Hyperdactyly

A congenital anomaly of the hand or foot, marked by the presence of supernumerary digits.

Synonym
Polydactylia
Polydactyly
Hyperdactyly
Polydactylism

Excerpt	Reference
"Polydactyly is a common congenital limb deformity."	( Fu, Q; Geng, J; Li, Y; Shen, Y; Wang, J; Wang, Z; Xu, Y, 2014)
"Polydactyly is a highly common congenital limb defect."	( Birk, OS; Langer, Y; Volodarsky, M, 2014)
"Preaxial polydactyly is a congenital hand anomaly predominantly of sporadic occurrence, which is frequently associated with abnormalities of the Sonic hedgehog signalling pathway."	( Davey, MG; Johnson, EJ; Lam, WL; Oh, JDH; Pertinez, SP; Stephens, C, 2019)
"Wassel VI radial polydactyly is associated with metacarpal adduction and radial deviation of the metacarpophalangeal joint of the ulnar duplicate."	( Morimoto, N; Saito, S; Tsuge, I; Yamanaka, H, 2021)
"Type B ulnar polydactyly is one of the most commonly encountered congenital hand differences and can be treated with ligation or excision."	( Adkinson, JM; Goebel, GJ; Loewenstein, SN, 2023)
"Preaxial or radial polydactyly is one of the most common hand congenital anomalies in newborns."	( Chung, SH; Kim, HJ; Kim, PT; Lee, HJ; Lee, KS; Park, KH; Park, SH, 2022)

Excerpt	Reference
"In homozygous Lx/Lx progeny, polydactyly prevailed in forelimbs of SHR/BXH2 following RA administration, whilst in BN/BN progeny oligodactyly was the most frequent affliction."	( Bíla, V; Kren, V; Liska, F, 2000)
"Non-treated homozygous polydactyly/arhinencephaly (Pdn/Pdn) mouse fetuses exhibited exencephaly in 16."	( Katagiri, R; Maekawa, M; Naruse, I; Ohta, K; Ueta, E, 2005)
"Preaxial mirror polydactyly of foot is a rare congenital anomaly with even fewer documentations for definitive treatment."	( Jain, M; Kumar, V; Patel, S; Sudesh, P, 2010)
"Preaxial polydactyly can be caused in the developing embryo by acute maternal administration of a Smo agonist that activates HH signaling."	( Baker, LK; Fish, EW; Lamson, D; Murdaugh, LB; Parnell, SE; Sulik, KK; Williams, KP, 2017)
"Type B ulnar polydactyly is one of the most commonly encountered congenital hand differences and can be treated with ligation or excision."	( Adkinson, JM; Goebel, GJ; Loewenstein, SN, 2023)
"Post-axial polydactyly (PAP) is almost always treated by ablation of the sixth ray since the ulnar duplicate is universally inadequate and the radial one is normal."	( Mozaffarian, D; Mozaffarian, K; Vosoughi, AR, 2022)
"Simple postaxial polydactyly (type B) is a common congenital hand malformation often treated by suture or clip ligation."	( Peljovich, AE; Stults, WP, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	9 (6.04)	23.3326
1990's	31 (20.81)	12.5806
2000's	46 (30.87)	18.1394
2010's	39 (26.17)	28.8240
2020's	24 (16.11)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	1	0
salicylic acid	low	4	0
cytosine	low	1	0
2,4,5-trichlorophenoxyacetic acid	low	1	0
2,4-dichlorophenoxyacetic acid	low	1	0
phenytoin	low	1	0
hydroxyindoleacetic acid	low	1	0
busulfan	low	1	0
chlorambucil	low	1	0
valproic acid	low	1	0
flucytosine	low	1	0
fluorouracil	low	1	0
hydroxychloroquine	low	1	0
lidocaine	low	1	0
apnea	low	2	0
ondansetron	low	1	0
tetracaine	low	1	0
thalidomide	low	1	0
thyroxine	low	1	0
alanine	low	2	0
bromodeoxyuridine	low	5	0
ethyl methanesulfonate	low	1	0
cytarabine	low	1	0
histidine	low	1	0
threonine	low	1	0
isoleucine	low	1	0
arginine	low	1	0
thiophenes	low	2	0
ethylnitrosourea	low	3	0
titanium	low	1	0
calcium sulfate	low	1	0
trolamine salicylate	low	3	0
agent orange	low	1	0
captopril	low	1	0
adefovir	low	1	0
cidofovir anhydrous	low	1	0
methotrexate	low	1	0
dactylariol	low	1	0
ropivacaine	medium	1	1
organophosphonates	low	1	0
povidone-iodine	low	1	0
7-dehydrocholesterol	low	1	0
ochratoxin a	low	3	0
tretinoin	low	9	0
bromochloroacetic acid	low	1	0
glycosides	low	1	0
dermatan sulfate	low	1	0
misoprostol	low	1	0
purmorphamine	low	1	0
phenylephrine hydrochloride	low	8	0
dexmedetomidine	medium	1	1
lead	low	1	0
strontium	low	1	0
arsenic	low	1	0
cysteine	low	1	0
strontium radioisotopes	low	1	0
caesium-137	low	1	0
oligonucleotides	low	1	0
chondroitin	low	1	0
heparitin sulfate	low	2	0
transforming growth factor beta	low	8	0
folic acid	low	1	0
eye	low	1	0

Protein Targets (733)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Luciferase	5	0	0	5
thioredoxin reductase	15	0	0	15
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
AR protein	21	0	0	21
progesterone receptor	6	0	0	6
retinoid X nuclear receptor alpha	13	0	0	13
estrogen-related nuclear receptor alpha	17	0	0	17
estrogen nuclear receptor alpha	25	0	0	25
peroxisome proliferator-activated receptor delta	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
thyroid hormone receptor beta isoform 2	13	0	0	13
serine/threonine-protein kinase PLK1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial	0	1	0	1
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	13	0	0	13
peroxisome proliferator activated receptor gamma	9	0	0	9
thyroid hormone receptor beta isoform a	10	0	0	10
Androgen receptor	0	3	0	3
Vitamin D3 receptor	0	0	0	1
GLI family zinc finger 3	12	0	0	12
Caspase-7	3	0	0	3
caspase-3	3	0	0	3
geminin	21	0	0	21
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
Solute carrier family 22 member 6	0	1	0	4
Phosphoribosyl pyrophosphate synthase-associated protein 2	0	1	0	2
Adenylate kinase isoenzyme 1	0	0	0	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Adenosine deaminase	0	1	0	2
Capsid protein	0	0	1	1
Solute carrier family 22 member 6	0	3	0	7
Solute carrier family 22 member 8	0	1	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	15	0	0	15
TDP1 protein	17	0	0	17
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
glucocorticoid receptor [Homo sapiens]	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
heat shock protein beta-1	3	0	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
lamin isoform A-delta10	20	0	0	20
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Bile salt export pump	0	20	0	20
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	7	0	0	7
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	9	0	0	9
Carbonic anhydrase 1	0	3	0	6
Carbonic anhydrase 2	0	3	1	7
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	2
Proton-coupled amino acid transporter 1	0	2	0	2
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
ATAD5 protein, partial	6	0	0	6
Microtubule-associated protein tau	11	0	0	11
arylsulfatase A	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	20	0	0	20
Bloom syndrome protein isoform 1	7	0	0	7
D(1A) dopamine receptor	1	0	0	1
neuropeptide S receptor isoform A	3	0	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
phosphopantetheinyl transferase	7	0	0	7
NFKB1 protein, partial	3	0	0	3
GLS protein	6	0	0	6
thyroid stimulating hormone receptor	9	0	0	9
alpha-galactosidase	5	0	0	5
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	14	0	0	14
flap endonuclease 1	6	0	0	6
DNA polymerase iota isoform a (long)	6	0	0	6
muscarinic acetylcholine receptor M1	6	0	0	6
lethal factor (plasmid)	4	0	0	4
Cytochrome P450 3A4	0	3	1	5
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	17	0	0	17
retinoic acid nuclear receptor alpha variant 1	13	0	0	13
thyroid stimulating hormone receptor	5	0	0	5
Cellular tumor antigen p53	16	0	0	16
Nuclear receptor ROR-gamma	5	1	1	7
interleukin 8	5	0	0	5
pregnane X receptor	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
IDH1	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
cellular tumor antigen p53 isoform a	3	0	0	3
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
peripheral myelin protein 22	10	0	0	10
survival motor neuron protein isoform d	6	0	0	6
Thymidine kinase, cytosolic	0	2	0	2
Thymidine phosphorylase	0	0	1	2
Thymidylate kinase	0	1	0	1
Spike glycoprotein	5	0	1	6
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
15-lipoxygenase, partial	4	0	0	4
apical membrane antigen 1, AMA1	2	0	0	2
EWS/FLI fusion protein	13	0	0	13
aryl hydrocarbon receptor	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
ATP-binding cassette sub-family C member 3	0	12	0	12
Multidrug resistance-associated protein 4	0	12	0	14
Matrix metalloproteinase-9	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Canalicular multispecific organic anion transporter 1	0	13	0	13
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Thrombopoietin	3	0	0	3
thioredoxin glutathione reductase	4	0	0	4
Metallo-beta-lactamase type 2	0	1	1	2
peripheral myelin protein 22 isoform 1	5	0	0	5
M-phase phosphoprotein 8	4	0	0	4
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Prothrombin	0	1	0	1
Renin	0	1	0	1
Neprilysin	0	1	0	1
Neprilysin	0	1	0	1
Leukotriene A-4 hydrolase	0	2	1	3
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	2	1	3
Angiotensin-converting enzyme	0	2	0	3
Leukotriene A-4 hydrolase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	2	0	2
Mu-type opioid receptor	0	0	1	1
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	2
Angiotensin-converting enzyme 2	0	1	1	2
Beta-lactamase class B VIM-2	0	1	1	2
GALC protein	2	0	0	2
caspase 7, apoptosis-related cysteine protease	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
caspase-3	1	0	0	1
activating transcription factor 6	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	6	0	0	6
vitamin D3 receptor isoform VDRA	8	0	0	8
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
muscleblind-like protein 1 isoform 1	4	0	0	4
Carbonic anhydrase 12	0	2	0	3
Cytochrome P450 2D6	0	2	1	3
Carbonic anhydrase 9	0	2	0	3
Solute carrier organic anion transporter family member 1B3	0	2	0	3
acetylcholinesterase	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
USP1 protein, partial	8	0	0	8
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	4	0	0	4
Parkin	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
prostaglandin E2 receptor EP2 subtype	0	0	0	1
mitogen-activated protein kinase 1	4	0	0	4
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
cytochrome P450 3A4 isoform 1	6	0	0	6
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	6	3	0	9
Acetylcholinesterase	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	6	3	0	9
Gamma-aminobutyric acid receptor subunit delta	6	3	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-5	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	6	3	0	9
Gamma-aminobutyric acid receptor subunit gamma-1	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-4	6	3	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	6	3	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	6	3	0	9
Gamma-aminobutyric acid receptor subunit beta-3	6	3	0	9
Gamma-aminobutyric acid receptor subunit beta-2	6	3	0	9
Carboxylic ester hydrolase	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
GABA theta subunit	6	3	0	9
Gamma-aminobutyric acid receptor subunit epsilon	6	3	0	9
ORF73	0	0	1	1
Thymidine kinase	0	1	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
endonuclease IV	4	0	0	4
glp-1 receptor, partial	5	0	0	5
G	7	0	0	7
67.9K protein	3	0	0	3
LMP1 [Human herpesvirus 4]	0	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Thymidine kinase 2, mitochondrial	0	1	0	1
Interferon beta	7	0	0	7
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	4	0	5
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
D(1A) dopamine receptor	1	0	0	1
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Inositol hexakisphosphate kinase 1	7	0	0	7
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
cytochrome P450 2C9, partial	7	0	0	7
Deoxycytidine kinase	0	0	0	1
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	4	0	0	4
Alpha-2A adrenergic receptor	0	4	1	5
Alpha-1B adrenergic receptor	0	6	0	6
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	3	0	3
Alpha-1D adrenergic receptor	0	5	0	5
Alpha-1A adrenergic receptor	0	6	0	6
Histamine H2 receptor	4	0	0	4
Skn7p	0	0	0	2
nonstructural protein 1	3	0	0	3
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	1	0	0	1
Vpr	3	0	0	3
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	2	0	2
Amyloid-beta precursor protein	1	1	0	2
Aromatase	0	2	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Ferritin light chain	4	0	0	4
acid sphingomyelinase	2	0	0	2
glucocerebrosidase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
DNA polymerase beta	3	0	0	3
Thymidylate synthase	0	4	0	4
Dihydrofolate reductase	0	2	3	5
Aldo-keto reductase family 1 member B1	0	2	0	2
Alpha-synuclein	1	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	4
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	1	0	2
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	1	0	2
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 13	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Muscarinic acetylcholine receptor M1	0	3	0	3
Alpha-2B adrenergic receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Fumarate hydratase	2	0	0	2
Smad3	2	0	0	2
hypothetical protein, conserved	1	0	0	1
regulator of G-protein signaling 4	5	0	0	5
polyprotein	2	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
Potassium channel subfamily K member 3	0	3	0	3
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	3
Sodium channel protein type 5 subunit alpha	0	3	0	3
Sodium channel protein type 9 subunit alpha	0	4	0	4
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	3	0	3
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase kappa isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Bile salt export pump	0	3	0	3
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Integrin beta-3	1	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Integrin alpha-IIb	1	1	0	2
5-hydroxytryptamine receptor 2C	0	2	0	3
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	3	0	3
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	3	0	3
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	2
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	0	2
PPM1D protein	1	0	0	1
cytochrome P450 2D6	4	0	0	4
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Metabotropic glutamate receptor 6	0	1	0	1
Acetylcholinesterase	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Cytochrome P450 1A2	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 1A2	0	1	1	2
Tyrosine-protein kinase Fyn	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
ATP-dependent translocase ABCB1	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Adenosine receptor A3	0	4	0	4
Cytochrome P450 2C9	0	2	2	4
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	3	0	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
5-hydroxytryptamine receptor 1A	0	5	0	5
ATP-dependent translocase ABCB1	0	2	0	2
Substance-K receptor	0	2	0	2
Cannabinoid receptor 1	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Acetylcholinesterase	0	2	0	2
Aromatase	0	0	1	1
Heme oxygenase 2	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Histamine H2 receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	5	0	5
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 1B	0	3	0	3
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Cytochrome P450 2C19	0	1	1	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Malate dehydrogenase, cytoplasmic	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	6	0	6
Melanocortin receptor 3	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	3
Cholinesterase	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Sodium-dependent dopamine transporter	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Calcium release-activated calcium channel protein 1	0	1	0	1
heat shock protein 90, putative	0	0	0	1
methionyl-tRNA synthetase, putative	0	1	0	1
Chain A, Cruzipain	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Inositol monophosphatase 1	2	0	0	2
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	0	1	0	1
Solute carrier family 22 member 19	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
5-hydroxytryptamine receptor 3E	0	1	1	3
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	1	3
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Beta-2 adrenergic receptor	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Interleukin-6 receptor subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
Beta-3 adrenergic receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
5-hydroxytryptamine receptor 3A	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
5-hydroxytryptamine receptor 3A	0	2	1	4
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Thyrotropin-releasing hormone receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Glycine receptor subunit alpha-4	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	1	3
Multidrug and toxin extrusion protein 2	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	1	3
5-hydroxytryptamine receptor 3B	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	1	3
Histamine H3 receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Nischarin	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Gamma-aminobutyric acid	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
interferon gamma precursor	0	0	0	1
Smoothened homolog	0	0	1	1
Sonic hedgehog protein	0	0	1	1
Smoothened homolog	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
cGMP-gated cation channel alpha-1	0	0	1	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	4	6
UDP-glucuronosyltransferase 1A1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Cocaine esterase	0	1	0	1
Histone deacetylase 3	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (149)

Protein Targets (733)

Hyperdactyly

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (149)

Drugs Studied (73)

Protein Targets (733)