Compounds > 17-hydroxyjolkinolide b
Page last updated: 2024-12-08

17-hydroxyjolkinolide b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

You're asking about **17-hydroxyjolkinolide B**, a compound that is **not well-known or commonly researched**.

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17-hydroxyjolkinolide B: isolated from Euphorbia fischeriana [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
EuphorbiagenusA large plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. They have a milky sap and a female flower consisting of a single pistil surrounded by numerous male flowers of one stamen each. Euphorbia hirta is rarely called milkweed but that name is normally used for ASCLEPIAS.[MeSH]EuphorbiaceaeThe spurge family of flowering plants in the order Malpighiales. The family consists of annual and perennial herbs and woody shrubs or trees. Members contain securinine.[MeSH]
Euphorbia fischerianaspecies[no description available]EuphorbiaceaeThe spurge family of flowering plants in the order Malpighiales. The family consists of annual and perennial herbs and woody shrubs or trees. Members contain securinine.[MeSH]

Cross-References

ID SourceID
PubMed CID6712607
CHEMBL ID2373855
CHEMBL ID1992827
CHEBI ID69828
MeSH IDM0161805

Synonyms (12)

Synonym
nsc700088
17-hydroxyjolkinolide b
NCI60_035897 ,
nsc-700088
CHEBI:69828 ,
CHEMBL2373855
(1s,3r,8r,10r,11r,12r,17r)-5-(hydroxymethyl)-12,16,16-trimethyl-2,7,9-trioxahexacyclo[9.8.0.01,3.04,8.08,10.012,17]nonadec-4-en-6-one
Q27138169
CHEMBL1992827
DTXSID701099661
(4ar,6as,7ar,10ar,11ar,11br,11cr)-1,2,3,4,4a,5,6,11a,11b,11c-decahydro-8-(hydroxymethyl)-4,4,11c-trimethylbisoxireno[1,10a:3,4]phenanthro[3,2-b]furan-9(7ah)-one
247037-88-3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
diterpene lactone
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1707187Cytotoxicity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID1707201Cytotoxicity against human LNCaP C4-2B cells incubated for 48 hrs by MTT assay2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID1707202Cytotoxicity against human HCT-15 cells incubated for 48 hrs by MTT assay2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID1490879Antimycobacterial activity against Mycobacterium smegmatis after 24 hrs by microplate alamar blue assay2017Journal of natural products, 05-26, Volume: 80, Issue:5
ent-Abietane and Tigliane Diterpenoids from the Roots of Euphorbia fischeriana and Their Inhibitory Effects against Mycobacterium smegmatis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's3 (50.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.		2.1510kanamycinsbacterial metabolite
triptonide
triptonide: extracted from Tripterygium wilfordii; structure given in first source. triptonide : A diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii.		2.2510butenolide;
cyclic ketone;
diterpene triepoxide;
organic heteroheptacyclic compound		anti-inflammatory agent;
antineoplastic agent;
immunosuppressive agent
nagilactone c
nagilactone C: norditerpene lactone isolated from leaves of Podocarpus; structure		2.2510
brusatol
brusatol: quassinoid from B. javanica; structure		2.2510triterpenoid
triptolide
[no description available]		2.2510diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound		antispermatogenic agent;
plant metabolite
parthenolide
[no description available]		2.2510germacranolide
obacunone
obacunone: from bark of Chinese plant Phellodendron amurense; shortens sleeping time induced in mice by alpha-chloralose-urethane		2.2510limonoid
chlorolissoclimide
chlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson		2.2510
bruceine a
bruceine A: quassinoid which inhibits protein synthesis & DNA synthesis in cells; RN given refers to (11 beta,12 alpha,15 beta)-isomer; structure given in first source		2.2510quassinoid
bruceine b
bruceine B: quassinoid which inhibits protein synthesis & DNA synthesis in cells; structure in first source		2.2510triterpenoid
jolkinolide a
jolkinolide A: isolated from Euphorbia fischeriana		2.7330diterpene lactonemetabolite
jolkinolide b
jolkinolide B: isolated from Euphorbia fischeriana		2.9840diterpene lactonemetabolite
limonin
[no description available]		2.2510epoxide;
furans;
hexacyclic triterpenoid;
lactone;
limonoid;
organic heterohexacyclic compound		inhibitor;
metabolite;
volatile oil component
tripdiolide
tripdiolide: structure		2.2510oxacycle
thapsigargin
Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.. thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.		2.2510butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone		calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
12-deoxyphorbol 13-acetate
[no description available]		2.1510phorbol estermetabolite
phorbol 13-monoacetate
phorbol 13-monoacetate: RN given refers to (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha)-isomer); RN for cpd without isomeric designation not in Chemlne 11/86		2.1510phorbol ester
bruceantin
[no description available]		2.2510triterpenoid
andrographolide
[no description available]		2.2510carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol		anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite
shihulimonin a
shihulimonin A: isolated from Evodia rutaecarpa; structure in first source		2.2510limonoid
ag-490
[no description available]		2.0510catechols;
enamide;
monocarboxylic acid amide;
nitrile;
secondary carboxamide		anti-inflammatory agent;
antioxidant;
apoptosis inducer;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
geroprotector;
STAT3 inhibitor
dichapetalin a
dichapetalin A: isolated from Dichapetalum; structure in first source		2.2510
ginkgolide b
[no description available]		2.2510
bn 52020
[no description available]		2.2510
dichlorolissoclimide
dichlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson		2.2510
14-o-phosphonooxymethyltriptolide
14-O-phosphonooxymethyltriptolide disodium salt: pro-drug of triptolide; has antineoplastic activity		2.2510
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.5120
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.5120
Metastase
[description not available]		02.3110
Animal Mammary Carcinoma
[description not available]		02.3110
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.3110