Page last updated: 2024-12-11

citrusinine i

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

citrusinine I: acridone alkaloid isolated from Rutaceae [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
RutaceaefamilyA plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH]RutaceaeA plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH]

Cross-References

ID SourceID
PubMed CID5487772
CHEMBL ID451705
CHEBI ID184245
MeSH IDM0171875

Synonyms (14)

Synonym
bdbm50336481
9(10h)-acridinone, 1,5-dihydroxy-3,4-dimethoxy-10-methyl-
1,5-dihydroxy-3,4-dimethoxy-10-methyl-acridin-9-one
citrusinine-i
citrusinine i
CHEMBL451705 ,
86680-32-2
CHEBI:184245
1,5-dihydroxy-3,4-dimethoxy-10-methylacridin-9-one
DTXSID10235760
1,5-dihydroxy-3,4-dimethoxy-10-methyl-9,10-dihydroacridin-9-one
1,5-dihydroxy-3,4-dimethoxy-10-methyl-9(10h)-acridinone
1,5-dihydroxy-3,4-dimethoxy-10-methylacridone
AKOS040763313
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
acridines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cathepsin L2Homo sapiens (human)IC50 (µMol)2.20000.07502.214110.0000AID568360
Cathepsin L2Homo sapiens (human)Ki1.00000.00000.12791.0000AID568361
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (7)

Processvia Protein(s)Taxonomy
apoptotic processCathepsin L2Homo sapiens (human)
antigen processing and presentation of exogenous peptide antigen via MHC class IICathepsin L2Homo sapiens (human)
extracellular matrix disassemblyCathepsin L2Homo sapiens (human)
immune responseCathepsin L2Homo sapiens (human)
positive regulation of apoptotic signaling pathwayCathepsin L2Homo sapiens (human)
positive regulation of peptidase activityCathepsin L2Homo sapiens (human)
proteolysis involved in protein catabolic processCathepsin L2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
cysteine-type endopeptidase activityCathepsin L2Homo sapiens (human)
serine-type endopeptidase activityCathepsin L2Homo sapiens (human)
protein bindingCathepsin L2Homo sapiens (human)
cysteine-type peptidase activityCathepsin L2Homo sapiens (human)
cysteine-type endopeptidase activator activity involved in apoptotic processCathepsin L2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
extracellular regionCathepsin L2Homo sapiens (human)
lysosomal lumenCathepsin L2Homo sapiens (human)
extracellular spaceCathepsin L2Homo sapiens (human)
lysosomeCathepsin L2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID379435Antiproliferative activity against human A549 cells after 3 days by alamar blue assay1999Journal of natural products, Apr, Volume: 62, Issue:4
The antiproliferative effect of acridone alkaloids on several cancer cell lines.
AID568361Inhibition of human recombinant cathepsin V expressed in Pichia pastoris by Lineweaver-Burk double-reciprocal plots2011Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4
Acridone alkaloids as potent inhibitors of cathepsin V.
AID568360Inhibition of human recombinant cathepsin V expressed in Pichia pastoris2011Bioorganic & medicinal chemistry, Feb-15, Volume: 19, Issue:4
Acridone alkaloids as potent inhibitors of cathepsin V.
AID379437Antiproliferative activity against human CCRF-HSB-2 cells after 3 days by alamar blue assay1999Journal of natural products, Apr, Volume: 62, Issue:4
The antiproliferative effect of acridone alkaloids on several cancer cell lines.
AID357322Cytotoxicity against human Hep3B cells2001Journal of natural products, Aug, Volume: 64, Issue:8
Constituents of the root bark of Severinia buxifolia collected in Hainan.
AID379436Antiproliferative activity against mouse B16 cells after 3 days by alamar blue assay1999Journal of natural products, Apr, Volume: 62, Issue:4
The antiproliferative effect of acridone alkaloids on several cancer cell lines.
AID379438Antiproliferative activity against human TGBC11TKB cells after 3 days by alamar blue assay1999Journal of natural products, Apr, Volume: 62, Issue:4
The antiproliferative effect of acridone alkaloids on several cancer cell lines.
AID357321Cytotoxicity against human COLO205 cells2001Journal of natural products, Aug, Volume: 64, Issue:8
Constituents of the root bark of Severinia buxifolia collected in Hainan.
AID357323Cytotoxicity against human KB cells2001Journal of natural products, Aug, Volume: 64, Issue:8
Constituents of the root bark of Severinia buxifolia collected in Hainan.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's4 (44.44)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.86 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]