Page last updated: 2024-12-06

illimaquinone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Illimaquinone is a natural product isolated from the roots of the Hawaiian medicinal plant _Ochrosia grandiflora_. It exhibits a variety of biological activities, including anti-cancer, anti-inflammatory, and anti-microbial properties. Its unique structure, containing a highly substituted naphthoquinone core, has attracted significant interest from synthetic chemists, leading to several successful total syntheses. The compound's potent biological activity and challenging chemical structure make it a valuable target for drug discovery research. Illimaquinone has shown promise in inhibiting the growth of various cancer cell lines, including breast, colon, and prostate cancer cells. Its anti-inflammatory activity has been attributed to its ability to suppress the production of pro-inflammatory cytokines. Additionally, illimaquinone has demonstrated antimicrobial activity against a range of bacteria and fungi, making it a potential candidate for the development of new antibiotics. The complex and intricate structure of illimaquinone poses a significant challenge for its synthesis, making it an attractive target for synthetic chemists to develop new methodologies and strategies. The development of efficient and scalable synthetic routes to illimaquinone and its analogs is crucial for further investigation of its biological properties and potential therapeutic applications.'

illimaquinone: structure given in first source; isolated from the Red Sea sponge Smenospongia; inhibits the RNase H. activity of HIV-1 reverse transcriptase [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID72291
CHEBI ID70133
SCHEMBL ID517890
MeSH IDM0184625

Synonyms (25)

Synonym
ilimaquinone
SMP2_000173
71678-03-0
3-[[(1r,2s,4as,8as)-1,2,4a-trimethyl-5-methylene-decalin-1-yl]methyl]-2-hydroxy-5-methoxy-1,4-benzoquinone
illimaquinone
3-[[(1r,2s,4as,8as)-1,2,4a-trimethyl-5-methylidene-3,4,6,7,8,8a-hexahydro-2h-naphthalen-1-yl]methyl]-2-hydroxy-5-methoxycyclohexa-2,5-diene-1,4-dione
chebi:70133 ,
imaquinone
5u0wan3n8q ,
2,5-cyclohexadiene-1,4-dione, 3-((decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl)methyl)-2-hydroxy-5-methoxy-, (1r-(1alpha,2beta,4abeta,8aalpha))-
unii-5u0wan3n8q
2,5-cyclohexadiene-1,4-dione,3-[[(1r,2s,4as,8as)-decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl] methyl]-2-hydroxy-5-methoxy-
FD7195
SCHEMBL517890
DTXSID90221909
ilimaquinone, (-)-
ilimaquinone [mi]
2,5-cyclohexadiene-1,4-dione, 3-(((1r,2s,4as,8as)-decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl)methyl)-2-hydroxy-5-methoxy-
AKOS027338228
Q27138473
HY-119500
AMY15369
CS-0068556
2-hydroxy-5-methoxy-3-(((1r,2s,4as,8as)-1,2,4a-trimethyl-5-methylenedecahydronaphthalen-1-yl)methyl)cyclohexa-2,5-diene-1,4-dione
3-[(decahydro-1beta,2beta,4alphabeta-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone;imaquinone

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" This method was successfully applied in a pharmacokinetic study of ilimaquinone after oral administration in rats."( HPLC-MS/MS analysis of ilimaquinone and its application in a pharmacokinetic study in rats.
Kang, C; Kang, W; Na, M; Noh, K; Oh, S; Son, H; Song, IS, 2019
)
0.51

Bioavailability

ExcerptReferenceRelevance
" Since most efforts have focused on the development of nucleoside analog inhibitors, issues regarding bioavailability and selectivity have been major challenges."( A new structural class of S-adenosylhomocysteine hydrolase inhibitors.
Chun, TG; Kim, BG; Lee, HY; Snapper, ML, 2009
)
0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
prenylquinoneA quinone substituted by a polyprenyl-derived side-chain. Prenylquinones occur in all living cells. Due to their amphiphilic character, they are mainly located in biological membranes where they function as electron and proton carriers in the photosynthetic and respiratory electron transport chains. Some prenylquinones also perform more specialised roles sucy as antioxidants and enzyme cofactors. Prenylquinones are classified according to ring structure: the main classes are menaquinones, phylloquinones, ubiquinones and plastoquinones.
monohydroxy-1,4-benzoquinonesAny 1,4-benzoquinone carrying a single hydroxy substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA polymerase betaHomo sapiens (human)IC50 (µMol)45.20001.40006.56679.0000AID333392
AdenosylhomocysteinaseHomo sapiens (human)IC50 (µMol)40.00000.00152.11118.7000AID477475
M-phase inducer phosphatase 2Homo sapiens (human)IC50 (µMol)92.00000.10002.31039.5100AID333393
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (35)

Processvia Protein(s)Taxonomy
nucleotide-excision repair, DNA gap fillingDNA polymerase betaHomo sapiens (human)
in utero embryonic developmentDNA polymerase betaHomo sapiens (human)
DNA-templated DNA replicationDNA polymerase betaHomo sapiens (human)
DNA repairDNA polymerase betaHomo sapiens (human)
base-excision repairDNA polymerase betaHomo sapiens (human)
base-excision repair, gap-fillingDNA polymerase betaHomo sapiens (human)
pyrimidine dimer repairDNA polymerase betaHomo sapiens (human)
inflammatory responseDNA polymerase betaHomo sapiens (human)
DNA damage responseDNA polymerase betaHomo sapiens (human)
salivary gland morphogenesisDNA polymerase betaHomo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damageDNA polymerase betaHomo sapiens (human)
response to gamma radiationDNA polymerase betaHomo sapiens (human)
somatic hypermutation of immunoglobulin genesDNA polymerase betaHomo sapiens (human)
response to ethanolDNA polymerase betaHomo sapiens (human)
lymph node developmentDNA polymerase betaHomo sapiens (human)
spleen developmentDNA polymerase betaHomo sapiens (human)
homeostasis of number of cellsDNA polymerase betaHomo sapiens (human)
neuron apoptotic processDNA polymerase betaHomo sapiens (human)
response to hyperoxiaDNA polymerase betaHomo sapiens (human)
immunoglobulin heavy chain V-D-J recombinationDNA polymerase betaHomo sapiens (human)
DNA biosynthetic processDNA polymerase betaHomo sapiens (human)
double-strand break repair via nonhomologous end joiningDNA polymerase betaHomo sapiens (human)
one-carbon metabolic processAdenosylhomocysteinaseHomo sapiens (human)
S-adenosylmethionine cycleAdenosylhomocysteinaseHomo sapiens (human)
G2/M transition of mitotic cell cycleM-phase inducer phosphatase 2Homo sapiens (human)
mitotic cell cycleM-phase inducer phosphatase 2Homo sapiens (human)
oocyte maturationM-phase inducer phosphatase 2Homo sapiens (human)
protein phosphorylationM-phase inducer phosphatase 2Homo sapiens (human)
female meiosis IM-phase inducer phosphatase 2Homo sapiens (human)
positive regulation of cell population proliferationM-phase inducer phosphatase 2Homo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycleM-phase inducer phosphatase 2Homo sapiens (human)
positive regulation of cytokinesisM-phase inducer phosphatase 2Homo sapiens (human)
positive regulation of mitotic cell cycleM-phase inducer phosphatase 2Homo sapiens (human)
cell divisionM-phase inducer phosphatase 2Homo sapiens (human)
positive regulation of G2/MI transition of meiotic cell cycleM-phase inducer phosphatase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (14)

Processvia Protein(s)Taxonomy
damaged DNA bindingDNA polymerase betaHomo sapiens (human)
DNA-directed DNA polymerase activityDNA polymerase betaHomo sapiens (human)
DNA-(apurinic or apyrimidinic site) endonuclease activityDNA polymerase betaHomo sapiens (human)
protein bindingDNA polymerase betaHomo sapiens (human)
microtubule bindingDNA polymerase betaHomo sapiens (human)
lyase activityDNA polymerase betaHomo sapiens (human)
enzyme bindingDNA polymerase betaHomo sapiens (human)
metal ion bindingDNA polymerase betaHomo sapiens (human)
5'-deoxyribose-5-phosphate lyase activityDNA polymerase betaHomo sapiens (human)
class I DNA-(apurinic or apyrimidinic site) endonuclease activityDNA polymerase betaHomo sapiens (human)
adenosylhomocysteinase activityAdenosylhomocysteinaseHomo sapiens (human)
protein bindingAdenosylhomocysteinaseHomo sapiens (human)
phosphoprotein phosphatase activityM-phase inducer phosphatase 2Homo sapiens (human)
protein tyrosine phosphatase activityM-phase inducer phosphatase 2Homo sapiens (human)
protein bindingM-phase inducer phosphatase 2Homo sapiens (human)
protein kinase bindingM-phase inducer phosphatase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (12)

Processvia Protein(s)Taxonomy
nucleusDNA polymerase betaHomo sapiens (human)
nucleoplasmDNA polymerase betaHomo sapiens (human)
cytoplasmDNA polymerase betaHomo sapiens (human)
microtubuleDNA polymerase betaHomo sapiens (human)
spindle microtubuleDNA polymerase betaHomo sapiens (human)
protein-containing complexDNA polymerase betaHomo sapiens (human)
nucleusDNA polymerase betaHomo sapiens (human)
nucleusAdenosylhomocysteinaseHomo sapiens (human)
endoplasmic reticulumAdenosylhomocysteinaseHomo sapiens (human)
cytosolAdenosylhomocysteinaseHomo sapiens (human)
melanosomeAdenosylhomocysteinaseHomo sapiens (human)
extracellular exosomeAdenosylhomocysteinaseHomo sapiens (human)
cytosolAdenosylhomocysteinaseHomo sapiens (human)
spindle poleM-phase inducer phosphatase 2Homo sapiens (human)
nucleoplasmM-phase inducer phosphatase 2Homo sapiens (human)
centrosomeM-phase inducer phosphatase 2Homo sapiens (human)
cytosolM-phase inducer phosphatase 2Homo sapiens (human)
nucleusM-phase inducer phosphatase 2Homo sapiens (human)
cytoplasmM-phase inducer phosphatase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (46)

Assay IDTitleYearJournalArticle
AID359617Inhibition of bee venom PLA21992Journal of natural products, Dec, Volume: 55, Issue:12
Phospholipase A2 inhibitors from marine organisms.
AID462418Golgi-disturbing activity in golgi apparatus of rat NRK cells assessed as golgi fragmentation after 60 mins by Hoechst 3342 staining-based immunofluorescence microscopy2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Chemical biology studies on norrisolide.
AID568751Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans.
AID1647967Antiproliferative activity against human PC3 cells assessed as reduction in cell viability by MTT assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Quintaquinone, a Merosesquiterpene from the Yellow Sponge
AID377195Inhibition of thymidine kinase at 1 ug/uL2000Journal of natural products, Aug, Volume: 63, Issue:8
Pelorol from the tropical marine sponge Dactylospongia elegans.
AID402134Cytotoxicity against human KB16 cells after 3 days by MTT assay1997Journal of natural products, Feb, Volume: 60, Issue:2
New sesquiterpene hydroquinones from a Taiwanese marine sponge Polyfibrospongia australis.
AID1439821Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production at 40 uM by Griess assay relative to control2017Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7
Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity.
AID333108Inhibition of human MDA-MB-231 cells invasion at <50 ug/mL by Matrigel cell invasion assay2004Journal of natural products, Aug, Volume: 67, Issue:8
Strongylophorine-26, a new meroditerpenoid isolated from the marine sponge Petrosia (Strongylophora) corticata that exhibits anti-invasion activity.
AID1467592Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by WST8 assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities.
AID568752Cytotoxicity against human CHOK1 cells after 48 hrs by SRB assay2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans.
AID377196Antitrypanosomal activity against Trypanosoma rhodesiense2000Journal of natural products, Aug, Volume: 63, Issue:8
Pelorol from the tropical marine sponge Dactylospongia elegans.
AID1439822Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess assay2017Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7
Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity.
AID1178613Antiproliferative activity against human DU145 cells assessed as growth inhibition under hypoxic condition at 1 to 30 uM after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Jul-15, Volume: 24, Issue:14
Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells.
AID1467595Antibacterial activity against Bacillus subtilis NBRC 13719 after 12 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities.
AID1467596Antibacterial activity against Staphylococcus aureus NBRC 100910 after 12 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities.
AID477475Inhibition of S-adenosyl-L-homocysteine hydrolase after 10 mins by scintillation counting2009Bioorganic & medicinal chemistry, Sep-15, Volume: 17, Issue:18
A new structural class of S-adenosylhomocysteine hydrolase inhibitors.
AID462413Golgi-disturbing activity in golgi apparatus of rat NRK cells assessed as complete golgi vesiculation without fusion with endoplasmic reticulum at 30 uM after 60 mins by Hoechst 3342 staining-based immunofluorescence microscopy2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Chemical biology studies on norrisolide.
AID751051Cytotoxicity against human T47D cells assessed as growth inhibition at 3 to 30 uM after 48 hrs by SRB assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Inducers of hypoxic response: marine sesquiterpene quinones activate HIF-1.
AID1467593Antibacterial activity against Escherichia coli NBRC 102203 after 12 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities.
AID568750Cytotoxicity against human H460 cells after 48 hrs by SRB assay2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans.
AID328641Antidepressant like activity in ip dosed Swiss Webster mouse assessed as reduction of immobility time by forced-swim test2008Journal of natural products, Feb, Volume: 71, Issue:2
Secondary metabolites from three Florida sponges with antidepressant activity.
AID333393Inhibition of GST-fused human recombinant Cdc25B2 (275-539) catalytic domain2004Journal of natural products, Oct, Volume: 67, Issue:10
Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.
AID333392Inhibition of DNA polymerase beta lyase activity2004Journal of natural products, Oct, Volume: 67, Issue:10
Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.
AID1647966Inhibition of steroid 5-alpha-reductase in human LNCAP cells assessed as reduction in 5- dihydrotestosterone formation at 100 uM incubated for 60 mins by LC-MS analysis relative to control2020Journal of natural products, 02-28, Volume: 83, Issue:2
Quintaquinone, a Merosesquiterpene from the Yellow Sponge
AID568748Cytotoxicity against human SF268 cells after 48 hrs by SRB assay2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans.
AID1467590Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by WST8 assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities.
AID1467589Cytotoxicity against human WI38 cells assessed as decrease in cell viability after 72 hrs by WST8 assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities.
AID751056Activation of HIF-1 (unknown origin) transfected in human T47D cells at 10 uM after 16 hrs by luciferase reporter gene assay relative to control2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Inducers of hypoxic response: marine sesquiterpene quinones activate HIF-1.
AID377198Antiplasmodial activity against Plasmodium falciparum NF542000Journal of natural products, Aug, Volume: 63, Issue:8
Pelorol from the tropical marine sponge Dactylospongia elegans.
AID1647968Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Quintaquinone, a Merosesquiterpene from the Yellow Sponge
AID402133Cytotoxicity against mouse P388 cells after 3 days by MTT assay1997Journal of natural products, Feb, Volume: 60, Issue:2
New sesquiterpene hydroquinones from a Taiwanese marine sponge Polyfibrospongia australis.
AID402135Cytotoxicity against human A549 cells after 6 days by MTT assay1997Journal of natural products, Feb, Volume: 60, Issue:2
New sesquiterpene hydroquinones from a Taiwanese marine sponge Polyfibrospongia australis.
AID1439823Cytotoxicity against mouse BV2 cells assessed as cell viability at 40 uM relative to control2017Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7
Sesquiterpene derivatives from marine sponge Smenospongia cerebriformis and their anti-inflammatory activity.
AID751052Cytotoxicity against human T47D cells assessed as growth inhibition at 30 uM after 48 hrs by SRB assay relative to control2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Inducers of hypoxic response: marine sesquiterpene quinones activate HIF-1.
AID1647969Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay2020Journal of natural products, 02-28, Volume: 83, Issue:2
Quintaquinone, a Merosesquiterpene from the Yellow Sponge
AID751053Activation of HIF-1 in human T47D cells assessed as increase in cellular VEGF production at 10 uM after 16 hrs by ELISA2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Inducers of hypoxic response: marine sesquiterpene quinones activate HIF-1.
AID377197Antiplasmodial activity against Plasmodium falciparum K12000Journal of natural products, Aug, Volume: 63, Issue:8
Pelorol from the tropical marine sponge Dactylospongia elegans.
AID568749Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans.
AID751049Activation of HIF-1 in human PC3 cells assessed as increase in VEGF production at 10 uM after 16 hrs by ELISA2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Inducers of hypoxic response: marine sesquiterpene quinones activate HIF-1.
AID462416Golgi-disturbing activity in golgi apparatus of rat NRK cells assessed as golgi fragmentation after 60 mins by Hoechst 3342 staining-based immunofluorescence microscopy in presence of PKD inhibitor H892010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Chemical biology studies on norrisolide.
AID1467591Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by WST8 assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities.
AID751050Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition at 3 to 30 uM after 48 hrs by SRB assay2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Inducers of hypoxic response: marine sesquiterpene quinones activate HIF-1.
AID333394Cytotoxicity against human A2780 cells2004Journal of natural products, Oct, Volume: 67, Issue:10
Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.
AID1467594Antibacterial activity against Klebsiella pneumoniae NBRC 14940 after 12 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 07-15, Volume: 27, Issue:14
New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities.
AID462417Golgi-disturbing activity in golgi apparatus of rat NRK cells assessed as irreversible golgi fragmentation after 60 mins by Hoechst 3342 staining-based immunofluorescence microscopy2010Bioorganic & medicinal chemistry, Mar-15, Volume: 18, Issue:6
Chemical biology studies on norrisolide.
AID751054Activation of HIF-1 in human T47D cells assessed as increase in secreted VEGF production at 10 uM after 16 hrs by ELISA2013Journal of natural products, Jun-28, Volume: 76, Issue:6
Inducers of hypoxic response: marine sesquiterpene quinones activate HIF-1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (57)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's19 (33.33)18.2507
2000's17 (29.82)29.6817
2010's14 (24.56)24.3611
2020's7 (12.28)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.47 (24.57)
Research Supply Index4.08 (2.92)
Research Growth Index4.55 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (3.45%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other56 (96.55%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]