biotinyl-n-hydroxysulfosuccinimide ester profile

This compound is a biotinylation reagent, commonly used to label proteins and other biomolecules with biotin. It is synthesized through a reaction between biotin and N-hydroxysulfosuccinimide (sulfo-NHS). Biotinylation is a common technique used in various research applications, including affinity purification, immunoprecipitation, and enzyme-linked immunosorbent assays (ELISA). Biotinyl-N-hydroxysulfosuccinimide ester reacts with primary amines on target molecules to form a stable amide bond, attaching biotin to the molecule. The high affinity of biotin for streptavidin or avidin allows for the subsequent purification or detection of the labeled molecule. This reagent is studied extensively due to its ease of use, high specificity, and versatility in diverse applications. Its importance lies in its ability to facilitate the study and manipulation of various biological molecules and processes.'

biotinyl-N-hydroxysulfosuccinimide ester: reagent for identifying cell surface antigens; used to identify & isolate cuticular proteins of Brugia malayi [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	83894
SCHEMBL ID	17385535
MeSH ID	M0152300

Synonym
biotinyl-n-hydroxysulfosuccinimide ester
2,5-dioxo-1-[5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanoyloxy]pyrrolidine-3-sulfonic acid
105248-43-9
3-pyrrolidinesulfonic acid, 1-((5-(hexahydro-2-oxo-1h-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)oxy)-2,5-dioxo-
snhs-biotin
nhss-biotin
sulfosuccinimide-biotin
SCHEMBL17385535
DTXSID90909396
1-{[5-(2-hydroxy-3a,4,6,6a-tetrahydro-1h-thieno[3,4-d]imidazol-6-yl)pentanoyl]oxy}-2,5-dioxopyrrolidine-3-sulfonic acid

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (25.00)	18.7374
1990's	4 (33.33)	18.2507
2000's	4 (33.33)	29.6817
2010's	1 (8.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	2.38	2	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2.42	2	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
trinitrobenzenesulfonic acid Trinitrobenzenesulfonic Acid: A reagent that is used to neutralize peptide terminal amino groups.. 2,4,6-trinitrobenzenesulfonic acid : The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.	1.97	1	arenesulfonic acid; C-nitro compound	epitope; explosive; reagent
1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenylglycoluril 1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenylglycoluril: reagent for protein iodinations; structure	2.38	2
3-(n-maleimidopropionyl)biocytin 3-(N-maleimidopropionyl)biocytin: thiol-specific biotinylating reagent; structure given in first source	2.01	1	peptide
biotin vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.	3.86	12	biotins; vitamin B7	coenzyme; cofactor; Escherichia coli metabolite; fundamental metabolite; human metabolite; mouse metabolite; nutraceutical; prosthetic group; Saccharomyces cerevisiae metabolite
sulfosuccinimidyl 6-(biotinamido)hexanoate [no description available]	1.97	1
arsenic Arsenic: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)	2.01	1	metalloid atom; pnictogen	micronutrient
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.01	1	cysteinium	fundamental metabolite
4-(n-(s-glutathionylacetyl)amino)phenylarsenoxide 4-(N-(S-glutathionylacetyl)amino)phenylarsenoxide: structure in first source	2.01	1	glutathione derivative
pituitrin Pituitrin: A substance or extract from the neurohypophysis (PITUITARY GLAND, POSTERIOR).	1.97	1
chitosan [no description available]	2.03	1

Condition	Relationship Strength	Studies
Hepatocellular Carcinoma [description not available]	2.03	1
Cancer of Liver [description not available]	2.03	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.03	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.03	1
Leucocythaemia [description not available]	1.97	1
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	1.97	1

biotinyl-n-hydroxysulfosuccinimide ester

Description

Cross-References

Synonyms (10)

Research

Studies (12)

Market Indicators

Research Demand Index: 11.90

Study Types