gentamicin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

gentamicin B: RN given refers to gentamicin B; see also records for gentamicin A and gentamicin C [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	11754987
CHEMBL ID	2110604
SCHEMBL ID	509198
MeSH ID	M0081453

Synonyms (24)

Synonym
betamicina [inn-spanish]
gentamicin b
betamicine [inn-french]
d-streptamine, o-6-amino-6-deoxy-alpha-d-glucopyranosyl-(1-4)-o-(3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl-(1-6))-2-deoxy-
betamicinum [inn-latin]
betamicin [inn]
betamicin
gentamycin b
o-6-amino-6-deoxy-alpha-d-glucopyranosyl-(1-4)-o-(3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl-(1-6))-2-deoxy-d-streptamine
betamicine
unii-67w9dgg4c7
betamicinum
betamicina
67w9dgg4c7 ,
36889-15-3
d-streptamine, o-6-amino-6-deoxy-.alpha.-d-glucopyranosyl-(1->4)-o-(3-deoxy-4-c-methyl-3-(methylamino)-.beta.-l-arabinopyranosyl-(1->6))-2-deoxy-
sch-14342
SCHEMBL509198
RHRAMPXHWHSKQB-GGEUKFTFSA-N
CHEMBL2110604
(2r,3s,4s,5r,6r)-2-(aminomethyl)-6-((1r,2r,3s,4r,6s)-4,6-diamino-3-((2r,3r,4r,5r)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2h-pyran-2-yloxy)-2-hydroxycyclohexyloxy)tetrahydro-2h-pyran-3,4,5-triol
(2r,3s,4s,5r,6r)-2-(aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-diamino-3-[(2r,3r,4r,5r)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol
Q27264175
DTXSID101043341

Research Excerpts

Overview

Gentamicin B is a naturally occurring minor component isolated from Micromonospora echinospora.

Excerpt	Reference	Relevance
"Gentamicin B is a naturally occurring minor component isolated from Micromonospora echinospora."	( Assembly of a novel biosynthetic pathway for gentamicin B production in Micromonospora echinospora. Cui, H; Gu, Y; Ni, X; Sun, Z; Xia, H, 2016)	1.42

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID1586839	Induction of read through activity at cricket paralysis virus-internal ribosome entry site premature termination codon UGA assessed as ratio of plateau octapeptide to FKVRQ-tRNAGln measured after 20 mins in presence of Typ-tRNA, Leu-tRNA and [35S]-Met-tRN	2018	ACS medicinal chemistry letters, Dec-13, Volume: 9, Issue:12	New
AID1586838	Induction of read through activity at cricket paralysis virus-internal ribosome entry site premature termination codon UGA assessed as increase in octapeptide formation from FKVRQ-tRNAGln measured after 20 mins in presence of Typ-tRNA, Leu-tRNA and [35S]-	2018	ACS medicinal chemistry letters, Dec-13, Volume: 9, Issue:12	New
AID1586840	Induction of read through activity at cricket paralysis virus-internal ribosome entry site codon UGG assessed as increase in octapeptide formation from FKVRQ-tRNAGln at EC50 to 2 times EC50 measured after 20 mins in presence of Typ-tRNA, Leu-tRNA and [35S	2018	ACS medicinal chemistry letters, Dec-13, Volume: 9, Issue:12	New
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (22.22)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (66.67)	24.3611
2020's	1 (11.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	25.36 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.32 (4.65)
Search Engine Demand Index	26.69 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (25.36)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (11.11%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (88.89%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gamma-aminobutyric acid gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	1.96	1	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule
gentamicin Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.	4.64	8
kanamycin a Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.	7.11	1	kanamycins	bacterial metabolite
antibiotic g 418 antibiotic G 418: from Micromonospora rhodorangea	1.95	1
zithromax Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.. azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.	2.17	1	macrolide antibiotic	antibacterial drug; environmental contaminant; xenobiotic
dibekacin Dibekacin: Analog of KANAMYCIN with antitubercular as well as broad-spectrum antimicrobial properties.. dibekacin : A kanamycin that is kanamycin B lacking the 3- and 4-hydroxy groups on the 2,6-diaminosugar ring.	7.11	1	kanamycins	antibacterial agent; protein synthesis inhibitor
isepamicin [no description available]	2.21	1
gentamicin c gentamicin C: RN given refers to cpd with unknown MF; see also record for micronomicin for which gentamicin C2b is synonym	7.15	1
tylosin [no description available]	2.17	1	aldehyde; disaccharide derivative; enone; leucomycin; macrolide antibiotic; monosaccharide derivative	allergen; bacterial metabolite; environmental contaminant; xenobiotic
negamycin negamycin: broad spectrum hydrazide antibiotic obtained from Streptomyces species; action seems to be due to its binding to ribosomes & interference with amino coding in protein synthesis; precursor is probably leucyl-negamycin; minor descriptor (76-85); on-line & Index Medicus search AMINO ACIDS, DIAMINO (76-85); RN given refers to (threo-L)-isomer	2.17	1
ptc 124 [no description available]	2.17	1	oxadiazole; ring assembly

Condition	Relationship Strength	Studies
Disseminated Fusariosis [description not available]	3.09	1
Aspergillus Infection [description not available]	3.09	1
Aspergillosis Infections with fungi of the genus ASPERGILLUS.	3.09	1
Fusariosis OPPORTUNISTIC INFECTIONS with the soil fungus FUSARIUM. Typically the infection is limited to the nail plate (ONYCHOMYCOSIS). The infection can however become systemic especially in an IMMUNOCOMPROMISED HOST (e.g., NEUTROPENIA) and results in cutaneous and subcutaneous lesions, fever, KERATITIS, and pulmonary infections.	3.09	1
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	1.95	1
Proteinuria The presence of proteins in the urine, an indicator of KIDNEY DISEASES.	1.95	1

chemdatabank.com