17-hydroxyjolkinolide b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

You're asking about **17-hydroxyjolkinolide B**, a compound that is **not well-known or commonly researched**.

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17-hydroxyjolkinolide B: isolated from Euphorbia fischeriana [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Euphorbia	genus	A large plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. They have a milky sap and a female flower consisting of a single pistil surrounded by numerous male flowers of one stamen each. Euphorbia hirta is rarely called milkweed but that name is normally used for ASCLEPIAS.[MeSH]	Euphorbiaceae	The spurge family of flowering plants in the order Malpighiales. The family consists of annual and perennial herbs and woody shrubs or trees. Members contain securinine.[MeSH]
Euphorbia fischeriana	species	[no description available]	Euphorbiaceae	The spurge family of flowering plants in the order Malpighiales. The family consists of annual and perennial herbs and woody shrubs or trees. Members contain securinine.[MeSH]

Cross-References

ID Source	ID
PubMed CID	6712607
CHEMBL ID	2373855
CHEMBL ID	1992827
CHEBI ID	69828
MeSH ID	M0161805

Synonyms (12)

Synonym
nsc700088
17-hydroxyjolkinolide b
NCI60_035897 ,
nsc-700088
CHEBI:69828 ,
CHEMBL2373855
(1s,3r,8r,10r,11r,12r,17r)-5-(hydroxymethyl)-12,16,16-trimethyl-2,7,9-trioxahexacyclo[9.8.0.01,3.04,8.08,10.012,17]nonadec-4-en-6-one
Q27138169
CHEMBL1992827
DTXSID701099661
(4ar,6as,7ar,10ar,11ar,11br,11cr)-1,2,3,4,4a,5,6,11a,11b,11c-decahydro-8-(hydroxymethyl)-4,4,11c-trimethylbisoxireno[1,10a:3,4]phenanthro[3,2-b]furan-9(7ah)-one
247037-88-3

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

Class	Description
diterpene lactone
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID1707187	Cytotoxicity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID1707201	Cytotoxicity against human LNCaP C4-2B cells incubated for 48 hrs by MTT assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID1707202	Cytotoxicity against human HCT-15 cells incubated for 48 hrs by MTT assay	2020	Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24	Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID1490879	Antimycobacterial activity against Mycobacterium smegmatis after 24 hrs by microplate alamar blue assay	2017	Journal of natural products, 05-26, Volume: 80, Issue:5	ent-Abietane and Tigliane Diterpenoids from the Roots of Euphorbia fischeriana and Their Inhibitory Effects against Mycobacterium smegmatis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (16.67)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	1 (16.67)	24.3611
2020's	3 (50.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
kanamycin a Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.	2.15	1	kanamycins	bacterial metabolite
triptonide triptonide: extracted from Tripterygium wilfordii; structure given in first source. triptonide : A diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii.	2.25	1	butenolide; cyclic ketone; diterpene triepoxide; organic heteroheptacyclic compound	anti-inflammatory agent; antineoplastic agent; immunosuppressive agent
nagilactone c nagilactone C: norditerpene lactone isolated from leaves of Podocarpus; structure	2.25	1
brusatol brusatol: quassinoid from B. javanica; structure	2.25	1	triterpenoid
triptolide [no description available]	2.25	1	diterpenoid; epoxide; gamma-lactam; organic heteroheptacyclic compound	antispermatogenic agent; plant metabolite
parthenolide [no description available]	2.25	1	germacranolide
obacunone obacunone: from bark of Chinese plant Phellodendron amurense; shortens sleeping time induced in mice by alpha-chloralose-urethane	2.25	1	limonoid
chlorolissoclimide chlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson	2.25	1
bruceine a bruceine A: quassinoid which inhibits protein synthesis & DNA synthesis in cells; RN given refers to (11 beta,12 alpha,15 beta)-isomer; structure given in first source	2.25	1	quassinoid
bruceine b bruceine B: quassinoid which inhibits protein synthesis & DNA synthesis in cells; structure in first source	2.25	1	triterpenoid
jolkinolide a jolkinolide A: isolated from Euphorbia fischeriana	2.73	3	diterpene lactone	metabolite
jolkinolide b jolkinolide B: isolated from Euphorbia fischeriana	2.98	4	diterpene lactone	metabolite
limonin [no description available]	2.25	1	epoxide; furans; hexacyclic triterpenoid; lactone; limonoid; organic heterohexacyclic compound	inhibitor; metabolite; volatile oil component
tripdiolide tripdiolide: structure	2.25	1	oxacycle
thapsigargin Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.. thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.	2.25	1	butyrate ester; organic heterotricyclic compound; sesquiterpene lactone	calcium channel blocker; EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
12-deoxyphorbol 13-acetate [no description available]	2.15	1	phorbol ester	metabolite
phorbol 13-monoacetate phorbol 13-monoacetate: RN given refers to (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha)-isomer); RN for cpd without isomeric designation not in Chemlne 11/86	2.15	1	phorbol ester
bruceantin [no description available]	2.25	1	triterpenoid
andrographolide [no description available]	2.25	1	carbobicyclic compound; gamma-lactone; labdane diterpenoid; primary alcohol; secondary alcohol	anti-HIV agent; anti-inflammatory drug; antineoplastic agent; metabolite
shihulimonin a shihulimonin A: isolated from Evodia rutaecarpa; structure in first source	2.25	1	limonoid
ag-490 [no description available]	2.05	1	catechols; enamide; monocarboxylic acid amide; nitrile; secondary carboxamide	anti-inflammatory agent; antioxidant; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; geroprotector; STAT3 inhibitor
dichapetalin a dichapetalin A: isolated from Dichapetalum; structure in first source	2.25	1
ginkgolide b [no description available]	2.25	1
bn 52020 [no description available]	2.25	1
dichlorolissoclimide dichlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson	2.25	1
14-o-phosphonooxymethyltriptolide 14-O-phosphonooxymethyltriptolide disodium salt: pro-drug of triptolide; has antineoplastic activity	2.25	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	2.51	2
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.51	2
Metastase [description not available]	2.31	1
Animal Mammary Carcinoma [description not available]	2.31	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.31	1

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