Page last updated: 2024-09-27

Afferent Loop Syndrome

A complication of gastrojejunostomy (BILLROTH II PROCEDURE), a reconstructive GASTROENTEROSTOMY. It is caused by acute (complete) or chronic (intermittent) obstruction of the afferent jejunal loop due to HERNIA, intussusception, kinking, VOLVULUS, etc. It is characterized by PAIN and VOMITING of BILE-stained fluid.

Synonyms(1)

Synonym
Afferent Loop Syndrome

Research Excerpts

Overview

ExcerptReference
"Afferent loop syndrome is caused by intermittent mechanical obstruction of the afferent loop of a gastrojejunostomy and may present early as an acute type or late as a chronic type."( Kumar, S; Muthukrishnan, A; Shanthly, N, 2000)

Research

Studies (32)

TimeframeStudies, This Condition (%)All Conditions %
pre-199023 (71.88)23.3326
1990's2 (6.25)12.5806
2000's6 (18.75)18.1394
2010's0 (0.00)28.8240
2020's1 (3.13)9.53
DrugIndicatedRelationship StrengthStudiesTrials
glycine0low10
1-anilino-8-naphthalenesulfonate0low20
fluorouracil0low10
guaifenesin0low10
tolbutamide0low10
kanamycin a0low10
technetium0low70
barium sulfate0low60
xylose0low10
technetium tc 99m pentetate0low10
nitinol0low10
bilirubin0low30
sulfur0low10
radium0low10
pentagastrin0low10
technetium tc 99m disofenin0low20
technetium tc 99m mebrofenin0low10
cholecystokinin0low10
gastrins0low30
intrinsic factor0low10
technetium tc 99m lidofenin0low10
vitamin b 120low10
levoleucovorin0low10

Protein Targets (259)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase1001
thioredoxin reductase2002
USP1 protein, partial2002
TDP1 protein2002
vitamin D3 receptor isoform VDRA2002
importin subunit beta-1 isoform 11001
flap endonuclease 13003
serine/threonine-protein kinase PLK11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
GTP-binding nuclear protein Ran isoform 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin4004
DNA polymerase kappa isoform 12002
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0101
Transthyretin0011
Fatty acid-binding protein, intestinal0112
Fatty acid-binding protein, adipocyte0112
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20112
Choline O-acetyltransferase0101
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G1001
Fatty acid-binding protein 50011
Fatty acid-binding protein 50011
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Cruzipain1001
phosphopantetheinyl transferase1001
Microtubule-associated protein tau2002
aldehyde dehydrogenase 1 family, member A13003
caspase-1 isoform alpha precursor1001
lamin isoform A-delta103003
Caspase-71001
Inositol monophosphatase 11001
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10203
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase1001
interleukin 81001
endonuclease IV1001
acetylcholinesterase2002
glp-1 receptor, partial1001
Skn7p0001
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit1001
RAR-related orphan receptor gamma1001
ATAD5 protein, partial1001
GLI family zinc finger 33003
Thrombopoietin1001
AR protein3003
thyroid stimulating hormone receptor2002
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor1001
EWS/FLI fusion protein2002
nonstructural protein 11001
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 12002
retinoid X nuclear receptor alpha2002
estrogen-related nuclear receptor alpha1001
farnesoid X nuclear receptor2002
pregnane X nuclear receptor2002
estrogen nuclear receptor alpha1001
67.9K protein1001
peroxisome proliferator-activated receptor delta1001
peroxisome proliferator activated receptor gamma3003
arylsulfatase A1001
IDH11001
euchromatic histone-lysine N-methyltransferase 21001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x2002
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
chromobox protein homolog 11001
nuclear factor erythroid 2-related factor 2 isoform 21001
thyroid hormone receptor beta isoform 21001
huntingtin isoform 21001
serine/threonine-protein kinase mTOR isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 11001
Vpr1001
peripheral myelin protein 221001
survival motor neuron protein isoform d1001
muscleblind-like protein 1 isoform 12002
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Voltage-dependent calcium channel gamma-2 subunit1001
Solute carrier family 22 member 80001
Bile salt export pump0505
Epidermal growth factor receptor0101
Cellular tumor antigen p531001
Amyloid-beta precursor protein1001
Thymidylate synthase0101
Aromatase0101
Glutamate receptor 21001
Canalicular multispecific organic anion transporter 10404
ATPase family AAA domain-containing protein 51001
Ataxin-21001
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
ATP-dependent phosphofructokinase1001
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 1 0213
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0213
Glutamate receptor ionotropic, NMDA 2B0213
Glutamate receptor ionotropic, NMDA 2C0213
Large neutral amino acids transporter small subunit 10101
Glutamate receptor ionotropic, NMDA 2D0213
Proton-coupled amino acid transporter 10101
Glutamate receptor ionotropic, NMDA 3B0213
Serine racemase0101
Olfactory receptor 51E20011
Glutamate receptor ionotropic, NMDA 3A0213
Sodium- and chloride-dependent glycine transporter 20101
SMAD family member 22002
SMAD family member 32002
Rap guanine nucleotide exchange factor 31001
3-oxoacyl-[acyl-carrier-protein] synthase 30101
Gap junction alpha-1 protein0101
Gap junction beta-2 protein0101
Spike glycoprotein1001
Acyl-protein thioesterase 10101
cytochrome P450 family 3 subfamily A polypeptide 42002
cytochrome P450 2D61001
aryl hydrocarbon receptor1001
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0011
Gastrin/cholecystokinin type B receptor0112
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0101
Stromelysin-10101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-synuclein0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
Solute carrier family 22 member 80001
P2Y purinoceptor 120101
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Solute carrier family 22 member 70001
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Solute carrier family 22 member 1 0102
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 60101
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
G1001
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)1001
Solute carrier family 22 member 60101
Bile salt export pump0101
Potassium channel subfamily K member 20011
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Albumin0112
Albumin0011
Cytochrome P450 2C9 0202
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
UDP-glucuronosyltransferase 2B10 0101
Lanosterol 14-alpha demethylase0101
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
Hsf1 protein0011
Aldo-keto reductase family 1 member B10001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]