Page last updated: 2024-12-06

bisbenzimidazole trihydrochloride

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Cross-References

ID SourceID
PubMed CID31953
CHEMBL ID34922
MeSH IDM0010486

Synonyms (73)

Synonym
einecs 245-690-6
phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1h-benzimidazol)-2'-yl)-, trihydrochloride
h 33258
4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1h-benzimidazol)-2'-yl)phenol, trihydrochloride
bisbenzimidazole trihydrochloride
p-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1h-benzimidazol)-2'-yl)phenol trihydrochloride
33258 hoechst
phenol, p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-, trihydrochloride
hoechst dye 33258
23491-45-4
hoe 33258
CHEMBL34922 ,
unii-mht095273m
4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1h-benzimidazol)-2'-yl)phenol trihydrochloride
phenol, 4-(6-(4-methyl-1-piperazinyl)(2,6'-bi-1h-benzimidazol)-2'-yl)-, hydrochloride (1:3)
mht095273m ,
bisbenzimide h 33258
phenol, 4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1h-benzimidazol]-2'-yl]-, trihydrochloride
AKOS015903038
2'-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bibenzimidazole trihydrochloride
H1343
2-(2-(4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperzyl)
bisbenzimide trihydrochloride
h-33258
4-(5-(4-methyl-1-piperazinyl) (2,5'-bi-1h-benzimidazol)-2'-yl)-phenol, trihydrochloride
pibenzimol trihydrochloride
bisbenzimide trihydrochloride [mi]
hoechst-33258
ho-33258
pibenzimol hydrochloride
DTXSID5066900
hoechst 33258, ultrapure grade
2'-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi(1h-benzimidazole) trihydrochloride
J-100038
B6236
CS-7568
bisbenzimide h 33258 trihydrochloride
AKOS030210959
bisbenzimide h 33258 fluorochrome trihydrochloride
(2'-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi(1h-benzimidazole) trihydrochloride
mfcd00044760
4-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1h-benzimidazol]-2'-yl]phenol trihydrochloride
p-(5-(5-(4-methyl-1-piperazinyl)-1h-2-benzimidazolyl)-1h-2-benzimidazolyl)phenol trihydrochloride
p-(5-(5-(4-methyl-1-piperazinyl)-1h-2-benzo[d]imidazolyl)-1h-2-benzo[d]imidazolyl)phenol trihydrochloride
AKOS030632783
hoechst 33258 trihydrochloride
HY-15558A
4-(5-(4-methylpiperazin-1-yl)-1h,1'h-2,5'-bibenzo[d]imidazol-2'-yl)phenol trihydrochloride
hoechst 33258 3hcl
bisbenzimide trihydrochloride;bisbenzimide h 33258 trihydrochloride; h 33258 trihydrochloride; pibenzimol trihydrochloride
BCP19630
c25h24n6o 3hcl
HB0786
bisbenzimide h 33258 fluorochrome, trihydrochloride - cas 23491-45-4
bdbm50561016
4-(5-(4-methylpiperazin-1-yl)-1h,1'h-[2,5'-bibenzo[d]imidazol]-2'-yl)phenol trihydrochloride
4-{6-[6-(4-methylpiperazin-1-yl)-1h-1,3-benzodiazol-2-yl]-1h-1,3-benzodiazol-2-yl}phenol trihydrochloride
AS-75157
h 33258 trihydrochloride
EX-A2897
hoechst 33258 trihydrochloride; h 33258 trihydrochloride
bis-benzimide h 33258
Q27284034
C74213
A912877
2'-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-1h-benzimidazole trihydrochloride
4-[6-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-benzimidazol-2-yl]phenol;trihydrochloride
4-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1h-benzimidazol]-2'-yl]-phenol, trihydrochloride
23491-45-4 (hcl)
bisbenzimide hcl
bisbenzimide h 33258 (0.2ml*5) (1mg/ml in water) [for cell staining]
2 inverted exclamation mark -(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5 inverted exclamation mark -bibenzimidazole trihydrochloride
SY057920
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA topoisomerase 1Homo sapiens (human)IC50 (µMol)30.00000.02101.862610.0000AID1724032
DNA topoisomerase 2-alphaHomo sapiens (human)IC50 (µMol)30.00000.48004.35649.9400AID1724052
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (24)

Processvia Protein(s)Taxonomy
DNA topological changeDNA topoisomerase 1Homo sapiens (human)
chromatin remodelingDNA topoisomerase 1Homo sapiens (human)
circadian rhythmDNA topoisomerase 1Homo sapiens (human)
response to xenobiotic stimulusDNA topoisomerase 1Homo sapiens (human)
programmed cell deathDNA topoisomerase 1Homo sapiens (human)
phosphorylationDNA topoisomerase 1Homo sapiens (human)
peptidyl-serine phosphorylationDNA topoisomerase 1Homo sapiens (human)
circadian regulation of gene expressionDNA topoisomerase 1Homo sapiens (human)
embryonic cleavageDNA topoisomerase 1Homo sapiens (human)
chromosome segregationDNA topoisomerase 1Homo sapiens (human)
DNA replicationDNA topoisomerase 1Homo sapiens (human)
hematopoietic progenitor cell differentiationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topological changeDNA topoisomerase 2-alphaHomo sapiens (human)
DNA ligationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA damage responseDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome segregationDNA topoisomerase 2-alphaHomo sapiens (human)
female meiotic nuclear divisionDNA topoisomerase 2-alphaHomo sapiens (human)
apoptotic chromosome condensationDNA topoisomerase 2-alphaHomo sapiens (human)
embryonic cleavageDNA topoisomerase 2-alphaHomo sapiens (human)
regulation of circadian rhythmDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of apoptotic processDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of single stranded viral RNA replication via double stranded DNA intermediateDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIDNA topoisomerase 2-alphaHomo sapiens (human)
rhythmic processDNA topoisomerase 2-alphaHomo sapiens (human)
negative regulation of DNA duplex unwindingDNA topoisomerase 2-alphaHomo sapiens (human)
resolution of meiotic recombination intermediatesDNA topoisomerase 2-alphaHomo sapiens (human)
sister chromatid segregationDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (20)

Processvia Protein(s)Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA bindingDNA topoisomerase 1Homo sapiens (human)
DNA bindingDNA topoisomerase 1Homo sapiens (human)
chromatin bindingDNA topoisomerase 1Homo sapiens (human)
double-stranded DNA bindingDNA topoisomerase 1Homo sapiens (human)
single-stranded DNA bindingDNA topoisomerase 1Homo sapiens (human)
RNA bindingDNA topoisomerase 1Homo sapiens (human)
DNA topoisomerase type I (single strand cut, ATP-independent) activityDNA topoisomerase 1Homo sapiens (human)
protein serine/threonine kinase activityDNA topoisomerase 1Homo sapiens (human)
protein bindingDNA topoisomerase 1Homo sapiens (human)
ATP bindingDNA topoisomerase 1Homo sapiens (human)
DNA binding, bendingDNA topoisomerase 1Homo sapiens (human)
protein domain specific bindingDNA topoisomerase 1Homo sapiens (human)
supercoiled DNA bindingDNA topoisomerase 1Homo sapiens (human)
magnesium ion bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
chromatin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
RNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activityDNA topoisomerase 2-alphaHomo sapiens (human)
protein kinase C bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP-dependent activity, acting on DNADNA topoisomerase 2-alphaHomo sapiens (human)
DNA binding, bendingDNA topoisomerase 2-alphaHomo sapiens (human)
protein homodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
ubiquitin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein heterodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (16)

Processvia Protein(s)Taxonomy
nuclear chromosomeDNA topoisomerase 1Homo sapiens (human)
P-bodyDNA topoisomerase 1Homo sapiens (human)
fibrillar centerDNA topoisomerase 1Homo sapiens (human)
male germ cell nucleusDNA topoisomerase 1Homo sapiens (human)
nucleusDNA topoisomerase 1Homo sapiens (human)
nucleoplasmDNA topoisomerase 1Homo sapiens (human)
nucleolusDNA topoisomerase 1Homo sapiens (human)
perikaryonDNA topoisomerase 1Homo sapiens (human)
protein-DNA complexDNA topoisomerase 1Homo sapiens (human)
nucleolusDNA topoisomerase 1Homo sapiens (human)
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
nuclear chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
centrioleDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome, centromeric regionDNA topoisomerase 2-alphaHomo sapiens (human)
condensed chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
male germ cell nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
cytoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complexDNA topoisomerase 2-alphaHomo sapiens (human)
protein-containing complexDNA topoisomerase 2-alphaHomo sapiens (human)
ribonucleoprotein complexDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (38)

Assay IDTitleYearJournalArticle
AID1330457Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as decrease in CD band intensity at 263 nanometer measured after 5 mins by circular dichroism titration method2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding.
AID1566495Inhibition of biotinylated pre-let-7d (unknown origin) maturation at 1 mM preincubated for 15 mins followed by Pre-let-7d addition and measured after 5 hrs by cat-ELCCA2019ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5
Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition.
AID1448240Antibacterial activity against Escherichia coli K-12 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1448228Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1448246Cytotoxicity against human DU145 cells after 48 hrs by SRB assay2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1330459Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as change in CD band intensity at 266 nanometer measured after 5 mins by circular dichroism titration method2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding.
AID1855247Binding affinity to calf thymus DNA at 50 uM incubated for 30 mins and measured by fluorescence spectroscopy2022European journal of medicinal chemistry, Nov-05, Volume: 241Discovery of 2,5-diphenyl-1,3,4-thiadiazole derivatives as HDAC inhibitors with DNA binding affinity.
AID1448239Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1537193Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay2019Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability.
AID1448244Antibacterial activity against Enterobacter cloacae ATCC 13047 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1448243Antibacterial activity against Klebsiella pneumoniae NR15410 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1330473Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as isosbestic point at 3 uM by UV-vis absorption method2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding.
AID1448242Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1566490Inhibition of Dicer mediated biotinylated pre-miRNA-21 (unknown origin) maturation at 1 mM measured after 15 mins by cat-ELCCA relative to control2019ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5
Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition.
AID1330465Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as thermal stability by measuring change in melting temperature at 5 uM in presence of neomycin by UV-Vis spectrophotometry2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding.
AID1537194Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay2019Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability.
AID1330456Inhibition of ethidium bromide binding to r(CGCAAAUUUGCG)2 RNA (unknown origin) at 1:1 ratio of ligand:RNA measured after 5 mins by fluorescent intercalator displacement assay relative to control2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding.
AID1379617Binding affinity to calf thymus DNA assessed as increase in relative viscosity of DNA-compound complex at 5 uM by viscometry2017European journal of medicinal chemistry, Nov-10, Volume: 140Synthesis of substituted phenanthrene-9-benzimidazole conjugates: Cytotoxicity evaluation and apoptosis inducing studies.
AID1448238Antibacterial activity against Shigella flexneri 2457NR517 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1724032Inhibition of Topoisomerase 1 (unknown origin)2020Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors.
AID1330471Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as hypochromicity at 3 uM by UV-vis absorption method2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding.
AID1448226Antibacterial activity against Staphylococcus aureus ATCC 33591 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1330458Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as appearance of induced CD band at 320 to 380 nanometer measured after 5 mins by circular dichroism titration method2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding.
AID1537210Binding affinity to calf thymus DNA assessed as DNA intercalation by measuring increase in viscosity at 5 uM by Ostwald viscometric method2019Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability.
AID1819516Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay2022Journal of medicinal chemistry, 02-24, Volume: 65, Issue:4
Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity.
AID1566486Binding affinity to biotinylated pre-miRNA-21 (unknown origin) by SPR analysis2019ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5
Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition.
AID1330468Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as thermal stability by measuring change in melting temperature at 5 uM by UV-Vis spectrophotometry2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding.
AID1855246Binding affinity to calf thymus DNA at 50 uM incubated for 30 mins and measured by UV-vis absorption spectroscopy2022European journal of medicinal chemistry, Nov-05, Volume: 241Discovery of 2,5-diphenyl-1,3,4-thiadiazole derivatives as HDAC inhibitors with DNA binding affinity.
AID1448223Antibacterial activity against Enterococcus faecium BM4105RF after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1448224Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1330472Binding affinity to poly(rA).(rU) RNA duplex (unknown origin) assessed as red shift at 3 uM by UV-vis absorption method2016Bioorganic & medicinal chemistry letters, 12-15, Volume: 26, Issue:24
Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding.
AID1448225Antibacterial activity against Staphylococcus epidermidis ATCC 12384 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1537192Antiproliferative activity against human A549 cells after 48 hrs by MTT assay2019Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability.
AID1448237Antibacterial activity against methicillin-resistant Staphylococcus aureus 33591 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1448245Antibacterial activity against Citrobacter freundii 4747CFAA after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1448241Antibacterial activity against Acinetobacter baumannii ATCC 19606 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1448227Antibacterial activity against methicillin-resistant Staphylococcus aureus A960649 after 24 hrs by microbroth dilution method2017Journal of medicinal chemistry, 06-22, Volume: 60, Issue:12
Selective Inhibition of Escherichia coli RNA and DNA Topoisomerase I by Hoechst 33258 Derived Mono- and Bisbenzimidazoles.
AID1724052Inhibition of Topoisomerase 2 (unknown origin)2020Bioorganic & medicinal chemistry, 09-15, Volume: 28, Issue:18
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (62.50)24.3611
2020's3 (37.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.42

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.42 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.42)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]