Conditions > Bowen Disease
Page last updated: 2024-09-28

Bowen Disease

A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)

Synonyms(2)

Synonym
Bowen Disease
Bowen's Disease

Research Excerpts

Overview

ExcerptReference
"Bowen's disease is a precancerous lesion of the superficial layers of the skin."( Castro, VL; Mouded, IM; Newman, HR; Tolia, BM, 1976)
""Bowen's disease" is a clinical and histologic diagnosis describing the lesions (single or multiple) of cutaneous in situ squamous cell carcinoma."( Cunningham-Rundles, W; Krown, SE; Oettgen, HF; Pinsky, CM; Raaf, JH; Safai, B, 1976)
"Bowen's disease is an intraepidermal squamous cell carcinoma usually consisting of a solitary lesion."( Ko, SS; Sheu, HM; Yu, HS, 1991)
"Bowen's disease is a squamous cell carcinoma characterized by isolated, grouped or confluent nodules, either flat, scaling, or crusted, with an arcuate or serpiginous configuration."( Espinoza, CG; Fenske, NA; Waisman, M, 1983)
"Bowen's disease is in situ squamous cell carcinoma of the skin."( Strong, ML, 1983)
"A case of Bowen's disease is described in which striking quantities of amyloid were detected in the papillary dermis visualized easily by routine haematoxylin and eosin staining."( Lawrence, CM; Milne, DS; Speight, EL, 1993)
"Genital Bowen disease is known to have a strong association with human papillomavirus (HPV) type 16."( Bernard, PM; Birembaut, PL; Clavel, CE; Derancourt, CG; Durlach, AP; Huu, VP, 1999)
"Bowen's disease is a well-known precancerous lesion, in which invasive squamous carcinoma may develop."( Kim, HJ; Lee, ES; Min, HG, 1999)
"Bowen disease is a variant of squamous cell carcinoma in situ."( Ayala, AG; Colome, MI; Medeiros, LJ; Sahin, A; Williamson, JD, 2000)
"Therapy for Bowen's disease is essential to prevent invasive squamous cell carcinoma and metastases."( Tantikun, N, 2000)
"Bowen's disease is a well-established in situ malignancy of the epidermis."( Kikuchi, K; Komine, M; Murakami, T; Nashiro, K; Okinaga, M; Soma, Y; Takeda, F; Tamaki, K, 2001)
"The lesions of Bowen's disease are slow-growing, erythematous scaly skin plaques that cause few, if any, symptoms."( , 2004)
"Bowen's disease is a special form of squamous cell carcinoma in situ that usually develops in photoexposed areas of skin."( Alfaro-Rubio, A; Botella, R; Guillén, C; Hueso, L; Llombart, B; Nagore, E; Requena, C; Sanmartín, O; Serra, C, 2005)
"Bowen Disease is squamous cell carcinoma in situ in which the basement membrane is intact on histopathology."( Dogra, S; Gupta, S; Kanwar, AJ, 2009)
"Bowen's disease is a neoplastic skin disease, known as squamous cell carcinoma in situ."( Calin, MA; Diaconeasa, A; Savastru, D; Tautan, M, 2011)
"Bowen's disease is the clinical term for in situ squamous cell carcinoma of the skin."( Bath-Hextall, FJ; Leonardi-Bee, J; Matin, RN; Wilkinson, D, 2013)
"Bowen's disease is a cutaneous squamous cell carcinoma (SCC) in situ with a potential risk of progression to invasive SCC."( Corbeddu, M; Ferreli, C; Fumo, G; Robustelli Test, E; Rongioletti, F, 2020)

Context

ExcerptReference
"Bowen's disease has previously been associated with the development of other malignancies particularly in patients with a history of arsenic exposure."( Allen, RB; Futrell, JW; Richardson, DR, 1979)
"Genital Bowen's disease has been strongly linked in recent studies to human papillomavirus (HPV)."( Buffone, G; Kettler, AH; Rutledge, M; Tschen, JA, 1990)
"Bowen's disease has long has been associated with arsenic ingestion."( Person, JR, 1996)
"Bowen's disease has a particular predilection for the lower leg, especially in women."( Ball, SB; Dawber, RP, 1998)

Actions

ExcerptReference
"A case of Bowen's disease affecting the palm, an unusual location, is reported."( Espinoza, CG; Fenske, NA; Waisman, M, 1983)

Treatment

ExcerptReference
"Sixty-six confirmed cases of Bowen's disease (intraepidermal squamous cell carcinoma) were seen from 1965 through 1976: twenty-four cases were treated surgically-four by excision (two recurrences) and twenty by desiccation and curettage (four recurrences); one was treated with x-ray radiation; and forty-one were treated with topical 5-fluorouracil (5-FU) (three recurrences)."( Sturm, HM, 1979)
"A case of extensive Bowen's disease of the skin treated successfully with topical 5-fluor-uracil is described."( Grussendorf, EI; Krause, H, 1979)
"The 12th case of Bowen's disease, presented here, offers an alternative method of treatment using 5-fluorouracil combined with a keratolytic ointment."( Defiebre, BK, 1978)
"Four cases of Bowen's disease of the finger have been treated, three during the past two years."( Kern, AB; Schiff, BL, 1977)
"An ususual case of Bowen's disease of the skin of the penile shaft treated successfully with topical 5-fluorouracil is presented along with a review of different modes of treatment."( Castro, VL; Mouded, IM; Newman, HR; Tolia, BM, 1976)
"For large areas of Bowen's disease, particularly in anatomically difficult areas and in elderly patients, PDT using ALA may constitute a single simple alternative outpatient treatment to existing therapies."( Ash, DV; Brown, SB; Cairnduff, F; Hudson, EJ; Stringer, MR, 1994)
"An early diagnosis and treatment of Bowen's disease is important for preventing its progression to invasive epidermoid carcinoma and later dissemination."( Borbujo Martínez, J; de Miguel Sánchez, C; Gázquez Abad, I; Olmos Carrasco, O; Rodríguez García, MD; Sáez-Berlana, A, 1994)
"Twenty-six patients with biopsy-proven Bowen's disease received eight 5-FU iontophoretic treatments in 4 weeks."( Anderson, LL; Grabski, WJ; McCollough, ML; Menon, PA; Skelton, HG; Smith, KJ; Welch, ML, 1997)
"Large patches of Bowen's disease (intraepidermal carcinoma in situ) can be difficult to treat by conventional methods."( Ash, DV; Robinson, DJ; Stables, GI; Stringer, MR, 1997)
"A review of the literature for treating Bowen's disease is presented and the problems associated with treating the lower leg emphasized."( Ball, SB; Dawber, RP, 1998)
"Twenty-nine sites of Bowen's disease in eight patients, confirmed by skin biopsy, were treated with 166Ho patches."( Bang, D; Chung, YL; Lee, JB; Lee, JD; Lee, MG; Park, KB, 2000)
"Therapy for Bowen's disease is essential to prevent invasive squamous cell carcinoma and metastases."( Tantikun, N, 2000)
"Large-diameter lesions of Bowen's disease at sites such as the shin may be difficult to treat surgically and may require alternate treatment modalities."( de Launey, J; Kossard, S; Mackenzie-Wood, A; Owens, ML; Wilkinson, B, 2001)
"We contribute a new case of perianal Bowen's disease, which responded to treatment with imiquimod with no evidence of clinical recurrence after 3 years of follow up."( Alfaro-Rubio, A; Botella, R; Guillén, C; Hueso, L; Llombart, B; Nagore, E; Requena, C; Sanmartín, O; Serra, C, 2005)
"Five Bowen's disease lesions and 7 invasive SCC lesions on 10 patients were treated with imiquimod once daily 5 times a week for a maximum of 16 weeks."( Chimenti, S; Fargnoli, MC; Lozzi, GP; Micantonio, T; Peris, K, 2006)
"The response rate of Bowen's disease to MAL-PDT is also at least equivalent to cryotherapy and 5-fluorouracil, again with superior cosmesis."( Morton, CA, 2007)
"While the standard treatments for Bowen's disease (BD) (surgery, cryotherapy and antimitotic agents) are efficient, they are associated with extensive scarring."( Bédane, C; Bonnetblanc, JM; Doffoel-Hantz, V; Durox, H; Marin, B; Sparsa, A, 2008)
"The treatment options for Bowen's disease are: cryotherapy, curettage, surgery, topical therapy and radiotherapy."( Calin, MA; Diaconeasa, A; Savastru, D; Tautan, M, 2011)
"Imiquimod cream, effective in treating Bowen's disease in healthy women, may be a useful postsurgical treatment in immunocompromised women."( Kaushal, S; Kopparthy, P; Merideth, M; Pulanic, TK; Stratton, P, 2012)
"In general, people with Bowen's disease have an excellent prognosis because the disease is typically slow-growing and responds favourably to treatment."( Bath-Hextall, FJ; Leonardi-Bee, J; Matin, RN; Wilkinson, D, 2013)
"The high cure rates for Bowen's disease and the principles of photodynamic therapy, suggest that this technique may be a great option in the management of this kind of lesion."( Caldas, A; Jeunon, T; Marques-da-Costa, J; Ortiz, B; Valente, L; Zink, BS, 2013)
"We report the successful treatment of Bowen disease with ingenol mebutate in a patient being treated with the multikinase inhibitor sunitinib for to metastatic clear cell renal carcinoma."( Braun, SA; Gerber, PA; Homey, B, 2014)
"We report three Bowen's disease (BD) cases treated with ingenol mebutate (IM), a novel topical chemotherapeutic agent approved for the treatment of actinic keratosis (AK) that is available in two doses: 0."( Quintana Codina, M; Salleras Redonnet, M, 2016)
"The second case of Bowen's disease was treated with 500 μg IM for 2 consecutive days leading to complete clinical remission."( Hofbauer, GF; Mohanna, MT, 2016)

Research

Studies (474)

TimeframeStudies, This Condition (%)All Conditions %
pre-199086 (18.14)23.3326
1990's78 (16.46)12.5806
2000's160 (33.76)18.1394
2010's123 (25.95)28.8240
2020's27 (5.70)9.53
DrugIndicatedRelationship StrengthStudiesTrials
dinitrochlorobenzene0low30
aminolevulinic acid0medium11225
5-aminovaleric acid0low10
acetic acid0low20
acetone0low10
salicylic acid0low120
cytosine0low10
dimethyl sulfoxide0low10
formaldehyde0low20
niacinamide0low10
2,2'-dipyridyl0low10
azathioprine0low10
clioquinol0low10
deferoxamine0medium21
diclofenac0low20
erythrosine0low10
fluorouracil0medium494
2-propanol0low10
khellin0low20
lomustine0low10
methoxsalen0low10
mitoxantrone0low10
nimesulide0low10
protoporphyrin ix0medium94
tazarotene0low10
tetracaine0medium11
prednisolone0low10
thymidine0low10
prednisone0low10
serine0low10
glutamine0low10
uridine0low10
bromodeoxyuridine0low20
edetic acid0low10
leucine0low10
colchicine0low30
cycloheximide0low10
triaziquone0low10
stearyl alcohol0low10
betamethasone0low10
reticulin0low10
mustard gas0low30
gentian violet0low10
4,4'-bipyridyl0low10
arsenic trioxide0low10
paraquat0low20
thiocholchicine0low10
fluorescein-5-isothiocyanate0low10
azo rubin s0low10
vidarabine0low10
silver0low10
thulium0low10
argon0low10
holmium0medium31
silver nitrate0low10
tetradecanoylphorbol acetate0low10
phenyl acetate0low30
triamcinolone0low10
imiquimod0medium885
cidofovir anhydrous0low10
temoporfin0low10
diphenylcyclopropenone0low10
metaperiodate0low10
fluorodeoxyglucose f180low10
diflorasone0low10
methotrexate0low30
methyl 5-aminolevulinate0medium418
resiquimod0low10
beta-solamarine0low10
biotin0low10
organophosphonates0low10
demecolcine0low20
glycogen0low20
inositol 3-phosphate0low20
phalloidine0low10
tretinoin0low30
retinol0low10
tacrolimus0low10
keratan sulfate0low10
arsphenamine0low10
bromochloroacetic acid0low290
glycosides0low10
fludarabine0low10
curcumin0low10
sulindac0low10
terbinafine0low10
calcitriol0low10
cucurbitacin i0low10
etretinate0low60
isotretinoin0low30
phenylephrine hydrochloride0low10
acitretin0low40
sirolimus0low20
morphine0low10
clobetasol0low10
arsenic0low580
lewisite0low10
phosphorus0low10
strontium radioisotopes0low10
tetrodotoxin0low10
radium0low20
maxacalcitol0low10
ro 13-62980low10
involucrin0low20
everolimus0low10
pep0050low60
mart-1 antigen0low10
nystatin a10low10
podophyllin0low30
sodium borate0low10
kx-010low10
interleukin-80low10
heparitin sulfate0low10
transforming growth factor beta0low30
cyclin d10low40
transforming growth factor alpha0low10
cyclosporine0low40
lewis y antigen0low10
deoxyguanosine0low20
amido black0low10
8-hydroxy-2'-deoxyguanosine0low20
eye0low20
concanavalin a0low20
phosphorus radioisotopes0low10

Protein Targets (1,195)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit170017
RAR-related orphan receptor gamma320032
GLI family zinc finger 3300030
AR protein420042
aldehyde dehydrogenase 1 family, member A1180018
retinoic acid nuclear receptor alpha variant 1300030
retinoid X nuclear receptor alpha290029
estrogen nuclear receptor alpha450045
peroxisome proliferator-activated receptor delta230023
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a260026
activating transcription factor 6200020
v-jun sarcoma virus 17 oncogene homolog (avian)190019
Histone H2A.x170017
thyroid hormone receptor beta isoform a120012
heat shock protein beta-1160016
nuclear factor erythroid 2-related factor 2 isoform 1340034
lamin isoform A-delta10240024
Voltage-dependent calcium channel gamma-2 subunit240024
Glutamate receptor 2250025
Chain A, Putative fructose-1,6-bisphosphate aldolase6006
Chain A, JmjC domain-containing histone demethylation protein 3A8008
Chain A, 2-oxoglutarate Oxygenase110011
thioredoxin reductase220022
Fumarate hydratase120012
apical membrane antigen 1, AMA17007
nuclear receptor subfamily 1, group I, member 3270027
progesterone receptor220022
glucocorticoid receptor [Homo sapiens]320032
estrogen-related nuclear receptor alpha330033
farnesoid X nuclear receptor210021
pregnane X nuclear receptor270027
polyprotein120012
bromodomain adjacent to zinc finger domain 2B7007
peroxisome proliferator activated receptor gamma260026
arylsulfatase A110011
euchromatic histone-lysine N-methyltransferase 2270027
Caspase-76006
Bloom syndrome protein isoform 1140014
runt-related transcription factor 1 isoform AML1b1001
chromobox protein homolog 1180018
caspase-36006
core-binding factor subunit beta isoform 21001
importin subunit beta-1 isoform 16006
DNA polymerase beta5005
snurportin-16006
geminin410041
C-C chemokine receptor type 10112
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha0101
Protein farnesyltransferase subunit beta0101
C-C chemokine receptor type 50112
C-C chemokine receptor type 80011
Methionine aminopeptidase 10011
Deoxyhypusine hydroxylase0202
Transmembrane prolyl 4-hydroxylase0101
ATP-dependent phosphofructokinase130013
ATAD5 protein, partial160016
TDP1 protein440044
Microtubule-associated protein tau200021
vitamin D (1,25- dihydroxyvitamin D3) receptor230023
aryl hydrocarbon receptor220022
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a9009
DNA polymerase iota isoform a (long)140014
Gamma-aminobutyric acid receptor subunit rho-30001
NFKB1 protein, partial4004
cytochrome P450 2D6 isoform 16006
Gamma-aminobutyric acid receptor subunit rho-10102
Gamma-aminobutyric acid receptor subunit rho-20001
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor 10202
Glutamate receptor 20202
Glutamate receptor 30202
Glutamate receptor ionotropic, kainate 31203
Solute carrier family 15 member 10202
Glutamate receptor 40202
Chain A, Avidin0022
Chain A, Avidin0022
Chain B, Avidin0022
Free fatty acid receptor 30011
Free fatty acid receptor 20112
Tyrosine-protein kinase Lck0044
Tyrosine-protein kinase Fyn0246
Fibrinogen C domain-containing protein 10101
thyroid hormone receptor beta isoform 2300030
Luciferase110011
USP1 protein, partial210021
vitamin D3 receptor isoform VDRA180018
flap endonuclease 19009
serine/threonine-protein kinase PLK14004
eyes absent homolog 2 isoform a2002
DNA polymerase eta isoform 15005
peripheral myelin protein 22250025
survival motor neuron protein isoform d160016
histone acetyltransferase KAT2A isoform 1130013
ATP-binding cassette sub-family C member 3020020
Multidrug resistance-associated protein 4020021
Bile salt export pump0505
Bile salt export pump025025
Rap guanine nucleotide exchange factor 33003
Cellular tumor antigen p53330033
Rap guanine nucleotide exchange factor 42002
Chain A, Beta-lactamase100010
Solute carrier family 15 member 10101
Solute carrier family 15 member 20101
nuclear receptor subfamily 1, group I, member 2100010
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE170017
Chain A, TYROSYL-DNA PHOSPHODIESTERASE130013
Chain A, Ferritin light chain130013
interleukin 87007
acetylcholinesterase100010
phosphopantetheinyl transferase130013
SMAD family member 2120012
SMAD family member 3120012
thioredoxin glutathione reductase100010
EWS/FLI fusion protein150016
G140014
P532002
IDH1160016
thyroid stimulating hormone receptor150015
peripheral myelin protein 22 isoform 16006
hemoglobin subunit beta3003
cellular tumor antigen p53 isoform a9009
cytochrome P450 3A4 isoform 1150015
M-phase phosphoprotein 86006
muscleblind-like protein 1 isoform 1100010
muscarinic acetylcholine receptor M16006
Gamma-aminobutyric acid receptor subunit pi150015
Interferon beta210021
HLA class I histocompatibility antigen, B alpha chain 140014
Gamma-aminobutyric acid receptor subunit beta-1150015
Gamma-aminobutyric acid receptor subunit delta150015
Gamma-aminobutyric acid receptor subunit gamma-2150015
Gamma-aminobutyric acid receptor subunit alpha-5150015
Gamma-aminobutyric acid receptor subunit alpha-3150015
Gamma-aminobutyric acid receptor subunit gamma-1150015
Gamma-aminobutyric acid receptor subunit alpha-2150015
Gamma-aminobutyric acid receptor subunit alpha-4150015
Gamma-aminobutyric acid receptor subunit gamma-3150015
Gamma-aminobutyric acid receptor subunit alpha-6150015
Nuclear receptor ROR-gamma111113
Gamma-aminobutyric acid receptor subunit alpha-1150015
Gamma-aminobutyric acid receptor subunit beta-3150015
Gamma-aminobutyric acid receptor subunit beta-2150015
GABA theta subunit150015
Inositol hexakisphosphate kinase 1140014
Canalicular multispecific organic anion transporter 1018018
ATPase family AAA domain-containing protein 5200020
Ataxin-2210021
Gamma-aminobutyric acid receptor subunit epsilon150015
Protein-arginine deiminase type-40202
cytochrome P450 2C9, partial140014
pregnane X receptor100010
cytochrome P450 family 3 subfamily A polypeptide 4170017
nuclear factor erythroid 2-related factor 2 isoform 2180018
galanin receptor type 30101
Glucocorticoid receptor09216
Glycine receptor subunit alpha-10808
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
ORF730011
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
nonstructural protein 10202
green fluorescent protein, partial0101
insulin-degrading enzyme isoform 10011
Streptavidin0011
Receptor-type tyrosine-protein phosphatase beta0001
Nuclear hormone receptor family member daf-120011
serine/threonine-protein kinase mTOR isoform 14004
oxysterols receptor LXR-beta isoform 10011
urokinase-type plasminogen activator precursor9009
plasminogen precursor9009
urokinase plasminogen activator surface receptor precursor9009
Thymidine kinase, cytosolic0408
Thymidine phosphorylase0002
Thymidylate kinase0202
Spike glycoprotein8019
Thymidine kinase0003
Thymidylate kinase0202
estrogen receptor 2 (ER beta)170017
DNA polymerase kappa isoform 1120012
Chain A, Vitamin D Nuclear Receptor0011
Vitamin D3 receptor0011
PPM1D protein8008
mitogen-activated protein kinase 1120012
nuclear receptor ROR-gamma isoform 1170017
Vitamin D-binding protein0011
Cytochrome P450 1A20315
Cytochrome P450 3A4011214
Androgen receptor0303
Cytochrome P450 2D60516
Vitamin D3 receptor0135
Cytochrome P450 2C9 07110
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0336
Cytochrome P450 2C190415
Kappa-type opioid receptor0213
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Vitamin D3 receptor A0022
Thymidine kinase 0203
Solute carrier family 22 member 60102
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Solute carrier family 22 member 60305
Chain A, Cruzipain8008
glp-1 receptor, partial100010
mu opioid receptor, partial0011
15-lipoxygenase, partial7007
90-kda heat shock protein beta HSP90 beta, partial0101
Smad3100010
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)110011
regulator of G-protein signaling 47007
nonstructural protein 14004
LAP40011
MEP20011
polyunsaturated fatty acid lipoxygenase ALOX125005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 18008
delta-type opioid receptor0112
kappa-type opioid receptor isoform 10101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor5005
potassium voltage-gated channel subfamily H member 2 isoform d9009
huntingtin isoform 26006
nuclear factor NF-kappa-B p105 subunit isoform 14004
ubiquitin carboxyl-terminal hydrolase 2 isoform a6006
heat shock protein HSP 90-alpha isoform 20103
DNA dC->dU-editing enzyme APOBEC-3F isoform a2002
Histone deacetylase 30202
Carbonic anhydrase 120102
Carbonic anhydrase 10406
Carbonic anhydrase 20417
Amyloid-beta precursor protein2508
Integrin beta-35005
Carbonic anhydrase 30102
Integrin alpha-IIb5005
Botulinum neurotoxin type A 0101
Spike glycoprotein0101
Alpha-1B adrenergic receptor0718
Catechol O-methyltransferase0101
Carbonic anhydrase 40203
Carbonic anhydrase 60102
Alpha-1D adrenergic receptor0213
Carbonic anhydrase 5A, mitochondrial0203
Alpha-synuclein4419
Alpha-1A adrenergic receptor0718
Carbonic anhydrase 70102
Histone deacetylase 40202
Disintegrin and metalloproteinase domain-containing protein 173003
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
TAR DNA-binding protein 436107
Histone deacetylase 10303
Carbonic anhydrase 90304
Beta-galactosidase0011
Histone deacetylase 70202
Histone deacetylase 20303
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Carbonic anhydrase 150202
Histone deacetylase 80303
Carbonic anhydrase 130102
Histone deacetylase 60202
Histone deacetylase 90202
Carbonic anhydrase 140102
Histone deacetylase 50202
HSP40, subfamily A [Plasmodium falciparum 3D7]0002
heat shock protein 90, putative0002
endonuclease IV2002
PAX80003
Thrombopoietin3003
thyroid stimulating hormone receptor7007
67.9K protein160016
glucocerebrosidase3003
nuclear receptor subfamily 0 group B member 10303
cytochrome P450 2C19 precursor5005
cytochrome P450 2C9 precursor4004
atrial natriuretic peptide receptor 2 precursor3003
ras-related protein Rab-9A4004
steroidogenic factor 10303
caspase-1 isoform alpha precursor3003
lethal factor (plasmid)7007
neuropeptide S receptor isoform A4004
Solute carrier family 22 member 30202
Tubulin alpha-1A chain0527
Tubulin beta chain0426
Plasma kallikrein0001
Tubulin beta-4A chain04410
ATP-dependent translocase ABCB10202
Tubulin beta chain04410
ATP-dependent translocase ABCB10405
Tubulin alpha-3C chain04410
Serine/threonine-protein kinase pim-10134
ATP-dependent translocase ABCB10202
Histamine H2 receptor100010
Tubulin alpha-1B chain04410
Tubulin alpha-4A chain04410
Tubulin beta-4B chain04410
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain04410
Tubulin beta-2A chain04410
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain04410
Tubulin beta-2B chain0505
Tubulin alpha-3E chain04410
Tubulin alpha-1A chain04410
Similar to alpha-tubulin isoform 1 0303
Similar to alpha-tubulin isoform 1 0303
CREB-binding protein1102
Tubulin alpha-1C chain04410
Tubulin beta-6 chain04410
Tubulin beta-2B chain04410
Tubulin beta-1 chain04410
Integrin alpha-L0101
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, HADH2 protein6006
Chain B, HADH2 protein6006
Nrf21001
GLS protein8008
alkaline phosphatase, intestinal0101
caspase 7, apoptosis-related cysteine protease4004
PINK11001
Parkin4004
toll-like receptor 90101
caspase-34004
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)5005
TPA: protein transporter TIM100101
thyrotropin-releasing hormone receptor5005
lysosomal alpha-glucosidase preproprotein2002
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
perilipin-50101
intestinal alkaline phosphatase precursor0101
perilipin-10101
transcriptional regulator ERG isoform 32002
pyruvate kinase PKM isoform a1001
histone-lysine N-methyltransferase 2A isoform 2 precursor5005
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
tumor susceptibility gene 101 protein2002
GTP-binding nuclear protein Ran isoform 13003
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
alkaline phosphatase, germ cell type preproprotein0101
hypothetical protein SA14220101
Prostaglandin E synthase0202
Polyunsaturated fatty acid lipoxygenase ALOX15B7007
Acetylcholinesterase0303
Lysine-specific histone demethylase 1A0101
D-amino-acid oxidase0101
Phospholipase A20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10303
Neuronal proto-oncogene tyrosine-protein kinase Src 0101
Prostaglandin G/H synthase 10505
Cholinesterase0101
Heme oxygenase 1 0101
Glutathione S-transferase P0101
Polyunsaturated fatty acid 5-lipoxygenase0303
60 kDa chaperonin0404
Replicase polyprotein 1ab0224
Replicase polyprotein 1ab0224
Microtubule-associated protein tau0102
60 kDa heat shock protein, mitochondrial0404
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0101
Tissue factor0202
Tyrosinase0101
Aminopeptidase N0101
Aminopeptidase N0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20202
Glycogen synthase kinase-3 beta0101
Amine oxidase [flavin-containing] A0404
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Acetylcholinesterase0404
Heme oxygenase 20101
Amine oxidase [flavin-containing] B0202
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Proteasome subunit beta type-50101
Prostaglandin G/H synthase 20606
17-beta-hydroxysteroid dehydrogenase type 20101
Glycogen synthase kinase-3 beta0134
Caspase-72002
Beta-secretase 10202
10 kDa heat shock protein, mitochondrial0404
Guanine nucleotide-binding protein G4004
Cholinesterase0202
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Lactoylglutathione lyase0202
Histone acetyltransferase p3000101
Serine/threonine-protein kinase PAK 10101
5-hydroxytryptamine receptor 40011
Sodium/bile acid cotransporter0011
Nuclear factor erythroid 2-related factor 20011
Thiosulfate sulfurtransferase0404
Thioredoxin reductase 1, cytoplasmic0101
60 kDa chaperonin 0404
10 kDa chaperonin 0404
Thioredoxin reductase 30101
Sortase A0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30202
Cysteine protease 0101
NACHT, LRR and PYD domains-containing protein 3 0101
Thioredoxin reductase 2, mitochondrial0101
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20406
Lymphocyte antigen 960011
Beta lactamase (plasmid)0101
RPL19A0011
Spike glycoprotein0011
Replicase polyprotein 1ab0011
NPC intracellular cholesterol transporter 1 precursor3003
transactivating tegument protein VP16 [Human herpesvirus 1]0303
COUP transcription factor 2 isoform a0101
Transmembrane protease serine 20011
Glucose transporter0101
Hexose transporter 1 0101
Procathepsin L0112
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Solute carrier family 2, facilitated glucose transporter member 10101
Eukaryotic initiation factor 4A-I0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0628
Peptidyl-prolyl cis-trans isomerase FKBP30101
Peptidyl-prolyl cis-trans isomerase FKBP40101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10314
Hypoxia-inducible factor 1-alpha0112
Endothelial PAS domain-containing protein 10101
Angiotensin-converting enzyme 2 0011
Peptidyl-prolyl cis-trans isomerase FKBP140101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 40101
Deoxycytidine kinase0001
Lysine-specific demethylase 4A0101
Methylcytosine dioxygenase TET20101
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0202
nuclear receptor coactivator 3 isoform a0202
Nuclear receptor subfamily 1 group I member 20033
Nuclear receptor subfamily 1 group I member 20011
Deoxycytidine kinase0034
AAA family ATPase 0001
Sterol O-acyltransferase 10202
Aldo-keto reductase family 1 member B100202
UDP-glucuronosyltransferase 1A90102
Prostaglandin G/H synthase 1 0101
Transient receptor potential cation channel subfamily A member 10011
Dihydrofolate reductase0304
Cytochrome c oxidase subunit 20101
Fatty acid-binding protein, liver0202
Transthyretin0013
Albumin0415
Interleukin-80101
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Fatty acid-binding protein, intestinal0101
Aldo-keto reductase family 1 member B10303
UDP-glucuronosyltransferase 2B70103
UDP-glucuronosyltransferase 1-60202
UDP-glucuronosyltransferase 1A1 0202
UDP-glucuronosyltransferase 1A40102
Prostaglandin G/H synthase 10303
Sodium- and chloride-dependent GABA transporter 10101
C-X-C chemokine receptor type 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin G/H synthase 2 0101
UDP-glucuronosyltransferase 1A30002
UDP-glucuronosyltransferase 2B10 0101
Sodium- and chloride-dependent betaine transporter0101
Cytochrome P450 2J20303
Prostaglandin G/H synthase 20202
Prostaglandin G/H synthase 20202
Prostaglandin G/H synthase 1 0101
Carbonic anhydrase 40101
Multidrug and toxin extrusion protein 10202
P2Y purinoceptor 120101
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
Cereblon isoform 40202
Insulin-like growth factor-binding protein 50011
Choline O-acetyltransferase 0101
Protein cereblon0404
Vpr4004
Glutathione S-transferase omega-10101
Eyes absent homolog 20101
Angiotensin-converting enzyme 0101
Metallo-beta-lactamase VIM-130101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase VIM-1 0101
Endothelin-1 receptor0101
Chain A, ATP-DEPENDENT DNA HELICASE Q16006
Genome polyprotein 0112
chaperonin-containing TCP-1 beta subunit homolog2002
hypothetical protein, conserved3003
cytochrome P450 2D69009
lethal(3)malignant brain tumor-like protein 1 isoform I1001
relaxin receptor 1 isoform 11001
Flavin reductase (NADPH)0011
large T antigen0101
Bone morphogenetic protein receptor type-1B0033
Cell division cycle 7-related protein kinase0022
Serine/threonine-protein kinase PLK40033
ATP-dependent RNA helicase DDX3X0033
Pyridoxal kinase0033
Citron Rho-interacting kinase0033
Serine/threonine-protein kinase Chk10033
Aurora kinase A0033
Cyclin-G-associated kinase0033
Ephrin type-B receptor 60033
Peroxisomal acyl-coenzyme A oxidase 30033
Receptor-interacting serine/threonine-protein kinase 20033
Mitotic checkpoint serine/threonine-protein kinase BUB10033
Dynamin-like 120 kDa protein, mitochondrial0033
Eukaryotic translation initiation factor 5B0033
Rho-associated protein kinase 20033
Serine/threonine-protein kinase ULK10033
Serine/threonine-protein kinase/endoribonuclease IRE10033
Ribosomal protein S6 kinase alpha-50033
U5 small nuclear ribonucleoprotein 200 kDa helicase0033
Ribosomal protein S6 kinase alpha-40033
Serine/threonine-protein kinase 160033
Serine/threonine-protein kinase 100033
Serine/threonine-protein kinase D30055
Structural maintenance of chromosomes protein 20033
Mitogen-activated protein kinase kinase kinase 60033
Mitogen-activated protein kinase kinase kinase kinase 40033
Serine/threonine-protein kinase LATS10033
Serine/threonine-protein kinase PAK 40033
Tyrosine-protein kinase ABL10246
Epidermal growth factor receptor0437
High affinity nerve growth factor receptor0033
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20033
Protein kinase C beta type0156
Insulin receptor0033
Cyclin-dependent kinase 10033
Glycogen phosphorylase, liver form0033
Tyrosine-protein kinase Fes/Fps0033
Adenine phosphoribosyltransferase0033
Tyrosine-protein kinase Yes0033
Tyrosine-protein kinase Lyn0134
Proto-oncogene tyrosine-protein kinase receptor Ret0033
Insulin-like growth factor 1 receptor0033
Signal recognition particle receptor subunit alpha0033
Cytochrome c1, heme protein, mitochondrial0033
Hepatocyte growth factor receptor0033
Tyrosine-protein kinase HCK0033
Platelet-derived growth factor receptor beta0033
Tyrosine-protein kinase Fgr0033
Serine/threonine-protein kinase A-Raf0033
Glycogen phosphorylase, brain form0033
Breakpoint cluster region protein0235
Fibroblast growth factor receptor 10033
DNA topoisomerase 2-alpha0135
Cyclin-dependent kinase 40033
ADP/ATP translocase 30033
Inosine-5'-monophosphate dehydrogenase 20033
Proto-oncogene tyrosine-protein kinase Src0235
cAMP-dependent protein kinase type II-alpha regulatory subunit0033
Serine/threonine-protein kinase B-raf0033
Potassium voltage-gated channel subfamily E member 10101
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0033
Ribosyldihydronicotinamide dehydrogenase [quinone]0033
Tyrosine-protein kinase Fer0033
Protein kinase C alpha type0156
cAMP-dependent protein kinase catalytic subunit alpha0033
General transcription and DNA repair factor IIH helicase subunit XPD0033
Casein kinase II subunit alpha'0134
Ras-related protein Rab-6A0033
Ephrin type-A receptor 10033
Multifunctional protein ADE20033
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0033
Ferrochelatase, mitochondrial0033
Ribosomal protein S6 kinase beta-10033
Tyrosine-protein kinase JAK10033
Cyclin-dependent kinase 20044
Beta-adrenergic receptor kinase 10033
Probable ATP-dependent RNA helicase DDX60033
Mitogen-activated protein kinase 3 0033
MAP/microtubule affinity-regulating kinase 30033
Mitogen-activated protein kinase 10235
Ephrin type-A receptor 20033
Ephrin type-B receptor 20033
Non-receptor tyrosine-protein kinase TYK20033
UMP-CMP kinase 0033
Phosphatidylethanolamine-binding protein 10033
Wee1-like protein kinase0033
Heme oxygenase 20033
S-adenosylmethionine synthase isoform type-20033
DnaJ homolog subfamily A member 10033
RAC-alpha serine/threonine-protein kinase0033
RAC-beta serine/threonine-protein kinase0033
Dual specificity protein kinase TTK0022
DNA replication licensing factor MCM40033
Myosin-100033
Dual specificity mitogen-activated protein kinase kinase 20033
Receptor-type tyrosine-protein kinase FLT30033
Bone morphogenetic protein receptor type-1A0033
Activin receptor type-1B0033
TGF-beta receptor type-10033
TGF-beta receptor type-20033
Electron transfer flavoprotein subunit beta0033
Tyrosine-protein kinase CSK0033
Glycine--tRNA ligase0033
Protein kinase C iota type0055
Exosome RNA helicase MTR40033
Serine/threonine-protein kinase mTOR0325
Tyrosine-protein kinase Tec0033
Tyrosine-protein kinase ABL20033
Tyrosine-protein kinase FRK0033
G protein-coupled receptor kinase 60033
Tyrosine-protein kinase SYK0033
26S proteasome regulatory subunit 6B0033
Mitogen-activated protein kinase 80033
Mitogen-activated protein kinase 90033
Dual specificity mitogen-activated protein kinase kinase 30033
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0033
Casein kinase I isoform alpha0033
Casein kinase I isoform delta0033
MAP kinase-activated protein kinase 20033
Elongation factor Tu, mitochondrial0033
Choline-phosphate cytidylyltransferase A0033
Cysteine--tRNA ligase, cytoplasmic0033
Casein kinase I isoform epsilon0033
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0033
Dual specificity protein kinase CLK10033
Dual specificity protein kinase CLK20033
Dual specificity protein kinase CLK30033
Glycogen synthase kinase-3 alpha0033
Cyclin-dependent kinase 70033
Cyclin-dependent kinase 90033
Ras-related protein Rab-27A0033
Interleukin-1 receptor-associated kinase 10033
Potassium voltage-gated channel subfamily KQT member 10101
Ribosomal protein S6 kinase alpha-30033
Serine/threonine-protein kinase Nek20033
Serine/threonine-protein kinase Nek30033
Dual specificity mitogen-activated protein kinase kinase 60033
Serine/threonine-protein kinase PLK10033
LIM domain kinase 10033
LIM domain kinase 20033
Mitogen-activated protein kinase 100033
Tyrosine--tRNA ligase, cytoplasmic0033
5'-AMP-activated protein kinase subunit gamma-10034
Ephrin type-B receptor 30033
Ephrin type-A receptor 50033
Ephrin type-B receptor 40033
Ephrin type-A receptor 40033
Adenylate kinase 2, mitochondrial0033
Adenosine kinase0033
Ras-related protein Rab-100033
Actin-related protein 30033
Actin-related protein 20033
GTP-binding nuclear protein Ran0033
Casein kinase I isoform gamma-20033
Cyclin-dependent kinase 30022
Cyclin-dependent kinase 60033
Cyclin-dependent-like kinase 5 0033
Cyclin-dependent kinase 160033
Cyclin-dependent kinase 170033
ATP-dependent 6-phosphofructokinase, platelet type0033
Dual specificity mitogen-activated protein kinase kinase 10033
DNA topoisomerase 2-beta0034
Protein kinase C theta type0055
Activin receptor type-10033
Macrophage-stimulating protein receptor0033
Focal adhesion kinase 10033
Protein kinase C delta type0156
Tyrosine-protein kinase BTK0134
Activated CDC42 kinase 10033
Epithelial discoidin domain-containing receptor 10033
Potassium voltage-gated channel subfamily H member 20404
Mitogen-activated protein kinase kinase kinase kinase 20033
Serine/threonine-protein kinase 40033
5'-AMP-activated protein kinase catalytic subunit alpha-10034
Dual specificity mitogen-activated protein kinase kinase 50033
Mitogen-activated protein kinase 70033
Serine/threonine-protein kinase PAK 20033
Serine/threonine-protein kinase 30033
Mitogen-activated protein kinase kinase kinase 10033
Integrin-linked protein kinase0033
Rho-associated protein kinase 10033
Non-receptor tyrosine-protein kinase TNK10033
Calcium/calmodulin-dependent protein kinase type II subunit gamma0033
Calcium/calmodulin-dependent protein kinase type II subunit delta0033
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0033
Activin receptor type-2B0033
Bone morphogenetic protein receptor type-20033
Protein-tyrosine kinase 60033
cGMP-dependent protein kinase 1 0033
Cyclin-dependent kinase 130033
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0033
Protein-tyrosine kinase 2-beta0033
Sodium channel protein type 5 subunit alpha0202
Maternal embryonic leucine zipper kinase0033
Structural maintenance of chromosomes protein 1A0033
Chromodomain-helicase-DNA-binding protein 40033
Peroxisomal acyl-coenzyme A oxidase 10033
Ephrin type-A receptor 70022
Delta(24)-sterol reductase0033
Ribosomal protein S6 kinase alpha-10033
Dual specificity testis-specific protein kinase 10033
Myosin light chain kinase, smooth muscle0033
Mitogen-activated protein kinase 110033
Serine/threonine-protein kinase STK110033
Serine/threonine-protein kinase N10033
Serine/threonine-protein kinase N20033
Mitogen-activated protein kinase 140134
Calcium/calmodulin-dependent protein kinase type IV0033
Mitogen-activated protein kinase kinase kinase 110033
Discoidin domain-containing receptor 20033
AP2-associated protein kinase 10033
Myosin light chain kinase 30033
Putative heat shock protein HSP 90-beta 20033
Serine/threonine-protein kinase MRCK alpha0033
Serine/threonine-protein kinase MRCK gamma0033
Acyl-CoA dehydrogenase family member 100033
Serine/threonine-protein kinase N30022
Serine/threonine-protein kinase ULK30033
Uncharacterized protein FLJ452520033
Acyl-CoA dehydrogenase family member 110033
Serine/threonine-protein kinase/endoribonuclease IRE20033
Serine/threonine-protein kinase MARK20033
ATP-dependent RNA helicase DHX300033
Serine/threonine-protein kinase TAO10033
STE20-related kinase adapter protein alpha0033
Myosin-140033
AarF domain-containing protein kinase 10033
ATP-dependent RNA helicase DDX420022
Mitogen-activated protein kinase kinase kinase kinase 30033
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0022
Regulatory-associated protein of mTOR0202
Atypical kinase COQ8A, mitochondrial0033
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0033
Mitogen-activated protein kinase 150033
Serine/threonine-protein kinase Nek90033
Serine/threonine-protein kinase Nek70022
ATP-dependent RNA helicase DDX10033
Mitogen-activated protein kinase kinase kinase kinase 10033
Aurora kinase B0033
MAP/microtubule affinity-regulating kinase 40033
Serine/threonine-protein kinase Nek10033
PAS domain-containing serine/threonine-protein kinase0033
Calcium/calmodulin-dependent protein kinase kinase 20033
EKC/KEOPS complex subunit TP53RK0033
Dual specificity testis-specific protein kinase 20033
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0033
Mitogen-activated protein kinase kinase kinase 50033
Mitogen-activated protein kinase kinase kinase 30033
Eukaryotic translation initiation factor 2-alpha kinase 10033
Target of rapamycin complex subunit LST80202
Nucleolar GTP-binding protein 10033
Serine/threonine-protein kinase D20033
NUAK family SNF1-like kinase 20022
RNA cytidine acetyltransferase0033
Serine/threonine-protein kinase SIK20033
STE20-like serine/threonine-protein kinase 0033
Serine/threonine-protein kinase TAO30033
dCTP pyrophosphatase 10033
Dual specificity protein kinase CLK40033
Casein kinase I isoform gamma-10033
Phenylalanine--tRNA ligase beta subunit0033
BMP-2-inducible protein kinase0033
Obg-like ATPase 10033
Midasin0033
Interleukin-1 receptor-associated kinase 40033
Mitogen-activated protein kinase kinase kinase 200033
Cyclin-dependent kinase 120033
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130022
Serine/threonine-protein kinase 260033
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0033
Serine/threonine-protein kinase NLK0033
5'-AMP-activated protein kinase subunit gamma-20034
Serine/threonine-protein kinase TBK10033
Septin-90033
Potassium voltage-gated channel subfamily D member 30101
Ribosomal protein S6 kinase alpha-60033
TRAF2 and NCK-interacting protein kinase0033
Serine/threonine-protein kinase TAO20033
Long-chain-fatty-acid--CoA ligase 50022
RAC-gamma serine/threonine-protein kinase0033
Serine/threonine-protein kinase SIK30033
Mitogen-activated protein kinase kinase kinase 20033
Thyroid hormone receptor-associated protein 30033
Mitogen-activated protein kinase kinase kinase kinase 50033
Receptor-interacting serine/threonine-protein kinase 30033
Serine/threonine-protein kinase MRCK beta0033
Interleukin-1 receptor-associated kinase 30033
Casein kinase I isoform gamma-30033
Mitogen-activated protein kinase kinase kinase 40033
corticotropin-releasing hormone receptor 20112
corticotropin releasing factor-binding protein0112
glycogen synthase kinase-3 beta isoform 10022
5'-nucleotidase0101
Adenosine receptor A30101
Adenosine deaminase 0002
Chain A, Uracil Phosphoribosyltransferase0101
Skn7p0001
Solute carrier family 22 member 80001
Thymidylate synthase0304
Aromatase0202
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]1001
alpha synuclein, partial1001
luciferase2002
tumor necrosis factor1001
histone deacetylase 9 isoform 32002
Solute carrier family 22 member 1 0203
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0415
Adenosine receptor A30606
Muscarinic acetylcholine receptor M10404
D(2) dopamine receptor0202
Androgen receptor0303
Alpha-2B adrenergic receptor0404
Alpha-2C adrenergic receptor0202
Muscarinic acetylcholine receptor M30202
Substance-K receptor0202
D(1A) dopamine receptor0202
Glutamate receptor ionotropic, kainate 11001
Histamine H2 receptor0404
Alpha-1D adrenergic receptor0404
5-hydroxytryptamine receptor 2A0404
Adenosine receptor A2a0404
Mu-type opioid receptor0416
D(3) dopamine receptor0303
Kappa-type opioid receptor0416
Glutamate receptor ionotropic, kainate 21001
Fatty-acid amide hydrolase 11102
Inositol monophosphatase 13003
Glutamate receptor ionotropic, kainate 41001
Sodium-dependent dopamine transporter 0404
Leukotriene B4 receptor 11001
Glutamate receptor ionotropic, kainate 51001
Leukotriene B4 receptor 21001
Chain A, Glutamine Binding Protein0011
Neutral amino acid transporter A0202
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0202
Carbonic anhydrase-like protein, putative0001
Amino acid transporter0202
Thioredoxin reductase 1, cytoplasmic0101
Dopamine beta-hydroxylase0101
Corticotropin-releasing factor receptor 10101
Cystathionine beta-synthase0101
Glutathione reductase0101
Integrase 0202
5-lipoxygenase 0101
Cysteine protease ATG4B0101
Thioredoxin reductase 2, mitochondrial0101
7,8-dihydro-8-oxoguanine triphosphatase0202
Toll-like receptor 80024
Toll-like receptor 70024
Ornithine decarboxylase0002
Retinoic acid receptor alpha0224
Retinoic acid receptor gamma0224
Retinoic acid receptor beta0224
Cellular retinoic acid-binding protein 20022
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10203
5-hydroxytryptamine receptor 2B0404
Cellular retinoic acid-binding protein 10022
Olfactory receptor 51E20101
GALC protein2002
Cytochrome P450 1A10202
Cytochrome P450 1B10101
Membrane-associated progesterone receptor component 10011
Tyrosine-protein kinase JAK20022
Tyrosine-protein kinase ABL10101
Serine/threonine-protein kinase receptor R30022
Dual specificity mitogen-activated protein kinase kinase 40011
Protein kinase C zeta type0044
Serine/threonine-protein kinase 380011
Uncharacterized aarF domain-containing protein kinase 50022
Rab-like protein 30011
Breakpoint cluster region protein0101
MAP kinase-activated protein kinase 50022
Misshapen-like kinase 10022
Isoleucine--tRNA ligase, mitochondrial0022
Serine/threonine-protein kinase pim-20011
Serine/threonine-protein kinase ICK0022
Serine/threonine-protein kinase 38-like0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0022
Serine/threonine-protein kinase 240022
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Large neutral amino acids transporter small subunit 10101
Proton-coupled amino acid transporter 10203
Phospholipase A-2-activating protein0101
HLA class I histocompatibility antigen, A alpha chain 0101
5-hydroxytryptamine receptor 2C0203
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2B0101
Gastrin/cholecystokinin type B receptor0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
dopamine D1 receptor2002
ClpP1001
Thymidylate synthase 0101
alpha-galactosidase3003
Thymidylate synthase 0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0112
Trifunctional purine biosynthetic protein adenosine-30101
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0102
Delta-type opioid receptor0315
Mu-type opioid receptor0317
Kappa-type opioid receptor0315
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200202
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60202
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30203
Solute carrier family 22 member 110001
Polyphenol oxidase 20113
Cytochrome P450 2A60112
Cytochrome P450 2A130112
Chain A, Probable serine/threonine-protein kinase pknB0101
WRN2002
DNA polymerase III, partial1001
LANA0001
pyruvate kinase2002
phospholipase A2, group III0101
interferon gamma precursor0001
atrial natriuretic peptide receptor 1 precursor1001
histone-lysine N-methyltransferase NSD2 isoform 10001
protein AF-9 isoform a0001
tyrosine-protein kinase Yes1001
dual specificity tyrosine-phosphorylation-regulated kinase 1A0001
rac GTPase-activating protein 1 isoform a0101
DNA repair protein RAD52 homolog isoform a0001
pyruvate kinase PKM isoform b1001
Solute carrier family 22 member 20101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40404
Glycoprotein hormones alpha chain1001
Receptor tyrosine-protein kinase erbB-20101
Aldo-keto reductase family 1 member B10404
Proto-oncogene tyrosine-protein kinase ROS0101
Ornithine decarboxylase1002
Polyunsaturated fatty acid lipoxygenase ALOX150101
Angiotensin-converting enzyme0202
DNA topoisomerase 20001
Sodium-dependent noradrenaline transporter 0415
5-hydroxytryptamine receptor 2C0404
Casein kinase II subunit beta0101
Casein kinase II subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
NEDD8-activating enzyme E1 regulatory subunit0011
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Nuclear receptor subfamily 3 group C member 3 0202
Multidrug and toxin extrusion protein 20101
Casein kinase II subunit alpha 30101
NEDD8-activating enzyme E1 catalytic subunit0011
Single-stranded DNA cytosine deaminase2002
P2Y purinoceptor 120101
phosphoglycerate kinase2002
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20101
Translocator protein0011
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0102
Kappa-type opioid receptor0214
Delta-type opioid receptor0214
Mu-type opioid receptor0215
Nociceptin receptor0101
5-hydroxytryptamine receptor 70101
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Beta-2 adrenergic receptor0101
Mas-related G-protein coupled receptor member X20011
Mu-type opioid receptor0101
Sigma non-opioid intracellular receptor 10505
Chain A, NAD-dependent deacetylase0101
Poly [ADP-ribose] polymerase 20101
NAD-dependent histone deacetylase SIR20101
Coagulation factor VII0101
Poly [ADP-ribose] polymerase 10101
Cytochrome P450 3A50202
NAD-dependent protein deacetylase HST20101
Protein mono-ADP-ribosyltransferase PARP150101
NAD(+) hydrolase SARM10101
NAD-dependent protein deacetylase sirtuin-20101
NAD-dependent protein deacetylase sirtuin-60101
NAD-dependent protein deacetylase sirtuin-10101
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
NAD-dependent protein deacetylase 0101
Interstitial collagenase0101
Myeloperoxidase0101
Leukotriene A-4 hydrolase0101
Glutamate receptor 12002
Glutamate receptor 32002
Glutamate receptor 42002
Photosystem I iron-sulfur center 0001
Protein kinase C gamma type0123
Protein kinase C eta type0022
Protein kinase C epsilon type0123
Serine/threonine-protein kinase D10022
beta-2 adrenergic receptor1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Regulatory protein E20011
Regulatory protein E20011
Regulatory protein E20011
Calcium-activated potassium channel subunit alpha-10101
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Histamine H1 receptor0022
Nociceptin receptor0011
Estrogen receptor beta0202
Chain A, RNA-directed RNA polymerase NS50101
SUMO-10101
isocitrate dehydrogenase 1, partial1001
POsterior Segregation0011
chaperonin GroEL1001
Exoribonuclease H 0101
Coproheme decarboxylase0011
Protease 0101
Zinc finger protein mex-50011
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Retinol-binding protein 40011
Beta-lactoglobulin0011
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Pyruvate kinase PKM0011
Cyclin-dependent kinase-like 50011
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Peptidyl-prolyl cis-trans isomerase FKBP1B0022
Cyclin-dependent kinase 180011
Tyrosine-protein kinase Mer0011
Peptidyl-prolyl cis-trans isomerase FKBP50202
Programmed cell death protein 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase mTOR 0101
Solute carrier organic anion transporter family member 1B10202
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
D(1A) dopamine receptor1001
Acetylcholinesterase0101
Complement C50011
Polyunsaturated fatty acid 5-lipoxygenase0101
Aldo-keto reductase family 1 member B10101
Glycine receptor subunit alpha-10011
Peroxisome proliferator-activated receptor gamma0022
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Splicing factor 3B subunit 30101
Retinoic acid receptor alpha0238
Retinoic acid receptor beta0238
Retinoic acid receptor gamma 0238
cystic fibrosis transmembrane conductance regulator0101
C-8 sterol isomerase0101
Squalene monooxygenase 0101
Squalene monooxygenase0202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Potassium channel subfamily K member 30101
cGMP-gated cation channel alpha-10011
Sodium channel protein type 7 subunit alpha0101
Sodium channel protein type 9 subunit alpha0303
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Luciferin 4-monooxygenase0011
Beta-1 adrenergic receptor0101
Ras guanyl-releasing protein 30011
Thymidine kinase0102
Thymidine phosphorylase0001
Thymidine kinase, cytosolic 0002
Thymidine kinase 0102
Thymidine kinase0001
Thymidine kinase0001
Chain A, Nuclear Receptor ROR-beta0101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 1A0101
Retinoic acid receptor RXR-beta0224
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Retinoic acid receptor RXR-gamma0224
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
procathepsin L isoform 1 preproprotein0101
Chain A, Cytidine Deaminase0101
Sodium/nucleoside cotransporter 10202
Sodium/nucleoside cotransporter 20202
Cytidine deaminase0101
Equilibrative nucleoside transporter 20202
Equilibrative nucleoside transporter 10202
Uridine-cytidine kinase 1 0001
Solute carrier family 28 member 30202
Dipeptidyl peptidase 40101
Adenosylhomocysteinase0101
RNA-directed RNA polymerase 0112
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]