Indophenyl acetate is a synthetic compound that has been studied for its potential applications in various fields, including medicine and materials science. It is a derivative of indophenol, a dye known for its color-changing properties. Indophenyl acetate itself is a colorless compound that exhibits a characteristic blue color upon hydrolysis, making it useful as a pH indicator. The compound is typically synthesized by reacting indophenol with acetic anhydride. Research on indophenyl acetate has focused on its potential as a marker for enzyme activity, particularly in the context of cholinesterase inhibition. The hydrolysis of indophenyl acetate by cholinesterase enzymes produces a colored product that can be measured spectrophotometrically, allowing for the assessment of enzyme activity. This property has led to the use of indophenyl acetate in studies investigating cholinesterase inhibitors, which are potential treatments for Alzheimer's disease and other neurological disorders.'
| ID Source | ID |
|---|---|
| PubMed CID | 82195 |
| CHEMBL ID | 3276936 |
| SCHEMBL ID | 10802302 |
| MeSH ID | M0066564 |
| Synonym |
|---|
| indophenol, acetate (ester) |
| nsc89187 |
| nsc-89187 |
| 2, 4-[[4-(acetyloxy)phenyl]imino]- |
| indolphenol acetate |
| 7761-80-0 |
| 2,5-cyclohexadien-1-one, 4-((4-(acetyloxy)phenyl)imino)- |
| nsc 89187 |
| i0h60v4i6s , |
| unii-i0h60v4i6s |
| 4-((4-oxocyclohexa-2,5-dien-1-yl)imino)phenyl acetate |
| einecs 231-852-3 |
| indophenol acetate |
| NCIOPEN2_005576 |
| indophenyl acetate |
| 4-((4-(acetyloxy)phenyl)imino)-2,5-cyclohexadien-1-one |
| [4-[(4-oxocyclohexa-2,5-dien-1-ylidene)amino]phenyl] acetate |
| FT-0636592 |
| 4-[(4-oxocyclohexa-2,5-dien-1-ylidene)amino]phenyl acetate |
| CHEMBL3276936 |
| 2,5-cyclohexadien-1-one, 4-[[4-(acetyloxy)phenyl]imino]- |
| DTXSID1064794 |
| AKOS024288229 |
| SCHEMBL10802302 |
| indophenolacetate |
| 4-(4-oxocyclohexa-2,5-dienylideneamino)phenyl acetate |
| indophenol, acetate |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1148227 | Antitumor activity against mouse Sarcoma 180 cells allografted in Swiss mouse assessed as weight gain at 20 mg/kg, ip three doses were given at 24 hrs interval starting 24 hrs after allograft injection measured after 3 days relative to control | 1978 | Journal of medicinal chemistry, Jan, Volume: 21, Issue:1 | Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice. |
| AID1148286 | Antitumor activity against mouse Sarcoma 180 cells allografted in Swiss mouse at 20 mg/kg, ip three doses were given at 24 hrs interval starting 24 hrs after allograft injection relative to control | 1978 | Journal of medicinal chemistry, Jan, Volume: 21, Issue:1 | Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice. |
| AID1148236 | Antitumor activity against mouse Sarcoma 180 cells allografted in Swiss mouse assessed as survival at 20 mg/kg, ip three doses were given at 24 hrs interval starting 24 hrs after allograft injection measured after 5 days | 1978 | Journal of medicinal chemistry, Jan, Volume: 21, Issue:1 | Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice. |
| AID1148271 | Antitumor activity against mouse Sarcoma 180 cells allografted in Swiss mouse assessed as survival time at 20 mg/kg, ip three doses were given at 24 hrs interval starting 24 hrs after allograft injection relative to control | 1978 | Journal of medicinal chemistry, Jan, Volume: 21, Issue:1 | Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice. |
| AID1148298 | Redox potential of the compound in octanol-water solution | 1978 | Journal of medicinal chemistry, Jan, Volume: 21, Issue:1 | Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice. |
| AID1148232 | Acute toxicity in single ip dosed Swiss mouse assessed as death up to 5 days | 1978 | Journal of medicinal chemistry, Jan, Volume: 21, Issue:1 | Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice. |
| AID1148261 | Antitumor activity against mouse Sarcoma 180 cells allografted in Swiss mouse assessed as cure at 20 mg/kg, ip three doses were given at 24 hrs interval starting 24 hrs after allograft injection measured after 60 days | 1978 | Journal of medicinal chemistry, Jan, Volume: 21, Issue:1 | Nitrogen analogues of 1,4-benzoquinones. Activities against the ascitic sarcoma 180 of mice. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (17.75) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||