Page last updated: 2024-09-28

Tuberculosis, Splenic

Infection of the spleen with species of MYCOBACTERIUM.

Synonyms(1)

Synonym
Tuberculosis, Splenic

Research Excerpts

Overview

ExcerptReference
"Splenic tuberculosis is a rare entity."( Aspiroz, C; Gimeno, E; Gotor, MA; Guerrero, L; Mur, M; Romero, D, 1995)

Research

Studies (51)

TimeframeStudies, This Condition (%)All Conditions %
pre-199024 (47.06)23.3326
1990's9 (17.65)12.5806
2000's9 (17.65)18.1394
2010's7 (13.73)28.8240
2020's2 (3.92)9.53
DrugIndicatedRelationship StrengthStudiesTrials
pyrazinamide0low60
pimagedine0low10
gentamicin0low10
isoniazid0low170
mesalamine0low10
rofecoxib0low10
hydrocortisone acetate0low10
prednisolone0low20
thymidine0low10
spironolactone0low10
prednisone0low20
estrone0low10
kanamycin a0low10
penicillanic acid0low10
betamethasone0low10
ethambutol0low50
streptomycin0low80
barium sulfate0low10
amikacin0low10
piperacillin0low10
fluorodeoxyglucose f180low20
tyloxapol0low10
methotrexate0low20
paromomycin0low10
cortisone0low30
glycosides0low10
phenylthiourea0low10
thiocarlide0low10
naloxone0low10
morphine0low10
indium0low10
bedaquiline0low10
ro13-99040low10
piperacillin, tazobactam drug combination0low10
rome0low10
technetium tc 99m sulfur colloid0low10
exudates0low10
rifampin0low100

Protein Targets (540)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
estrogen nuclear receptor alpha140014
peripheral myelin protein 223003
histone acetyltransferase KAT2A isoform 14004
lamin isoform A-delta104004
ATP-binding cassette sub-family C member 3011011
Multidrug resistance-associated protein 4011012
Bile salt export pump018018
Canalicular multispecific organic anion transporter 1011011
Aminoglycoside 3'-phosphotransferase 0001
ATP-dependent phosphofructokinase2002
cytochrome P450 family 3 subfamily A polypeptide 45005
G2002
cytochrome P450 2D62002
ATP synthase subunit c0011
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Cytochrome P450 1A20202
Cytochrome P450 3A40314
Replicase polyprotein 1ab0101
Cytochrome P450 2D60202
Cytochrome P450 2C9 0303
Cytochrome P450 2C190303
Spike glycoprotein6006
Potassium voltage-gated channel subfamily H member 20213
ATP synthase subunit c 0101
Sigma intracellular receptor 20101
Inositol hexakisphosphate kinase 12002
cytochrome P450 2C9, partial2002
Chain A, Integrase0101
Chain A, Integrase0101
Chain A, T4 LYSOZYME0011
Chain A, GCN4P10011
Chain B, GCN4P10011
Chain C, GCN4P10011
Chain A, T4 LYSOZYME0011
Chain A, T4 LYSOZYME0011
Chain A, Replicase polyprotein 1ab0101
Chain A, 3C-like proteinase0101
pregnane X receptor6006
thyroid stimulating hormone receptor5005
progesterone receptor8008
retinoid X nuclear receptor alpha8008
peroxisome proliferator-activated receptor delta6006
cellular tumor antigen p53 isoform a3003
Endolysin0011
Cellular tumor antigen p535005
Integrin beta-33003
Integrin alpha-IIb3003
GLI family zinc finger 38008
AR protein120012
glucocorticoid receptor [Homo sapiens]110011
estrogen-related nuclear receptor alpha8008
farnesoid X nuclear receptor4004
pregnane X nuclear receptor100010
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
IDH13003
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
nuclear receptor subfamily 1, group I, member 22002
thyroid hormone receptor beta isoform a4004
nuclear factor erythroid 2-related factor 2 isoform 25005
galanin receptor type 30101
nuclear factor erythroid 2-related factor 2 isoform 19009
Voltage-dependent calcium channel gamma-2 subunit5005
Glucocorticoid receptor010318
Glycine receptor subunit alpha-1010010
Glutamate receptor 25005
Glycine receptor subunit beta010010
Glycine receptor subunit alpha-2010010
Glycine receptor subunit alpha-3010010
ORF730011
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
endonuclease IV2002
dopamine D1 receptor3003
thioredoxin reductase3003
RAR-related orphan receptor gamma9009
GLS protein3003
TDP1 protein8008
aldehyde dehydrogenase 1 family, member A18008
regulator of G-protein signaling 42002
retinoic acid nuclear receptor alpha variant 17007
peroxisome proliferator activated receptor gamma6006
euchromatic histone-lysine N-methyltransferase 29009
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)5005
peripheral myelin protein 22 isoform 12002
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 15005
heat shock protein beta-11001
flap endonuclease 13003
geminin5005
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 15005
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M11001
Gamma-aminobutyric acid receptor subunit pi5005
Sex hormone-binding globulin0022
Corticosteroid-binding globulin0404
Gamma-aminobutyric acid receptor subunit beta-15005
Gamma-aminobutyric acid receptor subunit delta5005
Gamma-aminobutyric acid receptor subunit gamma-25005
Gamma-aminobutyric acid receptor subunit alpha-55005
Gamma-aminobutyric acid receptor subunit alpha-35005
Gamma-aminobutyric acid receptor subunit gamma-15005
Gamma-aminobutyric acid receptor subunit alpha-25005
Gamma-aminobutyric acid receptor subunit alpha-45005
Gamma-aminobutyric acid receptor subunit gamma-35005
Gamma-aminobutyric acid receptor subunit alpha-65005
Gamma-aminobutyric acid receptor subunit alpha-15106
Gamma-aminobutyric acid receptor subunit beta-35005
Gamma-aminobutyric acid receptor subunit beta-25005
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 434004
GABA theta subunit5005
Multidrug and toxin extrusion protein 10202
Gamma-aminobutyric acid receptor subunit epsilon5005
ATAD5 protein, partial4004
NFKB1 protein, partial2002
GALC protein1001
estrogen receptor 2 (ER beta)6006
nuclear receptor subfamily 1, group I, member 36006
nonstructural protein 11001
arylsulfatase A2002
activating transcription factor 63003
Bloom syndrome protein isoform 12002
hexokinase-4 isoform 11001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
glucokinase regulatory protein1001
DNA polymerase iota isoform a (long)2002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Rap guanine nucleotide exchange factor 31001
Estrogen receptor0629
Steryl-sulfatase0101
Aromatase0101
Polyunsaturated fatty acid lipoxygenase ALOX150202
17-beta-hydroxysteroid dehydrogenase type 10203
Androgen receptor0506
Sodium-dependent serotonin transporter0202
Mu-type opioid receptor05412
Alpha-synuclein0303
5-hydroxytryptamine receptor 2B0202
Solute carrier organic anion transporter family member 1A10202
Mu-type opioid receptor0527
Inositol monophosphatase 12002
Cytochrome P450 1B10101
Estrogen receptor beta0427
Ghrelin O-acyltransferase0101
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Enoyl-[acyl-carrier-protein] reductase [NADH]0206
Pantothenate synthetase0202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, Beta-lactamase1001
Luciferase4004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
transcriptional regulator ERG isoform 32002
importin subunit beta-1 isoform 12002
snurportin-12002
GTP-binding nuclear protein Ran isoform 11001
Chain A, 2-oxoglutarate Oxygenase3003
phosphopantetheinyl transferase3003
EWS/FLI fusion protein4004
67.9K protein3003
bromodomain adjacent to zinc finger domain 2B1001
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
cytochrome P450 2D6 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d1001
thyroid hormone receptor beta isoform 25005
nuclear receptor ROR-gamma isoform 12002
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20303
Bile salt export pump0505
Myeloperoxidase0101
Formamidopyrimidine-DNA glycosylase0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Cytochrome P450 2C80101
Cytochrome P450 2A60101
Macrophage migration inhibitory factor0101
Endonuclease III-like protein 10101
DNA gyrase subunit B0202
DNA gyrase subunit A0202
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0202
Endonuclease 8-like 10101
3-oxoacyl-[acyl-carrier-protein] synthase 30101
Gap junction alpha-1 protein0101
Gap junction beta-2 protein0101
Acyl-protein thioesterase 10101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
15-lipoxygenase, partial3003
USP1 protein, partial3003
thyroid stimulating hormone receptor1001
Histone H2A.x4004
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
vitamin D3 receptor isoform VDRA4004
microphthalmia-associated transcription factor isoform 90101
DNA polymerase kappa isoform 12002
caspase-1 isoform alpha precursor2002
Solute carrier organic anion transporter family member 2B1 0203
Tumor necrosis factor0101
Neuraminidase0101
Prostaglandin G/H synthase 10202
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0202
Platelet-activating factor receptor1001
Cystathionine gamma-lyase0101
Prostaglandin G/H synthase 20303
Histamine H2 receptor2002
Caspase-72002
10 kDa heat shock protein, mitochondrial0202
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Solute carrier organic anion transporter family member 1B30205
Protein-arginine deiminase type-40505
Cystine/glutamate transporter0101
Hydroxyacid oxidase 10101
Solute carrier organic anion transporter family member 1B10204
large T antigen0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, Ferritin light chain1001
acid sphingomyelinase1001
ClpP1001
Microtubule-associated protein tau3003
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
muscleblind-like protein 1 isoform 11001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20011
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0203
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0123
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0539
Kappa-type opioid receptor0438
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Solute carrier organic anion transporter family member 1A30001
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80002
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Solute carrier family 22 member 110002
Opioid receptor, delta 1b 0101
Solute carrier family 22 member 1 0101
Acetylcholinesterase0101
Opioid receptor homologue0101
ATP-dependent translocase ABCB10101
Acyl-CoA desaturase 10101
ATP-dependent translocase ABCB10202
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0011
Muscarinic acetylcholine receptor M20202
Translocator protein0011
ATP-dependent translocase ABCB10101
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0202
Delta-type opioid receptor0316
Kappa-type opioid receptor0316
Mu-type opioid receptor0428
UDP-glucuronosyltransferase 1A30001
Delta-type opioid receptor0428
Kappa-type opioid receptor0416
Kappa-type opioid receptor0439
Mu-type opioid receptor0317
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Beta-2 adrenergic receptor0202
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10202
D(3) dopamine receptor0101
Adenosine receptor A10101
Cytochrome P450 2J20202
Sigma non-opioid intracellular receptor 10101
UDP-glucuronosyltransferase 1A80001
Sigma non-opioid intracellular receptor 10101
30S ribosomal protein S60202
30S ribosomal protein S70202
50S ribosomal protein L150202
50S ribosomal protein L100202
50S ribosomal protein L110202
50S ribosomal protein L7/L120202
50S ribosomal protein L190202
50S ribosomal protein L10202
50S ribosomal protein L200202
50S ribosomal protein L270202
50S ribosomal protein L280202
50S ribosomal protein L290202
50S ribosomal protein L310202
50S ribosomal protein L31 type B0202
50S ribosomal protein L320202
50S ribosomal protein L330202
50S ribosomal protein L340202
50S ribosomal protein L350202
50S ribosomal protein L360202
30S ribosomal protein S100202
30S ribosomal protein S110202
30S ribosomal protein S120202
30S ribosomal protein S130202
30S ribosomal protein S160202
30S ribosomal protein S180202
30S ribosomal protein S190202
30S ribosomal protein S200202
30S ribosomal protein S20202
30S ribosomal protein S30202
30S ribosomal protein S40202
30S ribosomal protein S50202
30S ribosomal protein S80202
30S ribosomal protein S90202
50S ribosomal protein L130202
50S ribosomal protein L140202
50S ribosomal protein L160202
50S ribosomal protein L230202
30S ribosomal protein S150202
50S ribosomal protein L170202
50S ribosomal protein L210202
50S ribosomal protein L300202
50S ribosomal protein L60202
30S ribosomal protein S140202
30S ribosomal protein S170202
30S ribosomal protein S10202
50S ribosomal protein L180202
50S ribosomal protein L20202
50S ribosomal protein L30202
50S ribosomal protein L240202
50S ribosomal protein L40202
50S ribosomal protein L220202
50S ribosomal protein L50202
30S ribosomal protein S210202
50S ribosomal protein L250202
50S ribosomal protein L36 20202
Tyrosyl-DNA phosphodiesterase 10101
Chain A, PROTEIN (CATECHOL OXIDASE)0101
interleukin 82002
lethal factor (plasmid)2002
Tyrosinase0101
Tyrosinase0202
Succinyl-diaminopimelate desuccinylase0101
Nuclear receptor ROR-gamma2002
Taste receptor type 2 member 380012
Albumin0011
Aldo-keto reductase family 1 member B10101
Neutrophil elastase0101
Complement C1s subcomponent0101
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, brain0202
Nitric oxide synthase, inducible0101
Nitric oxide synthase, inducible0101
Collagenase 30202
Nitric oxide synthase, inducible0101
Beta-lactamase 0001
Beta-lactamase 0101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase0001
Beta-lactamase OXA-70001
Solute carrier family 15 member 10101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
BlaVIM-1 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Histamine H3 receptor0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase VIM-1 0001
luciferase0001
hypoxia-inducible factor 1 alpha subunit1001
Fatty acid-binding protein, liver0101
Progesterone receptor0416
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0416
Androgen receptor0415
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
thioredoxin glutathione reductase2002
NAD-dependent protein deacetylase sirtuin-60101
Chain A, Cruzipain2002
DNA-directed RNA polymerase subunit beta0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Solute carrier organic anion transporter family member 1A40101
Nuclear receptor subfamily 1 group I member 20011
Albumin0011
NH(3)-dependent NAD(+) synthetase0101
Cytochrome P450 2B60011
Arylacetamide deacetylase0102
Caspase-10101
Solute carrier organic anion transporter family member 1A20101
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Lanosterol 14-alpha demethylase0101
inositol monophosphatase 11001
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 2 0101
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Seed linoleate 13S-lipoxygenase-10101
Polyunsaturated fatty acid 5-lipoxygenase0202
Calpain-2 catalytic subunit0101
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10101
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 2 0101
C-X-C chemokine receptor type 30101
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 1 0101
Transporter0101
Sodium-dependent serotonin transporter0101
Sphingosine kinase 20202
Sphingosine kinase 10101
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
glp-1 receptor, partial1001
SMAD family member 21001
SMAD family member 31001
Smad31001
Vpr1001
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
72 kDa type IV collagenase0101
Stromelysin-10101
Multidrug transporter MdfA0101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0101
Alpha-1D adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Cannabinoid receptor 10101
Integrase 0101
P2Y purinoceptor 120101
Solute carrier family 22 member 70001
Hydrolase, alpha/beta hydrolase fold family0101
Thymidine kinase 0102
Thymidine kinase, cytosolic0204
Thymidine kinase0102
Thymidine phosphorylase0001
Thymidine phosphorylase0001
Thymidylate kinase0101
Thymidine kinase, cytosolic 0002
Thymidine kinase0001
Thymidylate kinase0101
Thymidine kinase 0102
Sterol O-acyltransferase 10101
Thymidine kinase0001
Thymidine kinase0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]