Bovine Spongiform Encephalopathy

A transmissible spongiform encephalopathy of cattle associated with abnormal prion proteins in the brain. Affected animals develop excitability and salivation followed by ATAXIA. This disorder has been associated with consumption of SCRAPIE infected ruminant derived protein. This condition may be transmitted to humans, where it is referred to as variant or new variant CREUTZFELDT-JAKOB SYNDROME. (Vet Rec 1998 Jul 25;143(41):101-5)

Synonym
Spongiform Encephalopathy, Bovine
Encephalitis, Bovine Spongiform
Bovine Spongiform Encephalopathy
Encephalopathy, Bovine Spongiform
Mad Cow Disease
BSE (Bovine Spongiform Encephalopathy)

Excerpt	Reference
"Bovine spongiform encephalopathy is a prion disease of ruminants that was first recognized in 1986 in the United Kingdom."	( Abete, MC; Crescio, MI; Ingravalle, F; Ru, G, 2007)
"Mad cow disease is the paradigmatic food safety crisis because it brings together the poles of production and consumption, of animals and humans."	( Keck, F, 2008)
"Bovine spongiform encephalopathy is an infectious disease of cattle that is transmitted through the consumption of meat-and-bone meal from infected cattle."	( Harman, JL; Silva, CJ, 2009)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	94 (25.20)	12.5806
2000's	225 (60.32)	18.1394
2010's	48 (12.87)	28.8240
2020's	6 (1.61)	9.53

Drug	Relationship Strength	Studies
gamma-aminobutyric acid	low	1
formic acid	low	2
methane	low	1
hydrochloric acid	low	2
3-hydroxybutyric acid	low	2
lactic acid	low	3
formaldehyde	low	4
sarcosine	low	1
uric acid	low	1
urea	low	1
gentamicin	low	1
guanidine	low	1
activins	low	1
tyramine	low	1
xylazine	low	1
alanine	low	1
glutamine	low	1
lysine	low	3
sucrose	low	1
edetic acid	low	1
tyrosine	low	1
methionine	low	8
cycloheximide	low	1
valine	low	3
threonine	low	1
alizarin	low	1
arginine	low	1
phthalimide	low	2
tolonium chloride	low	1
thiophenes	low	1
congo red	low	2
phosmet	low	4
durapatite	low	1
sodium hydroxide	low	6
vancomycin	low	1
d-alpha tocopherol	low	1
troclosene	low	1
streptomycin	low	1
manganese	low	3
mercury	low	2
mercuric chloride	low	1
calcium phosphate, dibasic, anhydrous	low	1
calcium phosphate, monobasic, anhydrous	low	1
tricalcium phosphate	low	3
chlorine	low	1
clodronic acid	low	1
cetylpyridinium chloride anhydrous	low	1
tributyl phosphate	low	1
glutamic acid	low	1
adenosine diphosphate ribose	low	1
trazodone hydrochloride	low	1
guanidine thiocyanate	low	2
metaperiodate	low	1
fluorodeoxyglucose f18	low	1
triheptanoin	low	1
fibrinogen	low	2
calcium pyrophosphate	low	1
biotin	low	1
atropine	low	2
benzofurans	low	1
glycogen	low	1
arginine ethyl ester	low	1
bromochloroacetic acid	low	1
freedom	low	2
sodium dodecyl sulfate	low	1
mtt formazan	low	1
myelin basic protein	low	1
bilirubin	low	1
dinoprostone	low	1
ubiquinone 9	low	1
coenzyme q10	low	1
lead	low	1
arsenic	low	1
cysteine	low	1
selenium	low	1
formazans	low	1
alpha-synuclein	low	3
thimerosal	low	1
ubiquinone	low	1
guanidine isothiocyanate	low	1
biotinyltyramide	low	1
sodium hypochlorite	low	3
sarkosyl	low	1
insulin, isophane	low	1
glycolipids	low	1
heparitin sulfate	low	1
tetracycline	low	1
transforming growth factor beta	low	1
hyaluronoglucosaminidase	low	1
lactoferrin	low	1
digitonin	low	1
muramidase	low	2
chondroitin sulfates	low	1
metallothionein	low	2

Protein Targets (675)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
TDP1 protein	12	0	0	12
Transient receptor potential cation channel subfamily M member 2	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Carbonic anhydrase 1	0	2	0	6
Carbonic anhydrase 2	0	3	1	8
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	5
Proton-coupled amino acid transporter 1	0	3	0	3
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Luciferase	6	0	0	6
endonuclease IV	1	0	0	1
15-lipoxygenase, partial	4	0	0	4
WRN	1	0	0	1
RAR-related orphan receptor gamma	14	0	0	14
USP1 protein, partial	7	0	0	7
Microtubule-associated protein tau	6	0	0	6
AR protein	20	0	0	20
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
estrogen receptor 2 (ER beta)	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
retinoid X nuclear receptor alpha	12	0	0	12
estrogen nuclear receptor alpha	20	0	0	20
G	4	0	0	4
cytochrome P450 2D6	8	0	0	8
peroxisome proliferator activated receptor gamma	8	0	0	8
aryl hydrocarbon receptor	7	0	0	7
thyroid stimulating hormone receptor	10	0	0	10
Histone H2A.x	9	0	0	9
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
chromobox protein homolog 1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
histone deacetylase 9 isoform 3	3	0	0	3
importin subunit beta-1 isoform 1	3	0	0	3
mitogen-activated protein kinase 1	6	0	0	6
flap endonuclease 1	4	0	0	4
serine/threonine-protein kinase PLK1	3	0	0	3
snurportin-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	14	0	0	14
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
tumor susceptibility gene 101 protein	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	6	0	0	6
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
geminin	10	0	0	10
DNA polymerase kappa isoform 1	2	0	0	2
Vpr	1	0	0	1
survival motor neuron protein isoform d	4	0	0	4
cytochrome P450 3A4 isoform 1	5	0	0	5
histone acetyltransferase KAT2A isoform 1	5	0	0	5
kelch-like ECH-associated protein 1	0	0	0	2
Gamma-aminobutyric acid receptor subunit pi	5	2	0	7
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Transthyretin	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Cellular tumor antigen p53	12	0	0	12
Apoptosis regulator Bcl-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	5	2	0	7
Gamma-aminobutyric acid receptor subunit delta	5	2	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	5	2	1	8
D(3) dopamine receptor	0	1	0	1
Glutamate receptor 1	1	2	1	4
Glutamate receptor 2	7	2	1	10
Glutamate receptor 3	1	2	1	4
Glutamate receptor 4	1	2	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	5	2	0	7
Amine oxidase [flavin-containing] A	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	5	2	0	7
Amine oxidase [flavin-containing] B	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	5	2	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	5	2	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	5	2	0	7
Histamine H2 receptor	3	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	5	2	1	8
Gamma-aminobutyric acid receptor subunit beta-3	5	2	0	7
Guanine nucleotide-binding protein G	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	5	2	1	8
Inositol monophosphatase 1	4	0	0	4
Induced myeloid leukemia cell differentiation protein Mcl-1	0	1	0	1
TAR DNA-binding protein 43	5	0	0	5
Cytochrome P450 1B1	0	1	0	1
RmtA	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	2
GABA theta subunit	5	2	0	7
Inositol hexakisphosphate kinase 1	4	0	0	4
Protein arginine N-methyltransferase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	5	2	0	7
cytochrome P450 2C9, partial	4	0	0	4
phosphoglycerate kinase	1	0	0	1
Chain A, Cruzipain	5	0	0	5
interleukin 8	3	0	0	3
phosphopantetheinyl transferase	6	0	0	6
GLS protein	6	0	0	6
glucocorticoid receptor [Homo sapiens]	12	0	0	12
farnesoid X nuclear receptor	9	0	0	9
peroxisome proliferator-activated receptor delta	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	9	0	0	9
peripheral myelin protein 22	6	0	0	6
lamin isoform A-delta10	9	0	0	9
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 3A4	0	1	1	3
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	7	0	0	7
NFKB1 protein, partial	1	0	0	1
thyroid stimulating hormone receptor	5	0	0	5
alpha-galactosidase	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
cytochrome P450 2C19 precursor	2	0	0	2
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	4	0	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	4	0	0	4
GLI family zinc finger 3	13	0	0	13
pregnane X nuclear receptor	10	0	0	10
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	1	0	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	1	0	3
ATP-binding cassette sub-family C member 3	0	3	0	3
Multidrug resistance-associated protein 4	0	3	0	4
5-hydroxytryptamine receptor 4	0	2	0	2
Bile salt export pump	0	6	0	6
Muscarinic acetylcholine receptor M2	0	3	1	7
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M1	0	2	1	5
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	2	1	6
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	2	1	5
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
apical membrane antigen 1, AMA1	2	0	0	2
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
Chain A, Ferritin light chain	4	0	0	4
acetylcholinesterase	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
caspase 7, apoptosis-related cysteine protease	2	0	0	2
progesterone receptor	6	0	0	6
estrogen-related nuclear receptor alpha	12	0	0	12
67.9K protein	4	0	0	4
caspase-3	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
activating transcription factor 6	7	0	0	7
thyrotropin-releasing hormone receptor	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	12	0	0	12
thyroid hormone receptor beta isoform 2	8	0	0	8
heat shock protein beta-1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	4	0	0	4
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Caspase-2	0	0	1	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
72 kDa type IV collagenase	0	2	0	2
Stromelysin-1	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Macrophage metalloelastase	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Chymotrypsinogen A	0	0	0	1
Beta-lactamase	0	1	0	1
Amyloid-beta precursor protein	0	3	0	3
Beta-lactamase	0	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	2
Beta-galactosidase	0	1	0	2
5-hydroxytryptamine receptor 1A	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
glp-1 receptor, partial	3	0	0	3
pregnane X receptor	2	0	0	2
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	3	0	0	3
PPM1D protein	1	0	0	1
Smad3	2	0	0	2
EWS/FLI fusion protein	2	0	0	2
polyprotein	3	0	0	3
P53	1	0	0	1
RPL19A	0	0	1	1
IDH1	2	0	0	2
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
thyroid hormone receptor beta isoform a	4	0	0	4
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
ras-related protein Rab-9A	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
COUP transcription factor 2 isoform a	0	1	0	1
Transmembrane protease serine 2	0	0	1	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Alpha-synuclein	2	1	0	3
Spike glycoprotein	4	0	1	5
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
regulator of G-protein signaling 4	6	0	0	6
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 6	0	0	0	2
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	1	0	3
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
arylsulfatase A	3	0	0	3
Bloom syndrome protein isoform 1	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	2	0	1	3
Integrin alpha-IIb	2	0	1	3
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	4
Glutamate receptor ionotropic, NMDA 2B	0	2	1	4
Glutamate receptor ionotropic, NMDA 2C	0	2	1	4
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	2	1	4
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	1	4
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	4
Chain A, Glutamine Binding Protein	0	0	1	1
peripheral myelin protein 22 isoform 1	1	0	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	2	0	3
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 6	0	1	0	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase 9	0	3	1	5
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Chain A, Beta-lactamase	2	0	0	2
nonstructural protein 1	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Peroxisome proliferator-activated receptor alpha	2	0	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Bile salt export pump	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Protein-arginine deiminase type-4	0	3	0	3
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Nrf2	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
hypothetical protein, conserved	1	0	0	1
glucocerebrosidase	1	0	0	1
toll-like receptor 9	0	1	0	1
caspase recruitment domain family, member 15	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
huntingtin isoform 2	1	0	0	1
neurotensin receptor type 1	0	0	1	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
large T antigen	0	1	0	1
Beta lactamase (plasmid)	0	1	0	1
Microtubule-associated protein tau	0	2	0	2
acid sphingomyelinase	1	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
dopamine D1 receptor	1	0	0	1
guanine nucleotide-binding protein subunit alpha-15	0	1	1	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
D(3) dopamine receptor isoform e	1	0	0	1
trace amine-associated receptor 1	0	1	1	2
Polyphenol oxidase 2	0	0	0	2
5-hydroxytryptamine receptor 2C	0	0	1	1
Phenylethanolamine N-methyltransferase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Dopamine beta-hydroxylase	0	0	0	1
D(1A) dopamine receptor	0	1	0	2
5-hydroxytryptamine receptor 1B	0	0	1	1
5-hydroxytryptamine receptor 1D	0	0	1	1
5-hydroxytryptamine receptor 1F	0	0	1	1
5-hydroxytryptamine receptor 2B	0	0	1	1
5-hydroxytryptamine receptor 6	0	0	1	1
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Beta-secretase 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Histamine H3 receptor	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase	0	0	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Albumin	0	0	1	1
Alpha-2A adrenergic receptor	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Transporter	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bovine Spongiform Encephalopathy

Synonyms(6)

Research Excerpts

Overview

Research

Studies (373)

Protein Targets (675)

Bovine Spongiform Encephalopathy

Synonyms(6)

Research Excerpts

Overview

Research

Studies (373)

Drugs Studied (110)

Protein Targets (675)