Compounds > achyrofuran
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achyrofuran

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

achyrofuran: a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides (Asteraceae); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AchyroclinegenusA plant genus of the family ASTERACEAE. Members contain TERPENES and achyrofuran, a prenylated dibenzofuran (BENZOFURANS).[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]
Achyrocline satureioidesspecies[no description available]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID11757338
CHEMBL ID465815
SCHEMBL ID505137
MeSH IDM0421009

Synonyms (4)

Synonym
achyrofuran
CHEMBL465815
SCHEMBL505137
2-methyl-1-[1,3,7,9-tetrahydroxy-4-(2-hydroxy-3-methylbut-3-enyl)-6-(2-methylbutanoyl)-8-(3-methylbut-2-enyl)dibenzofuran-2-yl]butan-1-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1176778Antimicrobial activity against Saccharomyces cerevisiae BY4741 after 24 hrs by broth microdilution method2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID332264Antihyperglycemic activity in db/db mouse model assessed as decrease in plasma glucose level at 20 mg/kg, po qd after 27 hrs2002Journal of natural products, Feb, Volume: 65, Issue:2
Achyrofuran, a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides.
AID332266Antihyperglycemic activity in db/db mouse model assessed as decrease in body weight at 20 mg/kg, po qd after 24 hrs2002Journal of natural products, Feb, Volume: 65, Issue:2
Achyrofuran, a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides.
AID1176780Antimicrobial activity against Candida glabrata ATCC 9984 after 24 hrs by broth microdilution method2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID1176779Antimicrobial activity against Candida albicans ATCC 1023 after 24 hrs by broth microdilution method2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID332268Antihyperglycemic activity in db/db mouse model assessed as decrease in food intake at 20 mg/kg, po qd2002Journal of natural products, Feb, Volume: 65, Issue:2
Achyrofuran, a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides.
AID332269Acute toxicity in db/db mouse model at 20 mg/kg, po qd2002Journal of natural products, Feb, Volume: 65, Issue:2
Achyrofuran, a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides.
AID1176775Antimicrobial activity against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus NRS402 after 24 hrs by broth microdilution method2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID1176777Antimicrobial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth microdilution method2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID1176774Antimicrobial activity against Escherichia coli ATCC 35218 after 24 hrs by broth microdilution method2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID1176776Antimicrobial activity against methicillin-sensitive and vancomycin-intermediate Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution method2015Journal of natural products, Jan-23, Volume: 78, Issue:1
Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
AID332263Antihyperglycemic activity in db/db mouse model assessed as decrease in plasma glucose level at 20 mg/kg, po qd after 3 hrs2002Journal of natural products, Feb, Volume: 65, Issue:2
Achyrofuran, a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phloroglucinol
Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.. phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.		2.1110benzenetriol;
phenolic donor		algal metabolite
metformin
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289). metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.		2.0110guanidinesenvironmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.		2.1110kanamycinsbacterial metabolite
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.1110beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
gnaphalin
gnaphalin: a lipophilic flavonol from Helichrysum sp.; structure in first source		2.1110
ConditionIndicatedRelationship StrengthStudiesTrials
Diabetes Mellitus, Adult-Onset
[description not available]		02.7130
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.		02.7130
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0210
Impotence
[description not available]		02.0210
Erectile Dysfunction
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.		02.0210