Page last updated: 2024-09-28

Auditory Hyperesthesia

An abnormally disproportionate increase in the sensation of loudness in response to auditory stimuli of normal volume. COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; FACIAL NERVE DISEASES; STAPES SURGERY; and other disorders may be associated with this condition.

Synonyms(7)

Synonym
Hyperacusia
Loudness Perception Disturbances
Loudness Recruitment
Hyperacusis
Recruitment, Loudness
Phonophobia
Auditory Hyperesthesia

Research Excerpts

Overview

ExcerptReference
"Tinnitus and hyperacusis are common and potentially serious hearing disorders associated with noise-, age- or drug-induced hearing loss."( Auerbach, BD; Chen, GD; Chen, YC; Manohar, S; Radziwon, K; Salvi, R, 2017)
"Tinnitus and hyperacusis are debilitating conditions often associated with aging or exposure to intense noise or ototoxic drugs."( Auerbach, BD; Chen, GD; Chen, YC; Ding, D; Lau, C; Liu, X; Manohar, S; Salvi, R, 2021)

Treatment

ExcerptReference
"In a prospective cohort, patients with hyperacusis were treated with a multi-modal step-wise migraine prophylactic regimen (nortriptyline, verapamil, topiramate, or a combination thereof) as well as lifestyle and dietary modifications."( Abouzari, M; Djalilian, HR; Ghavami, Y; Goshtasbi, K; Lin, HW; Parker, EM; Sarna, B; Tan, D, 2020)
"The majority of patients with hyperacusis demonstrated symptomatic improvement from migraine prophylaxis therapy, as indicated by self-reported and audiometric measures."( Abouzari, M; Djalilian, HR; Ghavami, Y; Goshtasbi, K; Lin, HW; Parker, EM; Sarna, B; Tan, D, 2020)

Research

Studies (79)

TimeframeStudies, This Condition (%)All Conditions %
pre-199012 (15.19)23.3326
1990's4 (5.06)12.5806
2000's22 (27.85)18.1394
2010's32 (40.51)28.8240
2020's9 (11.39)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
salicylic acid0low30
3,4-dihydroxyphenylacetic acid0low10
melatonin0low10
pyridoxine0low10
acetaminophen0medium31
amantadine0low10
amitriptyline0low10
aspirin0medium11
baclofen0low10
caffeine0medium11
verapamil0low10
carbamazepine0low10
chloral hydrate0low10
chlorzoxazone0low10
clonazepam0low10
diazepam0low10
diclofenac0medium21
diphenhydramine0medium11
valproic acid0low10
etidronate0low10
brl 428100low10
furosemide0low10
lidocaine0low30
ketorolac0medium11
meprobamate0low10
metoclopramide0low20
nortriptyline0low10
prochlorperazine0medium11
risperidone0low10
secobarbital0low10
risedronic acid0low10
sumatriptan0medium74
thalidomide0low20
vigabatrin0low20
corticosterone0low10
prednisone0medium21
aspartic acid0low10
kanamycin a0low20
methylprednisolone0low10
n-vinyl-2-pyrrolidinone0low10
quinoxalines0low10
pyrroles0medium11
2-aminopurine0low10
limestone0low10
streptomycin0low10
fluorides0low10
glutamic acid0low10
5,7-dihydroxytryptamine0low10
fomesafen0low100
metsulfuron methyl0low10
zolmitriptan0medium22
fluorophosphate0low10
caroverine0low10
sertraline0low10
oxazolidin-2-one0medium22
frovatriptan0medium21
eletriptan0medium21
homocysteine0low10
ramelteon0low10
povidone-iodine0low10
D-fructopyranose0low10
quinine0low10
hydromorphone0medium11
topiramate0low20
arachidonyl-2-chloroethylamide0low10
telcagepant0medium11
sodium salicylate0low70
salicylates0low30
vitamin b 120low10
acyclovir0low10

Protein Targets (842)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Beta-lactamase6006
thioredoxin reductase190019
aldehyde dehydrogenase 1 family, member A1160016
IDH19009
Phosphatidylinositol 4-kinase alpha0202
Xanthine dehydrogenase/oxidase0101
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 432002
Phosphatidylinositol 4-kinase type 2-beta0202
Phosphatidylinositol 4-kinase type 2-alpha0202
Phosphatidylinositol 4-kinase beta0202
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE110011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Chain A, HADH2 protein100010
Chain B, HADH2 protein100010
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, Protocatechuate 3,4-dioxygenase0011
Chain M, Protocatechuate 3,4-dioxygenase0011
Olfactory receptor class A-like protein 10011
Luciferase6006
endonuclease IV2002
RGS121001
phosphopantetheinyl transferase110011
NFKB1 protein, partial6006
GLS protein120012
TDP1 protein190019
Microtubule-associated protein tau5005
Thrombopoietin6006
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase2002
apical membrane antigen 1, AMA13003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
thyroid stimulating hormone receptor120012
hypothetical protein, conserved2002
regulator of G-protein signaling 4110011
euchromatic histone-lysine N-methyltransferase 2280028
Bloom syndrome protein isoform 1100010
lysosomal alpha-glucosidase preproprotein2002
peripheral myelin protein 22 isoform 13003
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 18008
intestinal alkaline phosphatase precursor0101
chromobox protein homolog 1150015
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
DNA polymerase beta2002
flap endonuclease 14004
DNA polymerase iota isoform a (long)5005
geminin180018
M-phase phosphoprotein 83003
alkaline phosphatase, germ cell type preproprotein0011
POsterior Segregation0011
muscarinic acetylcholine receptor M1110011
lamin isoform A-delta10190019
Prolyl 4-hydroxylase subunit alpha-10202
Sodium-dependent noradrenaline transporter 012315
Zinc finger protein mex-50011
ATP-dependent phosphofructokinase9009
5-hydroxytryptamine receptor 1A016218
RAR-related orphan receptor gamma130013
ATAD5 protein, partial7007
Smad36006
nuclear receptor subfamily 1, group I, member 3120012
progesterone receptor8008
EWS/FLI fusion protein130013
retinoic acid nuclear receptor alpha variant 1140014
retinoid X nuclear receptor alpha110011
estrogen-related nuclear receptor alpha150015
estrogen nuclear receptor alpha290029
peroxisome proliferator activated receptor gamma7007
aryl hydrocarbon receptor6006
thyroid hormone receptor beta isoform 2140014
peripheral myelin protein 22100010
cytochrome P450 3A4 isoform 17007
Gamma-aminobutyric acid receptor subunit pi75113
ATP-binding cassette sub-family C member 3027027
Multidrug resistance-associated protein 4027027
Solute carrier family 22 member 60405
Carbonic anhydrase 120406
UDP-glucuronosyltransferase 1A90104
Bile salt export pump0909
Voltage-dependent calcium channel gamma-2 subunit7007
Bile salt export pump036036
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 1011015
Carbonic anhydrase 2011116
Myoglobin0101
Cytochrome P450 1A10113
Cytochrome P450 1A20203
Prostaglandin G/H synthase 10404
Carbonic anhydrase 30404
Cytochrome P450 3A40707
Cytochrome P450 2D6011011
Cytochrome P450 2C9 011012
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-175113
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta75113
Gamma-aminobutyric acid receptor subunit gamma-275315
UDP-glucuronosyltransferase 1-60305
Glutamate receptor 272211
Gamma-aminobutyric acid receptor subunit alpha-575113
Gamma-aminobutyric acid receptor subunit alpha-375113
Arachidonate 5-lipoxygenase-activating protein0202
UDP-glucuronosyltransferase 1A1 0304
Carbonic anhydrase 40507
Prostaglandin G/H synthase 10707
Carbonic anhydrase 60406
Gamma-aminobutyric acid receptor subunit gamma-175113
Gamma-aminobutyric acid receptor subunit alpha-275113
Gamma-aminobutyric acid receptor subunit alpha-475113
Gamma-aminobutyric acid receptor subunit gamma-375113
Gamma-aminobutyric acid receptor subunit alpha-675113
Carbonic anhydrase 5A, mitochondrial0417
Prostaglandin G/H synthase 20506
Carbonic anhydrase 70406
Nuclear receptor ROR-gamma6006
Cytochrome P450 2J2011011
Gamma-aminobutyric acid receptor subunit alpha-176316
Gamma-aminobutyric acid receptor subunit beta-375113
Gamma-aminobutyric acid receptor subunit beta-275315
Carbonic anhydrase 90507
GABA theta subunit75113
Canalicular multispecific organic anion transporter 1026026
Carbonic anhydrase 150404
Carbonic anhydrase 130406
Gamma-aminobutyric acid receptor subunit epsilon75113
Carbonic anhydrase 140406
Carbonic anhydrase 5B, mitochondrial0406
toxin B0001
Chain E, Purine nucleoside phosphorylase0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain4004
Thymidine kinase 0101
arylsulfatase A8008
activating transcription factor 66006
Histone H2A.x3003
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Solute carrier family 22 member 1 010014
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60203
Thymidine kinase 0101
Solute carrier family 22 member 80102
Thymidine kinase0101
acetylcholinesterase8008
GLI family zinc finger 3160016
AR protein220022
signal transducer and activator of transcription 6, interleukin-4 induced1001
putative alpha-glucosidase1001
heat shock protein beta-12002
histone acetyltransferase KAT2A isoform 16006
Solute carrier family 22 member 20406
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3B0202
Matrix protein 20112
Matrix protein 20123
Glutamate receptor ionotropic, NMDA 1 0415
Spike glycoprotein100010
Glutamate receptor ionotropic, NMDA 2A 0415
Glutamate receptor ionotropic, NMDA 2B0516
Glutamate receptor ionotropic, NMDA 2C0415
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 2D0415
Solute carrier family 22 member 10607
Glutamate receptor ionotropic, NMDA 3A0202
Glutamate receptor ionotropic, NMDA 3B0415
Multidrug and toxin extrusion protein 10606
Solute carrier family 22 member 20606
Glutamate receptor ionotropic, NMDA 3A0415
USP1 protein, partial6006
cytochrome P450 family 3 subfamily A polypeptide 4110011
cytochrome P450 2D6130013
cytochrome P450 2D6 isoform 17007
D(1A) dopamine receptor9009
atrial natriuretic peptide receptor 2 precursor5005
serine/threonine-protein kinase mTOR isoform 16006
nuclear factor erythroid 2-related factor 2 isoform 1110011
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
Voltage-dependent L-type calcium channel subunit alpha-1F0415
5-hydroxytryptamine receptor 4018018
Albumin0066
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B1013013
Muscarinic acetylcholine receptor M2011011
Muscarinic acetylcholine receptor M4011011
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
5-hydroxytryptamine receptor 2C0808
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M5013013
Alpha-2A adrenergic receptor015015
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M1013013
Angiotensin-converting enzyme012012
D(2) dopamine receptor0909
5-hydroxytryptamine receptor 2A0808
Alpha-2B adrenergic receptor012012
Alpha-2C adrenergic receptor010010
Muscarinic acetylcholine receptor M3012012
D(1A) dopamine receptor0808
D(1B) dopamine receptor0101
UDP-glucuronosyltransferase 1A40203
Histamine H2 receptor0808
Alpha-1D adrenergic receptor0808
5-hydroxytryptamine receptor 2A020020
5-hydroxytryptamine receptor 2C019019
5-hydroxytryptamine receptor 1B013013
5-hydroxytryptamine receptor 1D0415
5-hydroxytryptamine receptor 1F0303
5-hydroxytryptamine receptor 2B0707
5-hydroxytryptamine receptor 60202
Histamine H1 receptor0202
Sodium-dependent serotonin transporter013316
5-hydroxytryptamine receptor 7 0303
5-hydroxytryptamine receptor 5A0202
5-hydroxytryptamine receptor 5B0202
Histamine H1 receptor010010
D(3) dopamine receptor012012
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0304
UDP-glucuronosyltransferase 1A30002
5-hydroxytryptamine receptor 3A0505
5-hydroxytryptamine receptor 2B016016
Alpha-1A adrenergic receptor0808
Histamine H2 receptor3208
D(1A) dopamine receptor5005
5-hydroxytryptamine receptor 60909
5-hydroxytryptamine receptor 70505
Voltage-dependent N-type calcium channel subunit alpha-1B0202
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0415
Sodium-dependent dopamine transporter 010212
Potassium voltage-gated channel subfamily H member 2015015
Voltage-dependent L-type calcium channel subunit alpha-1S0415
Voltage-dependent L-type calcium channel subunit alpha-1C0415
Sodium channel protein type 5 subunit alpha0505
Sodium channel protein type 9 subunit alpha0404
Sigma non-opioid intracellular receptor 10213
5-hydroxytryptamine receptor 4 0304
Nuclear receptor subfamily 3 group C member 3 012012
Sodium channel protein type 2 subunit alpha0101
Ataxin-2110011
Sigma non-opioid intracellular receptor 109110
5-hydroxytryptamine receptor 3B0505
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0404
Sodium channel protein type 10 subunit alpha0101
glucocerebrosidase4004
polyunsaturated fatty acid lipoxygenase ALOX121001
DNA polymerase kappa isoform 14004
Fatty-acid amide hydrolase 10101
Glutamate receptor 10224
Glutamate receptor 30224
Glutamate receptor 40224
Cannabinoid receptor 10011
Cannabinoid receptor 10101
Cannabinoid receptor 2 0101
cytochrome P450 2C19 precursor4004
lethal factor (plasmid)4004
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0518
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0002
Carbonic anhydrase 40304
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 82002
glucocorticoid receptor [Homo sapiens]150015
peroxisome proliferator-activated receptor delta3003
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Prostaglandin-H2 D-isomerase0101
Prostaglandin G/H synthase 1 0202
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0101
Fatty acid-binding protein, liver0404
Integrin beta-32114
Myeloperoxidase0303
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb2114
Glutathione hydrolase 1 proenzyme0101
Adenosine receptor A10304
Adenosine receptor A2a0305
Substance-P receptor0101
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0202
Ras-related protein Rab-2A0011
Prostaglandin G/H synthase 20303
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10213
67.9K protein5005
Gamma-aminobutyric acid type B receptor subunit 20325
Gamma-aminobutyric acid type B receptor subunit 20303
Gamma-aminobutyric acid type B receptor subunit 10325
Gamma-aminobutyric acid type B receptor subunit 10202
Chain A, Cruzipain1001
relaxin receptor 1 isoform 11001
Interferon beta9009
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
farnesoid X nuclear receptor7007
pregnane X nuclear receptor150015
thyroid stimulating hormone receptor5005
v-jun sarcoma virus 17 oncogene homolog (avian)6006
thyroid hormone receptor beta isoform a7007
nuclear receptor ROR-gamma isoform 13003
Potassium channel subfamily K member 20314
Glycogen phosphorylase, muscle form0101
Renin0101
Cholinesterase0202
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0101
Adenosine receptor A30101
Replicase polyprotein 1ab0101
Amine oxidase [flavin-containing] A0101
Acetylcholinesterase0505
Amine oxidase [flavin-containing] B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0303
Adenosine receptor A30101
Adenosine receptor A2a0214
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10114
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10202
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0224
Endochitinase B10101
Muscarinic acetylcholine receptor0001
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20314
Guanine deaminase0101
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
nuclear factor erythroid 2-related factor 2 isoform 24004
mitogen-activated protein kinase 14004
Vpr2002
Major prion protein0011
Cellular tumor antigen p53100010
Sodium channel protein type 1 subunit alpha0303
Sodium channel protein type 2 subunit alpha0303
Sodium channel protein type 3 subunit alpha0202
UDP-glucuronosyltransferase 2B70306
Cytochrome P450 2B60011
Frizzled-80011
P2X purinoceptor 40101
bromodomain adjacent to zinc finger domain 2B4004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
muscleblind-like protein 1 isoform 12002
neuropeptide S receptor isoform A3003
UDP-glucuronosyltransferase 2B10 0202
Gamma-aminobutyric acid receptor subunit pi0606
Gamma-aminobutyric acid receptor subunit delta0606
Gamma-aminobutyric acid receptor subunit alpha-10303
Gamma-aminobutyric acid receptor subunit beta-10303
Neuronal acetylcholine receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit alpha-20303
Gamma-aminobutyric acid receptor subunit alpha-30303
Neuronal acetylcholine receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-10639
Gamma-aminobutyric acid receptor subunit beta-10617
Gamma-aminobutyric acid receptor subunit gamma-20628
Gamma-aminobutyric acid receptor subunit alpha-40303
Gamma-aminobutyric acid receptor subunit gamma-20303
Gamma-aminobutyric acid receptor subunit beta-30628
Translocator protein0202
Translocator protein0202
Cholecystokinin receptor type A0202
Gastrin/cholecystokinin type B receptor0202
Gamma-aminobutyric acid receptor subunit alpha-50639
Gamma-aminobutyric acid receptor subunit alpha-30628
Gamma-aminobutyric acid receptor subunit alpha-20628
Gamma-aminobutyric acid receptor subunit beta-20628
Gamma-aminobutyric acid receptor subunit alpha-40617
Gamma-aminobutyric acid receptor subunit epsilon0606
Gamma-aminobutyric acid receptor subunit alpha-60617
Gamma-aminobutyric acid receptor subunit gamma-10606
Gamma-aminobutyric acid receptor subunit gamma-30606
Gamma-aminobutyric acid receptor subunit theta0606
pregnane X receptor3003
GALC protein2002
nonstructural protein 14004
G7007
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
survival motor neuron protein isoform d4004
Solute carrier family 22 member 30102
Solute carrier family 22 member 30101
HLA class I histocompatibility antigen, B alpha chain 7007
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0011
Androgen receptor0303
C-8 sterol isomerase0101
Solute carrier organic anion transporter family member 1A10202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Inositol hexakisphosphate kinase 17007
cytochrome P450 2C9, partial7007
Gamma-aminobutyric acid 0112
glp-1 receptor, partial5005
estrogen receptor 2 (ER beta)5005
Alpha-1-acid glycoprotein 10001
Albumin0449
ATP-dependent translocase ABCB106117
Translocator protein0113
Gamma-aminobutyric acid receptor subunit alpha-60112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit delta0112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit gamma-30112
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30112
Neuronal acetylcholine receptor subunit alpha-70202
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit pi0112
Sphingosine-1-phosphate lyase 10101
ATPase family AAA domain-containing protein 53003
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit theta0112
Gamma-aminobutyric acid receptor subunit gamma-10112
Aldo-keto reductase family 1 member B100101
Transient receptor potential cation channel subfamily A member 10011
Dihydrofolate reductase0101
Cytochrome c oxidase subunit 20101
Transthyretin0013
Interleukin-80101
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Fatty acid-binding protein, intestinal0213
Aldo-keto reductase family 1 member B10202
Sodium- and chloride-dependent GABA transporter 10202
C-X-C chemokine receptor type 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Prostaglandin G/H synthase 2 0101
Sodium- and chloride-dependent betaine transporter0202
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 1 0101
P2Y purinoceptor 120101
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
vitamin D3 receptor isoform VDRA6006
potassium voltage-gated channel subfamily H member 2 isoform d7007
huntingtin isoform 24004
Histamine H1 receptor0102
Histamine N-methyltransferase0001
Calcium release-activated calcium channel protein 10101
Protein orai-20101
Protein orai-30101
Histamine H4 receptor0101
Histamine H3 receptor0001
5-hydroxytryptamine receptor 1B0538
acid sphingomyelinase1001
Type IV secretion-like conjugative transfer relaxase protein TraI 0101
Carbonic anhydrase0202
caspase 7, apoptosis-related cysteine protease2002
caspase-32002
Caspase-71001
NPC intracellular cholesterol transporter 1 precursor4004
caspase-31001
ras-related protein Rab-9A5005
Sodium-dependent noradrenaline transporter0101
Cytochrome P450 2C80404
Dipeptidyl peptidase 40101
Alpha-1B adrenergic receptor0505
Alpha-2B adrenergic receptor0314
Acetylcholinesterase0101
Alpha-2C adrenergic receptor0314
Alpha-2A adrenergic receptor0314
Alpha-1D adrenergic receptor0505
Sodium-dependent dopamine transporter0404
Potassium voltage-gated channel subfamily C member 10101
Sodium-dependent serotonin transporter0303
Cytochrome P450 2C190404
D(2) dopamine receptor0909
Gastrin/cholecystokinin type B receptor 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Cytochrome P450 1B10202
Sigma intracellular receptor 20202
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Transporter0202
Beta-2 adrenergic receptor0101
Transporter0303
hypoxia-inducible factor 1 alpha subunit2002
5-hydroxytryptamine receptor 1A0538
POU domain, class 2, transcription factor 10001
thyrotropin-releasing hormone receptor1001
Glucose-6-phosphate 1-dehydrogenase0101
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
6-phosphogluconate dehydrogenase, decarboxylating0202
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Histone deacetylase 30303
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 10202
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Histone deacetylase 40303
4-aminobutyrate aminotransferase, mitochondrial0102
4-aminobutyrate aminotransferase, mitochondrial0102
Histone deacetylase 10303
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Histone deacetylase 70303
Histone deacetylase 20303
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Histone deacetylase 80303
Platelet glycoprotein VI0011
Sodium- and chloride-dependent GABA transporter 20101
Histone deacetylase 60303
Histone deacetylase 90303
Histone deacetylase 50303
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Metabotropic glutamate receptor 80202
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
ATP-citrate synthase 0101
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10213
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Mu-type opioid receptor0112
Delta-type opioid receptor0101
Kappa-type opioid receptor0112
3-oxoacyl-[acyl-carrier-protein] synthase 30101
Gap junction alpha-1 protein0101
Gap junction beta-2 protein0101
Acyl-protein thioesterase 10101
Caspase-10101
Caspase-30101
Caspase-40101
Caspase-50101
Caspase-90101
Cell division control protein 42 homolog0101
Ras-related C3 botulinum toxin substrate 10101
Serine/threonine-protein kinase PAK 10101
Potassium channel subfamily K member 30101
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
ClpP1001
Cytochrome P450 1A2 0101
Cytochrome P450 2C11 0101
Aromatase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0202
Acetylcholinesterase 0101
Mu-type opioid receptor0303
Nociceptin receptor0101
Melatonin receptor type 1A0314
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0314
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Nuclear factor erythroid 2-related factor 20001
Carboxylic ester hydrolase 0101
PPM1D protein2002
nuclear receptor subfamily 1, group I, member 21001
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor0415
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Nuclear receptor subfamily 1 group I member 20011
5-hydroxytryptamine receptor 3E0112
5-hydroxytryptamine receptor 3B0112
D0303
D(3) dopamine receptor0303
D(2) dopamine receptor0101
5-hydroxytryptamine receptor 3A0101
D(1B) dopamine receptor0202
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 3A0112
Lactoperoxidase0101
5-hydroxytryptamine receptor 3D0112
5-hydroxytryptamine receptor 3C0112
5-hydroxytryptamine receptor 3B0101
dopamine D1 receptor1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
cellular tumor antigen p53 isoform a2002
Cytochrome P450 2D10202
Cytochrome P450 2D260202
Cytochrome P450 2D30202
Sodium- and chloride-dependent betaine transporter0101
Inositol monophosphatase 11001
Cytochrome P450 2D40202
Rap guanine nucleotide exchange factor 42002
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Mcl-10101
Snq2p0001
neutrophil cytosol factor 10101
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Tyrosine-protein kinase Fyn0101
D(4) dopamine receptor0303
Pleiotropic ABC efflux transporter of multiple drugs0102
Pyridoxal kinase0001
Solute carrier family 22 member 10101
Solute carrier organic anion transporter family member 1A40101
Solute carrier family 22 member 20101
Histidine-rich protein PFHRP-II0101
Butyrophilin subfamily 3 member A10011
4-hydroxy-3-methylbut-2-enyl diphosphate reductase0101
Geranylgeranyl pyrophosphate synthase0202
Farnesyl pyrophosphate synthase0202
Farnesyl pyrophosphate synthase 0202
Farnesyl diphosphate synthase0101
Farnesyl pyrophosphate synthase 0101
H0101
Phosphotransferase 0101
Farnesyl diphosphate synthase0101
Beta-1 adrenergic receptor0101
Glycine receptor subunit alpha-10011
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70202
Alpha-1A adrenergic receptor0303
5-hydroxytryptamine receptor 2A0101
Alpha-1B adrenergic receptor0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 1A0202
Multidrug and toxin extrusion protein 20101
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Matrix metalloproteinase-90101
Fumarate hydratase1001
polyprotein1001
Rap guanine nucleotide exchange factor 31001
Transcriptional activator protein LuxR0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Melanocortin receptor 50202
Envelope glycoprotein0011
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
Protein-arginine deiminase type-40202
Carboxypeptidase M0101
5-hydroxytryptamine receptor 1E0101
5-hydroxytryptamine receptor 1F0213
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1B0101
Chain B, Calcitonin gene-related peptide type 1 receptor0011
Chain C, Receptor activity-modifying protein 10011
Chain A, Calcitonin gene-related peptide type 1 receptor0011
Chain D, Receptor activity-modifying protein 10011
Receptor activity-modifying protein 10101
Calcitonin gene-related peptide 10101
Calcitonin gene-related peptide 10202
Calcitonin gene-related peptide type 1 receptor0213
Cereblon isoform 40202
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Chain A, Carbonic anhydrase 10101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110001
Polyunsaturated fatty acid 5-lipoxygenase0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Delta-type opioid receptor0202
Delta-type opioid receptor0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Carbonic anhydrase 0101
Carbonic anhydrase 130101
Cocaine esterase0101
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10102
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
Multidrug resistance-associated protein 1 0214
Kappa-type opioid receptor0101
Chloroquine resistance transporter0101
Solute carrier organic anion transporter family member 1B10202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]