arsenic has been researched along with succimer in 83 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (16.87) | 18.7374 |
| 1990's | 20 (24.10) | 18.2507 |
| 2000's | 26 (31.33) | 29.6817 |
| 2010's | 18 (21.69) | 24.3611 |
| 2020's | 5 (6.02) | 2.80 |
| Authors | Studies |
|---|---|
| Duke, BO | 1 |
| Cuccia, D; Friedheim, E; Graziano, JH | 1 |
| Forth, W; Kreppel, H; Reichl, FX | 1 |
| Burns, LA; Munson, AE; Saady, JJ; Sikorski, EE | 1 |
| Bosque, MA; Domingo, JL; Piera, V | 1 |
| Fichtl, B; Forth, W; Kreppel, H; Reichl, FX; Schäfer, B | 1 |
| Bright, JE; Inns, RH; Marrs, TC; Rice, P | 1 |
| Fichtl, B; Forth, W; Kreppel, H; Reichl, FX; Szinicz, L | 1 |
| Dill, K; Hallowell, SF; McGown, EL; O'Connor, RJ | 1 |
| Fichtl, B; Forth, W; Kreppel, H; Reichl, FX | 1 |
| Sheabar, FZ; Taitelman, U; Yannai, S | 1 |
| Aposhian, HV; Maiorino, RM | 1 |
| Maehashi, H; Murata, Y | 1 |
| Liang, YY; Marlowe, C; Waddell, WJ | 1 |
| Aposhian, HV; Tadlock, CH | 1 |
| Druml, W; Eder, A; Gaszner, A; Hruby, K; Kleinberger, G; Lenz, K; Pichler, M; Weiser, M | 1 |
| Aposhian, HV; Moon, TE; Tadlock, CH | 1 |
| Aposhian, HV; Brinkley, FB; Hackley, BE; Hsu, CA; Mershon, MM | 1 |
| Aposhian, HV; Hoover, TD; Hsu, CA | 1 |
| Aposhian, HV; Carter, DE; Hoover, TD; Hsu, CA; Maiorino, RM; Stine, E | 1 |
| Maehashi, H; Tsutsumi, S; Yamaguchi, Y | 1 |
| Jones, MM; Kreppel, H; Paepcke, U; Reichl, FX; Singh, PK; Szinicz, L; Thiermann, H | 1 |
| Fichtl, B; Forth, W; Kreppel, H; Mückter, H; Reichl, FX; Szinicz, L | 1 |
| Hale, T; Shum, S; Vaughn, L; Whitehead, J | 1 |
| Jones, MM; Kleine, A; Kreppel, H; Reichl, FX; Singh, PK; Szinicz, L | 1 |
| Doklea, E; Fichtl, B; Forth, W; Liebl, B; Mückter, H | 1 |
| Stýblo, M; Thomas, DJ | 1 |
| Inns, RH; Rice, P | 1 |
| Burns, LA; Butterworth, LF; Munson, AE | 1 |
| Burns, LA; Munson, AE | 1 |
| Doklea, E; Fichtl, B; Forth, W; Hopfer, C; Islambouli, S; Mückter, H; Szinicz, L | 1 |
| Cullen, WR; Serves, SV; Styblo, M; Thomas, DJ | 1 |
| Hood, RD | 1 |
| Angle, CR; Centeno, JA; Chatterjee, A; De, BK; Dutta, S; Ghoshal, UC; Guha Mazumder, DN; Saha, J; Santra, A | 1 |
| Ayala-Fierro, F; Carter, DE; Rael, LT | 1 |
| Buchwald, AL | 1 |
| Flohé, S; Kehe, K; Krebs, G; Kreppel, H; Liebl, B; Reichl, FX; Szinicz, L | 1 |
| Chauhan, RS; Dubey, R; Flora, SJ; Jaiswal, DK; Kannan, GM; Pant, BP | 1 |
| Flora, SJ; Jaiswal, DK; Kannan, GM; Pant, BP | 1 |
| Buchet, JP; Hantson, P; Haufroid, V; Mahieu, P | 1 |
| DeLaune, RD; Fukushi, K; Jugsujinda, A; Parkpian, P; Wongkongkatep, J | 1 |
| Bhaskar, AS; Dube, SN; Flora, SJ; Kannan, GM; Mehta, A; Pant, BP; Rao, PV | 1 |
| Flora, SJ; Kannan, GM | 2 |
| Bhadauria, S; Flora, SJ | 1 |
| Dawson, AH; Isbister, GK; Whyte, IM | 1 |
| Kruszyna, HG; Rich, AM; Spuches, AM; Wilcox, DE | 1 |
| Bhadauria, S; Dhaked, RK; Flora, SJ; Pant, SC | 1 |
| Aposhian, HV; Aposhian, MM | 1 |
| Hancock, JR; Nelson, P; Sawyer, TW | 1 |
| Flora, SJ; Kalia, K; Kannan, GM; Narula, GD | 1 |
| Leikin, J; Mahajan, N; Wang, EE; Wills, B | 1 |
| Flora, SJ; Modi, M | 1 |
| Aasen, J; Jacobsen, D; Lierhagen, S; Mørland, J; Nermell, B; Stenehjem, AE; Vahter, M | 1 |
| Flora, G; Flora, SJ; Mishra, M; Saxena, G | 1 |
| Flora, SJ; Mishra, D | 1 |
| Caravati, EM; Crouch, BI; Horowitz, BZ; Mckeown, NJ; Stromness, JR; Yarris, JP | 1 |
| Palaniappan, PL; Vijayasundaram, V | 1 |
| Louters, LL; Opejin, A; Rekman, J; Scott, J; Stehouwer, N; Tidball, A | 1 |
| Flora, SJ; Gupta, R; Kushwah, P; Mishra, D; Pant, SC; Satish, HT | 1 |
| Palaniappan, PR; Prabu, SM; Vijayasundaram, V | 1 |
| Feng, SY; Roth, B; Schwarz, E; Young, A | 1 |
| Cox, RD; Orledge, J | 1 |
| Bhatt, K; Dwivedi, N; Flora, SJ; Kushwah, PK; Pachauri, V | 1 |
| Chowdhury, ST; Das, N; Dungdung, SR; Ghosh, D; Ghosh, S; Mandal, AK; Sarkar, S | 1 |
| Bhadauria, S; Flora, SJ; Pachauri, V; Yadav, A | 1 |
| Requejo, R; Tena, M | 1 |
| Acharya, S; Basu, AK; Bhattacharya, D; Chatterjee, S; Chaudhuri, S; Dasgupta, S; Flora, SJ; Kumar, P; Singh, MK | 1 |
| Flora, SJ; Kushwaha, P; Pachauri, V; Srivastava, P; Yadav, A | 1 |
| Bertoni, M; Boudry, I; Cléry-Barraud, C; Dorandeu, F; Emorine, S; Mouret, S; Nguon, N; Wartelle, J | 1 |
| Kosnett, MJ | 1 |
| Gottipolu, RR; Kadeyala, PK; Sannadi, S | 1 |
| Bao, W; Cai, X; Chen, B; Chen, Y; He, Z; Hua, W; Shen, F; Shi, Y; Wang, C; Wang, X; Xia, G; Yu, L; Zhang, Y | 1 |
| Babbar, AK; Flora, SJ; Kaushik, MP; Kushwaha, P; Lomash, V; Mathur, R; Mishra, AK; Pathak, U; Samim, M; Yadav, A | 1 |
| Flora, SJS; Kushwaha, P; Samim, M; Yadav, A | 1 |
| Burrow, J; Falhammar, H; Hoggett, K; Howard, D; Lindenmayer, G | 1 |
| Chatterjee, S; Flora, SJS; Mittal, M | 1 |
| Davuljigari, CB; Kumar, KP; Reddy, GR; Saritha, S | 1 |
| Aaseth, J; Alexander, J; Bjørklund, G; Crisponi, G; Djordjevic, AB; Nurchi, VM | 1 |
| Cassone, G; Chillè, D; Foti, C; Giacobello, F; Giuffrè, O; Nardo, VM; Ponterio, RC; Saija, F; Sponer, J; Trusso, S | 1 |
| Cheng, L; Huang, Y; Liu, B; Liu, Z; Wang, C; Yang, X; Zhang, C | 1 |
| Flora, SJS; Sachdeva, S; Sharma, A | 1 |
| Flora, SJS; Jain, K; Panghal, A; Patwa, J | 1 |
5 review(s) available for arsenic and succimer
| Article | Year |
|---|---|
Arsenic toxicology: five questions.
Topics: Animals; Arsenic; Arsenic Poisoning; Arsenites; Aryl Hydrocarbon Hydroxylases; Chelating Agents; Cytochrome P-450 CYP2C19; Dimercaprol; Enzyme Inhibitors; Glutathione Transferase; Hemoglobins; Humans; Metallothionein; Methylation; Mixed Function Oxygenases; Polymorphism, Genetic; Protein Binding; Pyruvate Dehydrogenase Complex; Reactive Oxygen Species; Succimer; Unithiol | 2006 |
Arsenic and lead induced free radical generation and their reversibility following chelation.
Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Animals; Antioxidants; Arsenic; Arsenic Poisoning; Ascorbic Acid; Calcium; Chelating Agents; Free Radicals; Humans; Lead; Lead Poisoning; Melatonin; Metals; Micronutrients; Molecular Structure; Succimer; Taurine; Thioctic Acid; Unithiol; Vitamin E | 2007 |
The role of chelation in the treatment of arsenic and mercury poisoning.
Topics: Animals; Arsenic Poisoning; Arsenicals; Chelating Agents; Chelation Therapy; Humans; Mercury Poisoning; Succimer; Treatment Outcome; Unithiol | 2013 |
Arsenic Toxicity: Molecular Targets and Therapeutic Agents.
Topics: Animals; Antidotes; Arsenic; Arsenic Poisoning; Arsenicals; Chelating Agents; Dimercaprol; Drinking Water; Humans; Models, Molecular; Occupational Exposure; Oxidative Stress; Succimer; Unithiol; Water Pollutants, Chemical | 2020 |
Chemistry, Pharmacology, and Toxicology of Monoisoamyl Dimercaptosuccinic Acid: A Chelating Agent for Chronic Metal Poisoning.
Topics: Animals; Antidotes; Antioxidants; Arsenic; Arsenic Poisoning; Cadmium; Chelating Agents; Heavy Metal Poisoning; Mercury; Rats; Rats, Wistar; Succimer | 2022 |
1 trial(s) available for arsenic and succimer
| Article | Year |
|---|---|
Randomized placebo-controlled trial of 2,3-dimercaptosuccinic acid in therapy of chronic arsenicosis due to drinking arsenic-contaminated subsoil water.
Topics: Adolescent; Adult; Antidotes; Arsenic; Chronic Disease; Double-Blind Method; Humans; India; Liver Function Tests; Male; Poisoning; Prospective Studies; Skin; Succimer; Water Pollutants, Chemical | 1998 |
77 other study(ies) available for arsenic and succimer
| Article | Year |
|---|---|
The effects of some drugs--pentamidine, stibocaptate, Hoechst 33258, F 151, compound 'E' and Nifurtimox--on Onchocerca volvulus in chimpanzees.
Topics: Animals; Anthelmintics; Antimony; Arsenicals; Bisbenzimidazole; Female; Male; Nifurtimox; Onchocerca; Onchocerciasis; Organometallic Compounds; Pan troglodytes; Pentamidine; Succimer; Succinates | 1977 |
The pharmacology of 2,3-dimercaptosuccinic acid and its potential use in arsenic poisoning.
Topics: Animals; Arsenic; Arsenic Poisoning; Dimercaprol; Dogs; Female; Lethal Dose 50; Male; Mice; Minerals; Rats; Succimer; Sulfhydryl Compounds | 1978 |
Pyruvate and lactate metabolism in livers of guinea pigs perfused with chelating agents after repeated treatment with As2O3.
Topics: Animals; Antidotes; Arsenic; Arsenic Trioxide; Arsenicals; Chelating Agents; Dimercaprol; Guinea Pigs; In Vitro Techniques; Lactates; Lactic Acid; Liver; Male; Oxides; Oxygen Consumption; Perfusion; Pyruvates; Pyruvic Acid; Succimer | 1991 |
Evidence for arsenic as the immunosuppressive component of gallium arsenide.
Topics: Animals; Antibody Formation; Arsenic; Arsenicals; Arsenites; Cells, Cultured; Dose-Response Relationship, Drug; Female; Gallium; Immune Tolerance; Immunoglobulin M; Mice; Models, Biological; Oxalates; Oxalic Acid; Sodium Compounds; Spectrophotometry, Atomic; Spleen; Succimer; Tissue Distribution | 1991 |
meso-2,3-Dimercaptosuccinic acid and prevention of arsenite embryotoxicity and teratogenicity in the mouse.
Topics: Animals; Arsenic; Arsenites; Embryo, Mammalian; Female; Gestational Age; Mice; Pregnancy; Sodium Compounds; Succimer; Teratogens | 1991 |
Effect of oral treatment with Bal, DMPS or DMSA arsenic in organs of mice injected with arsenic trioxide.
Topics: Administration, Oral; Animals; Arsenic; Arsenic Trioxide; Arsenicals; Dimercaprol; Male; Mice; Oxides; Succimer; Tissue Distribution; Unithiol | 1991 |
Evaluation of the efficacy of dimercapto chelating agents for the treatment of systemic organic arsenic poisoning in rabbits.
Topics: Animals; Arsenic; Arsenic Poisoning; Arsenicals; Body Weight; Chelating Agents; Dimercaprol; Gallbladder; Lethal Dose 50; Liver; Lung; Male; Rats; Succimer; Unithiol | 1990 |
Efficacy of various dithiol compounds in acute As2O3 poisoning in mice.
Topics: Animals; Arsenic; Arsenic Trioxide; Arsenicals; Dimercaprol; Guinea Pigs; Male; Mice; Oxides; Succimer; Sulfhydryl Compounds; Unithiol | 1990 |
Relative binding constants of arsenical-antidote adducts determined by NMR spectroscopy.
Topics: Antidotes; Arsenicals; Dimercaprol; Magnetic Resonance Spectroscopy; Solvents; Stereoisomerism; Succimer; Unithiol | 1990 |
Lack of effectiveness of D-penicillamine in experimental arsenic poisoning.
Topics: Animals; Arsenic; Arsenic Poisoning; Dimercaprol; Guinea Pigs; Male; Mice; Penicillamine; Succimer; Tissue Distribution; Unithiol | 1989 |
Efficiency of arsenic clearance from human blood in vitro and from dogs in vivo by extracorporeal complexing haemodialysis.
Topics: Animals; Arsenic; Arsenites; Chelating Agents; Dogs; Female; Glutathione; Hemoperfusion; Humans; Indicators and Reagents; Renal Dialysis; Succimer | 1989 |
Dimercaptan metal-binding agents influence the biotransformation of arsenite in the rabbit.
Topics: Animals; Arsenic; Arsenites; Biotransformation; Chelating Agents; Chromatography, Ion Exchange; Male; Phthalic Acids; Rabbits; Succimer; Sulfhydryl Compounds; Unithiol | 1985 |
Arsenic excretion after treatment of arsenic poisoning with DMSA or DMPS in mice.
Topics: Animals; Arsenic; Arsenic Poisoning; Dimercaprol; Feces; Male; Mice; Mice, Inbred ICR; Succimer; Sulfhydryl Compounds | 1986 |
Disposition of [14C]dimercaptosuccinic acid in mice.
Topics: Animals; Arsenic; Biotransformation; Carbon Radioisotopes; Extracellular Space; Male; Mercuric Chloride; Mice; Succimer; Sulfhydryl Compounds; Tissue Distribution | 1986 |
Protection of mice against the lethal effects of sodium arsenite by 2,3 dimercapto-1-propane-sulfonic acid and dimercaptosuccinic acid.
Topics: Animals; Arsenic; Arsenic Poisoning; Chelating Agents; Dimercaprol; Disease Models, Animal; Mice; Succimer; Sulfhydryl Compounds; Unithiol | 1980 |
2,3-Dimercaptosuccinic acid in human arsenic poisoning.
Topics: Antidotes; Arsenic Poisoning; Arsenicals; Humans; Male; Middle Aged; Succimer; Suicide; Sulfhydryl Compounds | 1981 |
Protection of mice against lethal effects of sodium arsenite--a quantitative comparison of a number of chelating agents.
Topics: Animals; Arsenic; Arsenites; Chelating Agents; Lethal Dose 50; Male; Mice; Sodium Compounds; Succimer; Sulfhydryl Compounds; Unithiol | 1981 |
Anti-lewisite activity and stability of meso-dimercaptosuccinic acid and 2,3-dimercapto-1-propanesulfonic acid.
Topics: Administration, Oral; Animals; Arsenic Poisoning; Arsenicals; Dimercaprol; Dose-Response Relationship, Drug; Drug Stability; Hydrogen-Ion Concentration; Injections, Subcutaneous; Male; Rabbits; Succimer; Unithiol | 1982 |
DL- and meso-dimercaptosuccinic acid: in vitro and in vivo studies with sodium arsenite.
Topics: Animals; Antidotes; Arsenic; Arsenites; Dose-Response Relationship, Drug; Enzyme Reactivators; In Vitro Techniques; Kidney; Lethal Dose 50; Male; Mice; Pyruvate Dehydrogenase Complex; Rabbits; Sodium Compounds; Stereoisomerism; Succimer; Sulfhydryl Compounds | 1983 |
DMSA, DMPS, and DMPA--as arsenic antidotes.
Topics: Animals; Antidotes; Arsenates; Arsenic; Arsenic Poisoning; Arsenicals; Arsenites; Brain; Dimercaprol; Guinea Pigs; Male; Mice; Organ Size; Phthalic Acids; Pyruvate Dehydrogenase Complex; Rabbits; Sodium Compounds; Succimer; Sulfhydryl Compounds; Unithiol | 1984 |
Arsenic and copper excretion after treatment of arsenic poisoning in rats with heavy-metal antagonists.
Topics: Animals; Arsenic; Arsenic Poisoning; Chelating Agents; Copper; Dimercaprol; Male; Rats; Rats, Inbred Strains; Succimer; Sulfhydryl Compounds; Unithiol | 1983 |
Therapeutic efficacy of new dimercaptosuccinic acid (DMSA) analogues in acute arsenic trioxide poisoning in mice.
Topics: Animals; Antidotes; Arsenic; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Injections, Intraperitoneal; Injections, Subcutaneous; Intubation, Gastrointestinal; Male; Mice; Oxides; Poisoning; Succimer | 1993 |
Effect of various antidotes on the biliary and intestinal excretion of arsenic in situ and into the feces in vivo in guinea-pigs after injection of As2O3.
Topics: Animals; Antidotes; Arsenic; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Bile; Colon; Dimercaprol; Feces; Guinea Pigs; Injections, Intravenous; Jejunum; Male; Oxides; Perfusion; Poisoning; Succimer; Sulfonamides; Unithiol | 1994 |
Chelation of organoarsenate with dimercaptosuccinic acid.
Topics: Administration, Oral; Adult; Arsenic; Arsenic Poisoning; Arsenicals; Blood Cell Count; Blood Chemical Analysis; Blood Gas Analysis; Chelating Agents; Cocaine; Drug Overdose; Herbicides; Humans; Kidney; Liver; Liver Function Tests; Male; Substance-Related Disorders; Succimer; Suicide, Attempted; Urine | 1995 |
Antidotal efficacy of newly synthesized dimercaptosuccinic acid (DMSA) monoesters in experimental arsenic poisoning in mice.
Topics: Animals; Antidotes; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Brain; Esters; Intestine, Large; Intestine, Small; Kidney; Male; Mice; Mice, Inbred Strains; Oxides; Succimer | 1995 |
Reversal of oxophenylarsine-induced inhibition of glucose uptake in MDCK cells.
Topics: Adenosine Triphosphate; Animals; Antidotes; Arsenic Poisoning; Arsenicals; Biological Transport; Cell Line; Dimercaprol; Dithiothreitol; Dogs; Enzyme Inhibitors; Glucose; L-Lactate Dehydrogenase; Mercaptoethanol; Succimer; Sulfonamides; Unithiol | 1995 |
In vitro inhibition of glutathione reductase by arsenotriglutathione.
Topics: Animals; Arsenicals; Arsenites; Drug Stability; Glutathione; Glutathione Disulfide; Glutathione Reductase; Oxidation-Reduction; Rabbits; Succimer; Yeasts | 1995 |
Efficacy of dimercapto chelating agents for the treatment of poisoning by percutaneously applied dichloro(2-chlorovinyl)arsine in rabbits.
Topics: Administration, Topical; Animals; Arsenic Poisoning; Arsenicals; Chelating Agents; Chemical and Drug Induced Liver Injury; Dimercaprol; Gallbladder; Lethal Dose 50; Liver; Lung; Male; Rabbits; Succimer; Sulfhydryl Compounds; Unithiol | 1993 |
Reversal of gallium arsenide-induced suppression of the antibody response by a mixed disulfide metabolite of meso-2,3-dimercaptosuccinic acid.
Topics: Animals; Antibody Formation; Arsenic; Arsenicals; Cysteine; Cystine; Dose-Response Relationship, Drug; Erythrocytes; Female; Gallium; In Vitro Techniques; Mice; Sheep; Succimer | 1993 |
Reversal of gallium arsenide-induced suppression of the antibody-forming cell response by vehicle supernatants. I. Pharmacokinetics after in vitro and in vivo exposure.
Topics: Animals; Antibody-Producing Cells; Arsenic; Arsenicals; Cells, Cultured; Culture Media, Conditioned; Female; Gallium; Immunosuppression Therapy; Immunosuppressive Agents; Mice; Solubility; Spleen; Succimer | 1993 |
Isolated rat kidney tubules as a screening system for arsenic antidotes.
Topics: Animals; Antidotes; Arsenates; Arsenic; Arsenic Poisoning; Arsenicals; Arsenites; Chelating Agents; Dimercaprol; Drug Evaluation, Preclinical; Gluconeogenesis; In Vitro Techniques; Kidney Tubules; Male; Mice; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley; Succimer; Unithiol | 1993 |
Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols.
Topics: Arsenicals; Chelating Agents; Cysteine; Glutathione; Glutathione Disulfide; Glutathione Reductase; NADP; Oxidation-Reduction; Structure-Activity Relationship; Succimer; Sulfhydryl Compounds; Yeasts | 1997 |
Developmental effects of methylated arsenic metabolites in mice.
Topics: Abnormalities, Drug-Induced; Animals; Arsenic Poisoning; Arsenicals; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Female; Fetal Death; Infusions, Parenteral; Methylation; Mice; Pregnancy; Succimer | 1998 |
The effects of sulfur, thiol, and thiol inhibitor compounds on arsine-induced toxicity in the human erythrocyte membrane.
Topics: Adult; Arsenicals; Calcium; Carbon Monoxide; Chelating Agents; Chlorides; Dithionitrobenzoic Acid; Drug Interactions; Erythrocyte Membrane; Ethylmaleimide; Female; Hemolysis; Humans; Magnesium; Male; Potassium; Sodium; Succimer; Sulfhydryl Compounds; Sulfhydryl Reagents; Sulfur; Thiosulfates | 2000 |
Intentional overdose of dimercaptosuccinic acid in the course of treatment for arsenic poisoning.
Topics: Adult; Animals; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Chelating Agents; Drug Overdose; Humans; Male; Mice; Oxides; Rats; Succimer; Suicide, Attempted | 2001 |
Effects of Lewisite on cell membrane integrity and energy metabolism in human keratinocytes and SCL II cells.
Topics: Adenosine Triphosphate; Arsenicals; Cell Membrane Permeability; Cell Survival; Chelating Agents; Energy Metabolism; Formazans; Glucose; Humans; Keratinocytes; L-Lactate Dehydrogenase; Lactic Acid; Succimer; Tetrazolium Salts; Time Factors; Tumor Cells, Cultured; Unithiol | 2001 |
Meso 2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA effect on gallium arsenide induced pathological liver injury in rats.
Topics: Alanine Transaminase; Animals; Arsenicals; Aspartate Aminotransferases; Catalase; Chelating Agents; Chemical and Drug Induced Liver Injury; Gallium; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver Function Tests; Male; Metals; Oxidation-Reduction; Oxidative Stress; Porphobilinogen Synthase; Rats; Succimer; Superoxide Dismutase | 2002 |
Combined administration of oxalic acid, succimer and its analogue for the reversal of gallium arsenide-induced oxidative stress in rats.
Topics: Aminolevulinic Acid; Animals; Arsenicals; Chelating Agents; Copper; Drug Therapy, Combination; Gallium; Glutathione; Glutathione Disulfide; Kidney; Liver; Male; Malondialdehyde; Oxalic Acid; Oxidative Stress; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Wistar; Spleen; Succimer; Tissue Distribution; Zinc | 2002 |
Acute arsenic poisoning treated by intravenous dimercaptosuccinic acid (DMSA) and combined extrarenal epuration techniques.
Topics: Acute Kidney Injury; Adult; Antidotes; Arsenic; Arsenic Poisoning; Fatal Outcome; Hemodynamics; Homicide; Humans; Injections, Intravenous; Male; Peritoneal Dialysis; Succimer | 2003 |
Arsenic uptake by native fern species in Thailand: effect of chelating agents on hyperaccumulation of arsenic by Pityrogramma calomelanos.
Topics: Arsenic; Chelating Agents; Edetic Acid; Ferns; Plant Leaves; Soil Pollutants; Succimer; Thailand; Tissue Distribution | 2003 |
Therapeutic potential of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats.
Topics: Aminolevulinic Acid; Animals; Antidotes; Arsenic Poisoning; Arsenicals; Biomarkers; Chelating Agents; Chelation Therapy; Comet Assay; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Gallium; Injections, Intraperitoneal; Liver; Male; Protoporphyrins; Rats; Rats, Wistar; Succimer; Treatment Outcome | 2004 |
Chronic arsenic poisoning in the rat: treatment with combined administration of succimers and an antioxidant.
Topics: Animals; Antioxidants; Arsenic; Arsenic Poisoning; Ascorbic Acid; Brain Chemistry; Chelating Agents; Drug Interactions; Drug Therapy, Combination; Heme; Male; Oxidative Stress; Rats; Rats, Wistar; Succimer; Tissue Distribution | 2004 |
Arsenic induced inhibition of delta-aminolevulinate dehydratase activity in rat blood and its response to meso 2,3-dimercaptosuccinic acid and monoisoamyl DMSA.
Topics: Administration, Oral; Animals; Arsenic Poisoning; Arsenicals; Enzyme Inhibitors; Injections, Intraperitoneal; Male; Mice; Porphobilinogen Synthase; Rats; Succimer | 2004 |
Arsenic trioxide poisoning: a description of two acute overdoses.
Topics: Acute Disease; Adult; Antidotes; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Drug Overdose; Feces; Humans; Male; Oxides; Powders; Succimer; Suicide, Attempted; Time Factors | 2004 |
Thermodynamics of the As(III)-thiol interaction: arsenite and monomethylarsenite complexes with glutathione, dihydrolipoic acid, and other thiol ligands.
Topics: Arsenates; Arsenic; Arsenic Poisoning; Arsenites; Calorimetry; Cations; Dithiothreitol; Glutathione; Ligands; Organometallic Compounds; Succimer; Sulfhydryl Compounds; Thermodynamics; Thioctic Acid | 2005 |
Arsenic induced blood and brain oxidative stress and its response to some thiol chelators in rats.
Topics: 5-Aminolevulinate Synthetase; Animals; Arsenic; Arsenic Poisoning; Chelating Agents; DNA Damage; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Male; Oxidative Stress; Porphobilinogen Synthase; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Unithiol | 2005 |
Therapeutic effects of hypothermia on Lewisite toxicity.
Topics: Animals; Arsenicals; Cell Survival; Cells, Cultured; Chelating Agents; Chemical Warfare Agents; Guinea Pigs; Humans; Hypothermia, Induced; Keratinocytes; Male; Skin Diseases; Succimer | 2006 |
Combined administration of N-acetylcysteine and monoisoamyl DMSA on tissue oxidative stress during arsenic chelation therapy.
Topics: Acetylcysteine; Animals; Arsenic; Chelation Therapy; Guinea Pigs; Male; Oxidative Stress; Succimer | 2006 |
Effects of combined administration of captopril and DMSA on arsenite induced oxidative stress and blood and tissue arsenic concentration in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antidotes; Antioxidants; Arsenic; Arsenites; Brain; Captopril; Copper; Drug Interactions; Glutathione; Glutathione Disulfide; Kidney; Liver; Male; Oxidative Stress; Porphobilinogen Synthase; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Thiobarbituric Acid Reactive Substances; Zinc | 2007 |
Successful treatment of potentially fatal heavy metal poisonings.
Topics: Adult; Arsenic Poisoning; Arsenic Trioxide; Arsenicals; Chelation Therapy; Decontamination; Dimercaprol; Drug Therapy, Combination; Humans; Male; Mercuric Chloride; Mercury Poisoning; Oxides; Polyethylene Glycols; Solvents; Succimer; Suicide, Attempted; Therapeutic Irrigation | 2007 |
Combined administration of iron and monoisoamyl-DMSA in the treatment of chronic arsenic intoxication in mice.
Topics: Animals; Arsenic; Arsenic Poisoning; Brain; Chronic Disease; Drug Therapy, Combination; Iron; Kidney; Liver; Male; Mice; Oxidative Stress; Succimer; Zinc | 2007 |
Slow recovery from severe inorganic arsenic poisoning despite treatment with DMSA (2.3-dimercaptosuccinic acid).
Topics: Adult; Antidotes; Arsenic; Arsenic Poisoning; Chelating Agents; Critical Care; Electromyography; Female; Hair; Humans; Mass Spectrometry; Nephritis, Interstitial; Paresthesia; Spectrophotometry, Atomic; Succimer; Walking | 2007 |
Quercetin administration during chelation therapy protects arsenic-induced oxidative stress in mice.
Topics: Animals; Antioxidants; Arsenic; Chelation Therapy; Glutathione; Male; Mice; Molecular Structure; Oxidative Stress; Porphobilinogen Synthase; Quercetin; Reactive Oxygen Species; Succimer; Treatment Outcome | 2008 |
Acute arsenic trioxide ant bait ingestion by toddlers.
Topics: Administration, Oral; Arsenic Trioxide; Arsenicals; Chelating Agents; Child, Preschool; Female; Household Products; Humans; Infant; Insecticides; Male; Oxides; Poison Control Centers; Poisoning; Succimer; Vomiting | 2008 |
The effect of arsenic exposure and the efficacy of DMSA on the proteins and lipids of the gill tissues of Labeo rohita.
Topics: Animals; Antidotes; Arsenic; Arsenicals; Chelating Agents; Cyprinidae; Gills; Lethal Dose 50; Lipid Metabolism; Proteins; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Succimer | 2009 |
Dual action of phenylarsine oxide on the glucose transport activity of GLUT1.
Topics: Animals; Arsenicals; Biological Transport; Cell Line; Cytochalasin B; Enzyme Inhibitors; Fibroblasts; Glucose; Glucose Transporter Type 1; Mice; Succimer | 2009 |
Co-administration of monoisoamyl dimercaptosuccinic acid and Moringa oleifera seed powder protects arsenic-induced oxidative stress and metal distribution in mice.
Topics: Animals; Antioxidants; Arsenic; Arsenic Poisoning; Body Weight; Brain; Chelating Agents; Drinking; Eating; Free Radicals; Glutathione; Kidney; Liver; Male; Metals; Mice; Moringa oleifera; Oxidative Stress; Seeds; Succimer; Tissue Distribution | 2009 |
A study of the subchronic effects of arsenic exposure on the liver tissues of Labeo rohita using Fourier transform infrared technique.
Topics: Animals; Arsenic; Chelating Agents; Cyprinidae; Dose-Response Relationship, Drug; Fish Proteins; Liver; Spectroscopy, Fourier Transform Infrared; Succimer; Water Pollutants, Chemical | 2011 |
Good outcomes despite high urinary arsenic concentrations from overdose with crabgrass killer.
Topics: Adolescent; Antidotes; Arsenic; Arsenic Poisoning; Arsenicals; Child, Preschool; Digitaria; Drug Overdose; Female; Gastric Lavage; Herbicides; Humans; Male; Succimer; Suicide, Attempted; Treatment Outcome | 2011 |
Inadvertent poisoning of seven teenagers with monosodium methanearsonate.
Topics: Accidents, Home; Adolescent; Antidotes; Arsenic Poisoning; Arsenicals; Chelating Agents; Cooking; Dimercaprol; Gastrointestinal Diseases; Herbicides; Humans; Male; Nausea; Succimer; Treatment Outcome; Vomiting | 2011 |
Co-administration of meso 2,3-dimercaptosuccinic acid monoesters reduces arsenic concentration and oxidative stress in gallium arsenide exposed rats.
Topics: Aminolevulinic Acid; Animals; Arsenic; Arsenic Poisoning; Arsenicals; Catalase; Copper; Gallium; Glutathione; Heme; Kidney; Lipid Peroxidation; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Superoxide Dismutase; Transaminases; Zinc | 2011 |
Encapsulation of the flavonoid quercetin with an arsenic chelator into nanocapsules enables the simultaneous delivery of hydrophobic and hydrophilic drugs with a synergistic effect against chronic arsenic accumulation and oxidative stress.
Topics: Animals; Antioxidants; Arsenic; Arsenic Poisoning; Brain; Chelating Agents; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Drug Synergism; Female; Humans; Hydrophobic and Hydrophilic Interactions; Lactic Acid; Liver; Nanoparticles; Oxidative Stress; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Quercetin; Rats; Rats, Wistar; Succimer | 2011 |
Monoisoamyl 2, 3-dimercaptosuccinic acid (MiADMSA) demonstrates higher efficacy by oral route in reversing arsenic toxicity: a pharmacokinetic approach.
Topics: Administration, Oral; Animals; Arsenic; Arsenic Poisoning; Chelating Agents; Chronic Disease; Copper; Dose-Response Relationship, Drug; Glutathione; Glutathione Disulfide; Kidney; Liver; Liver Function Tests; Male; Oxidative Stress; Rats; Rats, Wistar; Succimer; Zinc | 2012 |
Influence of glutathione chemical effectors in the response of maize to arsenic exposure.
Topics: Arsenates; Arsenic; Arsenites; Biological Transport; Biomass; Buthionine Sulfoximine; Chelating Agents; Enzyme Inhibitors; Glutathione; Glutathione Transferase; Hydroponics; Phytochelatins; Plant Roots; Plant Shoots; Seedlings; Succimer; Sulfhydryl Compounds; Thiazoles; Unithiol; Zea mays | 2012 |
Therapeutic profile of T11TS vs. T11TS+MiADMSA: a hunt for a more effective therapeutic regimen for arsenic exposure.
Topics: Animals; Apoptosis; Arsenic; Arsenic Poisoning; CD2 Antigens; Cell Transformation, Neoplastic; Chelating Agents; Chelation Therapy; Cytokines; Drug Therapy, Combination; Environmental Exposure; Lymphocytes; Mice; Oxidative Stress; Succimer | 2012 |
MiADMSA protects arsenic-induced oxidative stress in human keratinocyte 'HaCaT' cells.
Topics: Arsenic; Cell Line; Dose-Response Relationship, Drug; Humans; Keratinocytes; Oxidative Stress; Succimer | 2013 |
Topical efficacy of dimercapto-chelating agents against lewisite-induced skin lesions in SKH-1 hairless mice.
Topics: Administration, Topical; Animals; Arsenic Poisoning; Arsenicals; Chelating Agents; Dermatitis; Dimercaprol; Injections, Subcutaneous; Male; Mice; Mice, Hairless; Succimer; Volatilization | 2013 |
Alterations in apoptotic caspases and antioxidant enzymes in arsenic exposed rat brain regions: reversal effect of essential metals and a chelating agent.
Topics: Animals; Antioxidants; Apoptosis; Arsenic; Brain; Calcium; Caspases; Chelating Agents; Lipid Peroxidation; Metals; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Succimer; Zinc | 2013 |
Antitumor efficacy of DMSA modified Fe3O4 magnetic nanoparticles combined with arsenic trioxide and adriamycin in Raji cells.
Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Shape; Doxorubicin; Ferric Compounds; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Intracellular Space; Magnetite Nanoparticles; Oxides; Proto-Oncogene Proteins c-bcl-2; Succimer; Survivin; Tumor Suppressor Protein p53 | 2014 |
Nanoencapsulation of DMSA monoester for better therapeutic efficacy of the chelating agent against arsenic toxicity.
Topics: Animals; Arsenic; Arsenic Poisoning; Brain; Chelating Agents; Drug Carriers; Kidney; Liver; Male; Mice; Nanoparticles; Rabbits; Rats; Rats, Wistar; Succimer | 2014 |
Combinatorial drug delivery strategy employing nano-curcumin and nano-MiADMSA for the treatment of arsenic intoxication in mouse.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Arsenic; Arsenic Poisoning; Curcumin; Deoxyguanosine; Drug Carriers; Drug Synergism; Enzymes; Glutathione; Liver; Male; Mice; Nanoparticles; Oxidative Stress; Reactive Oxygen Species; Succimer | 2018 |
A Sickening Tale.
Topics: Adult; Arsenic; Arsenic Poisoning; Chelation Therapy; Diagnosis, Differential; Diarrhea; Fresh Water; Hallucinations; Hepatitis; Humans; Hypotension; Male; Northern Territory; Pancytopenia; Sensation Disorders; Succimer; Vomiting; Water Pollutants, Chemical | 2018 |
Combination therapy with vitamin C and DMSA for arsenic-fluoride co-exposure in rats.
Topics: Animals; Arsenic; Ascorbic Acid; Catalase; CD13 Antigens; DNA Damage; Fluorides; Glucosephosphate Dehydrogenase; Glutamyl Aminopeptidase; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Male; Oxidative Stress; Porphobilinogen Synthase; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Superoxide Dismutase | 2018 |
Effects of combined arsenic and lead exposure on the brain monoaminergic system and behavioral functions in rats: Reversal effect of MiADMSA.
Topics: Animals; Arsenic; Behavior, Animal; Biogenic Monoamines; Brain; Exploratory Behavior; Female; Lead; Male; Motor Activity; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Succimer | 2019 |
Removal of As(III) from Biological Fluids: Mono- versus Dithiolic Ligands.
Topics: Arsenic; Body Fluids; Chelating Agents; Humans; Hydrogen-Ion Concentration; Ligands; Molecular Dynamics Simulation; Molecular Structure; Succimer; Thermodynamics | 2020 |
Foliar application of the sulfhydryl compound 2,3-dimercaptosuccinic acid inhibits cadmium, lead, and arsenic accumulation in rice grains by promoting heavy metal immobilization in flag leaves.
Topics: Arsenic; Cadmium; Metals, Heavy; Oryza; Plant Leaves; Soil; Soil Pollutants; Succimer; Sulfhydryl Compounds | 2021 |
MiADMSA abrogates sodium tungstate-induced oxidative stress in rats.
Topics: Animals; Antidotes; Arsenic; Biomarkers; Chelating Agents; Glutathione Disulfide; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Thiobarbituric Acid Reactive Substances; Tungsten | 2022 |