Assay ID | Title | Year | Journal | Article |
AID1330457 | Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as decrease in CD band intensity at 263 nanometer measured after 5 mins by circular dichroism titration method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
| Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding. |
AID1566495 | Inhibition of biotinylated pre-let-7d (unknown origin) maturation at 1 mM preincubated for 15 mins followed by Pre-let-7d addition and measured after 5 hrs by cat-ELCCA | 2019 | ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5
| Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition. |
AID1448240 | Antibacterial activity against Escherichia coli K-12 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1448228 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1448246 | Cytotoxicity against human DU145 cells after 48 hrs by SRB assay | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1330459 | Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as change in CD band intensity at 266 nanometer measured after 5 mins by circular dichroism titration method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
| Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding. |
AID1855247 | Binding affinity to calf thymus DNA at 50 uM incubated for 30 mins and measured by fluorescence spectroscopy | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | Discovery of 2,5-diphenyl-1,3,4-thiadiazole derivatives as HDAC inhibitors with DNA binding affinity. |
AID1448239 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1537193 | Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
| Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability. |
AID1448244 | Antibacterial activity against Enterobacter cloacae ATCC 13047 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1448243 | Antibacterial activity against Klebsiella pneumoniae NR15410 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1330473 | Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as isosbestic point at 3 uM by UV-vis absorption method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
| Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding. |
AID1448242 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1566490 | Inhibition of Dicer mediated biotinylated pre-miRNA-21 (unknown origin) maturation at 1 mM measured after 15 mins by cat-ELCCA relative to control | 2019 | ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5
| Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition. |
AID1330465 | Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as thermal stability by measuring change in melting temperature at 5 uM in presence of neomycin by UV-Vis spectrophotometry | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
| Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding. |
AID1537194 | Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
| Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability. |
AID1330456 | Inhibition of ethidium bromide binding to r(CGCAAAUUUGCG)2 RNA (unknown origin) at 1:1 ratio of ligand:RNA measured after 5 mins by fluorescent intercalator displacement assay relative to control | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
| Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding. |
AID1379617 | Binding affinity to calf thymus DNA assessed as increase in relative viscosity of DNA-compound complex at 5 uM by viscometry | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of substituted phenanthrene-9-benzimidazole conjugates: Cytotoxicity evaluation and apoptosis inducing studies. |
AID1448238 | Antibacterial activity against Shigella flexneri 2457NR517 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1724032 | Inhibition of Topoisomerase 1 (unknown origin) | 2020 | Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18
| Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors. |
AID1330471 | Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as hypochromicity at 3 uM by UV-vis absorption method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
| Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding. |
AID1448226 | Antibacterial activity against Staphylococcus aureus ATCC 33591 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1330458 | Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as appearance of induced CD band at 320 to 380 nanometer measured after 5 mins by circular dichroism titration method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
| Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding. |
AID1537210 | Binding affinity to calf thymus DNA assessed as DNA intercalation by measuring increase in viscosity at 5 uM by Ostwald viscometric method | 2019 | Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
| Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability. |
AID1819516 | Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay | 2022 | Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
| Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity. |
AID1566486 | Binding affinity to biotinylated pre-miRNA-21 (unknown origin) by SPR analysis | 2019 | ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5
| Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition. |
AID1330468 | Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as thermal stability by measuring change in melting temperature at 5 uM by UV-Vis spectrophotometry | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
| Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding. |
AID1855246 | Binding affinity to calf thymus DNA at 50 uM incubated for 30 mins and measured by UV-vis absorption spectroscopy | 2022 | European journal of medicinal chemistry, Nov-05, Volume: 241 | Discovery of 2,5-diphenyl-1,3,4-thiadiazole derivatives as HDAC inhibitors with DNA binding affinity. |
AID1448223 | Antibacterial activity against Enterococcus faecium BM4105RF after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1448224 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1330472 | Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as red shift at 3 uM by UV-vis absorption method | 2016 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
| Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding. |
AID1448225 | Antibacterial activity against Staphylococcus epidermidis ATCC 12384 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1537192 | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay | 2019 | Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
| Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability. |
AID1448237 | Antibacterial activity against methicillin-resistant Staphylococcus aureus 33591 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1448245 | Antibacterial activity against Citrobacter freundii 4747CFAA after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1448241 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1448227 | Antibacterial activity against methicillin-resistant Staphylococcus aureus A960649 after 24 hrs by microbroth dilution method | 2017 | Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
| Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles. |
AID1724052 | Inhibition of Topoisomerase 2 (unknown origin) | 2020 | Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18
| Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |