Compounds > salicyl alcohol
Page last updated: 2024-09-20

salicyl alcohol

Description

salicyl alcohol: RN given refers to parent cpd; saligenin is the aglycone of salicin; structure; it is oxidatively metabolized to gentisic acid [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

salicyl alcohol : A hydroxybenzyl alcohol that is phenol substituted by a hydroxymethyl group at C-2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5146
CHEMBL ID280802
CHEBI ID16464
SCHEMBL ID15639
MeSH IDM0056242

Synonyms (119)

Synonym
salicain
EN300-39020
BRD-K08493205-001-02-3
.alpha.,2-dihydroxytoluene
diathesin
2-hydroxybenzenemethanol
o-methylolphenol
nsc-3814
.alpha.-hydroxy-o-cresol
benzyl alcohol, o-hydroxy-
benzenemethanol, 2-hydroxy-
o-hydroxybenzyl alcohol
o-(hydroxymethyl)phenol
2-hydroxymethylphenol
nsc3814
saligenol
2-methylolphenol
CHEBI:16464 ,
KBIO1_000657
DIVK1C_000657
nsc 3814
brn 1907195
salicylalkohol
einecs 201-960-5
alpha-hydroxy-o-cresol
salicyl alcohol [usan]
2-hydroxybenzylalkohol
alpha,2-dihydroxytoluene
ai3-03990
SPECTRUM_000944
D05790
salicyl alcohol (usan)
BSPBIO_002510
SPECTRUM5_001190
toluene,alpha,2-dihydroxy
inchi=1/c7h8o2/c8-5-6-3-1-2-4-7(6)9/h1-4,8-9h,5h
C02323
2-(hydroxymethyl)phenol
saligenin
2-hydroxybenzyl alcohol
90-01-7
salicyl alcohol
IDI1_000657
2-hydroxybenzyl alcohol, 99%
NCGC00094779-02
NCGC00094779-01
KBIO2_003992
KBIO2_006560
KBIO3_001812
KBIOGR_001421
KBIO2_001424
KBIOSS_001424
SPECTRUM4_000991
SPECTRUM3_000896
SPECTRUM2_001311
NINDS_000657
SPBIO_001401
SPECTRUM1500531
NCGC00094779-03
HMS2092G13
salicylic alcohol
CHEMBL280802
AKOS000249109
HMS502A19
BMSE000768
H0223
HMS1920P12
A26232
2-(hydroxymethyl)-phenol
nsc757317
pharmakon1600-01500531
nsc-757317
dtxcid7025843
tox21_111330
dtxsid9045843 ,
cas-90-01-7
sa9 ,
CCG-39249
FT-0686378
fa1n0842kb ,
4-06-00-05896 (beilstein handbook reference)
unii-fa1n0842kb
AM20060376
salicyl alcohol [who-dd]
salicyl alcohol [mi]
salicyl alcohol [mart.]
S5562
2-hydroxymethyl phenol
2-hydroxy benzyl alcohol
2-hydroxymethyl-phenol
2-hydoxybenzyl alcohol
2-hydroxybenzylalcohol
SCHEMBL15639
tox21_111330_1
NCGC00094779-05
CS-4863
saligenine
W-100346
BS-3756
F0001-2205
HY-B1419
AB00052088_02
mfcd00004617
a,2-toluenediol
sr-05000002088
SR-05000002088-1
2-hydroxybenzyl alcohol, purum, >=98.0% (hplc)
salicylsaure
SBI-0051508.P003
SY012296
Q411687
STL183340
salicyl-alcohol
2-hydroxybenzyl alcohol salicyl alcohol
O10523
salicylalcohol
27134-47-0
?2-hydroxybenzyl alcohol
Z335244902

Research Excerpts

Overview

ExcerptReference
"Salicyl alcohol oxidase is an extracellular enzyme that occurs in glandular reservoirs of chrysomelid leaf beetle larvae and catalyzes the formation of salicylaldehyde, a volatile deterrent used by the larvae against predators. "( Michalski, C; Mohagheghi, H; Nimtz, M; Ober, D; Pasteels, J, 2008)

Effects

ExcerptReference
"Salicyl alcohol, which has a hydroxyl group in the place of the carboxyl group that is present in salicylate, was an effective synergist with kanamycin."( Aumercier, M; Murray, DM; Rosner, JL, 1990)
"Salicyl alcohol, which has a hydroxyl group in the place of the carboxyl group that is present in salicylate, was an effective synergist with kanamycin."( Aumercier, M; Murray, DM; Rosner, JL, 1990)

Roles (1)

RoleDescription
human urinary metaboliteAny metabolite (endogenous or exogenous) found in human urine samples.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
hydroxybenzyl alcoholAny member of the class of benzyl alcohols that is a benzyl alcohol substituted by at least one hydroxy group on the benzene ring.
aromatic primary alcoholAny primary alcohol in which the alcoholic hydroxy group is attached to a carbon which is itself bonded to an aromatic ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2)

salicyl alcohol is involved in 2 pathway(s), involving a total of 23 unique proteins and 64 unique compounds

PathwayProteinsCompounds
Amino Sugar and Nucleotide Sugar Metabolism III2340
salicin biosynthesis012

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency7.49780.006038.004119,952.5996AID1159521
GLI family zinc finger 3Homo sapiens (human)Potency18.83360.000714.592883.7951AID1259369; AID1259392
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency10.59090.000657.913322,387.1992AID1259377
GVesicular stomatitis virusPotency2.45450.01238.964839.8107AID1645842
Interferon betaHomo sapiens (human)Potency2.45450.00339.158239.8107AID1645842
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency2.45450.01238.964839.8107AID1645842
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency3.98110.009610.525035.4813AID1479145
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency2.45450.01238.964839.8107AID1645842
cytochrome P450 2C9, partialHomo sapiens (human)Potency2.45450.01238.964839.8107AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (45)

Processvia Protein(s)Taxonomy
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell activation involved in immune responseInterferon betaHomo sapiens (human)
cell surface receptor signaling pathwayInterferon betaHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to virusInterferon betaHomo sapiens (human)
positive regulation of autophagyInterferon betaHomo sapiens (human)
cytokine-mediated signaling pathwayInterferon betaHomo sapiens (human)
natural killer cell activationInterferon betaHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT proteinInterferon betaHomo sapiens (human)
cellular response to interferon-betaInterferon betaHomo sapiens (human)
B cell proliferationInterferon betaHomo sapiens (human)
negative regulation of viral genome replicationInterferon betaHomo sapiens (human)
innate immune responseInterferon betaHomo sapiens (human)
positive regulation of innate immune responseInterferon betaHomo sapiens (human)
regulation of MHC class I biosynthetic processInterferon betaHomo sapiens (human)
negative regulation of T cell differentiationInterferon betaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIInterferon betaHomo sapiens (human)
defense response to virusInterferon betaHomo sapiens (human)
type I interferon-mediated signaling pathwayInterferon betaHomo sapiens (human)
neuron cellular homeostasisInterferon betaHomo sapiens (human)
cellular response to exogenous dsRNAInterferon betaHomo sapiens (human)
cellular response to virusInterferon betaHomo sapiens (human)
negative regulation of Lewy body formationInterferon betaHomo sapiens (human)
negative regulation of T-helper 2 cell cytokine productionInterferon betaHomo sapiens (human)
positive regulation of apoptotic signaling pathwayInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell differentiationInterferon betaHomo sapiens (human)
natural killer cell activation involved in immune responseInterferon betaHomo sapiens (human)
adaptive immune responseInterferon betaHomo sapiens (human)
T cell activation involved in immune responseInterferon betaHomo sapiens (human)
humoral immune responseInterferon betaHomo sapiens (human)
positive regulation of T cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
adaptive immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of T cell anergyHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
defense responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
detection of bacteriumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-12 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-6 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protection from natural killer cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
innate immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of dendritic cell differentiationHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class IbHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
inositol phosphate metabolic processInositol hexakisphosphate kinase 1Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
negative regulation of cold-induced thermogenesisInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (18)

Processvia Protein(s)Taxonomy
cytokine activityInterferon betaHomo sapiens (human)
cytokine receptor bindingInterferon betaHomo sapiens (human)
type I interferon receptor bindingInterferon betaHomo sapiens (human)
protein bindingInterferon betaHomo sapiens (human)
chloramphenicol O-acetyltransferase activityInterferon betaHomo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
signaling receptor bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
peptide antigen bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein-folding chaperone bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol heptakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
protein bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
ATP bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 1-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 3-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (23)

Processvia Protein(s)Taxonomy
extracellular spaceInterferon betaHomo sapiens (human)
extracellular regionInterferon betaHomo sapiens (human)
Golgi membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
endoplasmic reticulumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
Golgi apparatusHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
cell surfaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
ER to Golgi transport vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
secretory granule membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
phagocytic vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
early endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
recycling endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular exosomeHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
lumenal side of endoplasmic reticulum membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
MHC class I protein complexHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular spaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
external side of plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
virion membraneSpike glycoproteinSevere acute respiratory syndrome-related coronavirus
fibrillar centerInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
cytosolInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleusInositol hexakisphosphate kinase 1Homo sapiens (human)
cytoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (50)

Assay IDTitleYearJournalArticle
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347424RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347425Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347407qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1449689Cytotoxicity against HEK293 cells harboring pendrin P123S mutant assessed as decrease in cell viability at 15 mM after 72 hrs by MTT assay2017Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9
Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells.
AID46819Antiviral activity was measured on HIV-1 in wild-type CEM/O cells1998Journal of medicinal chemistry, Apr-23, Volume: 41, Issue:9
cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.
AID24226Partition coefficient (logP)1985Journal of medicinal chemistry, Sep, Volume: 28, Issue:9
Quantitative evaluation of the beta 2-adrenoceptor affinity of phenoxypropanolamines and phenylethanolamines.
AID46818The cytotoxicity was measured on wild type CEM/O cells.1998Journal of medicinal chemistry, Apr-23, Volume: 41, Issue:9
cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.
AID1449696Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as increase in localization of protein mutant in plasma membrane at 1 to 30 mM after 12 hrs by DAPI staining based immunofluorescence mi2017Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9
Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells.
AID46823Antiviral activity was measured on HIV-2 in wild-type CEM/O cells1998Journal of medicinal chemistry, Apr-23, Volume: 41, Issue:9
cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.
AID977602Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1695183Inhibition of recombinant bovine liver ARGI at 500 uM using L-arginine as substrate incubated for 60 mins by spectroscopic analysis relative to control2020RSC medicinal chemistry, May-01, Volume: 11, Issue:5
Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors.
AID282835Cytotoxicity against mouse L1210 cells2005Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23
Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.
AID977599Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1449688Cytotoxicity against HEK293 cells harboring pendrin P123S mutant after 72 hrs by MTT assay2017Bioorganic & medicinal chemistry, 05-01, Volume: 25, Issue:9
Discovery of (2-aminophenyl)methanol as a new molecular chaperone that rescues the localization of P123S mutant pendrin stably expressed in HEK293 cells.
AID282833Activity against caspase-mediated apoptosis in mouse L1210 cells at 0.1 mM2005Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23
Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.
AID1159550Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening2015Nature cell biology, Nov, Volume: 17, Issue:11
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (80)

TimeframeStudies, This Drug (%)All Drugs %
pre-199011 (13.75)18.7374
1990's10 (12.50)18.2507
2000's22 (27.50)29.6817
2010's28 (35.00)24.3611
2020's9 (11.25)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews6 (7.32%)6.00%
Case Studies4 (4.88%)4.05%
Observational0 (0.00%)0.25%
Other72 (87.80%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
benzene[no description available]medium10aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
benzyl alcohol[no description available]medium30benzyl alcoholsantioxidant;
fragrance;
metabolite;
solvent
catechol[no description available]medium50catecholsallelochemical;
genotoxin;
plant metabolite
acetanilide[no description available]medium10acetamides;
anilide		analgesic
naphthalene[no description available]medium10naphthalenes;
ortho-fused bicyclic arene		apoptosis inhibitor;
carcinogenic agent;
environmental contaminant;
mouse metabolite;
plant metabolite;
volatile oil component
phenol[no description available]medium20phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
toluene[no description available]medium10methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
albuterol[no description available]medium30phenols;
phenylethanolamines;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
environmental contaminant;
xenobiotic
betaxolol[no description available]medium10propanolamineantihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent
clenbuterol[no description available]medium10amino alcohol;
dichlorobenzene;
ethanolamines;
primary arylamine;
secondary amino compound;
substituted aniline		beta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent
isoproterenol[no description available]medium10catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
metaproterenol[no description available]medium10aralkylamino compound;
phenylethanolamines;
resorcinols;
secondary alcohol;
secondary amino compound
practolol[no description available]medium10acetamides;
ethanolamines;
propanolamine;
secondary alcohol;
secondary amino compound		anti-arrhythmia drug;
beta-adrenergic antagonist
pronethalol[no description available]medium10naphthalenes
resorcinol[no description available]medium50benzenediol;
phenolic donor;
resorcinols		erythropoietin inhibitor;
sensitiser
salicylamide[no description available]medium20phenols;
salicylamides		antirheumatic drug;
non-narcotic analgesic
sotalol[no description available]medium10ethanolamines;
secondary alcohol;
secondary amino compound;
sulfonamide		anti-arrhythmia drug;
beta-adrenergic antagonist;
environmental contaminant;
xenobiotic
terbutaline[no description available]medium20phenylethanolamines;
resorcinols		anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
hypoglycemic agent;
sympathomimetic agent;
tocolytic agent
tulobuterol[no description available]medium10organochlorine compound
2-aminophenol[no description available]medium30aminophenolbacterial metabolite
nifenalol[no description available]medium10C-nitro compound
2,6-dichlorophenol[no description available]medium10dichlorophenol
nitrobenzene[no description available]medium10nitroarene;
nitrobenzenes
benzonitrile[no description available]medium10benzenes;
nitrile
n-propylbenzene[no description available]medium10alkylbenzene
3-xylene[no description available]medium10xylene
chlorobenzene[no description available]medium20monochlorobenzenessolvent
sec-butylbenzene[no description available]medium10alkylbenzene
toliprolol[no description available]medium10aromatic ether
deterenol[no description available]medium10
colterol[no description available]medium10catechols;
ethanolamines;
secondary alcohol;
secondary amino compound;
triol		anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent
prenalterol[no description available]medium10aromatic ether
dihydroalprenolol[no description available]medium10
propranolol hydrochloride[no description available]medium10hydrochloride
cyclopropylbenzene[no description available]medium10
stavudine[no description available]medium30dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
zidovudine[no description available]medium10azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate[no description available]medium10
4-hydroxybenzaldehyde[no description available]medium10hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
2-cresol[no description available]medium10cresolhuman xenobiotic metabolite
3-cresol[no description available]medium10cresolhuman xenobiotic metabolite
guaiacol[no description available]medium20guaiacolsdisinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite
hydroquinone[no description available]medium50benzenediol;
hydroquinones		antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent
4-nitrophenol[no description available]medium104-nitrophenolshuman xenobiotic metabolite;
mouse metabolite
4-nonylphenol[no description available]medium10phenolsenvironmental contaminant
acetaminophen[no description available]medium10acetamides;
phenols		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
cyclooxygenase 3 inhibitor;
environmental contaminant;
ferroptosis inducer;
geroprotector;
hepatotoxic agent;
human blood serum metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
4-cresol[no description available]medium10cresolEscherichia coli metabolite;
human metabolite;
uremic toxin
4-chlorophenol[no description available]medium10monochlorophenol
propofol[no description available]medium10phenolsanticonvulsant;
antiemetic;
intravenous anaesthetic;
radical scavenger;
sedative
bisphenol a[no description available]medium10bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
2-tert-butylphenol[no description available]medium10alkylbenzene
2,6-di-tert-butyl-4-hydroxymethylphenol[no description available]medium10alkylbenzene
2-isopropylphenol[no description available]medium10phenols
2-nitrophenol[no description available]medium102-nitrophenols
2-ethylphenol[no description available]medium10phenols
pyrogallol 1,3-dimethyl ether[no description available]medium10dimethoxybenzene;
phenols		plant metabolite
2-bromophenol[no description available]medium10bromophenolmarine metabolite
2-chlorophenol[no description available]medium102-halophenol;
monochlorophenol
2-amino-4-methylphenol[no description available]medium10
2,4-di-tert-butylphenol[no description available]medium10alkylbenzene;
phenols		antioxidant;
bacterial metabolite;
marine metabolite
butylphen[no description available]medium10phenolsallergen
3-dimethylaminophenol[no description available]medium10
4-hydroxyacetophenone[no description available]medium10monohydroxyacetophenonefungal metabolite;
mouse metabolite;
plant metabolite
2,4-dimethylphenol[no description available]medium10aromatic fungicide;
phenols		disinfectant;
volatile oil component
4-bromophenol[no description available]medium10bromophenolhuman urinary metabolite;
human xenobiotic metabolite;
marine metabolite;
mouse metabolite;
persistent organic pollutant;
rat metabolite
3-chlorophenol[no description available]medium20monochlorophenol
syringaldehyde[no description available]medium10dimethoxybenzene;
hydroxybenzaldehyde		hypoglycemic agent;
plant metabolite
3-hydroxyanisole[no description available]medium10monomethoxybenzene;
phenols
mequinol[no description available]medium10methoxybenzenes;
phenols		metabolite
2-fluorophenol[no description available]medium10
4-fluorophenol[no description available]medium10fluorophenol;
monofluorobenzenes
3-fluorophenol[no description available]medium10
4-methylcatechol[no description available]medium10methylcatecholantioxidant;
carcinogenic agent;
hapten;
human metabolite;
plant metabolite
topanol 354[no description available]medium10methoxybenzenes;
phenols
2,4,6-trimethylphenol[no description available]medium10hydroxytoluene
2-iodophenol[no description available]medium102-halophenol;
iodophenol
4-iodophenol[no description available]medium10iodophenol
3-nitrophenol[no description available]medium103-nitrophenols
2,6-xylenol[no description available]medium10hydroxytoluene
3-bromophenol[no description available]medium10
3-aminophenol[no description available]medium10aminophenol
2-cyanophenol[no description available]medium10benzenes;
nitrile
3-ethylphenol[no description available]medium10phenols
3-hydroxyacetanilide[no description available]medium10acetamides;
phenols		non-narcotic analgesic
4-Ethoxyphenol[no description available]medium10aromatic ether;
phenols
2-propylphenol[no description available]medium10phenolsflavouring agent;
plant metabolite
4-propylphenol[no description available]medium10alkylbenzene
2,4,6-tri-tert-butylphenol[no description available]medium10
4-cyanophenol[no description available]medium10phenolsEC 1.4.3.4 (monoamine oxidase) inhibitor
4-phenoxyphenol[no description available]medium10phenoxyphenol
4-n-Butylphenol[no description available]medium10phenols
4-octylphenol[no description available]medium10phenolsmetabolite;
surfactant;
xenoestrogen
2-tert-butyl-4-methylphenol[no description available]medium10
acetosyringone[no description available]medium10acetophenones;
dimethoxybenzene;
phenols		anti-asthmatic drug;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug;
plant metabolite
butylated hydroxyanisole[no description available]medium10
4-n-Pentylphenol[no description available]medium10phenols
4-ethylphenol[no description available]medium10phenolsfungal xenobiotic metabolite
butylated hydroxytoluene[no description available]medium10phenolsantioxidant;
ferroptosis inhibitor;
food additive;
geroprotector
2,6-di-tert-butylphenol[no description available]medium10alkylbenzene;
phenols		antioxidant
4-hydroxybenzamide[no description available]medium10
guaethol[no description available]medium10aromatic ether;
phenols;
volatile organic compound		flavouring agent
2,6-di-tert-butyl-4-nitrophenol[no description available]medium10
3,5-di-tert-butyl-4-hydroxybenzaldehyde[no description available]medium10hydroxybenzaldehyde
equilenin[no description available]medium1017-oxo steroid;
3-hydroxy steroid		antioxidant;
mammalian metabolite
diethylstilbestrol[no description available]medium10olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
2-amino-4-nitrophenol[no description available]medium104-nitrophenols
sinapaldehyde[no description available]medium10cinnamaldehydes;
dimethoxybenzene;
phenols		antifungal agent;
plant metabolite
2,3-dihydroxybenzoic acid[no description available]medium10dihydroxybenzoic acidhuman xenobiotic metabolite;
plant metabolite
protocatechuic acid[no description available]medium10catechols;
dihydroxybenzoic acid		antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite
anthranilic acid[no description available]medium10aminobenzoic acidhuman metabolite;
mouse metabolite
salicylic acid[no description available]medium70monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
malonic acid[no description available]medium10alpha,omega-dicarboxylic acidhuman metabolite
aspirin[no description available]medium30benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
2,5-dihydroxybenzoic acid[no description available]medium10dihydroxybenzoic acidEC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
fungal metabolite;
human metabolite;
MALDI matrix material;
mouse metabolite
mesalamine[no description available]medium10amino acid;
aromatic amine;
monocarboxylic acid;
monohydroxybenzoic acid;
phenols		non-steroidal anti-inflammatory drug
2-thiosalicylic acid[no description available]medium10sulfanylbenzoic acidantipyretic;
non-narcotic analgesic
5-methylsalicylic acid[no description available]medium10
5-nitrosalicylic acid[no description available]medium104-nitrophenols;
monohydroxybenzoic acid
gamma-resorcylic acid[no description available]medium10dihydroxybenzoic acidmetabolite
2-hydroxyphenylacetic acid[no description available]medium10hydroxy monocarboxylic acid;
phenols		human metabolite;
mouse metabolite
2-aminobenzyl alcohol[no description available]medium20
4-aminobenzyl alcohol[no description available]medium10
salicylaldehyde[no description available]medium60hydroxybenzaldehydenematicide;
plant metabolite
1,2-diaminobenzene[no description available]medium10phenylenediaminehydrogen donor
ethyl salicylate[no description available]medium10hydroxybenzoic acid
1,3-benzodioxole[no description available]medium10benzodioxole
hydroxyhydroquinone[no description available]medium10benzenetriolmouse metabolite
1,8-dihydroxynaphthalene[no description available]medium10naphthalenediolfungal metabolite
1,2-benzenedithiol[no description available]medium10
3,4-dihydroxybenzylamine[no description available]medium10catechols
3,4-dihydroxybenzyl alcohol[no description available]medium10
a 3253[no description available]medium10catechols
methyl 3,4-dihydroxybenzoate[no description available]medium10catechols;
methyl ester		antioxidant;
neuroprotective agent;
plant metabolite
Nomega-hydroxy-nor-l-arginine[no description available]medium10L-alpha-amino acid
3,3',4,5'-tetrahydroxystilbene[no description available]medium10catechols;
polyphenol;
resorcinols;
stilbenol		antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor
caffeic acid[no description available]medium10caffeic acidgeroprotector;
mouse metabolite
(S)-2-amino-6-boronohexanoic acid[no description available]medium10non-proteinogenic L-alpha-amino acid;
organoboron compound
flavoglaucin[no description available]medium10hydroquinonesmetabolite
shikimic acid[no description available]medium10alpha,beta-unsaturated monocarboxylic acid;
cyclohexenecarboxylic acid;
hydroxy monocarboxylic acid		Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
2,5-dihydroxybenzyl alcohol[no description available]medium10aromatic primary alcohol;
phenols		antineoplastic agent;
antioxidant;
apoptosis inhibitor;
fungal metabolite
2'-hydroxy-2,4,4,7,4'-pentamethylflavan[no description available]medium10
glycosides[no description available]medium50
benzyl benzoate[no description available]medium10benzoate ester;
benzyl ester		acaricide;
plant metabolite;
scabicide
benzoyl-coenzyme a[no description available]medium10
cinnamoyl-coenzyme a[no description available]medium10cinnamoyl-CoA
glucose, (beta-d)-isomer[no description available]medium140D-glucopyranoseepitope;
mouse metabolite
tremulacin[no description available]medium10glycoside
salicin[no description available]medium100aromatic primary alcohol;
aryl beta-D-glucoside;
benzyl alcohols		antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug
salicortin[no description available]medium20glycoside
dimedone[no description available]medium10
tiletamine hydrochloride[no description available]medium10
xanthenes[no description available]medium10xanthene
tannins[no description available]medium10
methyl salicylate[no description available]medium10benzoate ester;
methyl ester;
salicylates		flavouring agent;
insect attractant;
metabolite
4-hydroxybenzyl alcohol[no description available]medium20benzyl alcohols;
phenols		plant metabolite
uridine diphosphate glucose[no description available]medium10UDP-D-glucosefundamental metabolite
phenylethyl alcohol[no description available]medium10benzenes;
primary alcohol		Aspergillus metabolite;
fragrance;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite
salicylates[no description available]medium50monohydroxybenzoateplant metabolite
2,3,4,6-tetrachlorophenol[no description available]medium10tetrachlorophenolxenobiotic metabolite
2-chloro-4-nitrophenol[no description available]medium10
phloroglucinol[no description available]medium10benzenetriol;
phenolic donor		algal metabolite
nitrophenols[no description available]medium10
tri-o-cresyl phosphate[no description available]medium30
trioctylmethylammonium[no description available]medium10quaternary ammonium ion
boric acid[no description available]medium10boric acidsastringent
boron[no description available]medium10boron group element atom;
metalloid atom;
nonmetal atom		micronutrient
imipramine[no description available]medium10dibenzoazepineadrenergic uptake inhibitor;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
iridoids[no description available]medium10
hydrogen sulfite[no description available]medium10sulfur oxoanionhuman metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
sulfites[no description available]medium10divalent inorganic anion;
sulfur oxide;
sulfur oxoanion
cardiovascular agents[no description available]medium10
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
aminopyrine[no description available]medium10pyrazolone;
tertiary amino compound		antipyretic;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
adenine[no description available]medium106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
adefovir[no description available]medium106-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent
organophosphonates[no description available]medium10divalent inorganic anion;
phosphite ion
methylparaben[no description available]medium10parabenantifungal agent;
antimicrobial food preservative;
neuroprotective agent;
plant metabolite
propylparaben[no description available]medium10benzoate ester;
paraben;
phenols		antifungal agent;
antimicrobial agent
acebutolol[no description available]medium10alpha-D-glucosyl-(1->4)-D-mannopyranose
verapamil[no description available]medium20aromatic ether;
nitrile;
polyether;
tertiary amino compound
myelin basic protein[no description available]medium10
flavin-adenine dinucleotide[no description available]medium10flavin adenine dinucleotide;
vitamin B2		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prosthetic group
berotek[no description available]medium10resorcinols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent;
tocolytic agent
piperidines[no description available]medium10
isoetharine[no description available]medium10catecholamine
hexoprenaline[no description available]medium10
formaldehyde[no description available]medium10aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
salithion[no description available]medium10organic thiophosphate
leucine[no description available]medium10amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
tetracycline[no description available]medium10
ampicillin[no description available]medium10beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
chloramphenicol[no description available]medium10C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
potassium chloride[no description available]medium10inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
paraoxon[no description available]medium10aryl dialkyl phosphate;
organophosphate insecticide		EC 3.1.1.7 (acetylcholinesterase) inhibitor;
mouse metabolite
phenylephrine[no description available]medium10phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent
arbutin[no description available]medium20beta-D-glucoside;
monosaccharide derivative		Escherichia coli metabolite;
plant metabolite
1-anilino-8-naphthalenesulfonate[no description available]medium10aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
D-fructopyranose[no description available]medium10cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent
syringomycin[no description available]medium10
phenyl acetate[no description available]medium20benzenes;
phenyl acetates
cadmium[no description available]medium10cadmium molecular entity;
zinc group element atom
kanamycin a[no description available]medium10kanamycinsbacterial metabolite
alpha-ketoadipic acid[no description available]low00oxo dicarboxylic acidhuman urinary metabolite;
mouse metabolite
butyric acid[no description available]low00fatty acid 4:0;
straight-chain saturated fatty acid		human urinary metabolite;
Mycoplasma genitalium metabolite
n(1)-methylnicotinamide[no description available]low00pyridinium ionalgal metabolite;
anti-inflammatory agent;
human urinary metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
niacinamide[no description available]low00pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
niacin[no description available]low00pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
3-methoxytyramine[no description available]low00monomethoxybenzene;
phenols;
phenylethylamine;
primary amino compound		biomarker;
human blood serum metabolite;
human urinary metabolite
vitamin k 3[no description available]low001,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
trigonelline[no description available]low00alkaloid;
iminium betaine		food component;
human urinary metabolite;
plant metabolite
androsterone[no description available]low0017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid		androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone
n-hexanal[no description available]low00medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde		human urinary metabolite
pyridoxic acid[no description available]low00hydroxymethylpyridine;
methylpyridines;
monohydroxypyridine;
vitamin B6		human urinary metabolite;
mouse metabolite
benzohydrol[no description available]low00benzyl alcohols;
secondary alcohol		bacterial xenobiotic metabolite;
human urinary metabolite;
human xenobiotic metabolite;
rat metabolite
(3,4-dimethoxyphenyl)acetic acid[no description available]low00dimethoxybenzene;
phenylacetic acids		human urinary metabolite;
human xenobiotic metabolite
4-cymene[no description available]low00monoterpene;
toluenes		human urinary metabolite;
plant metabolite;
volatile oil component
3,4,5-trimethoxybenzoic acid[no description available]low00benzoic acids;
methoxybenzenes		human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
2-naphthol[no description available]low00naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
2-methylfuran[no description available]low00furans;
volatile organic compound		flavouring agent;
fuel;
hepatotoxic agent;
human urinary metabolite;
plant metabolite
3-methoxybenzoic acid[no description available]low00methoxybenzoic acidflavouring agent;
human urinary metabolite
3-tyramine[no description available]low00primary amino compound;
tyramines		human urinary metabolite;
neurotransmitter
2,5-dimethylfuran[no description available]low00furansantifungal agent;
bacterial metabolite;
fuel;
fumigant;
human urinary metabolite;
Maillard reaction product;
plant metabolite
3-methyladipic acid[no description available]low00alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid		human urinary metabolite
nitrohexane[no description available]low00primary nitroalkanehuman urinary metabolite
5-methoxyindoleacetic acid[no description available]low00aromatic ether;
indole-3-acetic acids		antibacterial agent;
Brassica napus metabolite;
carcinogenic agent;
human urinary metabolite;
marine xenobiotic metabolite;
rat metabolite
2-pentylfuran[no description available]low00furansAspergillus metabolite;
bacterial metabolite;
flavouring agent;
human urinary metabolite;
insect repellent;
plant growth stimulator;
volatile oil component
3,5,6-trichloro-2-pyridinol[no description available]low00chloropyridine;
hydroxypyridine;
pyridone		human urinary metabolite;
human xenobiotic metabolite;
marine xenobiotic metabolite
s-methylcysteine[no description available]low00S-alkyl-L-cysteine zwitterion;
S-alkyl-L-cysteine		human urinary metabolite;
plant metabolite
4-anisaldehyde[no description available]low00benzaldehydesbacterial metabolite;
human urinary metabolite;
insect repellent;
plant metabolite
4-heptanone[no description available]low00dialkyl ketonebiomarker;
human urinary metabolite;
human xenobiotic metabolite;
rat metabolite
4-vinylphenol[no description available]low00phenolshuman urinary metabolite;
human xenobiotic metabolite
1,2,4-triazole-3-carboxamide[no description available]low00aromatic amide;
monocarboxylic acid amide;
primary carboxamide;
triazoles		drug metabolite;
human urinary metabolite
estradiol 17-sulfate[no description available]low003-hydroxy steroid;
phenolic steroid;
steroid sulfate		human urinary metabolite
n-acetyltyrosine[no description available]low00N-acetyltyrosine;
N-acyl-L-tyrosine		biomarker;
EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitor;
human urinary metabolite
nicotinuric acid[no description available]low00N-acylglycinehuman urinary metabolite
1-methylhypoxanthine[no description available]low00methylhypoxanthinehuman urinary metabolite;
rat metabolite
2,3,4-trihydroxbenzophenone[no description available]low00benzenetriol;
hydroxybenzophenone		drug metabolite;
EC 1.14.18.1 (tyrosinase) inhibitor;
human urinary metabolite;
quorum sensing inhibitor;
rat metabolite
n-myristoylglycine[no description available]low00fatty amide;
N-acylglycine		human blood serum metabolite;
human urinary metabolite
6-hydroxynicotinic acid[no description available]low00monohydroxypyridineArabidopsis thaliana metabolite;
human urinary metabolite;
mouse metabolite
2-(methylamino)isobutyric acid[no description available]low00alanine derivative;
alpha-amino acid zwitterion;
non-proteinogenic alpha-amino acid;
secondary amino compound		human urinary metabolite
5-methoxysalicylic acid[no description available]low00methoxysalicylic acidbacterial metabolite;
human urinary metabolite
2,5-furandicarboxylic acid[no description available]low00dicarboxylic acid;
furans		human urinary metabolite
1,3,7-trimethylurate[no description available]low00oxopurinehuman blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite
5-hydroxymethyl-2-furoic acid[no description available]medium00aromatic primary alcohol;
furoic acid		bacterial xenobiotic metabolite;
fungal metabolite;
human urinary metabolite;
nematicide
acetaminophen mercapturate[no description available]low00acetamides;
organic sulfide;
phenols;
S-substituted N-acetyl-L-cysteine		drug metabolite;
human urinary metabolite;
rat metabolite
n-butyrylglycine[no description available]low00N-acylglycinehuman urinary metabolite
n-acetyltyrosine, (dl)-isomer[no description available]low00N-acetyl-amino acid;
phenols;
tyrosine derivative		human urinary metabolite
salsolinol[no description available]low001-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diolhuman urinary metabolite
2,8-dihydroxyadenine[no description available]low006-aminopurines;
diol;
heteroaryl hydroxy compound;
oxopurine		human urinary metabolite;
mammalian metabolite;
mouse metabolite;
nephrotoxic agent
1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid[no description available]low00alpha-amino acid;
aromatic amino acid;
beta-carboline alkaloid		human urinary metabolite;
human xenobiotic metabolite;
plant metabolite;
rat metabolite
n-acetyldopamine[no description available]low00acetamides;
catechols;
N-(fatty acyl)-dopamine;
secondary carboxamide		human urinary metabolite;
marine metabolite
3 alpha,17 alpha-dihydroxy-5 beta-pregnan-20-one[no description available]low0017alpha-hydroxy steroid;
20-oxo steroid;
3alpha-hydroxy steroid;
C21-steroid;
corticosteroid hormone		human urinary metabolite
3-(3-hydroxyphenyl)-3-hydroxypropanoic acid[no description available]low00dihydroxy monocarboxylic acid;
phenols		human urinary metabolite
arsenocholine[no description available]low00arsonium ion;
organoarsenic compound		human urinary metabolite;
marine metabolite;
xenobiotic
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol[no description available]low00nitrosamine;
pyridines;
secondary alcohol		biomarker;
carcinogenic agent;
human urinary metabolite
s-benzyl-n-acetyl-l-cysteine[no description available]low00organic sulfide;
S-substituted N-acetyl-L-cysteine		human urinary metabolite;
rat metabolite
1-hydroxymethylmidazolam[no description available]medium00aromatic primary alcohol;
imidazobenzodiazepine;
monofluorobenzenes;
organochlorine compound		drug metabolite;
human blood serum metabolite;
human urinary metabolite
gamma-glutamylphenylalanine[no description available]low00dipeptidehuman urinary metabolite
mono(2-ethyl-5-oxohexyl)phthalate[no description available]low00methyl ketone;
phthalic acid monoester		human urinary metabolite;
human xenobiotic metabolite
testosterone-17-sulfate[no description available]low003-oxo-Delta(4) steroid;
androstanoid;
steroid sulfate		human urinary metabolite
dopamine 3-o-sulfate[no description available]low00aryl sulfate;
phenols;
primary amino compound;
zwitterion		human blood serum metabolite;
human urinary metabolite
estriol-16 alpha-glucuronide[no description available]low0017beta-hydroxy steroid;
3-hydroxy steroid;
beta-D-glucosiduronic acid;
phenols;
steroid glucosiduronic acid		human urinary metabolite
ursocholic acid[no description available]low0012alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7beta-hydroxy steroid;
bile acid;
C24-steroid;
trihydroxy-5beta-cholanic acid		EC 1.1.1.159 (7alpha-hydroxysteroid dehydrogenase) inhibitor;
human urinary metabolite
dopamine 4-o-sulfate[no description available]low00aryl sulfate;
phenols;
primary amino compound;
zwitterion		human blood serum metabolite;
human urinary metabolite
3-hydroxymethylantipyrine[no description available]low00pyrazolonedrug metabolite;
human urinary metabolite
4-hydroxymidazolam[no description available]low00imidazobenzodiazepine;
monofluorobenzenes;
organic hydroxy compound;
organochlorine compound		drug metabolite;
human blood serum metabolite;
human urinary metabolite
bay-s 9435[no description available]low00cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
organosulfonic acid;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		drug metabolite;
human urinary metabolite
1-hydroxymethylmidazolam glucuronide[no description available]low00beta-D-glucosiduronic acid;
imidazobenzodiazepine;
monofluorobenzenes;
monosaccharide derivative;
organochlorine compound		drug metabolite;
human blood serum metabolite;
human urinary metabolite
lanthionine ketimine[no description available]low001,4-thiazine;
dicarboxylic acid;
sulfur-containing amino acid		anti-inflammatory agent;
human urinary metabolite;
neuroprotective agent
cystathionine ketimine[no description available]low001-thia-4-azacyclohepta-3-ene-3,5-dicarboxylic acid;
sulfur-containing amino acid		human urinary metabolite;
mammalian metabolite;
rat metabolite;
reactive oxygen species generator
tyramine o-sulfate[no description available]low00aryl sulfate;
primary amino compound;
zwitterion		human urinary metabolite;
human xenobiotic metabolite
acetyltaurine[no description available]low00acetamides;
organosulfonic acid		human blood serum metabolite;
human urinary metabolite
2-s-cysteinyldopa[no description available]low00amino dicarboxylic acid;
aryl sulfide;
catechols;
diamine;
L-tyrosine derivative;
S-conjugate;
S-organyl-L-cysteine		human urinary metabolite
bradykinin, hydroxy-pro(3)-[no description available]low00oligopeptide;
peptide hormone		bradykinin receptor agonist;
human urinary metabolite
mono(2-ethyl-5-hydroxyhexyl) phthalate[no description available]low00phthalic acid monoesterhuman urinary metabolite;
human xenobiotic metabolite
5-hydroxyhexanoic acid[no description available]low00(omega-1)-hydroxy fatty acid;
medium-chain fatty acid		human urinary metabolite
hawkinsin[no description available]low00cycloalkene;
cysteine derivative;
dicarboxylic acid;
diol;
secondary allylic alcohol;
tertiary allylic alcohol		biomarker;
human urinary metabolite
3-hydroxyglutaric acid[no description available]low003-hydroxy carboxylic acid;
alpha,omega-dicarboxylic acid		human blood serum metabolite;
human urinary metabolite
adrenosterone[no description available]low0011-oxo steroid;
17-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
human urinary metabolite;
marine metabolite
3-octanone[no description available]low00dialkyl ketoneantifeedant;
biomarker;
fungal metabolite;
human urinary metabolite;
insect attractant;
plant metabolite;
toxin
s-adenosyl-3-methylthiopropylamine[no description available]low00adenosines;
sulfonium compound		Escherichia coli metabolite;
human urinary metabolite;
mouse metabolite;
rat metabolite
riboflavin[no description available]low00flavin;
vitamin B2		anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite
n-isovalerylglycine[no description available]low00N-acylglycinehuman urinary metabolite
s-phenyl-n-acetylcysteine[no description available]low00aryl sulfide;
S-substituted N-acetyl-L-cysteine		biomarker;
human urinary metabolite
3-(1H-imidazol-1-yl)propanoic acid[no description available]low00imidazolyl carboxylic acidhuman urinary metabolite
kaempferol[no description available]low007-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
20-carboxyleukotriene b4[no description available]low00alpha,omega-dicarboxylic acid;
hydroxy carboxylic acid;
leukotriene		human blood serum metabolite;
human urinary metabolite
genistein[no description available]low007-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
n-acetylleukotriene e4[no description available]low00leukotrienehuman urinary metabolite
methyl 2,5-dihydroxycinnamate[no description available]low00cinnamate ester;
hydroquinones;
methyl ester		EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
geroprotector;
human urinary metabolite;
plant metabolite
cedrene[no description available]low00bridged compound;
carbotricyclic compound;
polycyclic olefin;
sesquiterpene		human urinary metabolite;
volatile oil component
5,12-dihydroxy-6,8,14-eicosatrienoic acid[no description available]low00dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid		human urinary metabolite;
human xenobiotic metabolite
yunaconitine[no description available]low00acetate ester;
aromatic ether;
benzoate ester;
bridged compound;
diterpene alkaloid;
organic heteropolycyclic compound;
polyether;
secondary alcohol;
tertiary alcohol;
tertiary amino compound		antifeedant;
human urinary metabolite;
phytotoxin;
plant metabolite;
xenobiotic
4-hydroxyestrone[no description available]low0017-oxo steroid;
3-hydroxy steroid;
4-hydroxy steroid;
catechols;
phenolic steroid		carcinogenic agent;
estrogen;
human urinary metabolite
decanoylcarnitine[no description available]low00decanoate ester;
O-acylcarnitine		human urinary metabolite
n-isobutyrylglycine[no description available]low00N-acylglycinehuman urinary metabolite
prolyl-proline[no description available]low00dipeptidehuman urinary metabolite;
Mycoplasma genitalium metabolite
ethyl glucuronide[no description available]low00beta-D-glucosiduronic acidhuman urinary metabolite
dihydrotestosterone glucuronide[no description available]low003-oxo-5alpha-steroid;
steroid glucosiduronic acid		human urinary metabolite
3-hydroxybenzyl alcohol[no description available]low00hydroxybenzyl alcohol;
phenols		metabolite
toxopyrimidine[no description available]low00aminopyrimidine;
aromatic primary alcohol		Escherichia coli metabolite;
Saccharomyces cerevisiae metabolite
oxamniquine[no description available]low00aromatic primary alcohol;
C-nitro compound;
quinolines;
secondary amino compound
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole[no description available]low00aromatic primary alcohol;
furans;
indazoles		antineoplastic agent;
apoptosis inducer;
platelet aggregation inhibitor;
soluble guanylate cyclase activator;
vasodilator agent
nicotinyl alcohol[no description available]low00aromatic primary alcohol;
pyridines		antilipemic drug;
vasodilator agent
aloe emodin[no description available]low00aromatic primary alcohol;
dihydroxyanthraquinone		antineoplastic agent;
plant metabolite
5-hydroxymethylcytosine[no description available]low00aminopyrimidine;
aromatic primary alcohol;
nucleobase analogue;
pyrimidone		human metabolite;
mouse metabolite
12-hydroxynevirapine[no description available]low00aromatic primary alcohol;
cyclopropanes;
dipyridodiazepine		drug metabolite
4-aminopyridine-3-methanol[no description available]low00aminopyridine;
aromatic amine;
aromatic primary alcohol		potassium channel blocker
gsk 1016790a[no description available]low001-benzothiophenes;
aromatic primary alcohol;
dichlorobenzene;
N-acylpiperazine;
sulfonamide;
tertiary carboxamide		TRPV4 agonist
ConditionIndicatedRelationship StrengthStudiesTrials
Agricultural Worker Disease0low10
Agricultural Worker's Disease0low10
Agricultural Workers' Diseases0low10
Allergic Contact Dermatitis0low20
Anemia, Fanconi0low10
Benign Neoplasms0low10
Cancer0low10
Carcinoma, Ehrlich Tumor0low10
Carcinoma, Hepatocellular0low10
Cochlear Hearing Loss0low10
Congenital Zika Syndrome0low10
Congenital Zika Virus Infection0low10
Contact Dermatitis0low20
Deafness Neurosensory0low10
Delayed Hypersensitivity0low10
Depression0low10
Dermatitis Venenata0low20
Dermatitis, Allergic Contact0low20
Dermatitis, Allergic Eczematous0low20
Dermatitis, Contact0low20
Dermatitis, Contact, Allergic0low20
Dermatitis, Eczematous0low10
Dermatitis, Occupational0low30
Dermatosis, Industrial0low30
Disease Models, Animal0low10
Eczema0low10
Eczema, Contact0low20
Ehrlich Ascites Tumor0low10
Encephalitis, Polio0low10
Epidemic Acute Poliomyelitis0low10
Facial Dermatoses0low10
Facial Dermatosis0low10
Fanconi Anemia0low10
Fanconi Hypoplastic Anemia0low10
Fanconi Pancytopenia0low10
Fanconi Panmyelopathy0low10
Fanconi's Anemia0low10
Favre-Racouchot Syndrome0low10
Fever0low10
Fever, Zika0low10
Foot Dermatoses0low10
Foot Dermatosis0low10
Gastric Ulcer0low20
Goiter, Nodular0low10
Hand Dermatoses0low10
Hand Dermatosis0low10
Hearing Loss, Cochlear0low10
Hearing Loss, Sensorineural0low10
Hepatocellular Carcinoma0low10
Hepatoma0low10
HIV0low10
Hypersensitivity, Contact0low20
Hypersensitivity, Delayed0low10
Hypersensitivity, Tuberculin-Type0low10
Hypersensitivity, Type IV0low10
Industrial Dermatosis0low30
Infantile Paralysis0low10
Inflammation0low10
Innate Inflammatory Response0low10
Liver Cancer, Adult0low10
Liver Cell Carcinoma0low10
Liver Cell Carcinoma, Adult0low10
Malignancy0low10
Malignant Neoplasms0low10
Muscle Contraction0low10
Muscle Spasm0low10
Muscular Spasm0low10
Neoplasia0low10
Neoplasm0low10
Neoplasms0low10
Neoplasms, Benign0low10
Nodular Elastoidosis0low10
Nodular Elastosis0low10
Nodular Goiter0low10
Occupational Dermatitis0low30
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10
Pyrexia0low10
Sensitivity, Contact0low20
Sensorineural Hearing Loss0low10
Spasm0low10
Spasm, Ciliary Body0low10
Spasm, Generalized0low10
Stomach Ulcer0low20
Tuberculin-Type Hypersensitivity0low10
Tumors0low10
Type IV Hypersensitivity0low10
Zika Fever0low10
Zika Virus Disease0low10
Zika Virus Infection0low10
ZikV Infection0low10

Research Highlights

Safety/Toxicity (4)

ArticleYear
Predicting mixture toxicity of seven phenolic compounds with similar and dissimilar action mechanisms to Vibrio qinghaiensis sp.nov.Q67.
Ecotoxicology and environmental safety, Volume: 74, Issue: 6		2011
Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.
Journal of medicinal chemistry, Nov-17, Volume: 48, Issue: 23		2005
Potentiation by salicylate and salicyl alcohol of cadmium toxicity and accumulation in Escherichia coli.
Antimicrobial agents and chemotherapy, Volume: 34, Issue: 12		1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (2)

ArticleYear
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, Volume: 96, Issue: 5		2019
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
The Journal of biological chemistry, 11-15, Volume: 294, Issue: 46		2019
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
Novel neurological and immunological targets for salicylate-based phytopharmaceuticals and for the anti-depressant imipramine.
Phytomedicine : international journal of phytotherapy and phytopharmacology, Jul-15, Volume: 19, Issue: 10		2012
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (1)

ArticleYear
Structure of saligenin: microwave, UV and IR spectroscopy studies in a supersonic jet combined with quantum chemistry calculations.
Physical chemistry chemical physics : PCCP, Aug-28, Volume: 16, Issue: 32		2014
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]