Page last updated: 2024-09-28
Adenomatosis, Ovine Pulmonary
A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.
Synonyms(8)
| Synonym |
|---|
| Carcinoma, Ovine Pulmonary |
| Adenomatosis, Pulmonary, Ovine |
| Ovine Pulmonary Carcinoma |
| Ovine Pulmonary Adenomatosis |
| Pulmonary Adenomatosis, Ovine |
| Adenomatosis, Ovine Pulmonary |
| Pulmonary Ovine Adenomatosis |
| Jaagsiekte |
Research
Studies (22)
| Timeframe | Studies, This Condition (%) | All Conditions % |
|---|
| pre-1990 | 10 (45.45) | 23.3326 |
| 1990's | 0 (0.00) | 12.5806 |
| 2000's | 5 (22.73) | 18.1394 |
| 2010's | 7 (31.82) | 28.8240 |
| 2020's | 0 (0.00) | 9.53 |
Protein Targets (78)
| Protein | Potency Measurements | Inhibition Measurements | Activation Measurements | Drugs |
|---|
| Chain A, GTPase KRas, isoform 2B | 0 | 0 | 1 | 1 |
| Chain A, GTPase KRas, isoform 2B | 0 | 0 | 1 | 1 |
| progesterone receptor | 1 | 0 | 0 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | 1 | 0 | 0 | 1 |
| estrogen-related nuclear receptor alpha | 1 | 0 | 0 | 1 |
| geminin | 2 | 0 | 0 | 2 |
| Membrane primary amine oxidase | 0 | 1 | 0 | 1 |
| Cytochrome P450 2B1 | 0 | 1 | 0 | 2 |
| Cytochrome P450 1A1 | 0 | 1 | 0 | 2 |
| GTPase KRas | 0 | 0 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | 0 | 0 | 0 | 1 |
| Glutaminyl-peptide cyclotransferase | 0 | 1 | 0 | 1 |
| Lanosterol 14-alpha demethylase | 0 | 1 | 0 | 1 |
| Membrane primary amine oxidase | 0 | 1 | 0 | 1 |
| Glutaminyl-peptide cyclotransferase | 0 | 1 | 0 | 1 |
| ATP-binding cassette sub-family C member 3 | 0 | 1 | 0 | 1 |
| Multidrug resistance-associated protein 4 | 0 | 1 | 0 | 1 |
| Bile salt export pump | 0 | 1 | 0 | 1 |
| 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 0 | 1 | 0 | 1 |
| Gap junction alpha-1 protein | 0 | 1 | 0 | 1 |
| Gap junction beta-2 protein | 0 | 1 | 0 | 1 |
| Spike glycoprotein | 1 | 0 | 0 | 1 |
| Acyl-protein thioesterase 1 | 0 | 1 | 0 | 1 |
| Canalicular multispecific organic anion transporter 1 | 0 | 1 | 0 | 1 |
| Chain A, AMINOPEPTIDASE | 0 | 1 | 0 | 1 |
| Chain A, AMINOPEPTIDASE | 0 | 1 | 0 | 1 |
| Chain A, Leucine Aminopeptidase | 0 | 1 | 0 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme | 0 | 1 | 0 | 1 |
| Intestinal-type alkaline phosphatase | 0 | 1 | 0 | 1 |
| Large neutral amino acids transporter small subunit 1 | 0 | 1 | 0 | 1 |
| Proton-coupled amino acid transporter 1 | 0 | 1 | 0 | 2 |
| Phospholipase A-2-activating protein | 0 | 1 | 0 | 1 |
| Tyrosine-protein kinase Lck | 0 | 0 | 0 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | 0 | 0 | 0 | 1 |
| Growth factor receptor-bound protein 2 | 0 | 0 | 0 | 1 |
| Tyrosine-protein phosphatase non-receptor type 11 | 0 | 0 | 0 | 1 |
| Chain A, MALTOPORIN | 0 | 0 | 1 | 1 |
| Chain B, MALTOPORIN | 0 | 0 | 1 | 1 |
| pregnane X nuclear receptor | 1 | 0 | 0 | 1 |
| estrogen nuclear receptor alpha | 1 | 0 | 0 | 1 |
| peripheral myelin protein 22 | 2 | 0 | 0 | 2 |
| Carbonic anhydrase 2 | 0 | 1 | 1 | 2 |
| Carbonic anhydrase 9 | 0 | 1 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | 2 | 0 | 0 | 2 |
| Thymidine kinase | 0 | 1 | 0 | 2 |
| AR protein | 1 | 0 | 0 | 1 |
| glucocorticoid receptor [Homo sapiens] | 1 | 0 | 0 | 1 |
| Thymidine kinase, cytosolic | 0 | 2 | 0 | 4 |
| Thymidine kinase | 0 | 1 | 0 | 2 |
| Thymidylate synthase | 0 | 0 | 0 | 1 |
| Thymidine phosphorylase | 0 | 0 | 0 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | 0 | 1 | 0 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | 0 | 1 | 0 | 1 |
| Thymidine phosphorylase | 0 | 0 | 0 | 1 |
| Thymidylate kinase | 0 | 1 | 0 | 1 |
| Thymidine kinase, cytosolic | 0 | 0 | 0 | 2 |
| Thymidine kinase | 0 | 0 | 0 | 1 |
| Thymidylate kinase | 0 | 1 | 0 | 1 |
| Thymidine kinase | 0 | 1 | 0 | 2 |
| Sterol O-acyltransferase 1 | 0 | 1 | 0 | 1 |
| Thymidine kinase | 0 | 0 | 0 | 1 |
| Thymidine kinase | 0 | 0 | 0 | 1 |
| RAR-related orphan receptor gamma | 1 | 0 | 0 | 1 |
| retinoid X nuclear receptor alpha | 1 | 0 | 0 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | 1 | 0 | 0 | 1 |
| Chain A, Cytidine Deaminase | 0 | 1 | 0 | 1 |
| phosphopantetheinyl transferase | 1 | 0 | 0 | 1 |
| nonstructural protein 1 | 1 | 0 | 0 | 1 |
| DNA polymerase iota isoform a (long) | 1 | 0 | 0 | 1 |
| Sodium/nucleoside cotransporter 1 | 0 | 2 | 0 | 2 |
| Sodium/nucleoside cotransporter 2 | 0 | 2 | 0 | 2 |
| Rap guanine nucleotide exchange factor 3 | 1 | 0 | 0 | 1 |
| Cytidine deaminase | 0 | 1 | 0 | 1 |
| Equilibrative nucleoside transporter 2 | 0 | 2 | 0 | 2 |
| Protein cereblon | 0 | 2 | 0 | 2 |
| Equilibrative nucleoside transporter 1 | 0 | 2 | 0 | 2 |
| Uridine-cytidine kinase 1 | 0 | 0 | 0 | 1 |
| Solute carrier family 28 member 3 | 0 | 2 | 0 | 2 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |