Cacchi Ricci Disease

A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.

Synonym
Cacchi-Ricci Syndrome
Cacchi Ricci Disease
Kidney, Sponge
Medullary Sponge Kidney
Precalyceal Canalicular Ectasia

Excerpt	Reference
"Medullary sponge kidney is a developmental disorder characterized by ectatic and cystic malformation of the collecting ducts and tubules."	( Berkoben, M; Indridason, OS; Thomas, L, 1996)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	66 (73.33)	23.3326
1990's	7 (7.78)	12.5806
2000's	4 (4.44)	18.1394
2010's	10 (11.11)	28.8240
2020's	3 (3.33)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	3	0
citric acid, anhydrous	medium	4	1
chlorine	low	2	0
creatine	low	1	0
hydrogen carbonate	medium	6	1
hydrogen	low	1	0
oxalic acid	low	1	0
uric acid	low	9	0
urea	low	2	0
acetazolamide	low	1	0
alendronate	low	1	0
diatrizoic acid	low	1	0
p-aminohippuric acid	low	1	0
aspirin	low	1	0
bendroflumethiazide	low	2	0
furosemide	low	2	0
hydrochlorothiazide	low	4	0
iohexol	low	1	0
phenacetin	low	2	0
potassium chloride	low	1	0
alloxan	low	1	0
spironolactone	low	1	0
aldosterone	low	1	0
penicillamine	low	1	0
chloramphenicol	low	1	0
edetic acid	low	2	0
methylene blue	low	1	0
pyrrolidonecarboxylic acid	low	1	0
potassium citrate	low	5	0
streptomycin	low	1	0
mercury	low	1	0
sodium sulfate	low	1	0
tricalcium phosphate	low	2	0
chlorine	low	1	0
chlormerodrin	low	1	0
ammonium chloride	medium	6	1
calcium oxalate	low	3	0
fomesafen	low	1	0
dirhodium tetraacetate	low	1	0
technetium tc 99m pentetate	low	1	0
retinol	low	1	0
sodium bicarbonate	low	1	0
arsenic	low	1	0
phosphorus	low	4	0
oxalates	low	7	0
lactulose	low	1	0
cellulose	low	2	0
technetium tc 99m medronate	low	1	0
allopurinol	low	1	0

Protein Targets (558)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	4	0	4
thioredoxin reductase	3	0	0	3
GALC protein	1	0	0	1
GLI family zinc finger 3	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
glucocorticoid receptor [Homo sapiens]	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	7	0	0	7
estrogen-related nuclear receptor alpha	14	0	0	14
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
arylsulfatase A	2	0	0	2
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
Bloom syndrome protein isoform 1	5	0	0	5
thyroid hormone receptor beta isoform a	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	14	0	0	14
geminin	12	0	0	12
peripheral myelin protein 22	4	0	0	4
survival motor neuron protein isoform d	4	0	0	4
muscleblind-like protein 1 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	3	1	0	4
ATP-binding cassette sub-family C member 3	0	9	0	9
Multidrug resistance-associated protein 4	0	9	0	9
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	5	0	6
Carbonic anhydrase 12	0	4	1	8
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	14	0	14
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	11	1	17
Carbonic anhydrase 2	0	12	1	17
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	2	0	3
Carbonic anhydrase 3	0	4	1	7
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	4	0	4
5-hydroxytryptamine receptor 2A	0	1	0	1
Androgen receptor	0	4	0	5
Gamma-aminobutyric acid receptor subunit beta-1	3	1	0	4
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	3	1	0	4
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	9	1	12
Carbonic anhydrase 6	0	4	1	7
Gamma-aminobutyric acid receptor subunit gamma-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	3	1	0	4
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	3	1	0	4
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	3	1	0	4
Adenosine receptor A2a	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 2C19	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	4	0	4
Carbonic anhydrase 5A, mitochondrial	0	7	1	11
Carbonic anhydrase	0	5	0	5
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	4	1	7
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	2	0	5
Gamma-aminobutyric acid receptor subunit beta-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit beta-2	3	1	0	4
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	6	1	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	3	1	0	4
Canalicular multispecific organic anion transporter 1	0	8	0	9
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 15	0	3	0	4
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	4	0	6
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	3	1	0	4
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase 14	0	4	1	8
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	5	1	9
AR protein	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	3	2	6
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Acetylcholinesterase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
interleukin 8	4	0	0	4
TDP1 protein	9	0	0	9
thyroid stimulating hormone receptor	3	0	0	3
estrogen receptor 2 (ER beta)	5	0	0	5
progesterone receptor	6	0	0	6
estrogen nuclear receptor alpha	16	0	0	16
IDH1	4	0	0	4
transcriptional regulator ERG isoform 3	1	0	0	1
thyroid hormone receptor beta isoform 2	6	0	0	6
ras-related protein Rab-9A	1	0	0	1
lamin isoform A-delta10	6	0	0	6
Polyphenol oxidase 2	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Cellular tumor antigen p53	6	0	0	6
Glutamate receptor 2	6	0	0	6
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	0	1	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	3	0	0	3
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Xcogt	0	0	1	1
Chain A, Xcogt	0	0	1	1
Chain A, Xcogt	0	0	1	1
phosphopantetheinyl transferase	5	0	0	5
USP1 protein, partial	3	0	0	3
Microtubule-associated protein tau	5	0	0	5
vitamin D3 receptor isoform VDRA	6	0	0	6
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
GLS protein	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
hypothetical protein, conserved	2	0	0	2
EWS/FLI fusion protein	3	0	0	3
cytochrome P450 2D6	3	0	0	3
glucocerebrosidase	1	0	0	1
peroxisome proliferator-activated receptor delta	7	0	0	7
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	5	0	0	5
DNA polymerase kappa isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	0	1	0	1
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	2	0	0	2
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
acetylcholinesterase	4	0	0	4
glp-1 receptor, partial	3	0	0	3
RAR-related orphan receptor gamma	9	0	0	9
chromobox protein homolog 1	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
Histone H2A.x	7	0	0	7
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	7	0	0	7
G	3	0	0	3
peroxisome proliferator activated receptor gamma	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
aryl hydrocarbon receptor	5	0	0	5
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
heat shock protein beta-1	3	0	0	3
streptokinase A precursor	0	0	1	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	3	0	0	3
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	3	0	0	3
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Amyloid-beta precursor protein	0	3	0	3
Angiotensin-converting enzyme	0	1	0	1
Histamine H2 receptor	3	0	0	3
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Luciferase	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
Bile salt export pump	0	3	0	3
Albumin	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Spike glycoprotein	6	0	0	6
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Multidrug and toxin extrusion protein 1	0	3	0	3
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
ATAD5 protein, partial	3	0	0	3
Hsf1 protein	0	0	1	1
peripheral myelin protein 22 isoform 1	1	0	0	1
cytochrome P450 2C9 precursor	2	0	0	2
ATP-dependent phosphofructokinase	2	0	0	2
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
cytochrome P450 2C19 precursor	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	1	0	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Tumor necrosis factor	0	1	0	1
Neuraminidase	0	1	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	2	0	2
Caspase-7	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Protein-arginine deiminase type-4	0	3	0	3
Cystine/glutamate transporter	0	1	0	1
Hydroxyacid oxidase 1	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
large T antigen	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, Ferritin light chain	1	0	0	1
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
SMAD family member 2	3	0	0	3
Fumarate hydratase	1	0	0	1
PPM1D protein	1	0	0	1
SMAD family member 3	3	0	0	3
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
Smad3	4	0	0	4
caspase 7, apoptosis-related cysteine protease	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
polyprotein	1	0	0	1
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
caspase-3	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
huntingtin isoform 2	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
flap endonuclease 1	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Vpr	2	0	0	2
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Albumin	0	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent noradrenaline transporter	0	0	1	1
Cruzipain	0	1	0	1
Alpha-synuclein	1	1	0	2
Alpha-1A adrenergic receptor	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
Chain A, Pyruvate kinase, M2 isozyme	0	1	0	1
Chain A, Phosphonopyruvate hydrolase	0	1	0	1
Chain A, Phosphoenolpyruvate-protein phosphotransferase	0	1	0	1
Peptidylglycine alpha-amidating monooxygenase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Solute carrier family 22 member 6	0	3	0	5
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 8	0	2	0	3
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Cytochrome P450 1A2	0	0	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
Arylacetamide deacetylase	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Chain A, Cruzipain	1	0	0	1
pregnane X receptor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
67.9K protein	1	0	0	1
Estrogen receptor	0	2	1	3
Glucocorticoid receptor	0	2	1	3
Progesterone receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Androgen receptor	0	2	1	3
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Estrogen receptor beta	0	1	1	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Overview

Research

Studies (90)

Protein Targets (558)

Cacchi Ricci Disease

Synonyms(5)

Research Excerpts

Overview

Research

Studies (90)

Drugs Studied (63)

Protein Targets (558)