Page last updated: 2024-11-05

arsine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

arsine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

arsine : Arsane (AsH3) and compounds derived from it by substituting one, two or three hydrogen atoms by hydrocarbyl groups: RAsH2, R2AsH, R3As (R =/= H) are called primary, secondary and tertiary arsines, respectively. A specific arsine is preferably named as a substituted arsane. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID23969
MeSH IDM0049266

Synonyms (13)

Synonym
arsenic trihydride
arsine
arsenic hydride
hydrogen arsenide
arseniuretted hydrogen
[ash3]
ash3
7784-42-1
arsane
trihydridoarsenic
arsenous hydride
arsenic hydrid
Q334599

Research Excerpts

Overview

Arsine is an arsenic compound generated as a by-product in metal refineries. Arsine gas is a potent hemolytic agent. The effects of exposure to tolerated concentrations on pregnancy and prenatal development have not been reported.

ExcerptReferenceRelevance
"Arsine is an arsenic compound generated as a by-product in metal refineries. "( Possible production of arsenic hemoglobin adducts via exposure to arsine.
Endo, G; Endo, Y; Hata, A; Kuroda, Y; Nakadate, T; Yamanaka, K; Yamano, Y; Yamauchi, T, 2015
)
2.1
"Arsine gas exposure is a rare occupational event and can be completely prevented with the use of appropriate protective gear. "( Occupational arsine gas exposure.
Pullen-James, S; Woods, SE, 2006
)
2.15
"Arsine poisoning is a well-recognized phenomenon generally associated with the smelting and refining of metals. "( Suspected arsine poisoning during the restoration of a large cyclorama painting.
Rubenstein, M; Spain, WH; Williams, PL, 1981
)
2.11
"Arsine gas is a potent hemolytic agent but the effects of exposure to tolerated concentrations on pregnancy and prenatal development have not been reported. "( Arsine: absence of developmental toxicity in rats and mice.
Fowler, BA; Harris, MW; Jameson, CW; Moorman, MP; Morrissey, RE; Schwetz, BA, 1990
)
3.16
"Arsine gas is a potent hemolytic agent. "( Hematopoietic effects in mice exposed to arsine gas.
Boorman, GA; Fowler, BA; Hong, HL, 1989
)
1.99

Effects

ExcerptReferenceRelevance
"Arsine has long been recognized as a selective toxin that targets the membrane of erythrocytes and causes leakage of the internal contents of these cells. "( The possible use of arsine (AsH3) as therapy for malaria.
Parris, GE, 2005
)
2.09

Toxicity

ExcerptReferenceRelevance
"Arsine, the hydride of arsenic (AsH3), is the most acutely toxic form of arsenic, causing rapid and severe hemolysis upon exposure."( Sequence of toxic events in arsine-induced hemolysis in vitro: implications for the mechanism of toxicity in human erythrocytes.
Barber, DS; Carter, DE; Rael, LT; Winski, SL, 1997
)
2.03
" AsIII concentrations up to 1 mM were not toxic to red blood cells using these indicators."( In vitro tissue specificity for arsine and arsenite toxicity in the rat.
Ayala-Fierro, F; Barber, DS; Carter, DE; Rael, LT, 1999
)
0.59
" The hypothesis was that As(III) is the toxic metabolite responsible for the renal toxicity of AsH3."( LLC-PK1 cells as a model for renal toxicity caused by arsine exposure.
Ayala-Fierro, F; Carter, DE, 2000
)
0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
arsineArsane (AsH3) and compounds derived from it by substituting one, two or three hydrogen atoms by hydrocarbyl groups: RAsH2, R2AsH, R3As (R =/= H) are called primary, secondary and tertiary arsines, respectively. A specific arsine is preferably named as a substituted arsane.
arsanesThe saturated hydrides of tervalent arsenic, having the general formula AsnHn+2.
mononuclear parent hydride
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (155)

TimeframeStudies, This Drug (%)All Drugs %
pre-199074 (47.74)18.7374
1990's16 (10.32)18.2507
2000's28 (18.06)29.6817
2010's34 (21.94)24.3611
2020's3 (1.94)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 69.23

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index69.23 (24.57)
Research Supply Index5.12 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index115.47 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (69.23)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews13 (7.83%)6.00%
Case Studies16 (9.64%)4.05%
Observational0 (0.00%)0.25%
Other137 (82.53%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]