Page last updated: 2024-09-27

TDP-43 Proteinopathies

Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.

Synonyms(1)

Synonym
TDP-43 Proteinopathies

Research

Studies (43)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's1 (2.33)18.1394
2010's27 (62.79)28.8240
2020's15 (34.88)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
cytosine0low10
glycine0low20
nickel0low10
spermidine0low10
trimethyloxamine0low10
oxyquinoline0low10
berberine0low10
carbamazepine0low10
hexachlorophene0low10
riluzole0low10
mitomycin0low10
sorbitol0low10
thyroxine0low10
triiodothyronine0low10
serine0low30
valine0low10
arginine0low10
methsuximide0low10
tetraethyl lead0low10
pyrroles0low20
alpha-aminopyridine0low10
2-piperidone0low10
manganese0low10
mercury0low10
palladium0low10
silver0low10
cadmium0low10
chromium0low10
vanadium0low10
glutathione disulfide0low10
fluorodeoxyglucose f180low10
cobalt0low10
fingolimod hydrochloride0low10
withaferin a0low20
withanolides0low10
sodium arsenite0low20
isomethyleugenol0low10
tamoxifen0low10
myelin basic protein0low10
sirolimus0low10
lead0low10
antimony0low10
barium0low10
aluminum0low10
arsenic0low10
beryllium0low10
radium0low10
alpha-synuclein0low90
pha 7674910low10
gw 48690low10
oligonucleotides0low10
pexidartinib0low10
amyloid beta-peptides0low10

Protein Targets (886)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
Peptidyl-prolyl cis-trans isomerase FKBP50112
AR protein110011
retinoic acid nuclear receptor alpha variant 17007
estrogen nuclear receptor alpha100010
thyroid stimulating hormone receptor4004
thyroid hormone receptor beta isoform 28008
Voltage-dependent calcium channel gamma-2 subunit6006
Heat shock protein HSP 90-alpha0011
Botulinum neurotoxin type A 0202
Neutrophil cytosol factor 10101
Glutamate receptor 26006
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, brain0102
Nitric oxide synthase, brain 0102
Nitric oxide synthase, inducible0114
Kappa-type opioid receptor0011
Phosphatidylinositol 4-kinase alpha0101
Mu-type opioid receptor0011
Tyrosine-protein kinase 0011
Phosphatidylinositol 4-kinase type 2-beta0101
Phosphatidylinositol 4-kinase type 2-alpha0101
Phosphatidylinositol 4-kinase beta0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase5005
phosphopantetheinyl transferase4004
NFKB1 protein, partial2002
GLS protein3003
thyroid stimulating hormone receptor7007
alpha-galactosidase1001
euchromatic histone-lysine N-methyltransferase 29009
cytochrome P450 2C19 precursor1001
chromobox protein homolog 15005
flap endonuclease 14004
DNA polymerase iota isoform a (long)3003
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)5005
Cytochrome P450 3A40304
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, inducible0001
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase1001
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Fumarate hydratase5005
PPM1D protein5005
Microtubule-associated protein tau4004
aldehyde dehydrogenase 1 family, member A11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
EWS/FLI fusion protein6006
polyprotein5005
cytochrome P450 2D6 isoform 12002
peripheral myelin protein 225005
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 14004
Gamma-aminobutyric acid receptor subunit pi4217
Telomerase reverse transcriptase0101
Acetylcholinesterase0202
Lysine-specific histone demethylase 1A0101
Interferon beta8008
Neuraminidase0101
Neuraminidase0101
Cholinesterase0202
Gamma-aminobutyric acid receptor subunit beta-14217
Tyrosine-protein phosphatase non-receptor type 10101
Gamma-aminobutyric acid receptor subunit delta4217
Gamma-aminobutyric acid receptor subunit gamma-24228
Gamma-aminobutyric acid receptor subunit alpha-54217
Gamma-aminobutyric acid receptor subunit alpha-34217
Acetylcholinesterase0303
Gamma-aminobutyric acid receptor subunit gamma-14217
Gamma-aminobutyric acid receptor subunit alpha-24217
Gamma-aminobutyric acid receptor subunit alpha-44217
Gamma-aminobutyric acid receptor subunit gamma-34217
Gamma-aminobutyric acid receptor subunit alpha-64217
Aldo-keto reductase family 1 member C30101
Prolyl endopeptidase0101
Aldo-keto reductase family 1 member C2 0101
Gamma-aminobutyric acid receptor subunit alpha-14228
Gamma-aminobutyric acid receptor subunit beta-34217
Gamma-aminobutyric acid receptor subunit beta-24228
Cholinesterase0202
Inositol monophosphatase 12002
Potassium voltage-gated channel subfamily H member 20505
Cytochrome P450 1B10202
GABA theta subunit4217
Gamma-aminobutyric acid receptor subunit epsilon4217
Chain A, Beta-lactamase2002
acetylcholinesterase4004
RAR-related orphan receptor gamma9009
USP1 protein, partial7007
TDP1 protein9009
glucocorticoid receptor [Homo sapiens]8008
estrogen-related nuclear receptor alpha9009
pregnane X nuclear receptor7007
IDH15005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
thyroid hormone receptor beta isoform a5005
nuclear factor erythroid 2-related factor 2 isoform 23003
mitogen-activated protein kinase 11001
geminin100010
Vpr2002
lamin isoform A-delta106006
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Bile salt export pump0101
Bile salt export pump0606
Albumin0011
Major prion protein0011
Cellular tumor antigen p538008
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Cytochrome P450 2C9 0303
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 2B60112
Sodium channel protein type 4 subunit alpha0102
Cytochrome P450 2J20101
Sodium channel protein type 9 subunit alpha0202
Frizzled-80011
Canalicular multispecific organic anion transporter 10303
P2X purinoceptor 40101
GLI family zinc finger 35005
Deoxycytidine kinase0001
Sphingosine 1-phosphate receptor 10011
RCG53912, isoform CRA_a 0001
Sphingosine kinase 1 0001
Sphingosine kinase 20001
Sphingosine kinase 10001
Chain A, Ferritin light chain3003
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
ATAD5 protein, partial5005
Hsf1 protein0011
regulator of G-protein signaling 43003
bromodomain adjacent to zinc finger domain 2B4004
arylsulfatase A3003
Bloom syndrome protein isoform 13003
D(1A) dopamine receptor2002
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
histone acetyltransferase KAT2A isoform 13003
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10213
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10213
Gamma-aminobutyric acid receptor subunit gamma-20213
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30213
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50213
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit beta-20213
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40213
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0202
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 433003
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60213
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10303
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30202
Histone deacetylase 80112
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0202
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Glutathione reductase0001
Multidrug resistance-associated protein 1 0001
Histone-lysine N-methyltransferase EHMT20101
Histone-lysine N-methyltransferase EHMT10101
Glycine receptor subunit alpha-10011
Glutamate receptor ionotropic, NMDA 1 0213
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0213
Glutamate receptor ionotropic, NMDA 2B0213
Glutamate receptor ionotropic, NMDA 2C0213
Large neutral amino acids transporter small subunit 10202
Glutamate receptor ionotropic, NMDA 2D0213
Glutamate receptor ionotropic, NMDA 3B0213
Serine racemase0101
Olfactory receptor 51E20011
Glutamate receptor ionotropic, NMDA 3A0213
Sodium- and chloride-dependent glycine transporter 20101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain1001
Luciferase3003
calpain II, partial0101
PAX80001
glp-1 receptor, partial2002
SUMO-10101
15-lipoxygenase, partial3003
pregnane X receptor1001
Mcl-10101
hypoxia-inducible factor 1 alpha subunit4004
SMAD family member 22002
SMAD family member 32002
Valosin-containing protein0101
TSHR protein1001
Estrogen receptor 10101
Smad33003
PINK11001
envelope glycoprotein0101
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 37007
progesterone receptor5005
cytochrome P450 family 3 subfamily A polypeptide 45005
nonstructural protein 13003
retinoid X nuclear receptor alpha4004
farnesoid X nuclear receptor5005
G3003
cytochrome P450 2D62002
67.9K protein4004
Parkin2002
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma6006
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
heat shock protein 900011
heat shock 70kDa protein 1A0101
activating transcription factor 63003
thyrotropin-releasing hormone receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
v-jun sarcoma virus 17 oncogene homolog (avian)5005
nuclear receptor subfamily 1, group I, member 22002
Histone H2A.x4004
Caspase-73003
galactokinase1001
NPC intracellular cholesterol transporter 1 precursor3003
tumor necrosis factor1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
neuropeptide Y receptor type 10011
neuropeptide Y receptor type 20011
small ubiquitin-related modifier 2 isoform b precursor0101
vitamin D3 receptor isoform VDRA2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-33003
estrogen receptor beta isoform 10101
heat shock protein beta-13003
huntingtin isoform 21001
DNA polymerase beta1001
enteropeptidase precursor1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
fatty acid synthase0101
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
serine/threonine-protein kinase PLK12002
heat shock protein HSP 90-alpha isoform 20102
nuclear factor erythroid 2-related factor 2 isoform 15005
DNA polymerase eta isoform 12002
heat shock cognate 71 kDa protein isoform 10101
eukaryotic translation initiation factor 4E isoform 10101
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
nuclear receptor ROR-gamma isoform 15005
4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase1001
replicative DNA helicase0001
recombinase A0011
streptokinase A precursor0022
exodeoxyribonuclease V subunit RecD0101
exodeoxyribonuclease V subunit RecB0101
exodeoxyribonuclease V subunit RecC0101
POsterior Segregation0011
heat shock cognate 71 kDa protein isoform 20101
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
5-hydroxytryptamine receptor 40404
Rap guanine nucleotide exchange factor 32002
Epidermal growth factor receptor0426
Urokinase-type plasminogen activator0101
Tissue-type plasminogen activator0101
HLA class I histocompatibility antigen, B alpha chain 3003
Receptor tyrosine-protein kinase erbB-20303
Plasminogen activator inhibitor 10101
Cytochrome P450 1A20202
Estrogen receptor0023
Tyrosine-protein kinase Lck0325
Tyrosine-protein kinase Fyn0224
Urokinase-type plasminogen activator0101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0404
60 kDa chaperonin0101
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Adenosine receptor A30404
Replicase polyprotein 1ab0224
60 kDa heat shock protein, mitochondrial0101
Muscarinic acetylcholine receptor M20101
Endoplasmic reticulum chaperone BiP0101
Macrophage migration inhibitory factor0202
Androgen receptor0404
Alpha-1B adrenergic receptor0404
Alpha-2C adrenergic receptor0202
Substance-K receptor0404
Sodium-dependent noradrenaline transporter 0415
Thromboxane-A synthase 0202
Adenosine receptor A11001
Mitogen-activated protein kinase 3 0123
5-hydroxytryptamine receptor 2C0404
Mitogen-activated protein kinase 10224
Adenosine receptor A2a0404
Sodium-dependent serotonin transporter0404
Cytochrome P450 2C190303
Prostaglandin G/H synthase 20101
Alpha-synuclein5005
5-hydroxytryptamine receptor 2B0404
Alpha-1A adrenergic receptor0404
Histamine H2 receptor4004
Nuclear receptor ROR-gamma2002
Caspase-71001
Spike glycoprotein3014
10 kDa heat shock protein, mitochondrial0101
Mitogen-activated protein kinase 140123
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
Estrogen receptor beta0023
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D0101
10 kDa chaperonin 0101
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D0101
Rap guanine nucleotide exchange factor 41001
Inositol hexakisphosphate kinase 13003
ATPase family AAA domain-containing protein 54004
Ataxin-24004
Zinc finger protein mex-50011
cytochrome P450 2C9, partial3003
phosphoglycerate kinase1001
heat shock protein 90, putative0001
M1-family alanyl aminopeptidase0101
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
BZLF20101
large T antigen0101
caspase 7, apoptosis-related cysteine protease3003
caspase-33003
aryl hydrocarbon receptor5005
Indoleamine 2,3-dioxygenase 10202
Chain A, Bacterial leucyl aminopeptidase0101
interleukin 81001
90-kda heat shock protein beta HSP90 beta, partial0101
GALC protein1001
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
26S proteasome non-ATPase regulatory subunit 140101
Thermolysin0203
72 kDa type IV collagenase0101
Catechol O-methyltransferase0101
Catechol O-methyltransferase0101
Methionine aminopeptidase 20101
Methionine aminopeptidase 10101
Glutaminyl-peptide cyclotransferase0101
Bone morphogenetic protein receptor type-1B0022
Membrane-associated progesterone receptor component 10011
Cell division cycle 7-related protein kinase0123
Serine/threonine-protein kinase PLK40022
ATP-dependent RNA helicase DDX3X0022
Pyridoxal kinase0022
Citron Rho-interacting kinase0022
Serine/threonine-protein kinase Chk10123
Aurora kinase A0123
Cyclin-G-associated kinase0022
Ephrin type-B receptor 60022
Peroxisomal acyl-coenzyme A oxidase 30022
Receptor-interacting serine/threonine-protein kinase 20022
Mitotic checkpoint serine/threonine-protein kinase BUB10022
Dynamin-like 120 kDa protein, mitochondrial0022
Rho-associated protein kinase 20022
Serine/threonine-protein kinase ULK10022
Serine/threonine-protein kinase/endoribonuclease IRE10022
Ribosomal protein S6 kinase alpha-50123
U5 small nuclear ribonucleoprotein 200 kDa helicase0022
Ribosomal protein S6 kinase alpha-40123
Serine/threonine-protein kinase 160022
Serine/threonine-protein kinase 100022
Serine/threonine-protein kinase D30123
Structural maintenance of chromosomes protein 20022
Mitogen-activated protein kinase kinase kinase 60022
Mitogen-activated protein kinase kinase kinase kinase 40022
Serine/threonine-protein kinase LATS10022
Serine/threonine-protein kinase PAK 40123
Tyrosine-protein kinase ABL10123
High affinity nerve growth factor receptor0123
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20022
Protein kinase C beta type0224
Insulin receptor0123
Cyclin-dependent kinase 10123
Glycogen phosphorylase, liver form0022
Tyrosine-protein kinase Fes/Fps0022
Macrophage colony-stimulating factor 1 receptor0101
Tyrosine-protein kinase Yes0022
Tyrosine-protein kinase Lyn0022
Proto-oncogene tyrosine-protein kinase receptor Ret0123
Insulin-like growth factor 1 receptor0022
Signal recognition particle receptor subunit alpha0022
Cytochrome c1, heme protein, mitochondrial0022
Hepatocyte growth factor receptor0224
Tyrosine-protein kinase HCK0022
Macrophage colony-stimulating factor 1 receptor0101
Platelet-derived growth factor receptor beta0123
Serine/threonine-protein kinase A-Raf0022
Mast/stem cell growth factor receptor Kit0202
Glycogen phosphorylase, brain form0022
Breakpoint cluster region protein0022
Serine/threonine-protein kinase pim-10022
Fibroblast growth factor receptor 10123
DNA topoisomerase 2-alpha0123
Cyclin-dependent kinase 40022
ADP/ATP translocase 30022
Inosine-5'-monophosphate dehydrogenase 20022
Proto-oncogene tyrosine-protein kinase Src0022
cAMP-dependent protein kinase type II-alpha regulatory subunit0022
Serine/threonine-protein kinase B-raf0022
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0022
Ribosyldihydronicotinamide dehydrogenase [quinone]0022
Platelet-derived growth factor receptor alpha0101
Tyrosine-protein kinase Fer0022
Protein kinase C alpha type0123
cAMP-dependent protein kinase catalytic subunit alpha0123
General transcription and DNA repair factor IIH helicase subunit XPD0022
Casein kinase II subunit alpha'0022
Ras-related protein Rab-6A0022
Ephrin type-A receptor 10022
Multifunctional protein ADE20022
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0022
Ferrochelatase, mitochondrial0022
Ribosomal protein S6 kinase beta-10022
Tyrosine-protein kinase JAK10022
Cyclin-dependent kinase 20123
Beta-adrenergic receptor kinase 10022
Probable ATP-dependent RNA helicase DDX60022
MAP/microtubule affinity-regulating kinase 30022
Deoxycytidine kinase0022
Ephrin type-A receptor 20022
Ephrin type-B receptor 20022
Non-receptor tyrosine-protein kinase TYK20022
Wee1-like protein kinase0022
Heme oxygenase 20022
DnaJ homolog subfamily A member 10022
RAC-alpha serine/threonine-protein kinase0123
RAC-beta serine/threonine-protein kinase0022
Dual specificity protein kinase TTK0022
DNA replication licensing factor MCM40022
Myosin-100022
Vascular endothelial growth factor receptor 20202
Dual specificity mitogen-activated protein kinase kinase 20022
Receptor-type tyrosine-protein kinase FLT30123
Bone morphogenetic protein receptor type-1A0022
Activin receptor type-1B0022
TGF-beta receptor type-10022
TGF-beta receptor type-20022
Tyrosine-protein kinase CSK0022
Glycine--tRNA ligase0022
Protein kinase C iota type0123
Exosome RNA helicase MTR40022
Tyrosine-protein kinase Tec0022
Tyrosine-protein kinase ABL20022
Tyrosine-protein kinase FRK0022
G protein-coupled receptor kinase 60022
Tyrosine-protein kinase SYK0022
26S proteasome regulatory subunit 6B0022
Mitogen-activated protein kinase 80022
Mitogen-activated protein kinase 90022
Dual specificity mitogen-activated protein kinase kinase 30022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0022
Casein kinase I isoform alpha0022
Casein kinase I isoform delta0022
MAP kinase-activated protein kinase 20123
Elongation factor Tu, mitochondrial0022
Cysteine--tRNA ligase, cytoplasmic0022
Casein kinase I isoform epsilon0022
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0022
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20022
Glycogen synthase kinase-3 alpha0022
Glycogen synthase kinase-3 beta0123
Cyclin-dependent kinase 70123
Cyclin-dependent kinase 90123
Ras-related protein Rab-27A0022
Interleukin-1 receptor-associated kinase 10022
Ribosomal protein S6 kinase alpha-30022
Serine/threonine-protein kinase Nek20022
Serine/threonine-protein kinase Nek30022
Dual specificity mitogen-activated protein kinase kinase 60022
LIM domain kinase 10022
LIM domain kinase 20022
Mitogen-activated protein kinase 100022
Tyrosine--tRNA ligase, cytoplasmic0022
5'-AMP-activated protein kinase subunit gamma-10022
Ephrin type-B receptor 30022
Ephrin type-A receptor 50022
Ephrin type-B receptor 40022
Ephrin type-A receptor 40022
Adenylate kinase 2, mitochondrial0022
Adenosine kinase0022
Ras-related protein Rab-100022
Actin-related protein 30022
Actin-related protein 20022
GTP-binding nuclear protein Ran0022
Casein kinase I isoform gamma-20022
Cyclin-dependent kinase 30011
Cyclin-dependent kinase 60022
Cyclin-dependent-like kinase 5 0123
Cyclin-dependent kinase 160022
Cyclin-dependent kinase 170022
Dual specificity mitogen-activated protein kinase kinase 10022
DNA topoisomerase 2-beta0022
Protein kinase C theta type0123
Activin receptor type-10022
Macrophage-stimulating protein receptor0022
Focal adhesion kinase 10022
Protein kinase C delta type0123
Tyrosine-protein kinase BTK0022
Activated CDC42 kinase 10022
Epithelial discoidin domain-containing receptor 10022
Mitogen-activated protein kinase kinase kinase kinase 20022
Tyrosine-protein kinase Mer0022
Serine/threonine-protein kinase 40022
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Dual specificity mitogen-activated protein kinase kinase 50022
Mitogen-activated protein kinase 70022
Serine/threonine-protein kinase 30022
Mitogen-activated protein kinase kinase kinase 10022
Integrin-linked protein kinase0022
Rho-associated protein kinase 10022
Non-receptor tyrosine-protein kinase TNK10022
Calcium/calmodulin-dependent protein kinase type II subunit gamma0022
Calcium/calmodulin-dependent protein kinase type II subunit delta0022
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0022
Activin receptor type-2B0022
Bone morphogenetic protein receptor type-20022
Protein-tyrosine kinase 60022
cGMP-dependent protein kinase 1 0022
Cyclin-dependent kinase 130022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0022
Protein-tyrosine kinase 2-beta0022
Maternal embryonic leucine zipper kinase0022
Structural maintenance of chromosomes protein 1A0022
Chromodomain-helicase-DNA-binding protein 40022
Peroxisomal acyl-coenzyme A oxidase 10022
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0022
Ribosomal protein S6 kinase alpha-10022
Dual specificity testis-specific protein kinase 10022
Myosin light chain kinase, smooth muscle0022
Mitogen-activated protein kinase 110123
Serine/threonine-protein kinase STK110022
Serine/threonine-protein kinase N10224
Serine/threonine-protein kinase N20224
Calcium/calmodulin-dependent protein kinase type IV0022
Mitogen-activated protein kinase kinase kinase 110022
MAP kinase-activated protein kinase 30112
Discoidin domain-containing receptor 20022
AP2-associated protein kinase 10022
Myosin light chain kinase 30022
Putative heat shock protein HSP 90-beta 20022
Rab-like protein 30011
Serine/threonine-protein kinase MRCK alpha0022
Serine/threonine-protein kinase MRCK gamma0022
Acyl-CoA dehydrogenase family member 100022
Serine/threonine-protein kinase ULK30022
Uncharacterized protein FLJ452520022
Acyl-CoA dehydrogenase family member 110022
Serine/threonine-protein kinase/endoribonuclease IRE20022
Serine/threonine-protein kinase MARK20022
ATP-dependent RNA helicase DHX300022
Serine/threonine-protein kinase TAO10022
STE20-related kinase adapter protein alpha0022
AarF domain-containing protein kinase 10022
ATP-dependent RNA helicase DDX420011
Mitogen-activated protein kinase kinase kinase kinase 30022
MAP kinase-activated protein kinase 50123
Atypical kinase COQ8A, mitochondrial0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0022
Mitogen-activated protein kinase 150022
Serine/threonine-protein kinase Nek90022
ATP-dependent RNA helicase DDX10022
Mitogen-activated protein kinase kinase kinase kinase 10022
Aurora kinase B0224
MAP/microtubule affinity-regulating kinase 40022
Serine/threonine-protein kinase Nek10022
PAS domain-containing serine/threonine-protein kinase0022
Calcium/calmodulin-dependent protein kinase kinase 20022
EKC/KEOPS complex subunit TP53RK0022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0022
Mitogen-activated protein kinase kinase kinase 50022
Mitogen-activated protein kinase kinase kinase 30022
Eukaryotic translation initiation factor 2-alpha kinase 10022
Nucleolar GTP-binding protein 10022
Serine/threonine-protein kinase D20022
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0022
Serine/threonine-protein kinase SIK20022
STE20-like serine/threonine-protein kinase 0123
Serine/threonine-protein kinase TAO30123
dCTP pyrophosphatase 10022
Dual specificity protein kinase CLK40022
Casein kinase I isoform gamma-10022
Phenylalanine--tRNA ligase beta subunit0022
BMP-2-inducible protein kinase0022
Midasin0022
Interleukin-1 receptor-associated kinase 40022
Mitogen-activated protein kinase kinase kinase 200022
Cyclin-dependent kinase 120022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase pim-20011
Serine/threonine-protein kinase 260022
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0022
Serine/threonine-protein kinase NLK0022
5'-AMP-activated protein kinase subunit gamma-20022
Serine/threonine-protein kinase TBK10022
Septin-90022
Ribosomal protein S6 kinase alpha-60022
TRAF2 and NCK-interacting protein kinase0022
Serine/threonine-protein kinase TAO20022
Long-chain-fatty-acid--CoA ligase 50011
ALK tyrosine kinase receptor0112
Serine/threonine-protein kinase ICK0022
RAC-gamma serine/threonine-protein kinase0022
Serine/threonine-protein kinase 38-like0011
Serine/threonine-protein kinase SIK30022
Mitogen-activated protein kinase kinase kinase 20022
Mitogen-activated protein kinase kinase kinase kinase 50022
Receptor-interacting serine/threonine-protein kinase 30022
Serine/threonine-protein kinase MRCK beta0022
Interleukin-1 receptor-associated kinase 30022
Serine/threonine-protein kinase 240022
Casein kinase I isoform gamma-30022
Mitogen-activated protein kinase kinase kinase 40022
Inhibitor of nuclear factor kappa-B kinase subunit beta0101
Cyclin-T10101
Serine/threonine-protein kinase Chk20101
Receptor tyrosine-protein kinase erbB-30101
Vascular endothelial growth factor receptor 30101
Tyrosine-protein kinase ZAP-700101
Serine/threonine-protein kinase PLK10112
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0101
Receptor tyrosine-protein kinase erbB-40101
Serine/threonine-protein kinase NIM10101
MAP kinase-interacting serine/threonine-protein kinase 10101
MAP kinase-interacting serine/threonine-protein kinase 20101
Serine/threonine-protein kinase Nek60101
Protein DBF4 homolog A0101
pyruvate kinase1001
lysosomal alpha-glucosidase preproprotein1001
peripheral myelin protein 22 isoform 11001
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C9 precursor2002
mu-type opioid receptor isoform MOR-10011
potassium voltage-gated channel subfamily H member 2 isoform d1001
histone deacetylase 9 isoform 31001
ras-related protein Rab-9A2002
5-hydroxytryptamine receptor 2A0011
pyruvate kinase PKM isoform b1001
Potassium channel subfamily K member 20011
Dihydrofolate reductase0101
Integrin beta-32002
Aldo-keto reductase family 1 member B10404
Integrin alpha-IIb2002
Ornithine decarboxylase1001
Neuronal acetylcholine receptor subunit alpha-41001
Cytochrome P450 2D60101
Neuronal acetylcholine receptor subunit beta-21001
UDP-glucuronosyltransferase 1A1 0202
Disintegrin and metalloproteinase domain-containing protein 171001
Pteridine reductase 10202
Chain A, 2-oxoglutarate Oxygenase1001
DNA polymerase kappa isoform 12002
Pyruvate kinase PKM0112
Neutral amino acid transporter A0101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Tyrosine-protein kinase JAK20011
Eukaryotic translation initiation factor 5B0011
Nuclear receptor subfamily 1 group I member 20022
Cyclin-dependent kinase-like 50011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Eukaryotic translation initiation factor 4E0011
Adenine phosphoribosyltransferase0011
ATP-dependent translocase ABCB10314
Tyrosine-protein kinase Fgr0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
S-adenosylmethionine synthase isoform type-20011
Serine/threonine-protein kinase receptor R30011
Electron transfer flavoprotein subunit beta0011
Serine/threonine-protein kinase mTOR0112
Choline-phosphate cytidylyltransferase A0011
Dual specificity protein kinase CLK30011
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
ATP-dependent 6-phosphofructokinase, platelet type0011
Protein kinase C zeta type0112
Cyclin-dependent kinase 180011
Serine/threonine-protein kinase PAK 20011
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
Serine/threonine-protein kinase N30011
Myosin-140011
Regulatory-associated protein of mTOR0101
Misshapen-like kinase 10011
Calcium/calmodulin-dependent protein kinase type 1G0011
Dual specificity testis-specific protein kinase 20011
Target of rapamycin complex subunit LST80101
Serine/threonine-protein kinase mTOR 0101
Isoleucine--tRNA ligase, mitochondrial0011
Obg-like ATPase 10011
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Solute carrier organic anion transporter family member 1B10103
Thrombopoietin1001
serine/threonine-protein kinase mTOR isoform 12002
Carbonic anhydrase 120101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 30101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
Cannabinoid receptor 10101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
Sulfate anion transporter 10001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Carbonic anhydrase 90101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
Chain A, CES1 protein0101
apical membrane antigen 1, AMA13003
DNA polymerase III, partial1001
glucocerebrosidase2002
Spike glycoprotein0011
Replicase polyprotein 1ab0011
interferon gamma precursor0001
ubiquitin-conjugating enzyme E2 N0101
M-phase phosphoprotein 81001
Transmembrane protease serine 20011
Estrogen receptor0214
Lysosomal acid glucosylceramidase0011
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Progesterone receptor0101
Procathepsin L0011
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Beta-1 adrenergic receptor0202
Muscarinic acetylcholine receptor M50202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1ab0011
Muscarinic acetylcholine receptor M10202
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Alpha-2B adrenergic receptor0202
5-hydroxytryptamine receptor 1A0202
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Prostaglandin G/H synthase 10101
Protein kinase C eta type0101
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 1B0202
B2 bradykinin receptor0202
Adenosine receptor A10404
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Melanocortin receptor 30202
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Sodium-dependent dopamine transporter 0202
Protein kinase C epsilon type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Serine/threonine-protein kinase D10101
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
Sigma non-opioid intracellular receptor 10202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Solute carrier organic anion transporter family member 1A40103
Solute carrier organic anion transporter family member 1A50002
Transthyretin0103
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
muscleblind-like protein 1 isoform 11001
Prothrombin0011
Androgen receptor0101
Thyroid hormone receptor beta0101
Sigma non-opioid intracellular receptor 10011
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Solute carrier organic anion transporter family member 1B30001
Chain A, Arginase 10101
Nuclear factor NF-kappa-B p105 subunit0101
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]