Tooth Resorption

Resorption of calcified dental tissue, involving demineralization due to reversal of the cation exchange and lacunar resorption by osteoclasts. There are two types: external (as a result of tooth pathology) and internal (apparently initiated by a peculiar inflammatory hyperplasia of the pulp). (From Jablonski, Dictionary of Dentistry, 1992, p676)

Synonym
Tooth Resorption

Excerpt	Reference
"Tooth resorption affected 12 teeth (0."	( Collados, J; Garcia, C; Rice, CA; Soltero-Rivera, M, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	57 (54.29)	23.3326
1990's	10 (9.52)	12.5806
2000's	20 (19.05)	18.1394
2010's	14 (13.33)	28.8240
2020's	4 (3.81)	9.53

Drug	Relationship Strength	Studies	Trials
citric acid, anhydrous	low	1	0
hydrochloric acid	low	1	0
lactic acid	low	2	0
formaldehyde	low	2	0
iodine	low	1	0
phenytoin	low	2	0
alendronate	low	2	0
glutaral	medium	1	1
haloperidol	medium	2	1
indomethacin	low	2	0
methenamine	medium	1	1
phenobarbital	low	1	0
potassium iodide	low	1	0
sodium fluoride	low	2	0
thyroxine	low	1	0
sucrose	low	1	0
edetic acid	low	3	0
colchicine	low	1	0
trichloroacetic acid	low	2	0
triamcinolone acetonide	low	1	0
isoprene	low	1	0
tolonium chloride	low	1	0
limestone	low	1	0
mercury	low	1	0
silver	medium	1	1
thorium	low	3	0
titanium	medium	1	1
gold	low	2	0
fluorine	low	2	0
chlorine	low	1	0
ferric sulfate	medium	2	2
clodronic acid	low	1	0
tricalcium silicate	low	1	0
fluorides	low	3	0
cetylpyridinium chloride anhydrous	low	1	0
calcium oxalate	low	2	0
tebuconazole	low	2	0
mk 0663	low	1	0
bradykinin	low	1	0
bromochloroacetic acid	low	1	0
osteoprotegerin	low	4	0
dinoprostone	low	1	0
dinoprost	low	1	0
calcitriol	low	1	0
cholecalciferol	low	2	0
bismuth	medium	1	1
arsenic	low	1	0
phosphorus	low	5	0
radium	low	5	0
thorium x	low	1	0
oxalates	low	1	0
acid phosphatase	low	8	0
jaw	low	5	0
sodium hypochlorite	medium	3	1
tetracycline	low	2	0
salicylates	low	1	0
demeclocycline	low	1	0
ledermix	low	1	0
hyaluronoglucosaminidase	low	1	0
chondroitin sulfates	low	1	0
cyclic gmp	low	1	0
pemetrexed	low	1	0
formocresol	medium	2	2

Protein Targets (723)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Acetylcholinesterase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Angiotensin-converting enzyme	0	1	0	2
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
RAR-related orphan receptor gamma	13	0	0	13
AR protein	20	0	0	20
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	17	0	0	17
thyroid stimulating hormone receptor	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	17	0	0	17
Cellular tumor antigen p53	12	0	0	12
Nuclear receptor ROR-gamma	7	0	0	7
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, Ferritin light chain	4	0	0	4
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	6	0	0	6
PPM1D protein	2	0	0	2
Microtubule-associated protein tau	5	0	0	5
thioredoxin glutathione reductase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
mitogen-activated protein kinase 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	7	0	0	7
geminin	9	0	0	9
peripheral myelin protein 22	7	0	0	7
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	9
Bile salt export pump	0	9	0	9
Interferon beta	6	0	0	6
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	0	0	1
Cytochrome P450 3A4	0	4	1	7
Androgen receptor	0	1	1	2
Cytochrome P450 2D6	0	1	0	1
Vitamin D3 receptor	0	2	3	8
Cytochrome P450 2C9	0	3	0	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	3	3
Cytochrome P450 2C19	0	1	0	1
Kappa-type opioid receptor	0	1	1	2
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	7	0	7
Vitamin D3 receptor A	0	0	2	2
GLI family zinc finger 3	12	0	0	12
progesterone receptor	11	0	0	11
estrogen-related nuclear receptor alpha	17	0	0	17
estrogen nuclear receptor alpha	22	0	0	22
Histone H2A.x	5	0	0	5
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Glutamate receptor 2	9	0	0	9
acetylcholinesterase	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
TDP1 protein	9	0	0	9
caspase 7, apoptosis-related cysteine protease	2	0	0	2
estrogen receptor 2 (ER beta)	7	0	0	7
glucocorticoid receptor [Homo sapiens]	17	0	0	17
retinoid X nuclear receptor alpha	10	0	0	10
farnesoid X nuclear receptor	9	0	0	9
67.9K protein	3	0	0	3
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
caspase-3	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
activating transcription factor 6	5	0	0	5
thyrotropin-releasing hormone receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
vitamin D3 receptor isoform VDRA	5	0	0	5
thyroid hormone receptor beta isoform 2	10	0	0	10
heat shock protein beta-1	5	0	0	5
survival motor neuron protein isoform d	2	0	0	2
Caspase-2	0	0	1	1
Inositol monophosphatase 1	2	0	0	2
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	5	0	0	5
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, Cruzipain	3	0	0	3
Luciferase	7	0	0	7
interleukin 8	5	0	0	5
15-lipoxygenase, partial	2	0	0	2
pregnane X nuclear receptor	13	0	0	13
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
thyroid hormone receptor beta isoform a	6	0	0	6
DNA polymerase kappa isoform 1	4	0	0	4
cytochrome P450 3A4 isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	1	0	5
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	4	1	0	5
Gamma-aminobutyric acid receptor subunit delta	4	1	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	4	1	0	5
Glycine receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	4	1	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	4	1	0	5
10 kDa heat shock protein, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	1	0	5
Gamma-aminobutyric acid receptor subunit beta-3	4	1	0	5
Gamma-aminobutyric acid receptor subunit beta-2	4	1	0	5
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
GABA theta subunit	4	1	0	5
Gamma-aminobutyric acid receptor subunit epsilon	4	1	0	5
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
72 kDa type IV collagenase	0	2	0	2
Stromelysin-1	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Macrophage metalloelastase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
endonuclease IV	2	0	0	2
PAX8	0	0	0	1
thioredoxin reductase	5	0	0	5
pregnane X receptor	2	0	0	2
ATAD5 protein, partial	4	0	0	4
Fumarate hydratase	3	0	0	3
Thrombopoietin	2	0	0	2
Smad3	1	0	0	1
thyroid stimulating hormone receptor	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
polyprotein	3	0	0	3
glucocerebrosidase	3	0	0	3
IDH1	2	0	0	2
aryl hydrocarbon receptor	7	0	0	7
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
cytochrome P450 2D6 isoform 1	3	0	0	3
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	4	0	0	4
chromobox protein homolog 1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
flap endonuclease 1	3	0	0	3
ras-related protein Rab-9A	2	0	0	2
steroidogenic factor 1	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	2	0	0	2
lamin isoform A-delta10	7	0	0	7
neuropeptide S receptor isoform A	2	0	0	2
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	4	0	6
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Histamine H2 receptor	5	0	0	6
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
ATP-dependent phosphofructokinase	4	0	0	4
Phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
dopamine D1 receptor	1	0	0	1
GLS protein	2	0	0	2
regulator of G-protein signaling 4	4	0	0	4
arylsulfatase A	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
M-phase phosphoprotein 8	2	0	0	2
Solute carrier family 22 member 2	0	0	0	2
Solute carrier family 22 member 1	0	1	0	3
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Thromboxane A2 receptor	0	1	1	2
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin E2 receptor EP1 subtype	0	3	2	5
Prostaglandin G/H synthase 2	0	5	1	6
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	2	4
Prostaglandin E2 receptor EP3 subtype	0	3	2	5
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	3	1	4
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	1	0	3
Solute carrier family 22 member 7	0	0	0	3
Solute carrier family 22 member 8	0	1	0	4
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	3
Solute carrier family 22 member 7	0	0	0	3
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Eyes absent homolog 2	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Amyloid-beta precursor protein	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	5	1	6
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase 15	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
glp-1 receptor, partial	2	0	0	2
NFKB1 protein, partial	1	0	0	1
EWS/FLI fusion protein	5	0	0	5
nonstructural protein 1	1	0	0	1
cytochrome P450 2D6	5	0	0	5
Adenylate cyclase type 1	0	1	0	1
peripheral myelin protein 22 isoform 1	3	0	0	3
D(1A) dopamine receptor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Integrin alpha-4	0	1	0	1
D(2) dopamine receptor	0	2	1	5
5-hydroxytryptamine receptor 2A	0	2	0	2
Alpha-1B adrenergic receptor	0	3	0	3
Carbonyl reductase [NADPH] 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Alpha-2B adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	3	0	3
Alpha-2B adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
D(1A) dopamine receptor	0	2	0	3
D(4) dopamine receptor	0	2	1	5
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	3	0	3
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Histamine H1 receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	3
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
D(3) dopamine receptor	0	2	1	5
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 4 subunit alpha	0	2	0	3
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Spike glycoprotein	4	0	0	4
D(2) dopamine receptor	0	2	0	2
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
TAR DNA-binding protein 43	2	0	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Zinc finger protein 664	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase 9	0	3	1	4
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
G	4	0	0	4
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
DNA polymerase iota isoform a (long)	1	0	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Albumin	0	1	1	2
Prostaglandin G/H synthase 1	0	3	0	4
Procathepsin L	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Interleukin-8	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Inositol hexakisphosphate kinase 1	4	0	0	4
Multidrug and toxin extrusion protein 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	3
cytochrome P450 2C9, partial	4	0	0	4
histone deacetylase 9 isoform 3	2	0	0	2
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
Chymotrypsinogen A	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Chain A, Thymidylate Synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
tyrosine-protein kinase Yes	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	2	0	2
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Serine hydroxymethyltransferase, cytosolic	0	1	1	2
Reduced folate transporter	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Proton-coupled folate transporter	0	2	0	3
Gamma-aminobutyric acid	0	1	0	1
Bloom syndrome protein isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Cytochrome P450 14alpha-demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-synuclein	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Microtubule-associated protein tau	0	2	0	2
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Studies (105)

Protein Targets (723)

Tooth Resorption

Synonyms(1)

Research Excerpts

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Research

Studies (105)

Drugs Studied (82)

Protein Targets (723)