Page last updated: 2024-09-27

Disorders, Sex Chromosome

Clinical conditions caused by an abnormal sex chromosome constitution (SEX CHROMOSOME ABERRATIONS), in which there is extra or missing sex chromosome material (either a whole chromosome or a chromosome segment).

Synonyms(4)

Synonym
Sex Chromosome Abnormality Disorders
Sex Chromosome Disorders
Disorders, Sex Chromosome
Disorders, Sex Chromosome Abnormality

Research

Studies (256)

TimeframeStudies, This Condition (%)All Conditions %
pre-1990238 (92.97)23.3326
1990's0 (0.00)12.5806
2000's6 (2.34)18.1394
2010's6 (2.34)28.8240
2020's6 (2.34)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
phenanthrene0low10
spermine0low10
estriol0low10
prednisone0low10
phenylalanine0low10
valine0low10
testosterone enanthate0low10
dihydrotestosterone0medium11
arsenic trioxide0low10
d-alpha tocopherol0low30
cortisone0low10
fibrin0low10
tretinoin0low10
17-ketosteroids0low10
arsenic0low10
sodium ethylxanthate0low30
phenprocoumon0low10
transforming growth factor beta0low10
vitamin b 120low10
thromboplastin0low90
phenanthrenes0low10

Protein Targets (336)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
TDP1 protein5005
AR protein9009
glucocorticoid receptor [Homo sapiens]7007
estrogen nuclear receptor alpha9009
peroxisome proliferator activated receptor gamma4004
nuclear receptor subfamily 1, group I, member 21001
thyroid hormone receptor beta isoform 27007
Cellular tumor antigen p534004
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
endonuclease IV1001
dopamine D1 receptor2002
thioredoxin reductase4004
pregnane X receptor3003
RAR-related orphan receptor gamma4004
GLS protein2002
GLI family zinc finger 36006
aldehyde dehydrogenase 1 family, member A14004
progesterone receptor5005
regulator of G-protein signaling 43003
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha5005
pregnane X nuclear receptor6006
peroxisome proliferator-activated receptor delta4004
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
euchromatic histone-lysine N-methyltransferase 24004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)5005
peripheral myelin protein 22 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 14004
heat shock protein beta-14004
flap endonuclease 11001
nuclear factor erythroid 2-related factor 2 isoform 17007
geminin5005
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M12002
Gamma-aminobutyric acid receptor subunit pi3205
Bile salt export pump0303
Glucocorticoid receptor0719
Sex hormone-binding globulin0134
Glycine receptor subunit alpha-10606
Corticosteroid-binding globulin0303
Gamma-aminobutyric acid receptor subunit beta-13205
Gamma-aminobutyric acid receptor subunit delta3205
Gamma-aminobutyric acid receptor subunit gamma-23216
Gamma-aminobutyric acid receptor subunit alpha-53205
Gamma-aminobutyric acid receptor subunit alpha-33205
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Gamma-aminobutyric acid receptor subunit gamma-13205
Gamma-aminobutyric acid receptor subunit alpha-23205
Glycine receptor subunit alpha-30606
Gamma-aminobutyric acid receptor subunit alpha-43205
Gamma-aminobutyric acid receptor subunit gamma-33205
Gamma-aminobutyric acid receptor subunit alpha-63205
Gamma-aminobutyric acid receptor subunit alpha-13216
Gamma-aminobutyric acid receptor subunit beta-33205
Gamma-aminobutyric acid receptor subunit beta-23216
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 432002
GABA theta subunit3205
Multidrug and toxin extrusion protein 10101
Gamma-aminobutyric acid receptor subunit epsilon3205
USP1 protein, partial2002
Microtubule-associated protein tau2002
cytochrome P450 family 3 subfamily A polypeptide 42002
estrogen-related nuclear receptor alpha6006
activating transcription factor 62002
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta102002
Rap guanine nucleotide exchange factor 31001
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Chain A, Sex Hormone-Binding Globulin0011
interleukin 82002
glp-1 receptor, partial1001
estrogen receptor 2 (ER beta)5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyrotropin-releasing hormone receptor2002
Histone H2A.x2002
vitamin D3 receptor isoform VDRA3003
potassium voltage-gated channel subfamily H member 2 isoform d2002
transcriptional regulator ERG isoform 32002
peripheral myelin protein 224004
Voltage-dependent calcium channel gamma-2 subunit3003
Plasma kallikrein0102
Progesterone receptor0101
Progesterone receptor0112
Glucocorticoid receptor0101
Mineralocorticoid receptor 0101
Sex hormone-binding globulin0101
Androgen receptor0226
Aromatase0102
Androgen receptor0314
Androgen receptor0112
Glutamate receptor 23003
Mineralocorticoid receptor0101
Testosterone 17-beta-dehydrogenase 30101
Angiotensin-converting enzyme0011
Cannabinoid receptor 20101
Nuclear receptor ROR-gamma2114
G-protein coupled bile acid receptor 10011
Muscarinic acetylcholine receptor0101
Neuropeptide FF receptor 20001
ALK tyrosine kinase receptor0101
Estrogen receptor0202
Polyunsaturated fatty acid lipoxygenase ALOX150101
UDP-glucuronosyltransferase 2B70001
Sodium-dependent serotonin transporter0202
Alpha-synuclein0202
Solute carrier organic anion transporter family member 1A10101
Lanosterol 14-alpha demethylase0011
Olfactory receptor 51E20011
UDP-glucuronosyltransferase 1A100001
Chain A, Ferritin light chain2002
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
ATAD5 protein, partial1001
Hsf1 protein0011
thyroid stimulating hormone receptor2002
bromodomain adjacent to zinc finger domain 2B2002
arylsulfatase A1001
Bloom syndrome protein isoform 12002
D(1A) dopamine receptor1001
thyroid hormone receptor beta isoform a3003
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
histone acetyltransferase KAT2A isoform 12002
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Luciferase4004
hypoxia-inducible factor 1 alpha subunit3003
nuclear receptor subfamily 1, group I, member 34004
farnesoid X nuclear receptor3003
thyroid stimulating hormone receptor2002
Cytochrome P450 2A60101
Cytochrome P450 2A50101
Gag-Pol polyprotein0101
Cytochrome P450 2D60112
Gag-Pol polyprotein0101
Spike glycoprotein1001
Protease 0202
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Carbonic anhydrase 120102
Carbonic anhydrase 10102
Carbonic anhydrase 20102
Alkaline phosphatase, tissue-nonspecific isozyme0101
Carbonic anhydrase 30102
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0102
Glutamate receptor ionotropic, NMDA 1 0113
Carbonic anhydrase0001
Carbonic anhydrase 70102
Carbonic anhydrase0001
E3 ubiquitin-protein ligase XIAP0101
Glutamate receptor ionotropic, NMDA 2A 0102
Glutamate receptor ionotropic, NMDA 2B0113
Glutamate receptor ionotropic, NMDA 2C0102
Large neutral amino acids transporter small subunit 10203
SLC16A10 protein0001
Carbonic anhydrase 90102
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0102
Large neutral amino acids transporter small subunit 1 0101
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0102
Monocarboxylate transporter 100001
Carbonic anhydrase 150102
Carbonic anhydrase 130102
Glutamate receptor ionotropic, NMDA 3A0102
Carbonic anhydrase 140102
Phospholipase A-2-activating protein0101
Carbonic anhydrase 5B, mitochondrial0102
thioredoxin glutathione reductase2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
nuclear factor erythroid 2-related factor 2 isoform 22002
nuclear receptor ROR-gamma isoform 12002
Caspase-72002
caspase-32002
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
15-lipoxygenase, partial1001
phosphopantetheinyl transferase2002
Thrombopoietin1001
cytochrome P450 2C19 precursor1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
DNA topoisomerase 2-alpha0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
Cannabinoid receptor 10101
Caspase-20011
Histamine H2 receptor1001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Glutamate receptor ionotropic, NMDA 2B0011
ATP-dependent phosphofructokinase2002
Chain A, Nuclear Receptor ROR-beta0101
Chain A, Beta-lactamase1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Cruzipain1001
nonstructural protein 11001
G1001
Parkin1001
aryl hydrocarbon receptor1001
DNA polymerase kappa isoform 11001
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Ornithine decarboxylase0001
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Amyloid-beta precursor protein0101
Cytochrome P450 1A20011
Cytochrome P450 3A40011
Ornithine decarboxylase0001
60 kDa chaperonin0101
Adenosine receptor A30202
Retinoic acid receptor alpha0227
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Cytochrome P450 2C9 0011
Retinoic acid receptor gamma 0227
Alpha-1B adrenergic receptor0202
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
5-hydroxytryptamine receptor 1A0101
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Alpha-1D adrenergic receptor0101
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2C190011
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0202
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Inositol hexakisphosphate kinase 11001
Nuclear receptor ROR-beta0101
Canalicular multispecific organic anion transporter 10101
ATPase family AAA domain-containing protein 51001
Ataxin-21001
cytochrome P450 2C9, partial1001
Chain A, Arginase 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]