Page last updated: 2024-12-07

octopine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Octopine is a guanidino compound produced by some bacteria, particularly those in the genus *Agrobacterium*. It is synthesized through the condensation of arginine and pyruvate, catalyzed by the enzyme octopine dehydrogenase. Octopine is known to act as a chemoattractant for certain bacteria, including *Agrobacterium tumefaciens*. This bacterium is responsible for crown gall disease in plants, and octopine plays a role in the bacterium's ability to infect and utilize plant tissues. Octopine production is also associated with the development of tumors in plants. The compound is widely studied in the context of plant-microbe interactions and as a model system for understanding the molecular basis of tumor formation. Octopine is also used as a marker for the presence of *Agrobacterium* in plant tissues.'

D-octopine : The (1R)-1-carboxyethyl derivative of L-arginine. It is a metabolite released by plant tumours. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID108172
CHEBI ID15805
SCHEMBL ID4572685
MeSH IDM0046907

Synonyms (26)

Synonym
n(2)-[(1r)-1-carboxyethyl]-l-arginine
CHEBI:15805
n(2)-(d-1-carboxyethyl)-l-arginine
(+)-octopine
l-arginine, n2-(1-carboxyethyl)-, (r)-
d-(+)-octopine
n2-(1-carboxyethyl)-l-arginine
arginine, n2-(1-carboxyethyl)-, l-
d-octopine
34522-32-2
l-arginine, n2-[(1r)-1-carboxyethyl]-
octopine
n2-(d-1-carboxyethyl)-l-arginine
l-arginine, n2-((1r)-1-carboxyethyl)-
n'-(1-carboxyethyl)arginine
n2-((1r)-1-carboxyethyl)-l-arginine
IMXSCCDUAFEIOE-RITPCOANSA-N
SCHEMBL4572685
6db ,
n~2~-[(1r)-1-carboxyethyl]-l-arginine
(s)-2-((r)-1-carboxyethylamino)-5-guanidinopentanoic acid
DTXSID70946103
(2s)-2-[[(1r)-1-carboxyethyl]amino]-5-(diaminomethylideneamino)pentanoic acid
(2s)-2-[[(1r)-1-carboxylatoethyl]azaniumyl]-5-(diaminomethylideneazaniumyl)pentanoate
(2s)-2-{[(1r)-1-carboxyethyl]amino}-5-[(diaminomethylidene)amino]pentanoic acid
((r)-1-carboxyethyl)-l-arginine

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
xenobiotic metaboliteAny metabolite produced by metabolism of a xenobiotic compound.
animal metaboliteAny eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (6)

ClassDescription
D-alpha-amino acid zwitterionZwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group.
amino acid opineAny opine whose structure is based on the condensation of an amino acid with a carbohydrate or a keto-acid.
D-arginine derivativeA non-proteinogenic amino acid derivative resulting from reaction of D-arginine at the amino group, the carboxy group, or the guanidyl group, or from the replacement of any hydrogen of D-arginine by a heteroatom.
guanidinesAny organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R(1)R(2)N)(R(3)R(4)N)C=N-R(5) and are related structurally to amidines and ureas.
secondary amino compoundA compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups.
amino dicarboxylic acid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (156)

TimeframeStudies, This Drug (%)All Drugs %
pre-199085 (54.49)18.7374
1990's40 (25.64)18.2507
2000's14 (8.97)29.6817
2010's13 (8.33)24.3611
2020's4 (2.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.25 (24.57)
Research Supply Index5.08 (2.92)
Research Growth Index4.55 (4.65)
Search Engine Demand Index47.56 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (2.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other156 (97.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]