diphetarsone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

diphetarsone: RN given refers to di-Na salt in Chemline [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	68198
SCHEMBL ID	160476
MeSH ID	M0114443

Synonyms (15)

Synonym
diphetarsone
515-76-4
n,n-ethylenediarsanilic acid disodium salt
einecs 208-209-0
difetarsone disodium
unii-ksf0s7w3i7
ksf0s7w3i7 ,
SCHEMBL160476
diphetarsone [mi]
disodium n,n'-ethylenebis(4-aminophenylarsonate)
anhydrous difetarsone sodium [mart.]
arsonic acid, (1,2-ethanediylbis(imino-4,1-phenylene))bis-, disodium salt
difetarsone sodium [who-dd]
disodium;hydroxy-[4-[2-[4-[hydroxy(oxido)arsoryl]anilino]ethylamino]phenyl]arsinate
Q27282411

Research Excerpts

Overview

Diphetarsone is an arsenical used in the treatment of intestinal amoebiasis and trichuriasis.

Excerpt	Reference	Relevance
"Diphetarsone is an arsenical used in the treatment of intestinal amoebiasis and trichuriasis. "	( Angioedema due to diphetarsone and a review of its toxicity. Keystone, JS; Krajden, S; McIntyre, L, 1983)	2.04

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (75.00)	18.7374
1990's	2 (25.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	19.56 (24.57)
Research Supply Index	2.40 (2.92)
Research Growth Index	4.32 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (19.56)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	4 (40.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (60.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
amodiaquine Amodiaquine: A 4-aminoquinoline compound with anti-inflammatory properties.. amodiaquine : A quinoline having a chloro group at the 7-position and an aryl amino group at the 4-position.	1.93	1	aminoquinoline; organochlorine compound; phenols; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; drug allergen; EC 2.1.1.8 (histamine N-methyltransferase) inhibitor; non-steroidal anti-inflammatory drug; prodrug
penicillin n penicillin N: RN given refers to (2S-(2alpha,5alpha,6beta(S*)))-isomer; structure in Merck, 9th ed, #6887	1.93	1	penicillin
azacrin azacrin: structure	1.93	1
methymycin methymycin: structure. methymycin : A twelve-membered macrolide antibiotic that is biosynthesised by Streptomyces venezuelae.	1.93	1	enone; macrolide antibiotic; monosaccharide derivative	bacterial metabolite
arsenic Arsenic: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)	3.45	8	metalloid atom; pnictogen	micronutrient
tetracycline Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.	1.93	1

Condition	Relationship Strength	Studies
Infection, Toxoplasma gondii [description not available]	1.93	1
Toxoplasmosis The acquired form of infection by Toxoplasma gondii in animals and man.	1.93	1
Abscess, Amebic [description not available]	3.03	5
Dysentery Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.	2.85	4
Entamoeba histolytica Infection [description not available]	3.33	7
Amebiasis, Intestinal [description not available]	2.85	4
Amebiasis Infection with any of various amebae. It is an asymptomatic carrier state in most individuals, but diseases ranging from chronic, mild diarrhea to fulminant dysentery may occur.	3.03	5
Aspiculariasis [description not available]	1.93	1
Trichocephaliasis [description not available]	1.96	1
Trichuriasis Infection with nematodes of the genus TRICHURIS, formerly called Trichocephalus.	6.96	1
Angioneurotic Edema [description not available]	1.96	1
Angioedema Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.	6.96	1
Abscess, Amebic, Hepatic [description not available]	1.98	1
Acute Liver Injury, Drug-Induced [description not available]	2.38	2
Bile Duct Obstruction [description not available]	1.98	1
Cholestasis Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).	1.98	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.38	2

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