Bowen Disease

A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)

Synonyms(2)

Synonym
Bowen Disease
Bowen's Disease

Research Excerpts

Overview

Excerpt	Reference
"Bowen's disease is a precancerous lesion of the superficial layers of the skin."	( Castro, VL; Mouded, IM; Newman, HR; Tolia, BM, 1976)
""Bowen's disease" is a clinical and histologic diagnosis describing the lesions (single or multiple) of cutaneous in situ squamous cell carcinoma."	( Cunningham-Rundles, W; Krown, SE; Oettgen, HF; Pinsky, CM; Raaf, JH; Safai, B, 1976)
"Bowen's disease is an intraepidermal squamous cell carcinoma usually consisting of a solitary lesion."	( Ko, SS; Sheu, HM; Yu, HS, 1991)
"Bowen's disease is a squamous cell carcinoma characterized by isolated, grouped or confluent nodules, either flat, scaling, or crusted, with an arcuate or serpiginous configuration."	( Espinoza, CG; Fenske, NA; Waisman, M, 1983)
"Bowen's disease is in situ squamous cell carcinoma of the skin."	( Strong, ML, 1983)
"A case of Bowen's disease is described in which striking quantities of amyloid were detected in the papillary dermis visualized easily by routine haematoxylin and eosin staining."	( Lawrence, CM; Milne, DS; Speight, EL, 1993)
"Genital Bowen disease is known to have a strong association with human papillomavirus (HPV) type 16."	( Bernard, PM; Birembaut, PL; Clavel, CE; Derancourt, CG; Durlach, AP; Huu, VP, 1999)
"Bowen's disease is a well-known precancerous lesion, in which invasive squamous carcinoma may develop."	( Kim, HJ; Lee, ES; Min, HG, 1999)
"Bowen disease is a variant of squamous cell carcinoma in situ."	( Ayala, AG; Colome, MI; Medeiros, LJ; Sahin, A; Williamson, JD, 2000)
"Therapy for Bowen's disease is essential to prevent invasive squamous cell carcinoma and metastases."	( Tantikun, N, 2000)
"Bowen's disease is a well-established in situ malignancy of the epidermis."	( Kikuchi, K; Komine, M; Murakami, T; Nashiro, K; Okinaga, M; Soma, Y; Takeda, F; Tamaki, K, 2001)
"The lesions of Bowen's disease are slow-growing, erythematous scaly skin plaques that cause few, if any, symptoms."	( , 2004)
"Bowen's disease is a special form of squamous cell carcinoma in situ that usually develops in photoexposed areas of skin."	( Alfaro-Rubio, A; Botella, R; Guillén, C; Hueso, L; Llombart, B; Nagore, E; Requena, C; Sanmartín, O; Serra, C, 2005)
"Bowen Disease is squamous cell carcinoma in situ in which the basement membrane is intact on histopathology."	( Dogra, S; Gupta, S; Kanwar, AJ, 2009)
"Bowen's disease is a neoplastic skin disease, known as squamous cell carcinoma in situ."	( Calin, MA; Diaconeasa, A; Savastru, D; Tautan, M, 2011)
"Bowen's disease is the clinical term for in situ squamous cell carcinoma of the skin."	( Bath-Hextall, FJ; Leonardi-Bee, J; Matin, RN; Wilkinson, D, 2013)
"Bowen's disease is a cutaneous squamous cell carcinoma (SCC) in situ with a potential risk of progression to invasive SCC."	( Corbeddu, M; Ferreli, C; Fumo, G; Robustelli Test, E; Rongioletti, F, 2020)

Context

Excerpt	Reference
"Bowen's disease has previously been associated with the development of other malignancies particularly in patients with a history of arsenic exposure."	( Allen, RB; Futrell, JW; Richardson, DR, 1979)
"Genital Bowen's disease has been strongly linked in recent studies to human papillomavirus (HPV)."	( Buffone, G; Kettler, AH; Rutledge, M; Tschen, JA, 1990)
"Bowen's disease has long has been associated with arsenic ingestion."	( Person, JR, 1996)
"Bowen's disease has a particular predilection for the lower leg, especially in women."	( Ball, SB; Dawber, RP, 1998)

Actions

Excerpt	Reference
"A case of Bowen's disease affecting the palm, an unusual location, is reported."	( Espinoza, CG; Fenske, NA; Waisman, M, 1983)

Treatment

Excerpt	Reference
"Sixty-six confirmed cases of Bowen's disease (intraepidermal squamous cell carcinoma) were seen from 1965 through 1976: twenty-four cases were treated surgically-four by excision (two recurrences) and twenty by desiccation and curettage (four recurrences); one was treated with x-ray radiation; and forty-one were treated with topical 5-fluorouracil (5-FU) (three recurrences)."	( Sturm, HM, 1979)
"A case of extensive Bowen's disease of the skin treated successfully with topical 5-fluor-uracil is described."	( Grussendorf, EI; Krause, H, 1979)
"The 12th case of Bowen's disease, presented here, offers an alternative method of treatment using 5-fluorouracil combined with a keratolytic ointment."	( Defiebre, BK, 1978)
"Four cases of Bowen's disease of the finger have been treated, three during the past two years."	( Kern, AB; Schiff, BL, 1977)
"An ususual case of Bowen's disease of the skin of the penile shaft treated successfully with topical 5-fluorouracil is presented along with a review of different modes of treatment."	( Castro, VL; Mouded, IM; Newman, HR; Tolia, BM, 1976)
"For large areas of Bowen's disease, particularly in anatomically difficult areas and in elderly patients, PDT using ALA may constitute a single simple alternative outpatient treatment to existing therapies."	( Ash, DV; Brown, SB; Cairnduff, F; Hudson, EJ; Stringer, MR, 1994)
"An early diagnosis and treatment of Bowen's disease is important for preventing its progression to invasive epidermoid carcinoma and later dissemination."	( Borbujo Martínez, J; de Miguel Sánchez, C; Gázquez Abad, I; Olmos Carrasco, O; Rodríguez García, MD; Sáez-Berlana, A, 1994)
"Twenty-six patients with biopsy-proven Bowen's disease received eight 5-FU iontophoretic treatments in 4 weeks."	( Anderson, LL; Grabski, WJ; McCollough, ML; Menon, PA; Skelton, HG; Smith, KJ; Welch, ML, 1997)
"Large patches of Bowen's disease (intraepidermal carcinoma in situ) can be difficult to treat by conventional methods."	( Ash, DV; Robinson, DJ; Stables, GI; Stringer, MR, 1997)
"A review of the literature for treating Bowen's disease is presented and the problems associated with treating the lower leg emphasized."	( Ball, SB; Dawber, RP, 1998)
"Twenty-nine sites of Bowen's disease in eight patients, confirmed by skin biopsy, were treated with 166Ho patches."	( Bang, D; Chung, YL; Lee, JB; Lee, JD; Lee, MG; Park, KB, 2000)
"Therapy for Bowen's disease is essential to prevent invasive squamous cell carcinoma and metastases."	( Tantikun, N, 2000)
"Large-diameter lesions of Bowen's disease at sites such as the shin may be difficult to treat surgically and may require alternate treatment modalities."	( de Launey, J; Kossard, S; Mackenzie-Wood, A; Owens, ML; Wilkinson, B, 2001)
"We contribute a new case of perianal Bowen's disease, which responded to treatment with imiquimod with no evidence of clinical recurrence after 3 years of follow up."	( Alfaro-Rubio, A; Botella, R; Guillén, C; Hueso, L; Llombart, B; Nagore, E; Requena, C; Sanmartín, O; Serra, C, 2005)
"Five Bowen's disease lesions and 7 invasive SCC lesions on 10 patients were treated with imiquimod once daily 5 times a week for a maximum of 16 weeks."	( Chimenti, S; Fargnoli, MC; Lozzi, GP; Micantonio, T; Peris, K, 2006)
"The response rate of Bowen's disease to MAL-PDT is also at least equivalent to cryotherapy and 5-fluorouracil, again with superior cosmesis."	( Morton, CA, 2007)
"While the standard treatments for Bowen's disease (BD) (surgery, cryotherapy and antimitotic agents) are efficient, they are associated with extensive scarring."	( Bédane, C; Bonnetblanc, JM; Doffoel-Hantz, V; Durox, H; Marin, B; Sparsa, A, 2008)
"The treatment options for Bowen's disease are: cryotherapy, curettage, surgery, topical therapy and radiotherapy."	( Calin, MA; Diaconeasa, A; Savastru, D; Tautan, M, 2011)
"Imiquimod cream, effective in treating Bowen's disease in healthy women, may be a useful postsurgical treatment in immunocompromised women."	( Kaushal, S; Kopparthy, P; Merideth, M; Pulanic, TK; Stratton, P, 2012)
"In general, people with Bowen's disease have an excellent prognosis because the disease is typically slow-growing and responds favourably to treatment."	( Bath-Hextall, FJ; Leonardi-Bee, J; Matin, RN; Wilkinson, D, 2013)
"The high cure rates for Bowen's disease and the principles of photodynamic therapy, suggest that this technique may be a great option in the management of this kind of lesion."	( Caldas, A; Jeunon, T; Marques-da-Costa, J; Ortiz, B; Valente, L; Zink, BS, 2013)
"We report the successful treatment of Bowen disease with ingenol mebutate in a patient being treated with the multikinase inhibitor sunitinib for to metastatic clear cell renal carcinoma."	( Braun, SA; Gerber, PA; Homey, B, 2014)
"We report three Bowen's disease (BD) cases treated with ingenol mebutate (IM), a novel topical chemotherapeutic agent approved for the treatment of actinic keratosis (AK) that is available in two doses: 0."	( Quintana Codina, M; Salleras Redonnet, M, 2016)
"The second case of Bowen's disease was treated with 500 μg IM for 2 consecutive days leading to complete clinical remission."	( Hofbauer, GF; Mohanna, MT, 2016)

Research

Studies (474)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	86 (18.14)	23.3326
1990's	78 (16.46)	12.5806
2000's	160 (33.76)	18.1394
2010's	123 (25.95)	28.8240
2020's	27 (5.70)	9.53

Drug	Relationship Strength	Studies	Trials
dinitrochlorobenzene	low	3	0
aminolevulinic acid	medium	112	25
5-aminovaleric acid	low	1	0
acetic acid	low	2	0
acetone	low	1	0
salicylic acid	low	12	0
cytosine	low	1	0
dimethyl sulfoxide	low	1	0
formaldehyde	low	2	0
niacinamide	low	1	0
2,2'-dipyridyl	low	1	0
azathioprine	low	1	0
clioquinol	low	1	0
deferoxamine	medium	2	1
diclofenac	low	2	0
erythrosine	low	1	0
fluorouracil	medium	49	4
2-propanol	low	1	0
khellin	low	2	0
lomustine	low	1	0
methoxsalen	low	1	0
mitoxantrone	low	1	0
nimesulide	low	1	0
protoporphyrin ix	medium	9	4
tazarotene	low	1	0
tetracaine	medium	1	1
prednisolone	low	1	0
thymidine	low	1	0
prednisone	low	1	0
serine	low	1	0
glutamine	low	1	0
uridine	low	1	0
bromodeoxyuridine	low	2	0
edetic acid	low	1	0
leucine	low	1	0
colchicine	low	3	0
cycloheximide	low	1	0
triaziquone	low	1	0
stearyl alcohol	low	1	0
betamethasone	low	1	0
reticulin	low	1	0
mustard gas	low	3	0
gentian violet	low	1	0
4,4'-bipyridyl	low	1	0
arsenic trioxide	low	1	0
paraquat	low	2	0
thiocholchicine	low	1	0
fluorescein-5-isothiocyanate	low	1	0
azo rubin s	low	1	0
vidarabine	low	1	0
silver	low	1	0
thulium	low	1	0
argon	low	1	0
holmium	medium	3	1
silver nitrate	low	1	0
tetradecanoylphorbol acetate	low	1	0
phenyl acetate	low	3	0
triamcinolone	low	1	0
imiquimod	medium	88	5
cidofovir anhydrous	low	1	0
temoporfin	low	1	0
diphenylcyclopropenone	low	1	0
metaperiodate	low	1	0
fluorodeoxyglucose f18	low	1	0
diflorasone	low	1	0
methotrexate	low	3	0
methyl 5-aminolevulinate	medium	41	8
resiquimod	low	1	0
beta-solamarine	low	1	0
biotin	low	1	0
organophosphonates	low	1	0
demecolcine	low	2	0
glycogen	low	2	0
inositol 3-phosphate	low	2	0
phalloidine	low	1	0
tretinoin	low	3	0
retinol	low	1	0
tacrolimus	low	1	0
keratan sulfate	low	1	0
arsphenamine	low	1	0
bromochloroacetic acid	low	29	0
glycosides	low	1	0
fludarabine	low	1	0
curcumin	low	1	0
sulindac	low	1	0
terbinafine	low	1	0
calcitriol	low	1	0
cucurbitacin i	low	1	0
etretinate	low	6	0
isotretinoin	low	3	0
phenylephrine hydrochloride	low	1	0
acitretin	low	4	0
sirolimus	low	2	0
morphine	low	1	0
clobetasol	low	1	0
arsenic	low	58	0
lewisite	low	1	0
phosphorus	low	1	0
strontium radioisotopes	low	1	0
tetrodotoxin	low	1	0
radium	low	2	0
maxacalcitol	low	1	0
ro 13-6298	low	1	0
involucrin	low	2	0
everolimus	low	1	0
pep005	low	6	0
mart-1 antigen	low	1	0
nystatin a1	low	1	0
podophyllin	low	3	0
sodium borate	low	1	0
kx-01	low	1	0
interleukin-8	low	1	0
heparitin sulfate	low	1	0
transforming growth factor beta	low	3	0
cyclin d1	low	4	0
transforming growth factor alpha	low	1	0
cyclosporine	low	4	0
lewis y antigen	low	1	0
deoxyguanosine	low	2	0
amido black	low	1	0
8-hydroxy-2'-deoxyguanosine	low	2	0
eye	low	2	0
concanavalin a	low	2	0
phosphorus radioisotopes	low	1	0

Protein Targets (1,195)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	17	0	0	17
RAR-related orphan receptor gamma	32	0	0	32
GLI family zinc finger 3	30	0	0	30
AR protein	42	0	0	42
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
retinoic acid nuclear receptor alpha variant 1	30	0	0	30
retinoid X nuclear receptor alpha	29	0	0	29
estrogen nuclear receptor alpha	45	0	0	45
peroxisome proliferator-activated receptor delta	23	0	0	23
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	26	0	0	26
activating transcription factor 6	20	0	0	20
v-jun sarcoma virus 17 oncogene homolog (avian)	19	0	0	19
Histone H2A.x	17	0	0	17
thyroid hormone receptor beta isoform a	12	0	0	12
heat shock protein beta-1	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 1	34	0	0	34
lamin isoform A-delta10	24	0	0	24
Voltage-dependent calcium channel gamma-2 subunit	24	0	0	24
Glutamate receptor 2	25	0	0	25
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
thioredoxin reductase	22	0	0	22
Fumarate hydratase	12	0	0	12
apical membrane antigen 1, AMA1	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	27	0	0	27
progesterone receptor	22	0	0	22
glucocorticoid receptor [Homo sapiens]	32	0	0	32
estrogen-related nuclear receptor alpha	33	0	0	33
farnesoid X nuclear receptor	21	0	0	21
pregnane X nuclear receptor	27	0	0	27
polyprotein	12	0	0	12
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
peroxisome proliferator activated receptor gamma	26	0	0	26
arylsulfatase A	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	27	0	0	27
Caspase-7	6	0	0	6
Bloom syndrome protein isoform 1	14	0	0	14
runt-related transcription factor 1 isoform AML1b	1	0	0	1
chromobox protein homolog 1	18	0	0	18
caspase-3	6	0	0	6
core-binding factor subunit beta isoform 2	1	0	0	1
importin subunit beta-1 isoform 1	6	0	0	6
DNA polymerase beta	5	0	0	5
snurportin-1	6	0	0	6
geminin	41	0	0	41
C-C chemokine receptor type 1	0	1	1	2
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	0	1	0	1
Protein farnesyltransferase subunit beta	0	1	0	1
C-C chemokine receptor type 5	0	1	1	2
C-C chemokine receptor type 8	0	0	1	1
Methionine aminopeptidase 1	0	0	1	1
Deoxyhypusine hydroxylase	0	2	0	2
Transmembrane prolyl 4-hydroxylase	0	1	0	1
ATP-dependent phosphofructokinase	13	0	0	13
ATAD5 protein, partial	16	0	0	16
TDP1 protein	44	0	0	44
Microtubule-associated protein tau	20	0	0	21
vitamin D (1,25- dihydroxyvitamin D3) receptor	23	0	0	23
aryl hydrocarbon receptor	22	0	0	22
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
DNA polymerase iota isoform a (long)	14	0	0	14
Gamma-aminobutyric acid receptor subunit rho-3	0	0	0	1
NFKB1 protein, partial	4	0	0	4
cytochrome P450 2D6 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor 1	0	2	0	2
Glutamate receptor 2	0	2	0	2
Glutamate receptor 3	0	2	0	2
Glutamate receptor ionotropic, kainate 3	1	2	0	3
Solute carrier family 15 member 1	0	2	0	2
Glutamate receptor 4	0	2	0	2
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	0	4	4
Tyrosine-protein kinase Fyn	0	2	4	6
Fibrinogen C domain-containing protein 1	0	1	0	1
thyroid hormone receptor beta isoform 2	30	0	0	30
Luciferase	11	0	0	11
USP1 protein, partial	21	0	0	21
vitamin D3 receptor isoform VDRA	18	0	0	18
flap endonuclease 1	9	0	0	9
serine/threonine-protein kinase PLK1	4	0	0	4
eyes absent homolog 2 isoform a	2	0	0	2
DNA polymerase eta isoform 1	5	0	0	5
peripheral myelin protein 22	25	0	0	25
survival motor neuron protein isoform d	16	0	0	16
histone acetyltransferase KAT2A isoform 1	13	0	0	13
ATP-binding cassette sub-family C member 3	0	20	0	20
Multidrug resistance-associated protein 4	0	20	0	21
Bile salt export pump	0	5	0	5
Bile salt export pump	0	25	0	25
Rap guanine nucleotide exchange factor 3	3	0	0	3
Cellular tumor antigen p53	33	0	0	33
Rap guanine nucleotide exchange factor 4	2	0	0	2
Chain A, Beta-lactamase	10	0	0	10
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	10	0	0	10
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	17	0	0	17
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
Chain A, Ferritin light chain	13	0	0	13
interleukin 8	7	0	0	7
acetylcholinesterase	10	0	0	10
phosphopantetheinyl transferase	13	0	0	13
SMAD family member 2	12	0	0	12
SMAD family member 3	12	0	0	12
thioredoxin glutathione reductase	10	0	0	10
EWS/FLI fusion protein	15	0	0	16
G	14	0	0	14
P53	2	0	0	2
IDH1	16	0	0	16
thyroid stimulating hormone receptor	15	0	0	15
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	3	0	0	3
cellular tumor antigen p53 isoform a	9	0	0	9
cytochrome P450 3A4 isoform 1	15	0	0	15
M-phase phosphoprotein 8	6	0	0	6
muscleblind-like protein 1 isoform 1	10	0	0	10
muscarinic acetylcholine receptor M1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	15	0	0	15
Interferon beta	21	0	0	21
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
Gamma-aminobutyric acid receptor subunit beta-1	15	0	0	15
Gamma-aminobutyric acid receptor subunit delta	15	0	0	15
Gamma-aminobutyric acid receptor subunit gamma-2	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-5	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-3	15	0	0	15
Gamma-aminobutyric acid receptor subunit gamma-1	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-2	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-4	15	0	0	15
Gamma-aminobutyric acid receptor subunit gamma-3	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-6	15	0	0	15
Nuclear receptor ROR-gamma	11	1	1	13
Gamma-aminobutyric acid receptor subunit alpha-1	15	0	0	15
Gamma-aminobutyric acid receptor subunit beta-3	15	0	0	15
Gamma-aminobutyric acid receptor subunit beta-2	15	0	0	15
GABA theta subunit	15	0	0	15
Inositol hexakisphosphate kinase 1	14	0	0	14
Canalicular multispecific organic anion transporter 1	0	18	0	18
ATPase family AAA domain-containing protein 5	20	0	0	20
Ataxin-2	21	0	0	21
Gamma-aminobutyric acid receptor subunit epsilon	15	0	0	15
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	14	0	0	14
pregnane X receptor	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	17	0	0	17
nuclear factor erythroid 2-related factor 2 isoform 2	18	0	0	18
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	9	2	16
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
nonstructural protein 1	0	2	0	2
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	9	0	0	9
plasminogen precursor	9	0	0	9
urokinase plasminogen activator surface receptor precursor	9	0	0	9
Thymidine kinase, cytosolic	0	4	0	8
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Spike glycoprotein	8	0	1	9
Thymidine kinase	0	0	0	3
Thymidylate kinase	0	2	0	2
estrogen receptor 2 (ER beta)	17	0	0	17
DNA polymerase kappa isoform 1	12	0	0	12
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
PPM1D protein	8	0	0	8
mitogen-activated protein kinase 1	12	0	0	12
nuclear receptor ROR-gamma isoform 1	17	0	0	17
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	3	1	5
Cytochrome P450 3A4	0	11	2	14
Androgen receptor	0	3	0	3
Cytochrome P450 2D6	0	5	1	6
Vitamin D3 receptor	0	1	3	5
Cytochrome P450 2C9	0	7	1	10
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	3	3	6
Cytochrome P450 2C19	0	4	1	5
Kappa-type opioid receptor	0	2	1	3
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Thymidine kinase	0	2	0	3
Solute carrier family 22 member 6	0	1	0	2
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Solute carrier family 22 member 6	0	3	0	5
Chain A, Cruzipain	8	0	0	8
glp-1 receptor, partial	10	0	0	10
mu opioid receptor, partial	0	0	1	1
15-lipoxygenase, partial	7	0	0	7
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
Smad3	10	0	0	10
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
regulator of G-protein signaling 4	7	0	0	7
nonstructural protein 1	4	0	0	4
LAP4	0	0	1	1
MEP2	0	0	1	1
polyunsaturated fatty acid lipoxygenase ALOX12	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
delta-type opioid receptor	0	1	1	2
kappa-type opioid receptor isoform 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
huntingtin isoform 2	6	0	0	6
nuclear factor NF-kappa-B p105 subunit isoform 1	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
Histone deacetylase 3	0	2	0	2
Carbonic anhydrase 12	0	1	0	2
Carbonic anhydrase 1	0	4	0	6
Carbonic anhydrase 2	0	4	1	7
Amyloid-beta precursor protein	2	5	0	8
Integrin beta-3	5	0	0	5
Carbonic anhydrase 3	0	1	0	2
Integrin alpha-IIb	5	0	0	5
Botulinum neurotoxin type A	0	1	0	1
Spike glycoprotein	0	1	0	1
Alpha-1B adrenergic receptor	0	7	1	8
Catechol O-methyltransferase	0	1	0	1
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 6	0	1	0	2
Alpha-1D adrenergic receptor	0	2	1	3
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Alpha-synuclein	4	4	1	9
Alpha-1A adrenergic receptor	0	7	1	8
Carbonic anhydrase 7	0	1	0	2
Histone deacetylase 4	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
TAR DNA-binding protein 43	6	1	0	7
Histone deacetylase 1	0	3	0	3
Carbonic anhydrase 9	0	3	0	4
Beta-galactosidase	0	0	1	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Carbonic anhydrase 15	0	2	0	2
Histone deacetylase 8	0	3	0	3
Carbonic anhydrase 13	0	1	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Carbonic anhydrase 14	0	1	0	2
Histone deacetylase 5	0	2	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
heat shock protein 90, putative	0	0	0	2
endonuclease IV	2	0	0	2
PAX8	0	0	0	3
Thrombopoietin	3	0	0	3
thyroid stimulating hormone receptor	7	0	0	7
67.9K protein	16	0	0	16
glucocerebrosidase	3	0	0	3
nuclear receptor subfamily 0 group B member 1	0	3	0	3
cytochrome P450 2C19 precursor	5	0	0	5
cytochrome P450 2C9 precursor	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
ras-related protein Rab-9A	4	0	0	4
steroidogenic factor 1	0	3	0	3
caspase-1 isoform alpha precursor	3	0	0	3
lethal factor (plasmid)	7	0	0	7
neuropeptide S receptor isoform A	4	0	0	4
Solute carrier family 22 member 3	0	2	0	2
Tubulin alpha-1A chain	0	5	2	7
Tubulin beta chain	0	4	2	6
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	4	4	10
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	4	4	10
ATP-dependent translocase ABCB1	0	4	0	5
Tubulin alpha-3C chain	0	4	4	10
Serine/threonine-protein kinase pim-1	0	1	3	4
ATP-dependent translocase ABCB1	0	2	0	2
Histamine H2 receptor	10	0	0	10
Tubulin alpha-1B chain	0	4	4	10
Tubulin alpha-4A chain	0	4	4	10
Tubulin beta-4B chain	0	4	4	10
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	4	4	10
Tubulin beta-2A chain	0	4	4	10
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	4	4	10
Tubulin beta-2B chain	0	5	0	5
Tubulin alpha-3E chain	0	4	4	10
Tubulin alpha-1A chain	0	4	4	10
Similar to alpha-tubulin isoform 1	0	3	0	3
Similar to alpha-tubulin isoform 1	0	3	0	3
CREB-binding protein	1	1	0	2
Tubulin alpha-1C chain	0	4	4	10
Tubulin beta-6 chain	0	4	4	10
Tubulin beta-2B chain	0	4	4	10
Tubulin beta-1 chain	0	4	4	10
Integrin alpha-L	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Nrf2	1	0	0	1
GLS protein	8	0	0	8
alkaline phosphatase, intestinal	0	1	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
PINK1	1	0	0	1
Parkin	4	0	0	4
toll-like receptor 9	0	1	0	1
caspase-3	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
TPA: protein transporter TIM10	0	1	0	1
thyrotropin-releasing hormone receptor	5	0	0	5
lysosomal alpha-glucosidase preproprotein	2	0	0	2
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
perilipin-5	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
perilipin-1	0	1	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
pyruvate kinase PKM isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
hypothetical protein SA1422	0	1	0	1
Prostaglandin E synthase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
Acetylcholinesterase	0	3	0	3
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	3	0	3
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Cholinesterase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
60 kDa chaperonin	0	4	0	4
Replicase polyprotein 1ab	0	2	2	4
Replicase polyprotein 1ab	0	2	2	4
Microtubule-associated protein tau	0	1	0	2
60 kDa heat shock protein, mitochondrial	0	4	0	4
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tissue factor	0	2	0	2
Tyrosinase	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Amine oxidase [flavin-containing] A	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Acetylcholinesterase	0	4	0	4
Heme oxygenase 2	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Prostaglandin G/H synthase 2	0	6	0	6
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	3	4
Caspase-7	2	0	0	2
Beta-secretase 1	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	4	0	4
Guanine nucleotide-binding protein G	4	0	0	4
Cholinesterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Lactoylglutathione lyase	0	2	0	2
Histone acetyltransferase p300	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
5-hydroxytryptamine receptor 4	0	0	1	1
Sodium/bile acid cotransporter	0	0	1	1
Nuclear factor erythroid 2-related factor 2	0	0	1	1
Thiosulfate sulfurtransferase	0	4	0	4
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
60 kDa chaperonin	0	4	0	4
10 kDa chaperonin	0	4	0	4
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	6
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
RPL19A	0	0	1	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
COUP transcription factor 2 isoform a	0	1	0	1
Transmembrane protease serine 2	0	0	1	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	1	1	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	6	2	8
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	3	1	4
Hypoxia-inducible factor 1-alpha	0	1	1	2
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Lysine-specific demethylase 4A	0	1	0	1
Methylcytosine dioxygenase TET2	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Deoxycytidine kinase	0	0	3	4
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	2	0	2
Aldo-keto reductase family 1 member B10	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	3	0	4
Cytochrome c oxidase subunit 2	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Transthyretin	0	0	1	3
Albumin	0	4	1	5
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	1	0	3
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	4	0	4
Vpr	4	0	0	4
Glutathione S-transferase omega-1	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
hypothetical protein, conserved	3	0	0	3
cytochrome P450 2D6	9	0	0	9
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	3	3
Cell division cycle 7-related protein kinase	0	0	2	2
Serine/threonine-protein kinase PLK4	0	0	3	3
ATP-dependent RNA helicase DDX3X	0	0	3	3
Pyridoxal kinase	0	0	3	3
Citron Rho-interacting kinase	0	0	3	3
Serine/threonine-protein kinase Chk1	0	0	3	3
Aurora kinase A	0	0	3	3
Cyclin-G-associated kinase	0	0	3	3
Ephrin type-B receptor 6	0	0	3	3
Peroxisomal acyl-coenzyme A oxidase 3	0	0	3	3
Receptor-interacting serine/threonine-protein kinase 2	0	0	3	3
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	3	3
Dynamin-like 120 kDa protein, mitochondrial	0	0	3	3
Eukaryotic translation initiation factor 5B	0	0	3	3
Rho-associated protein kinase 2	0	0	3	3
Serine/threonine-protein kinase ULK1	0	0	3	3
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	3	3
Ribosomal protein S6 kinase alpha-5	0	0	3	3
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	3	3
Ribosomal protein S6 kinase alpha-4	0	0	3	3
Serine/threonine-protein kinase 16	0	0	3	3
Serine/threonine-protein kinase 10	0	0	3	3
Serine/threonine-protein kinase D3	0	0	5	5
Structural maintenance of chromosomes protein 2	0	0	3	3
Mitogen-activated protein kinase kinase kinase 6	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	3	3
Serine/threonine-protein kinase LATS1	0	0	3	3
Serine/threonine-protein kinase PAK 4	0	0	3	3
Tyrosine-protein kinase ABL1	0	2	4	6
Epidermal growth factor receptor	0	4	3	7
High affinity nerve growth factor receptor	0	0	3	3
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	3	3
Protein kinase C beta type	0	1	5	6
Insulin receptor	0	0	3	3
Cyclin-dependent kinase 1	0	0	3	3
Glycogen phosphorylase, liver form	0	0	3	3
Tyrosine-protein kinase Fes/Fps	0	0	3	3
Adenine phosphoribosyltransferase	0	0	3	3
Tyrosine-protein kinase Yes	0	0	3	3
Tyrosine-protein kinase Lyn	0	1	3	4
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	3	3
Insulin-like growth factor 1 receptor	0	0	3	3
Signal recognition particle receptor subunit alpha	0	0	3	3
Cytochrome c1, heme protein, mitochondrial	0	0	3	3
Hepatocyte growth factor receptor	0	0	3	3
Tyrosine-protein kinase HCK	0	0	3	3
Platelet-derived growth factor receptor beta	0	0	3	3
Tyrosine-protein kinase Fgr	0	0	3	3
Serine/threonine-protein kinase A-Raf	0	0	3	3
Glycogen phosphorylase, brain form	0	0	3	3
Breakpoint cluster region protein	0	2	3	5
Fibroblast growth factor receptor 1	0	0	3	3
DNA topoisomerase 2-alpha	0	1	3	5
Cyclin-dependent kinase 4	0	0	3	3
ADP/ATP translocase 3	0	0	3	3
Inosine-5'-monophosphate dehydrogenase 2	0	0	3	3
Proto-oncogene tyrosine-protein kinase Src	0	2	3	5
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	3	3
Serine/threonine-protein kinase B-raf	0	0	3	3
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	3	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	3	3
Tyrosine-protein kinase Fer	0	0	3	3
Protein kinase C alpha type	0	1	5	6
cAMP-dependent protein kinase catalytic subunit alpha	0	0	3	3
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	3	3
Casein kinase II subunit alpha'	0	1	3	4
Ras-related protein Rab-6A	0	0	3	3
Ephrin type-A receptor 1	0	0	3	3
Multifunctional protein ADE2	0	0	3	3
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	3	3
Ferrochelatase, mitochondrial	0	0	3	3
Ribosomal protein S6 kinase beta-1	0	0	3	3
Tyrosine-protein kinase JAK1	0	0	3	3
Cyclin-dependent kinase 2	0	0	4	4
Beta-adrenergic receptor kinase 1	0	0	3	3
Probable ATP-dependent RNA helicase DDX6	0	0	3	3
Mitogen-activated protein kinase 3	0	0	3	3
MAP/microtubule affinity-regulating kinase 3	0	0	3	3
Mitogen-activated protein kinase 1	0	2	3	5
Ephrin type-A receptor 2	0	0	3	3
Ephrin type-B receptor 2	0	0	3	3
Non-receptor tyrosine-protein kinase TYK2	0	0	3	3
UMP-CMP kinase	0	0	3	3
Phosphatidylethanolamine-binding protein 1	0	0	3	3
Wee1-like protein kinase	0	0	3	3
Heme oxygenase 2	0	0	3	3
S-adenosylmethionine synthase isoform type-2	0	0	3	3
DnaJ homolog subfamily A member 1	0	0	3	3
RAC-alpha serine/threonine-protein kinase	0	0	3	3
RAC-beta serine/threonine-protein kinase	0	0	3	3
Dual specificity protein kinase TTK	0	0	2	2
DNA replication licensing factor MCM4	0	0	3	3
Myosin-10	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 2	0	0	3	3
Receptor-type tyrosine-protein kinase FLT3	0	0	3	3
Bone morphogenetic protein receptor type-1A	0	0	3	3
Activin receptor type-1B	0	0	3	3
TGF-beta receptor type-1	0	0	3	3
TGF-beta receptor type-2	0	0	3	3
Electron transfer flavoprotein subunit beta	0	0	3	3
Tyrosine-protein kinase CSK	0	0	3	3
Glycine--tRNA ligase	0	0	3	3
Protein kinase C iota type	0	0	5	5
Exosome RNA helicase MTR4	0	0	3	3
Serine/threonine-protein kinase mTOR	0	3	2	5
Tyrosine-protein kinase Tec	0	0	3	3
Tyrosine-protein kinase ABL2	0	0	3	3
Tyrosine-protein kinase FRK	0	0	3	3
G protein-coupled receptor kinase 6	0	0	3	3
Tyrosine-protein kinase SYK	0	0	3	3
26S proteasome regulatory subunit 6B	0	0	3	3
Mitogen-activated protein kinase 8	0	0	3	3
Mitogen-activated protein kinase 9	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 3	0	0	3	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	3	3
Casein kinase I isoform alpha	0	0	3	3
Casein kinase I isoform delta	0	0	3	3
MAP kinase-activated protein kinase 2	0	0	3	3
Elongation factor Tu, mitochondrial	0	0	3	3
Choline-phosphate cytidylyltransferase A	0	0	3	3
Cysteine--tRNA ligase, cytoplasmic	0	0	3	3
Casein kinase I isoform epsilon	0	0	3	3
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	3	3
Dual specificity protein kinase CLK1	0	0	3	3
Dual specificity protein kinase CLK2	0	0	3	3
Dual specificity protein kinase CLK3	0	0	3	3
Glycogen synthase kinase-3 alpha	0	0	3	3
Cyclin-dependent kinase 7	0	0	3	3
Cyclin-dependent kinase 9	0	0	3	3
Ras-related protein Rab-27A	0	0	3	3
Interleukin-1 receptor-associated kinase 1	0	0	3	3
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Ribosomal protein S6 kinase alpha-3	0	0	3	3
Serine/threonine-protein kinase Nek2	0	0	3	3
Serine/threonine-protein kinase Nek3	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 6	0	0	3	3
Serine/threonine-protein kinase PLK1	0	0	3	3
LIM domain kinase 1	0	0	3	3
LIM domain kinase 2	0	0	3	3
Mitogen-activated protein kinase 10	0	0	3	3
Tyrosine--tRNA ligase, cytoplasmic	0	0	3	3
5'-AMP-activated protein kinase subunit gamma-1	0	0	3	4
Ephrin type-B receptor 3	0	0	3	3
Ephrin type-A receptor 5	0	0	3	3
Ephrin type-B receptor 4	0	0	3	3
Ephrin type-A receptor 4	0	0	3	3
Adenylate kinase 2, mitochondrial	0	0	3	3
Adenosine kinase	0	0	3	3
Ras-related protein Rab-10	0	0	3	3
Actin-related protein 3	0	0	3	3
Actin-related protein 2	0	0	3	3
GTP-binding nuclear protein Ran	0	0	3	3
Casein kinase I isoform gamma-2	0	0	3	3
Cyclin-dependent kinase 3	0	0	2	2
Cyclin-dependent kinase 6	0	0	3	3
Cyclin-dependent-like kinase 5	0	0	3	3
Cyclin-dependent kinase 16	0	0	3	3
Cyclin-dependent kinase 17	0	0	3	3
ATP-dependent 6-phosphofructokinase, platelet type	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 1	0	0	3	3
DNA topoisomerase 2-beta	0	0	3	4
Protein kinase C theta type	0	0	5	5
Activin receptor type-1	0	0	3	3
Macrophage-stimulating protein receptor	0	0	3	3
Focal adhesion kinase 1	0	0	3	3
Protein kinase C delta type	0	1	5	6
Tyrosine-protein kinase BTK	0	1	3	4
Activated CDC42 kinase 1	0	0	3	3
Epithelial discoidin domain-containing receptor 1	0	0	3	3
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	3	3
Serine/threonine-protein kinase 4	0	0	3	3
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	3	4
Dual specificity mitogen-activated protein kinase kinase 5	0	0	3	3
Mitogen-activated protein kinase 7	0	0	3	3
Serine/threonine-protein kinase PAK 2	0	0	3	3
Serine/threonine-protein kinase 3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 1	0	0	3	3
Integrin-linked protein kinase	0	0	3	3
Rho-associated protein kinase 1	0	0	3	3
Non-receptor tyrosine-protein kinase TNK1	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	3	3
Activin receptor type-2B	0	0	3	3
Bone morphogenetic protein receptor type-2	0	0	3	3
Protein-tyrosine kinase 6	0	0	3	3
cGMP-dependent protein kinase 1	0	0	3	3
Cyclin-dependent kinase 13	0	0	3	3
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	3	3
Protein-tyrosine kinase 2-beta	0	0	3	3
Sodium channel protein type 5 subunit alpha	0	2	0	2
Maternal embryonic leucine zipper kinase	0	0	3	3
Structural maintenance of chromosomes protein 1A	0	0	3	3
Chromodomain-helicase-DNA-binding protein 4	0	0	3	3
Peroxisomal acyl-coenzyme A oxidase 1	0	0	3	3
Ephrin type-A receptor 7	0	0	2	2
Delta(24)-sterol reductase	0	0	3	3
Ribosomal protein S6 kinase alpha-1	0	0	3	3
Dual specificity testis-specific protein kinase 1	0	0	3	3
Myosin light chain kinase, smooth muscle	0	0	3	3
Mitogen-activated protein kinase 11	0	0	3	3
Serine/threonine-protein kinase STK11	0	0	3	3
Serine/threonine-protein kinase N1	0	0	3	3
Serine/threonine-protein kinase N2	0	0	3	3
Mitogen-activated protein kinase 14	0	1	3	4
Calcium/calmodulin-dependent protein kinase type IV	0	0	3	3
Mitogen-activated protein kinase kinase kinase 11	0	0	3	3
Discoidin domain-containing receptor 2	0	0	3	3
AP2-associated protein kinase 1	0	0	3	3
Myosin light chain kinase 3	0	0	3	3
Putative heat shock protein HSP 90-beta 2	0	0	3	3
Serine/threonine-protein kinase MRCK alpha	0	0	3	3
Serine/threonine-protein kinase MRCK gamma	0	0	3	3
Acyl-CoA dehydrogenase family member 10	0	0	3	3
Serine/threonine-protein kinase N3	0	0	2	2
Serine/threonine-protein kinase ULK3	0	0	3	3
Uncharacterized protein FLJ45252	0	0	3	3
Acyl-CoA dehydrogenase family member 11	0	0	3	3
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	3	3
Serine/threonine-protein kinase MARK2	0	0	3	3
ATP-dependent RNA helicase DHX30	0	0	3	3
Serine/threonine-protein kinase TAO1	0	0	3	3
STE20-related kinase adapter protein alpha	0	0	3	3
Myosin-14	0	0	3	3
AarF domain-containing protein kinase 1	0	0	3	3
ATP-dependent RNA helicase DDX42	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	3	3
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	2	2
Regulatory-associated protein of mTOR	0	2	0	2
Atypical kinase COQ8A, mitochondrial	0	0	3	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	3	3
Mitogen-activated protein kinase 15	0	0	3	3
Serine/threonine-protein kinase Nek9	0	0	3	3
Serine/threonine-protein kinase Nek7	0	0	2	2
ATP-dependent RNA helicase DDX1	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	3	3
Aurora kinase B	0	0	3	3
MAP/microtubule affinity-regulating kinase 4	0	0	3	3
Serine/threonine-protein kinase Nek1	0	0	3	3
PAS domain-containing serine/threonine-protein kinase	0	0	3	3
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	3	3
EKC/KEOPS complex subunit TP53RK	0	0	3	3
Dual specificity testis-specific protein kinase 2	0	0	3	3
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	3	3
Mitogen-activated protein kinase kinase kinase 5	0	0	3	3
Mitogen-activated protein kinase kinase kinase 3	0	0	3	3
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	3	3
Target of rapamycin complex subunit LST8	0	2	0	2
Nucleolar GTP-binding protein 1	0	0	3	3
Serine/threonine-protein kinase D2	0	0	3	3
NUAK family SNF1-like kinase 2	0	0	2	2
RNA cytidine acetyltransferase	0	0	3	3
Serine/threonine-protein kinase SIK2	0	0	3	3
STE20-like serine/threonine-protein kinase	0	0	3	3
Serine/threonine-protein kinase TAO3	0	0	3	3
dCTP pyrophosphatase 1	0	0	3	3
Dual specificity protein kinase CLK4	0	0	3	3
Casein kinase I isoform gamma-1	0	0	3	3
Phenylalanine--tRNA ligase beta subunit	0	0	3	3
BMP-2-inducible protein kinase	0	0	3	3
Obg-like ATPase 1	0	0	3	3
Midasin	0	0	3	3
Interleukin-1 receptor-associated kinase 4	0	0	3	3
Mitogen-activated protein kinase kinase kinase 20	0	0	3	3
Cyclin-dependent kinase 12	0	0	3	3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	2	2
Serine/threonine-protein kinase 26	0	0	3	3
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	3	3
Serine/threonine-protein kinase NLK	0	0	3	3
5'-AMP-activated protein kinase subunit gamma-2	0	0	3	4
Serine/threonine-protein kinase TBK1	0	0	3	3
Septin-9	0	0	3	3
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Ribosomal protein S6 kinase alpha-6	0	0	3	3
TRAF2 and NCK-interacting protein kinase	0	0	3	3
Serine/threonine-protein kinase TAO2	0	0	3	3
Long-chain-fatty-acid--CoA ligase 5	0	0	2	2
RAC-gamma serine/threonine-protein kinase	0	0	3	3
Serine/threonine-protein kinase SIK3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 2	0	0	3	3
Thyroid hormone receptor-associated protein 3	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	3	3
Receptor-interacting serine/threonine-protein kinase 3	0	0	3	3
Serine/threonine-protein kinase MRCK beta	0	0	3	3
Interleukin-1 receptor-associated kinase 3	0	0	3	3
Casein kinase I isoform gamma-3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 4	0	0	3	3
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
5'-nucleotidase	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine deaminase	0	0	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	3	0	4
Aromatase	0	2	0	2
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
alpha synuclein, partial	1	0	0	1
luciferase	2	0	0	2
tumor necrosis factor	1	0	0	1
histone deacetylase 9 isoform 3	2	0	0	2
Solute carrier family 22 member 1	0	2	0	3
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	4	1	5
Adenosine receptor A3	0	6	0	6
Muscarinic acetylcholine receptor M1	0	4	0	4
D(2) dopamine receptor	0	2	0	2
Androgen receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Histamine H2 receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
Adenosine receptor A2a	0	4	0	4
Mu-type opioid receptor	0	4	1	6
D(3) dopamine receptor	0	3	0	3
Kappa-type opioid receptor	0	4	1	6
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Fatty-acid amide hydrolase 1	1	1	0	2
Inositol monophosphatase 1	3	0	0	3
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Leukotriene B4 receptor 1	1	0	0	1
Glutamate receptor ionotropic, kainate 5	1	0	0	1
Leukotriene B4 receptor 2	1	0	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Amino acid transporter	0	2	0	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Dopamine beta-hydroxylase	0	1	0	1
Corticotropin-releasing factor receptor 1	0	1	0	1
Cystathionine beta-synthase	0	1	0	1
Glutathione reductase	0	1	0	1
Integrase	0	2	0	2
5-lipoxygenase	0	1	0	1
Cysteine protease ATG4B	0	1	0	1
Thioredoxin reductase 2, mitochondrial	0	1	0	1
7,8-dihydro-8-oxoguanine triphosphatase	0	2	0	2
Toll-like receptor 8	0	0	2	4
Toll-like receptor 7	0	0	2	4
Ornithine decarboxylase	0	0	0	2
Retinoic acid receptor alpha	0	2	2	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
5-hydroxytryptamine receptor 2B	0	4	0	4
Cellular retinoic acid-binding protein 1	0	0	2	2
Olfactory receptor 51E2	0	1	0	1
GALC protein	2	0	0	2
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1B1	0	1	0	1
Membrane-associated progesterone receptor component 1	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	2	2
Tyrosine-protein kinase ABL1	0	1	0	1
Serine/threonine-protein kinase receptor R3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Protein kinase C zeta type	0	0	4	4
Serine/threonine-protein kinase 38	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	2	2
Rab-like protein 3	0	0	1	1
Breakpoint cluster region protein	0	1	0	1
MAP kinase-activated protein kinase 5	0	0	2	2
Misshapen-like kinase 1	0	0	2	2
Isoleucine--tRNA ligase, mitochondrial	0	0	2	2
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	2	2
Serine/threonine-protein kinase 38-like	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	2	2
Serine/threonine-protein kinase 24	0	0	2	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	3
Phospholipase A-2-activating protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	3
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	2	0	0	2
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	3	0	0	3
Thymidylate synthase	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	1	0	2
Delta-type opioid receptor	0	3	1	5
Mu-type opioid receptor	0	3	1	7
Kappa-type opioid receptor	0	3	1	5
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier family 22 member 11	0	0	0	1
Polyphenol oxidase 2	0	1	1	3
Cytochrome P450 2A6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
WRN	2	0	0	2
DNA polymerase III, partial	1	0	0	1
LANA	0	0	0	1
pyruvate kinase	2	0	0	2
phospholipase A2, group III	0	1	0	1
interferon gamma precursor	0	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
protein AF-9 isoform a	0	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Glycoprotein hormones alpha chain	1	0	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Proto-oncogene tyrosine-protein kinase ROS	0	1	0	1
Ornithine decarboxylase	1	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
DNA topoisomerase 2	0	0	0	1
Sodium-dependent noradrenaline transporter	0	4	1	5
5-hydroxytryptamine receptor 2C	0	4	0	4
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
Single-stranded DNA cytosine deaminase	2	0	0	2
P2Y purinoceptor 12	0	1	0	1
phosphoglycerate kinase	2	0	0	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	2
Kappa-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Beta-2 adrenergic receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	5	0	5
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Interstitial collagenase	0	1	0	1
Myeloperoxidase	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Glutamate receptor 1	2	0	0	2
Glutamate receptor 3	2	0	0	2
Glutamate receptor 4	2	0	0	2
Photosystem I iron-sulfur center	0	0	0	1
Protein kinase C gamma type	0	1	2	3
Protein kinase C eta type	0	0	2	2
Protein kinase C epsilon type	0	1	2	3
Serine/threonine-protein kinase D1	0	0	2	2
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Regulatory protein E2	0	0	1	1
Regulatory protein E2	0	0	1	1
Regulatory protein E2	0	0	1	1
Calcium-activated potassium channel subunit alpha-1	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	2	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
SUMO-1	0	1	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
POsterior Segregation	0	0	1	1
chaperonin GroEL	1	0	0	1
Exoribonuclease H	0	1	0	1
Coproheme decarboxylase	0	0	1	1
Protease	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Pyruvate kinase PKM	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Cyclin-dependent kinase 18	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
D(1A) dopamine receptor	1	0	0	1
Acetylcholinesterase	0	1	0	1
Complement C5	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Retinoic acid receptor alpha	0	2	3	8
Retinoic acid receptor beta	0	2	3	8
Retinoic acid receptor gamma	0	2	3	8
cystic fibrosis transmembrane conductance regulator	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
cGMP-gated cation channel alpha-1	0	0	1	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Luciferin 4-monooxygenase	0	0	1	1
Beta-1 adrenergic receptor	0	1	0	1
Ras guanyl-releasing protein 3	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Cytidine deaminase	0	1	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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