0	8
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	5	0	0	5
thioredoxin reductase	8	0	0	8
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
Bloom syndrome protein isoform 1	6	0	0	6
D(1A) dopamine receptor	3	0	0	3
neuropeptide S receptor isoform A	3	0	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
phosphopantetheinyl transferase	5	0	0	5
NFKB1 protein, partial	1	0	0	1
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
flap endonuclease 1	4	0	0	4
DNA polymerase iota isoform a (long)	7	0	0	7
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	1	0	0	1
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	5	0	0	5
5-hydroxytryptamine receptor 3E	0	1	0	1
acetylcholinesterase	2	0	0	2
GLI family zinc finger 3	7	0	0	7
cytochrome P450 2D6	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
thyroid stimulating hormone receptor	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	6	1	7
5-hydroxytryptamine receptor 3B	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Beta-2 adrenergic receptor	0	3	0	3
Beta-1 adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	3
Alpha-2A adrenergic receptor	0	4	0	4
Angiotensin-converting enzyme	0	2	0	2
Beta-3 adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	5	0	5
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Insulin receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	6	0	6
Alpha-2C adrenergic receptor	0	4	0	4
D	0	2	0	2
5-hydroxytryptamine receptor 1A	0	5	0	5
Alpha-2B adrenergic receptor	0	2	0	2
D(1A) dopamine receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent dopamine transporter	0	3	0	3
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	6	0	6
5-hydroxytryptamine receptor 1B	0	4	0	4
5-hydroxytryptamine receptor 1D	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	0	1
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
D(3) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 2B	0	6	0	6
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Spike glycoprotein	6	0	0	6
D(2) dopamine receptor	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
5-hydroxytryptamine receptor 4	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Neutral alpha-glucosidase AB	0	1	0	1
5-hydroxytryptamine receptor 4	0	0	1	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	6	0	6
5-hydroxytryptamine receptor 3B	0	2	0	2
Heparanase	0	0	1	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Adenylate cyclase	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	1	1	2
Thromboxane-A synthase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Luciferase	3	0	0	3
Solute carrier family 22 member 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Delta-type opioid receptor	0	3	0	3
Delta-type opioid receptor	0	4	0	4
Mu-type opioid receptor	0	5	1	6
Kappa-type opioid receptor	0	2	0	2
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	4	1	5
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	4	0	4
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
Histone H2A.x	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	4	0	0	4
regulator of G-protein signaling 4	3	0	0	3
beta-2 adrenergic receptor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	1	0	1	2
Integrin alpha-IIb	1	0	1	2
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	4
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	1	4
Glutamate receptor ionotropic, NMDA 2B	0	2	1	4
Glutamate receptor ionotropic, NMDA 2C	0	2	1	4
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	2	1	4
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	1	4
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	4
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Plasma kallikrein	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
Adenosine receptor A1	0	0	1	2
Adenosine receptor A2a	0	0	1	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 4	0	0	0	1
Cellular tumor antigen p53	9	0	0	9
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Chymotrypsinogen A	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Chain A, Ferritin light chain	5	0	0	5
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	2	0	0	2
ClpP	2	0	0	2
USP1 protein, partial	5	0	0	5
estrogen receptor 2 (ER beta)	4	0	0	4
farnesoid X nuclear receptor	6	0	0	6
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	4	0	0	4
Thymidylate synthase	0	1	0	1
IDH1	2	0	0	2
Thymidylate synthase	0	1	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
vitamin D3 receptor isoform VDRA	6	0	0	6
transcriptional regulator ERG isoform 3	1	0	0	1
DNA polymerase beta	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
geminin	8	0	0	8
DNA polymerase kappa isoform 1	1	0	0	1
survival motor neuron protein isoform d	3	0	0	3
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Chain A, Beta-lactamase	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, PROGESTERONE RECEPTOR	0	1	0	1
Chain A, Cruzipain	2	0	0	2
Glucocorticoid receptor	0	1	0	1
pregnane X receptor	2	0	0	2
SMAD family member 2	3	0	0	3
Fumarate hydratase	1	0	0	1
SMAD family member 3	3	0	0	3
apical membrane antigen 1, AMA1	2	0	0	2
hypothetical protein, conserved	1	0	0	1
nonstructural protein 1	2	0	0	2
G	4	0	0	4
polyprotein	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
activating transcription factor 6	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
huntingtin isoform 2	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	4	0	0	4
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Estrogen receptor	1	2	1	4
Glucocorticoid receptor	1	2	2	7
Progesterone receptor	0	2	1	5
Tegument protein VP16	0	0	1	1
Glucocorticoid receptor	0	1	1	3
Glucocorticoid receptor	0	1	0	1
Glycine receptor subunit alpha-1	0	2	0	2
Mineralocorticoid receptor	1	2	1	5
Coagulation factor VII	0	1	0	1
Androgen receptor	1	2	1	4
Cytochrome P450 2C8	0	1	0	1
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Tissue factor	0	1	0	1
Androgen receptor	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Substance-P receptor	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Mitogen-activated protein kinase 14	0	1	0	1
Progesterone receptor	0	0	1	1
Inositol hexakisphosphate kinase 1	4	0	0	4
Estrogen receptor beta	1	2	1	4
Glucocorticoid receptor	0	1	0	1
cytochrome P450 2C9, partial	4	0	0	4
thioredoxin glutathione reductase	2	0	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Mcl-1	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
pyruvate kinase PKM isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Cytochrome P450 2C19	0	1	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Histamine H2 receptor	2	0	0	2
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
GALC protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Rap guanine nucleotide exchange factor 3	1	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Translocator protein	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Amine oxidase [flavin-containing]	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Congenital Oculofacial Paralysis, Moebius

Synonyms(8)

Research Excerpts

Overview

Research

Studies (52)

Protein Targets (610)

Congenital Oculofacial Paralysis, Moebius

Synonyms(8)

Research Excerpts

Overview

Research

Studies (52)

Drugs Studied (39)

Protein Targets (610)