Page last updated: 2024-09-28

XYY Karyotype

Abnormal genetic constitution in males characterized by an extra Y chromosome.

Synonyms(1)

Synonym
XYY Karyotype

Research

Studies (38)

TimeframeStudies, This Condition (%)All Conditions %
pre-199018 (47.37)23.3326
1990's6 (15.79)12.5806
2000's6 (15.79)18.1394
2010's5 (13.16)28.8240
2020's3 (7.89)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
5-hydroxytryptophan0low10
salicylic acid0low10
homovanillic acid0low10
hydroxyindoleacetic acid0low10
aspirin0low10
busulfan0low10
stallimycin0low10
methylphenidate0low10
probenecid0low10
mitomycin0low10
levodopa0low10
medroxyprogesterone acetate0low10
arginine0low10
testosterone enanthate0low10
medroxyprogesterone0low20
dihydrotestosterone0low10
arsenic trioxide0low10
cetylpyridinium chloride anhydrous0low10
tretinoin0low10
freedom0low20
phenylephrine hydrochloride0low10
arsenic0low10
quetiapine fumarate0low10
sapropterin0low10

Protein Targets (459)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase9009
phosphopantetheinyl transferase3003
NFKB1 protein, partial3003
GLS protein6006
thyroid stimulating hormone receptor6006
alpha-galactosidase3003
euchromatic histone-lysine N-methyltransferase 29009
cytochrome P450 2C19 precursor1001
chromobox protein homolog 19009
flap endonuclease 12002
DNA polymerase iota isoform a (long)5005
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)3003
Cytochrome P450 3A40012
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0012
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase4004
TDP1 protein100010
AR protein110011
glucocorticoid receptor [Homo sapiens]120012
estrogen nuclear receptor alpha130013
peroxisome proliferator activated receptor gamma7007
nuclear receptor subfamily 1, group I, member 23003
thyroid hormone receptor beta isoform 29009
Cellular tumor antigen p536006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase6006
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 83003
aldehyde dehydrogenase 1 family, member A17007
hypothetical protein, conserved2002
cytochrome P450 family 3 subfamily A polypeptide 45005
EWS/FLI fusion protein4004
retinoic acid nuclear receptor alpha variant 17007
estrogen-related nuclear receptor alpha100010
cytochrome P450 2D62002
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta6006
Rac1 protein0011
IDH14004
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 15005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
DNA polymerase kappa isoform 14004
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Solute carrier family 22 member 60303
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0707
Epidermal growth factor receptor0202
Carbonic anhydrase 10506
Carbonic anhydrase 20506
Fatty acid-binding protein, liver0101
Integrin beta-30101
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb0101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10303
Adenosine receptor A10102
Adenosine receptor A2a0102
Substance-P receptor0101
Prostaglandin G/H synthase 20303
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma3115
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-13317
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Canalicular multispecific organic anion transporter 10707
Sigma non-opioid intracellular receptor 10011
Sigma non-opioid intracellular receptor 10011
Chain A, JmjC domain-containing histone demethylation protein 3A2002
15-lipoxygenase, partial2002
apical membrane antigen 1, AMA12002
retinoid X nuclear receptor alpha7007
pregnane X nuclear receptor5005
aryl hydrocarbon receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 18008
geminin110011
lamin isoform A-delta106006
Matrix metalloproteinase-90101
Disintegrin and metalloproteinase domain-containing protein 171001
Chain A, Ferritin light chain3003
acetylcholinesterase1001
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma8008
SMAD family member 23003
USP1 protein, partial4004
SMAD family member 33003
GLI family zinc finger 38008
Microtubule-associated protein tau3003
caspase 7, apoptosis-related cysteine protease2002
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor6006
farnesoid X nuclear receptor4004
67.9K protein2002
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
caspase-32002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
activating transcription factor 62002
thyrotropin-releasing hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
vitamin D3 receptor isoform VDRA4004
heat shock protein beta-13003
mitogen-activated protein kinase 11001
nuclear receptor ROR-gamma isoform 12002
survival motor neuron protein isoform d4004
Voltage-dependent calcium channel gamma-2 subunit6006
Glutamate receptor 26006
Caspase-20011
Inositol monophosphatase 11001
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Chain A, Sex Hormone-Binding Globulin0011
glp-1 receptor, partial2002
Histone H2A.x2002
potassium voltage-gated channel subfamily H member 2 isoform d1001
transcriptional regulator ERG isoform 33003
peripheral myelin protein 226006
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3205
Plasma kallikrein0102
Glucocorticoid receptor0517
Sex hormone-binding globulin0123
Progesterone receptor0101
Progesterone receptor0325
Glucocorticoid receptor0101
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0202
Sex hormone-binding globulin0101
Androgen receptor04410
Aromatase0102
Androgen receptor0617
Gamma-aminobutyric acid receptor subunit beta-13205
Gamma-aminobutyric acid receptor subunit delta3205
Gamma-aminobutyric acid receptor subunit gamma-23216
Androgen receptor0123
Gamma-aminobutyric acid receptor subunit alpha-53205
Gamma-aminobutyric acid receptor subunit alpha-33205
Mineralocorticoid receptor0101
Gamma-aminobutyric acid receptor subunit gamma-13205
Gamma-aminobutyric acid receptor subunit alpha-23205
Gamma-aminobutyric acid receptor subunit alpha-43205
Gamma-aminobutyric acid receptor subunit gamma-33205
Gamma-aminobutyric acid receptor subunit alpha-63205
Testosterone 17-beta-dehydrogenase 30101
Angiotensin-converting enzyme0011
Cannabinoid receptor 20101
Gamma-aminobutyric acid receptor subunit beta-33205
Gamma-aminobutyric acid receptor subunit beta-23216
G-protein coupled bile acid receptor 10011
Muscarinic acetylcholine receptor0101
GABA theta subunit3205
Neuropeptide FF receptor 20001
Gamma-aminobutyric acid receptor subunit epsilon3205
ALK tyrosine kinase receptor0101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
ATAD5 protein, partial3003
Hsf1 protein0011
regulator of G-protein signaling 44004
bromodomain adjacent to zinc finger domain 2B2002
arylsulfatase A3003
D(1A) dopamine receptor1001
thyroid hormone receptor beta isoform a2002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
histone acetyltransferase KAT2A isoform 13003
neuropeptide S receptor isoform A3003
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 431001
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
ClpP1001
Fumarate hydratase3003
polyprotein3003
lysosomal alpha-glucosidase preproprotein2002
M-phase phosphoprotein 84004
Solute carrier family 22 member 80203
endonuclease IV1001
Smad31001
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C9 precursor1001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Histamine H2 receptor1001
Uracil nucleotide/cysteinyl leukotriene receptor0101
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Luciferase2002
dopamine D1 receptor1001
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
pyruvate kinase1001
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
importin subunit beta-1 isoform 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
Polyphenol oxidase 20103
Carbonic anhydrase 120203
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Carbonic anhydrase 30102
Polyunsaturated fatty acid lipoxygenase ALOX150101
Tyrosinase0101
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Carbonic anhydrase 5A, mitochondrial0102
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70102
Solute carrier family 15 member 10101
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 90203
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150102
Carbonic anhydrase 130102
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
phosphoglycerate kinase1001
Chain A, Beta-lactamase3003
GALC protein2002
PINK12002
G3003
Parkin3003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Cytochrome P450 2C190112
Spike glycoprotein5005
Inositol hexakisphosphate kinase 13003
cytochrome P450 2C9, partial3003
Chain A, Cruzipain2002
pregnane X receptor2002
nonstructural protein 12002
thyroid stimulating hormone receptor3003
nuclear factor erythroid 2-related factor 2 isoform 23003
Estrogen receptor0213
Histamine H2 receptor0202
5-hydroxytryptamine receptor 1B0101
Alpha-synuclein1102
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G1001
Aldo-keto reductase family 1 member C10101
Estrogen receptor beta0213
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0101
Sodium-dependent serotonin transporter0202
Sodium-dependent dopamine transporter 0202
Indoleamine 2,3-dioxygenase 10101
beta-2 adrenergic receptor1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
ras-related protein Rab-9A1001
Solute carrier organic anion transporter family member 1A40101
UDP-glucuronosyltransferase 1A90101
Bile salt export pump0202
Transient receptor potential cation channel subfamily A member 10011
Solute carrier family 22 member 80101
UDP-glucuronosyltransferase 1-60101
UDP-glucuronosyltransferase 1A1 0101
Solute carrier organic anion transporter family member 1A10101
Solute carrier family 22 member 60303
Solute carrier family 22 member 70102
Solute carrier family 22 member 10101
Canalicular multispecific organic anion transporter 10101
Solute carrier family 22 member 80303
Pannexin-10101
Solute carrier family 22 member 120101
Solute carrier organic anion transporter family member 1C10101
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
Pannexin-10101
Solute carrier family 22 member 110202
Solute carrier family 22 member 20101
Solute carrier family 22 member 70202
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
5'-AMP-activated protein kinase subunit beta-20001
Albumin0101
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
GTPase HRas0101
Neutrophil elastase0101
DNA topoisomerase 10101
Histamine H1 receptor0101
Chain A, Nuclear Receptor ROR-beta0101
thioredoxin glutathione reductase1001
Caspase-71001
caspase-31001
Ornithine decarboxylase0001
Amyloid-beta precursor protein0101
Cytochrome P450 1A20011
Ornithine decarboxylase0001
60 kDa chaperonin0101
Adenosine receptor A30202
Retinoic acid receptor alpha0227
Cytochrome P450 2D60011
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Cytochrome P450 2C9 0011
Retinoic acid receptor gamma 0227
Alpha-1B adrenergic receptor0202
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
5-hydroxytryptamine receptor 1A0101
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Alpha-1D adrenergic receptor0101
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0202
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]