acridine red

Description

Acridine red is a cationic dye that has been used as a fluorescent probe for DNA and RNA. It is known to intercalate into DNA and RNA, which results in an increase in fluorescence. Acridine red is also used as a stain for cell nuclei. The synthesis of acridine red is achieved through a series of reactions, typically starting with a nitro-substituted acridine derivative, which is then reduced to the corresponding amine. The dye's effects on biological systems are attributed to its ability to interact with nucleic acids, leading to potential cytotoxic effects. Acridine red is studied extensively due to its ability to bind to nucleic acids and alter their structure and function. This property makes it a valuable tool for studying DNA and RNA structure, as well as for developing potential therapeutic agents. The dye's potential to interfere with DNA replication and transcription, along with its ability to induce mutations, has led to its investigation as a potential anticancer agent. However, its cytotoxic nature has also limited its use in clinical applications.'

acridine red 3B : A hydrochloride obtained by combining the free base of acridine red 3B with one molar equivalent of hydrogen chloride. Used for staining RNA in conjunction with malachite green. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]