Compounds > heliomycin
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heliomycin

Description

heliomycin: Russian drug; antibiotic with antiviral properties isolated from Actinomyces flavochromogenes var. heliomycini; structure [MeSH]

Cross-References

ID SourceID
PubMed CID135430323
CHEMBL ID1320139
SCHEMBL ID2134180
CHEBI ID29671
MeSH IDM0051383

Synonyms (50)

Synonym
itamycin
antibiotic a 3733a
croceomycin
a 3733a
geliomycin
brn 2187224
heliomycin [inn]
geliomitsin
heliomycin
2h-benzo(cd)pyrene-2,6(1h)-dione, 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-
resistomycin
20004-62-0
NCGC00160672-01
3,5,7,10-tetrahydroxy-1,1,9-trimethyl-2h-benzo[cd]pyrene-2,6(1h)-dione
NCGC00160275-01
AKOS000715231
NCGC00160275-02
unii-7n3a092a5x
7n3a092a5x ,
4-08-00-03704 (beilstein handbook reference)
3,5,7,10-tetrahydroxy-1,1,9-trimethyl-2h-benzo(c,d)pyrene-2,6(1h)-dione
dtxsid4046101 ,
dtxcid2026101
tox21_111753
cas-20004-62-0
SCHEMBL2134180
CHEMBL1320139
chebi:29671 ,
11029-70-2
x-340
heliomycin [who-dd]
3,5,7,10-tetrahydroxy-1,1,9-trimethyl-2h-benzo(cf)pyrene-2,6(1h)-dione
antibiotic a-3733a
resistomycin [mi]
BRD-K64517075-001-01-9
tox21_111753_1
NCGC00160275-03
heliomycin (salt/mix)
1,2-dihydro-1,1,9-trimethyl-3,5,7,10-tetrahydroxy-6h-benzo[c,d]pyrene-2,6-dione
ABLACSIRCKEUOB-UHFFFAOYSA-N
3,5,7,10-tetrahydroxy-1,1,9-trimethyl-2h-benzo[cd]pyrene-2,6(1h)-dione #
2h-benzo[cf]pyrene-2,6(1h)-dione,3,5,7,10-tetrahydroxy-1,1,9-trimethyl-
SR-01000318568-1
sr-01000318568
J-012937
np285
2,4,10,14-tetrahydroxy-7,7,12-trimethylpentacyclo[13.3.1.05,18.08,17.011,16]nonadeca-1(18),2,4,8,10,12,14,16-octaene-6,19-dione
Q27110219
heliomycin; geliomycin; itamycin
6,10,14,19-tetrahydroxy-4,9,9-trimethylpentacyclo[13.3.1.05,18.08,17.011,16]nonadeca-1(19),3,5,7,10,13,15,17-octaene-2,12-dione

Protein Targets (45)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency1.7783AID2549
phosphopantetheinyl transferaseBacillus subtilisPotency56.2341AID1490
RAR-related orphan receptor gammaMus musculus (house mouse)Potency0.7613AID1159521; AID1159523
SMAD family member 2Homo sapiens (human)Potency3.7178AID1346859; AID1346924
Fumarate hydrataseHomo sapiens (human)Potency7.0795AID1347053
USP1 protein, partialHomo sapiens (human)Potency50.1187AID504865
GALC proteinHomo sapiens (human)Potency0.3162AID1159614
SMAD family member 3Homo sapiens (human)Potency3.7178AID1346859; AID1346924
TDP1 proteinHomo sapiens (human)Potency4.5496AID686978; AID686979
GLI family zinc finger 3Homo sapiens (human)Potency10.9399AID1259369; AID1259392
Microtubule-associated protein tauHomo sapiens (human)Potency8.9125AID1460
AR proteinHomo sapiens (human)Potency1.4397AID1259243; AID1259247; AID743036; AID743053
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency2.7662AID1224838; AID1224839; AID1224893
EWS/FLI fusion proteinHomo sapiens (human)Potency31.9709AID1259252; AID1259253; AID1259255
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.2391AID720692
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency2.2528AID1159553; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency0.6743AID1159527; AID1159531
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency0.8891AID1224848; AID1224849; AID1259401; AID1259403
farnesoid X nuclear receptorHomo sapiens (human)Potency9.6205AID743217; AID743220; AID743239
pregnane X nuclear receptorHomo sapiens (human)Potency1.4575AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency3.0272AID1259244; AID1259248; AID743069; AID743079; AID743080; AID743091
polyproteinZika virusPotency7.0795AID1347053
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency3.2093AID743212; AID743215
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency6.5112AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency3.6977AID743222; AID743241
aryl hydrocarbon receptorHomo sapiens (human)Potency13.3332AID743085
thyroid stimulating hormone receptorHomo sapiens (human)Potency14.5750AID1259385
activating transcription factor 6Homo sapiens (human)Potency2.9338AID1159516
Histone H2A.xCricetulus griseus (Chinese hamster)Potency9.5648AID1224845
Bloom syndrome protein isoform 1Homo sapiens (human)Potency10.6025AID2528
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency39.8107AID504847
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency7.0795AID1479
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency3.9811AID588834
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency0.6072AID743065; AID743067
huntingtin isoform 2Homo sapiens (human)Potency3.1623AID1688
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency8.0614AID743202; AID743219
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency15.5140AID2546; AID2551
gemininHomo sapiens (human)Potency4.0352AID624296; AID624297
DNA polymerase kappa isoform 1Homo sapiens (human)Potency15.8489AID588579
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency12.5797AID624044
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency3.6611AID1259244
Cellular tumor antigen p53Homo sapiens (human)Potency1.4832AID651631; AID720552
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency3.6611AID1259244
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency1.3333AID651632
Ataxin-2Homo sapiens (human)Potency1.3333AID651632

Bioassays (83)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
ISSN: 1095-9203		Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
ISSN: 2472-5560		Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
ISSN: 1521-0111		A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
ISSN: 1521-0111		A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
ISSN: 2211-1247		A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490		Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173ISSN: 1872-9096A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173ISSN: 1872-9096A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173ISSN: 1872-9096A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
ISSN: 1949-2553		Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347424RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
ISSN: 1083-351X		Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347407qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
ISSN: 1554-8937		High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID1347425Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
ISSN: 1083-351X		Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347600Antiproliferative activity against p53 deficient human HCT116 cells after 72 hrs by MTT assay2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1657478Antiviral activity against TBEV Absettarov infected in porcine PEK cells assessed as inhibition of viral reproduction by measuring plaque reduction preincubated for 1 hr followed by overlaying with 1.26% methylcellulose and measured after 6 days by gentia2020Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10
ISSN: 1464-3405		Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction.
AID1113004Antifungal activity against Fusarium oxysporum f. sp. melongenae assessed as inhibition of mycelial growth2013Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7
ISSN: 1520-5118		Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02.
AID1347628Induction of reactive oxygen species generation in human T24 cells at 1 uM after 30 mins by H2DCFDA dye-based flow cytometric method2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1225306Antimicrobial activity against Escherichia coli ATCC 25922 assessed as inhibition of microbial growth at 50 ug/ml2015Journal of natural products, Mar-27, Volume: 78, Issue:3
ISSN: 1520-6025		Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.
AID1347616Binding affinity to calf thymus double stranded DNA by Benesi-Hildebrand plot analysis2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1347618Inhibition of human DNA topoisomerase 1 assessed as decrease in relaxation of pBR322 at 20 uM after 30 to 40 mins by agarose gel electrophoresis2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1225299Antimicrobial activity against Firmicutes K9402015Journal of natural products, Mar-27, Volume: 78, Issue:3
ISSN: 1520-6025		Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.
AID1113001Antifungal activity against Magnaporthe grisea in fourth-leaf stage of rice plant assessed as curative efficacy at 100 ug/ml after 11 days relative to control2013Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7
ISSN: 1520-5118		Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02.
AID1225298Antimicrobial activity against Acinetobacter E9062015Journal of natural products, Mar-27, Volume: 78, Issue:3
ISSN: 1520-6025		Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.
AID1113009Antifungal activity against Valsa mali assessed as inhibition of mycelial growth2013Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7
ISSN: 1520-5118		Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02.
AID1347629Binding affinity to calf thymus DNA2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1882257Antibacterial activity against Escherichia coli LptD4213 assessed as growth inhibition incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 01-28, Volume: 85, Issue:1
ISSN: 1520-6025		Chlororesistoflavins A and B, Chlorinated Benzopyrene Antibiotics Produced by the Marine-Derived Actinomycete
AID1113005Antifungal activity against Fusarium oxysporum f. sp. cucumerinum assessed as inhibition of mycelial growth2013Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7
ISSN: 1520-5118		Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02.
AID1347627Upregulation of total p53 levels in human T24 cells at 0.5 to 1 uM after 18 hrs by Western blot method2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1347607Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1225297Retention time of the compound by HPLC method2015Journal of natural products, Mar-27, Volume: 78, Issue:3
ISSN: 1520-6025		Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.
AID1113007Antifungal activity against Dothiorella gregaria assessed as inhibition of mycelial growth2013Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7
ISSN: 1520-5118		Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02.
AID1347623Induction of apoptosis n human T24 cells assessed as upregulation of Bak levels at 0.5 to 1 uM after 18 hrs by Western blot method2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1225303Antimicrobial activity against Xanthomonas axonopodis ATCC 8718 assessed as inhibition of microbial growth at 50 ug/ml2015Journal of natural products, Mar-27, Volume: 78, Issue:3
ISSN: 1520-6025		Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.
AID1225307Antimicrobial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of microbial growth at 50 ug/ml2015Journal of natural products, Mar-27, Volume: 78, Issue:3
ISSN: 1520-6025		Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.
AID1882256Antibacterial activity against methicillin-resistant Staphylococcus aureus TCH1516 assessed as growth inhibition incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 01-28, Volume: 85, Issue:1
ISSN: 1520-6025		Chlororesistoflavins A and B, Chlorinated Benzopyrene Antibiotics Produced by the Marine-Derived Actinomycete
AID1347615Binding affinity to calf thymus double stranded DNA at 10 uM by fluorescence spectrophotometer2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1347599Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1347601Antiproliferative activity against human K562 cells after 72 hrs by MTT assay2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1347621Induction of apoptosis n human T24 cells at 1 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometric method2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1113010Antifungal activity against Magnaporthe grisea assessed as inhibition of mycelial growth2013Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7
ISSN: 1520-5118		Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02.
AID1225301Antimicrobial activity against Brucella neotomae ATCC 23459 assessed as inhibition of microbial growth at 50 ug/ml2015Journal of natural products, Mar-27, Volume: 78, Issue:3
ISSN: 1520-6025		Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.
AID1767167Cytotoxicity against human HMEC-1 cells assessed as growth inhibition after 72 hrs by MTT assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
ISSN: 1520-6025		Water-Soluble Heliomycin Derivatives to Target i-Motif DNA.
AID1347624Induction of apoptosis n human T24 cells assessed as downregulation of Bcl-2 levels at 0.5 to 1 uM after 18 hrs by Western blot method2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1657480Cytotoxicity against porcine PEK cells assessed as reduction in cell viability after 7 days by microscopic method2020Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10
ISSN: 1464-3405		Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction.
AID1767165Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
ISSN: 1520-6025		Water-Soluble Heliomycin Derivatives to Target i-Motif DNA.
AID1113008Antifungal activity against Fusarium graminearum assessed as inhibition of mycelial growth2013Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7
ISSN: 1520-5118		Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02.
AID1767166Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
ISSN: 1520-6025		Water-Soluble Heliomycin Derivatives to Target i-Motif DNA.
AID1657479Cytotoxicity against porcine PEK cells assessed as reduction in cell viability after 24 hrs by microscopic method2020Bioorganic & medicinal chemistry letters, 05-15, Volume: 30, Issue:10
ISSN: 1464-3405		Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction.
AID1225300Antimicrobial activity against Burkholderia vietnamiensis ATCC BAA-248 assessed as inhibition of microbial growth at 50 ug/ml2015Journal of natural products, Mar-27, Volume: 78, Issue:3
ISSN: 1520-6025		Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.
AID1225304Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of microbial growth at 50 ug/ml2015Journal of natural products, Mar-27, Volume: 78, Issue:3
ISSN: 1520-6025		Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.
AID1347626Induction of apoptosis n human T24 cells assessed as PARP cleavage at 0.5 to 1 uM after 18 hrs by Western blot method2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1113003Antifungal activity against Magnaporthe grisea assessed as inhibition of spore germination after 12 hr by light microscopic analysis2013Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7
ISSN: 1520-5118		Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02.
AID1347603Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1113002Antifungal activity against Magnaporthe grisea in fourth-leaf stage of rice plant assessed as preventive efficacy at 100 ug/ml after 11 days relative to control2013Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7
ISSN: 1520-5118		Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02.
AID1347617Growth inhibition of human T24 cells after 72 hrs by cell impedance method2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1225302Antimicrobial activity against Yersinia pestis A1122 assessed as inhibition of microbial growth at 50 ug/ml2015Journal of natural products, Mar-27, Volume: 78, Issue:3
ISSN: 1520-6025		Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.
AID1347602Antiproliferative activity against human K562/4 cells after 72 hrs by MTT assay2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1767164Antiproliferative activity against mouse L1210 cells assessed as growth inhibition after 72 hrs by MTT assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
ISSN: 1520-6025		Water-Soluble Heliomycin Derivatives to Target i-Motif DNA.
AID1113006Antifungal activity against Rhizoctonia solani assessed as inhibition of mycelial growth2013Journal of agricultural and food chemistry, Feb-20, Volume: 61, Issue:7
ISSN: 1520-5118		Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02.
AID1225305Antimicrobial activity against Enterococcus faecalis ATCC 29212 assessed as inhibition of microbial growth at 50 ug/ml2015Journal of natural products, Mar-27, Volume: 78, Issue:3
ISSN: 1520-6025		Phylum-specific regulation of resistomycin production in a Streptomyces sp. via microbial coculture.
AID1347605Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.
AID1347604Antiproliferative activity against human CEM cells after 72 hrs by MTT assay2018European journal of medicinal chemistry, Jan-01, Volume: 143ISSN: 1768-3254Aminomethylation of heliomycin: Preparation and anticancer characterization of the first series of semi-synthetic derivatives.

Research

Studies (64)

TimeframeStudies, This Drug (%)All Drugs %
pre-199027 (42.19)18.7374
1990's3 (4.69)18.2507
2000's9 (14.06)29.6817
2010's13 (20.31)24.3611
2020's12 (18.75)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (2.86%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other68 (97.14%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
ciprofloxacin
1
aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic		202220222.0low000001
cycloheximide
1
antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor		2013201311.0low000010
carbendazim
1
benzimidazole fungicide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		antifungal agrochemical;
antinematodal drug;
metabolite;
microtubule-destabilising agent		2013201311.0low000010
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
glycerol
5
alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent		1985198936.2medium050000
netropsin
1
2013201311.0low000010
diethylnitrosamine
1
nitrosaminecarcinogenic agent;
hepatotoxic agent;
mutagen		202120213.0low000001
chloramphenicol
2
C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor		1975198842.5low020000
sucrose
1
glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent		1988198836.0low010000
kanamycin a
3
kanamycinsbacterial metabolite1959196164.0low030000
lactose
1
lactose1985198539.0low010000
cycloheximide
1
antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor		2013201311.0low000010
furaldehyde
1
aldehyde;
furans		Maillard reaction product;
metabolite		1961196163.0low010000
oxazoles
1
1,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene		2013201311.0low000010
5-nitro-2-furaldehyde
1
C-nitro compound;
furans		1961196163.0low010000
5838 dni
1
2007200717.0low000100
exfoliazone
1
202020204.0medium000010
resistoflavin
4
1976201323.5high010210
arabinose
3
L-arabinoseEscherichia coli metabolite;
mouse metabolite		1985198936.7low030000
dactinomycin
1
actinomycinmutagen2011201113.0low000010
pyrophosphate
1
diphosphate ion1983198341.0low010000
sulfur
1
chalcogen;
nonmetal atom		macronutrient2013201311.0low000010
cysteine
1
cysteiniumfundamental metabolite2003200321.0low000100
altemicidin
1
2013201311.0medium000010
marmycin a
1
2013201311.0medium000010
proximicin a
1
2013201311.0medium000010
streptochlorin
1
2013201311.0low000010
tetracycline
1
1961196163.0low010000
rolitetracycline
1
1961196163.0low010000
agar
2
1975198444.5low020000
prodigiosin
1
202020204.0low000010
undecylprodigiosin
1
alkaloid;
aromatic ether;
tripyrrole		antibacterial agent;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite;
biological pigment;
immunosuppressive agent;
radiosensitizing agent		202020204.0low000010
echinosporin
1
2013201311.0medium000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Bacterial Disease0
1
2012201212.0low000010
Bacterial Infections0
1
2012201212.0low000010
Carcinoma, Hepatocellular0
1
202120213.0low000001
Congenital Zika Syndrome0
1
202020204.0low000010
Cytomegalovirus0
1
2005200519.0low000100
Dermatoses0
1
1963196361.0low010000
Disease Models, Animal0
1
202020204.0low000010
Enteric Fever0
1
1961196163.0low010000
ER-Negative PR-Negative HER2-Negative Breast Cancer0
1
202020204.0low000010
Experimental Hepatoma0
1
202120213.0low000001
Fungal Diseases0
1
2012201212.0low000010
Hepatocellular Carcinoma0
1
202120213.0low000001
Koch's Disease0
2
1960196163.5low020000
Mycoses0
1
2012201212.0low000010
Pulmonary Consumption0
2
1960196163.5low020000
Skin Diseases0
1
1963196361.0low010000
Triple Negative Breast Neoplasms0
1
202020204.0low000010
Tuberculosis0
2
1960196163.5low020000
Tuberculosis, Pulmonary0
2
1960196163.5low020000
Typhoid Fever0
1
1961196163.0low010000
Zika Virus Infection0
1
202020204.0low000010

Bioavailability (2)

ArticleYear
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, , Volume: 96, Issue:5		2019
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
The Journal of biological chemistry, , 11-15, Volume: 294, Issue:46		2019