Page last updated: 2024-09-27

Gestational Trophoblastic Disease

A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread.

Synonyms(1)

Synonym
Gestational Trophoblastic Disease

Research Excerpts

Overview

ExcerptReference
"Gestational trophoblastic disease is a fascinating group of pregnancy disorders characterised by abnormal proliferation of trophoblast, ranging from benign to malignant."( Khoo, SK, 2003)
"Because gestational trophoblastic disease is rare, little evidence is available from randomized controlled trials on optimal treatment and follow-up."( Coulter, J; Frijstein, MM; Golfier, F; Lok, CAR; Massuger, LFAG; Seckl, MJ; Ten Kate-Booij, MJ; van Trommel, NE, 2019)

Research

Studies (293)

TimeframeStudies, This Condition (%)All Conditions %
pre-19907 (2.39)23.3326
1990's0 (0.00)12.5806
2000's96 (32.76)18.1394
2010's128 (43.69)28.8240
2020's62 (21.16)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
dihydrouracil0medium11
uracil0medium11
chlorambucil0low10
fluorouracil0medium141
gabapentin0low10
hydroxyurea0low50
ifosfamide0low20
mitoxantrone0low30
activins0low10
ag 18790low10
tegafur0low10
floxuridine0medium133
thyroxine0low10
triiodothyronine0low10
cytarabine0low10
cordycepin0low10
phencyclidine0low10
quinazolines0low10
azacitidine0low10
deoxycytidine0low10
arsenic trioxide0low10
gold0low10
carbimazole0low10
prednimustine0low20
mifepristone0low10
gemcitabine0low10
fluorodeoxyglucose f180low80
carboplatin0low60
n-acetylneuraminic acid0low10
trichostatin a0low10
tretinoin0low10
retinol0medium22
decitabine0low10
melphalan0low20
bromochloroacetic acid0low10
enclomiphene0low10
n(alpha)-(4-amino-4-deoxy-n(10)--methylpteroyl-n(epsilon)-4'-fluoresceinthiocarbamoyl)-l-lysine trihydrate0low10
cactinomycin0low10
misoprostol0low40
arsenic0low10
beta-escin0low10
saracatinib0low10
phosphatidylcholines0low10
kiss1 protein, human0low10
angiogenin0low20
levoleucovorin0medium373
folic acid0low40
leptin0low10

Protein Targets (980)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Lck Kinase0101
Chain A, BCL-2-RELATED PROTEIN A10001
Chain A, Tyrosine-protein kinase Lyn0101
Chain A, Tyrosine-protein kinase Lyn0101
glp-1 receptor, partial110011
Skn7p0002
TDP1 protein230023
Smad35005
regulator of G-protein signaling 47007
nonstructural protein 14004
67.9K protein100010
LAP40011
RPL19A0011
nuclear factor erythroid 2-related factor 2 isoform 2110011
amino acid transporter AGP10011
geminin200020
survival motor neuron protein isoform d120012
Receptor-interacting serine/threonine-protein kinase 20112
Tyrosine-protein kinase JAK20112
Tyrosine-protein kinase ABL10325
Proto-oncogene tyrosine-protein kinase Src0112
Epidermal growth factor receptor0819
Tyrosine-protein kinase Lck0314
Proto-oncogene tyrosine-protein kinase LCK 0101
Tyrosine-protein kinase Fyn0516
Tyrosine-protein kinase Lyn0112
Tyrosine-protein kinase HCK0112
Proto-oncogene tyrosine-protein kinase Src0415
Ephrin type-A receptor 30011
Ephrin type-B receptor 20123
Alpha-synuclein3205
Tyrosine-protein kinase CSK0213
Tyrosine-protein kinase ZAP-700101
Casein kinase I isoform delta0112
TAR DNA-binding protein 435106
Mitogen-activated protein kinase 140213
HSP40, subfamily A [Plasmodium falciparum 3D7]0002
Vascular endothelial growth factor receptor 20202
AR protein190019
glucocorticoid receptor [Homo sapiens]150015
estrogen nuclear receptor alpha240024
peroxisome proliferator activated receptor gamma140014
nuclear receptor subfamily 1, group I, member 23003
thyroid hormone receptor beta isoform 2190019
Cellular tumor antigen p53210021
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
Chain A, Beta-lactamase8008
interleukin 85005
pregnane X receptor6006
RAR-related orphan receptor gamma160016
ATAD5 protein, partial9009
Fumarate hydratase6006
NFKB1 protein, partial4004
PPM1D protein4004
GLI family zinc finger 3120012
Thrombopoietin4004
aldehyde dehydrogenase 1 family, member A1130013
estrogen receptor 2 (ER beta)9009
nuclear receptor subfamily 1, group I, member 3140014
progesterone receptor9009
cytochrome P450 family 3 subfamily A polypeptide 4100010
retinoic acid nuclear receptor alpha variant 1130013
retinoid X nuclear receptor alpha130013
estrogen-related nuclear receptor alpha160016
farnesoid X nuclear receptor100010
pregnane X nuclear receptor150015
polyprotein6006
Parkin4004
peroxisome proliferator-activated receptor delta120012
vitamin D (1,25- dihydroxyvitamin D3) receptor110011
arylsulfatase A4004
IDH17007
euchromatic histone-lysine N-methyltransferase 2170017
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a100010
thyroid stimulating hormone receptor5005
activating transcription factor 67007
Bloom syndrome protein isoform 19009
peripheral myelin protein 22 isoform 14004
hemoglobin subunit beta2002
cellular tumor antigen p53 isoform a3003
chromobox protein homolog 1130013
huntingtin isoform 25005
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 15005
nuclear factor erythroid 2-related factor 2 isoform 1150015
urokinase-type plasminogen activator precursor8008
plasminogen precursor8008
urokinase plasminogen activator surface receptor precursor8008
peripheral myelin protein 22160016
histone acetyltransferase KAT2A isoform 17007
muscarinic acetylcholine receptor M14004
lamin isoform A-delta10180018
Interferon beta120012
Integrin beta-33205
Integrin alpha-IIb3104
Adenosine receptor A30505
DNA (cytosine-5)-methyltransferase 10202
Adenosine receptor A2a0101
Adenosine receptor A10303
D(1A) dopamine receptor3003
Nuclear receptor ROR-gamma6118
Spike glycoprotein7029
Multidrug and toxin extrusion protein 10202
Histone-lysine N-methyltransferase EHMT20202
ATPase family AAA domain-containing protein 5110011
Ataxin-2130013
ATP-dependent phosphofructokinase100010
Liver carboxylesterase 10001
USP1 protein, partial130013
Bile salt export pump016016
Lactoperoxidase0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
acetylcholinesterase4004
phosphopantetheinyl transferase8008
G7007
cytochrome P450 2D64004
vitamin D3 receptor isoform VDRA110011
histone-lysine N-methyltransferase 2A isoform 2 precursor5005
DNA polymerase kappa isoform 15005
HLA class I histocompatibility antigen, B alpha chain 7007
Inositol hexakisphosphate kinase 17007
cytochrome P450 2C9, partial7007
Luciferase4004
thioredoxin reductase120012
GALC protein2002
GLS protein6006
Microtubule-associated protein tau9009
thioredoxin glutathione reductase6006
caspase 7, apoptosis-related cysteine protease4004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
thyroid stimulating hormone receptor7007
EWS/FLI fusion protein130013
bromodomain adjacent to zinc finger domain 2B5005
caspase-34004
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x100010
potassium voltage-gated channel subfamily H member 2 isoform d6006
FAD-linked sulfhydryl oxidase ALR0001
muscleblind-like protein 1 isoform 15005
ATP-binding cassette sub-family C member 3012012
Multidrug resistance-associated protein 4012014
Carbonic anhydrase 120101
Carbonic anhydrase 10101
Carbonic anhydrase 20214
Cytochrome P450 2D60415
Carbonic anhydrase 90203
Canalicular multispecific organic anion transporter 1013014
Solute carrier organic anion transporter family member 1B308010
PINK11001
heat shock protein 900011
TPA: protein transporter TIM230101
Adenosine receptor A10112
Histamine H1 receptor0011
Sterol 14-alpha demethylase0101
RNA-directed RNA polymerase 0112
Carnitine O-palmitoyltransferase 1, muscle isoform0101
endonuclease IV2002
LMP1 [Human herpesvirus 4]0003
thyroid hormone receptor beta isoform a6006
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0303
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
DNA polymerase iota isoform a (long)6006
transactivating tegument protein VP16 [Human herpesvirus 1]0303
nuclear receptor coactivator 3 isoform a0303
Thymidine kinase 2, mitochondrial0101
Voltage-dependent calcium channel gamma-2 subunit9009
Thymidine kinase, cytosolic0101
Thymidine kinase0101
Thymidylate synthase0506
Cytochrome P450 3A40415
Thymidine kinase0101
Glutamate receptor 29009
Deoxycytidine kinase0014
Probable deoxycytidylate deaminase0002
Cytidine deaminase0104
E3 ubiquitin-protein ligase Mdm20101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Thymidine kinase0101
Deoxynucleoside kinase0101
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
Chain A, Ferritin light chain8008
Chain A, Cruzipain5005
15-lipoxygenase, partial5005
hypoxia-inducible factor 1 alpha subunit4004
RAD510101
Caspase-73003
caspase-33003
nuclear receptor ROR-gamma isoform 17007
cytochrome P450 3A4 isoform 16006
caspase-1 isoform alpha precursor2002
Gamma-aminobutyric acid receptor subunit pi6219
ATP-dependent translocase ABCB10408
Gamma-aminobutyric acid receptor subunit beta-16219
Gamma-aminobutyric acid receptor subunit delta6219
Gamma-aminobutyric acid receptor subunit gamma-262210
Gamma-aminobutyric acid receptor subunit alpha-56219
Gamma-aminobutyric acid receptor subunit alpha-36219
Gamma-aminobutyric acid receptor subunit gamma-16219
Gamma-aminobutyric acid receptor subunit alpha-26219
Gamma-aminobutyric acid receptor subunit alpha-46219
Gamma-aminobutyric acid receptor subunit gamma-36219
Gamma-aminobutyric acid receptor subunit alpha-66219
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Caspase-72002
Gamma-aminobutyric acid receptor subunit alpha-162210
Growth factor receptor-bound protein 20101
Gamma-aminobutyric acid receptor subunit beta-36219
Gamma-aminobutyric acid receptor subunit beta-262210
Pantothenate synthetase0101
Discoidin domain-containing receptor 20112
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0112
GABA theta subunit6219
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
Gamma-aminobutyric acid receptor subunit epsilon6219
exodeoxyribonuclease V subunit RecD0101
exodeoxyribonuclease V subunit RecB0101
exodeoxyribonuclease V subunit RecC0101
Thymidine kinase 2 0101
AAA family ATPase 0002
Chain A, JmjC domain-containing histone demethylation protein 3A3003
chaperonin-containing TCP-1 beta subunit homolog1001
ubiquitin-conjugating enzyme E2 N0101
protein AF-9 isoform a0002
5-hydroxytryptamine receptor 40404
Estrogen receptor1416
Receptor tyrosine-protein kinase erbB-20303
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Muscarinic acetylcholine receptor M10404
Beta-3 adrenergic receptor0202
Alpha-1B adrenergic receptor0404
Alpha-2B adrenergic receptor0404
Alpha-2C adrenergic receptor0202
Muscarinic acetylcholine receptor M30202
Substance-K receptor0404
Prostaglandin G/H synthase 10202
Sodium-dependent noradrenaline transporter 0404
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0404
Sodium-dependent serotonin transporter0202
C-8 sterol isomerase0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0404
Alpha-1A adrenergic receptor0404
5-hydroxytryptamine receptor 60202
Sodium-dependent dopamine transporter 0202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sigma non-opioid intracellular receptor 10505
SMAD family member 23003
SMAD family member 33003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
heat shock protein beta-14004
Prothrombin0012
Regulatory protein E20011
ATP-dependent translocase ABCB10101
DNA topoisomerase 10102
DNA topoisomerase 2-alpha02210
Cytochrome P450 2C9 0314
Polyunsaturated fatty acid lipoxygenase ALOX150303
DNA topoisomerase 20002
ATP-dependent translocase ABCB10213
UDP-glucuronosyltransferase 1A1 0203
Serum paraoxonase/arylesterase 10303
Glutamate receptor ionotropic, NMDA 1 0203
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0203
Glutamate receptor ionotropic, NMDA 2B0203
Glutamate receptor ionotropic, NMDA 2C0204
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta01210
Glutamate receptor ionotropic, NMDA 2D0203
Tubulin beta-2B chain0114
Integrase 0202
Similar to alpha-tubulin isoform 1 0114
Similar to alpha-tubulin isoform 1 0103
Glutamate receptor ionotropic, NMDA 3B0203
Glutamate receptor ionotropic, NMDA 3A0203
interferon gamma precursor0002
streptokinase A precursor0011
Sodium/nucleoside cotransporter 20101
Thymidine phosphorylase0001
Solute carrier family 15 member 10101
Thymidine kinase0001
Chain A, Uracil Phosphoribosyltransferase0101
flap endonuclease 13003
Vpr2002
Solute carrier family 22 member 80001
Amyloid-beta precursor protein2204
Aromatase0101
Chain A, Dihydrofolate reductase0011
Chain A, 2-oxoglutarate Oxygenase3003
acid sphingomyelinase2002
glucocerebrosidase4004
alpha-galactosidase2002
lysosomal alpha-glucosidase preproprotein1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
DNA polymerase beta3003
Thymidylate synthase0404
Dihydrofolate reductase0235
Aldo-keto reductase family 1 member B10101
Folylpolyglutamate synthase, mitochondrial0104
Solute carrier organic anion transporter family member 1A30104
Folylpolyglutamate synthase, mitochondrial0104
Multidrug resistance associated protein0103
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
D(1A) dopamine receptor2002
transcriptional regulator ERG isoform 32002
neuropeptide S receptor isoform A4004
Gamma-aminobutyric acid receptor subunit pi0303
Gamma-aminobutyric acid receptor subunit delta0303
Histone deacetylase 30305
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10314
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10314
Gamma-aminobutyric acid receptor subunit gamma-20314
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30314
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50314
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30314
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit beta-20314
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40314
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40317
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0303
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10327
Gamma-aminobutyric acid receptor subunit alpha-60314
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10303
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70305
Histone deacetylase 20316
Polyamine deacetylase HDAC100305
Histone deacetylase 11 0305
Gamma-aminobutyric acid receptor subunit gamma-30303
Histone deacetylase 80305
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60316
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90305
Gamma-aminobutyric acid receptor subunit theta0303
Histone deacetylase 50305
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, DEOXYNUCLEOSIDE KINASE0101
Spike glycoprotein0022
Replicase polyprotein 1ab0022
Transmembrane protease serine 20022
Procathepsin L0022
Replicase polyprotein 1a0022
Replicase polyprotein 1ab0022
Replicase polyprotein 1ab0022
Replicase polyprotein 1ab0022
Equilibrative nucleoside transporter 10101
Angiotensin-converting enzyme 2 0022
Stromelysin-10011
Urease subunit alpha0101
Carbonic anhydrase 40101
Ribonucleoside-diphosphate reductase large subunit0101
Carbonic anhydrase 5A, mitochondrial0101
Urease subunit beta0101
Inositol monophosphatase 12002
importin subunit beta-1 isoform 13003
snurportin-13003
Large neutral amino acids transporter small subunit 1 0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
dopamine D1 receptor3003
ClpP1001
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
DNA polymerase eta isoform 13003
M-phase phosphoprotein 84004
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20123
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0102
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
6-phosphogluconate dehydrogenase, decarboxylating0101
Dihydrofolate reductase0101
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60001
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20103
Chain A, PROGESTERONE RECEPTOR0101
Glucocorticoid receptor 0101
apical membrane antigen 1, AMA14004
hypothetical protein, conserved2002
atrial natriuretic peptide receptor 2 precursor2002
Glucocorticoid receptor1227
Prostaglandin G/H synthase 10101
Progesterone receptor0215
Tegument protein VP160011
Glucocorticoid receptor0113
Glucocorticoid receptor0101
Glycine receptor subunit alpha-10202
Mineralocorticoid receptor 1215
Coagulation factor VII0202
Androgen receptor1315
Cytochrome P450 2C80101
Thyroid hormone receptor alpha0336
Thyroid hormone receptor beta0336
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Tissue factor0202
Androgen receptor0202
5-hydroxytryptamine receptor 1A0202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Adenosine receptor A2a0011
Substance-P receptor0101
Mu-type opioid receptor0202
Kappa-type opioid receptor0202
Guanine nucleotide-binding protein G2002
Progesterone receptor0011
Estrogen receptor beta1214
Glucocorticoid receptor0101
Chain A, Probable serine/threonine-protein kinase pknB0101
WRN1001
DNA polymerase III, partial1001
nonstructural protein 10101
LANA0001
pyruvate kinase1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
phospholipase A2, group III0101
cytochrome P450 2D6 isoform 11001
NPC intracellular cholesterol transporter 1 precursor2002
atrial natriuretic peptide receptor 1 precursor1001
histone-lysine N-methyltransferase NSD2 isoform 10001
mitogen-activated protein kinase 12002
tyrosine-protein kinase Yes2002
GTP-binding nuclear protein Ran isoform 11001
dual specificity tyrosine-phosphorylation-regulated kinase 1A0001
rac GTPase-activating protein 1 isoform a0101
DNA repair protein RAD52 homolog isoform a0001
pyruvate kinase PKM isoform b1001
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Solute carrier family 22 member 30101
Glycoprotein hormones alpha chain1001
Proto-oncogene tyrosine-protein kinase ROS0101
Ornithine decarboxylase1002
Angiotensin-converting enzyme0202
Casein kinase II subunit alpha'0112
Histamine H2 receptor1102
Casein kinase II subunit beta0101
Casein kinase II subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Tyrosine-protein kinase BTK0112
Potassium voltage-gated channel subfamily H member 20202
NEDD8-activating enzyme E1 regulatory subunit0011
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Nuclear receptor subfamily 3 group C member 3 0202
Multidrug and toxin extrusion protein 20101
Casein kinase II subunit alpha 30101
NEDD8-activating enzyme E1 catalytic subunit0011
Single-stranded DNA cytosine deaminase1001
P2Y purinoceptor 120101
phosphoglycerate kinase1001
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Sialidase-40101
Sialidase-10101
Sialidase-30101
Sialidase-20101
Genome polyprotein 0101
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Integrin alpha-V 0101
Tubulin beta chain0113
60 kDa chaperonin0202
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0202
Fibroblast growth factor receptor 10213
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
UDP-glucuronosyltransferase 1A40101
Cholecystokinin receptor type A0202
Melanocortin receptor 50202
UDP-glucuronosyltransferase 2B10 0101
Delta-type opioid receptor0303
10 kDa heat shock protein, mitochondrial0202
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0101
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Thiosulfate sulfurtransferase0202
Beta-tubulin 0101
Tubulin beta-8 chain0113
60 kDa chaperonin 0202
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
10 kDa chaperonin 0202
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Nucleotide-binding oligomerization domain-containing protein 20101
Solute carrier organic anion transporter family member 1B10204
Chain A, Immunoglobulin0011
Chain B, Immunoglobulin0011
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor M30011
Muscarinic acetylcholine receptor M40011
Muscarinic acetylcholine receptor M50011
Muscarinic acetylcholine receptor M20011
Muscarinic acetylcholine receptor M10012
Cytochrome P450 2B60101
Sodium-dependent serotonin transporter0101
Muscarinic acetylcholine receptor M40012
Delta-type opioid receptor0001
Kappa-type opioid receptor0001
Lysosomal Pro-X carboxypeptidase0101
Mu-type opioid receptor0001
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 3A0101
Muscarinic acetylcholine receptor M50012
Muscarinic acetylcholine receptor M30012
Muscarinic acetylcholine receptor M20012
Sigma non-opioid intracellular receptor 10202
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Disintegrin and metalloproteinase domain-containing protein 171001
Chain A, Proto-oncogene tyrosine-protein kinase Src0101
Bone morphogenetic protein receptor type-1B0011
Serine/threonine-protein kinase PLK40011
ATP-dependent RNA helicase DDX3X0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase Chk10011
Aurora kinase A0011
Cyclin-G-associated kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
3-phosphoinositide-dependent protein kinase 10101
Mitotic checkpoint serine/threonine-protein kinase BUB10011
Dynamin-like 120 kDa protein, mitochondrial0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30011
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
High affinity nerve growth factor receptor0011
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20011
Protein kinase C beta type0011
Insulin receptor0011
Cyclin-dependent kinase 10011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Tyrosine-protein kinase Yes0112
Proto-oncogene tyrosine-protein kinase receptor Ret0011
Insulin-like growth factor 1 receptor0011
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0011
Platelet-derived growth factor receptor beta0112
Tyrosine-protein kinase Fgr0011
Serine/threonine-protein kinase A-Raf0011
Mast/stem cell growth factor receptor Kit0101
Glycogen phosphorylase, brain form0011
Breakpoint cluster region protein0011
Serine/threonine-protein kinase pim-10011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Ribosyldihydronicotinamide dehydrogenase [quinone]0011
Platelet-derived growth factor receptor alpha0101
Tyrosine-protein kinase Fer0011
Protein kinase C alpha type0011
cAMP-dependent protein kinase catalytic subunit alpha0112
Vascular endothelial growth factor receptor 1 0101
General transcription and DNA repair factor IIH helicase subunit XPD0011
Ras-related protein Rab-6A0011
Ephrin type-A receptor 10011
Multifunctional protein ADE20011
Nucleoside diphosphate kinase B0011
cAMP-dependent protein kinase catalytic subunit gamma0112
cAMP-dependent protein kinase catalytic subunit beta0112
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Mitogen-activated protein kinase 3 0011
MAP/microtubule affinity-regulating kinase 30011
Mitogen-activated protein kinase 10112
Ephrin type-A receptor 20011
Non-receptor tyrosine-protein kinase TYK20011
Wee1-like protein kinase0011
Heme oxygenase 20011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0011
RAC-beta serine/threonine-protein kinase0011
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40011
Myosin-100011
Vascular endothelial growth factor receptor 30101
Dual specificity mitogen-activated protein kinase kinase 20112
Receptor-type tyrosine-protein kinase FLT30011
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
TGF-beta receptor type-20011
Glycine--tRNA ligase0011
Protein kinase C iota type0011
Exosome RNA helicase MTR40011
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0011
26S proteasome regulatory subunit 6B0011
Mitogen-activated protein kinase 80112
Mitogen-activated protein kinase 90112
Dual specificity mitogen-activated protein kinase kinase 40011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0011
MAP kinase-activated protein kinase 20011
Elongation factor Tu, mitochondrial0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0112
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Interleukin-1 receptor-associated kinase 10011
Ribosomal protein S6 kinase alpha-30011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10011
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 100112
Tyrosine--tRNA ligase, cytoplasmic0011
5'-AMP-activated protein kinase subunit gamma-10011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Adenosine kinase0011
Ras-related protein Rab-100011
Actin-related protein 30011
Actin-related protein 20011
GTP-binding nuclear protein Ran0011
Casein kinase I isoform gamma-20011
Cyclin-dependent kinase 30011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
ATP-dependent 6-phosphofructokinase, platelet type0011
Dual specificity mitogen-activated protein kinase kinase 10112
Protein kinase C theta type0011
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10011
Protein kinase C zeta type0011
Protein kinase C delta type0011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Mitogen-activated protein kinase kinase kinase kinase 20011
Serine/threonine-protein kinase 40011
5'-AMP-activated protein kinase catalytic subunit alpha-10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
Integrin-linked protein kinase0011
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Serine/threonine-protein kinase ATR0011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Cyclin-dependent kinase 100011
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10011
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
AP2-associated protein kinase 10011
Myosin light chain kinase 30011
Putative heat shock protein HSP 90-beta 20011
Rab-like protein 30011
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
ATP-dependent RNA helicase DDX420011
Mitogen-activated protein kinase kinase kinase kinase 30011
MAP kinase-activated protein kinase 50011
Misshapen-like kinase 10011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
Serine/threonine-protein kinase Nek70011
ATP-dependent RNA helicase DDX10011
Mitogen-activated protein kinase kinase kinase kinase 10011
Aurora kinase B0112
MAP/microtubule affinity-regulating kinase 40011
Serine/threonine-protein kinase Nek10011
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0213
Mitogen-activated protein kinase kinase kinase 50011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Serine/threonine-protein kinase D20011
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
dCTP pyrophosphatase 10011
Casein kinase I isoform gamma-10011
Serine/threonine-protein kinase PAK 60011
Phenylalanine--tRNA ligase beta subunit0011
BMP-2-inducible protein kinase0011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase pim-20011
Serine/threonine-protein kinase 260011
Serine/threonine-protein kinase NLK0011
5'-AMP-activated protein kinase subunit gamma-20011
Serine/threonine-protein kinase TBK10011
Septin-90011
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase TAO20011
Long-chain-fatty-acid--CoA ligase 50011
Serine/threonine-protein kinase ICK0011
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
serine/threonine-protein kinase PLK11001
Solute carrier organic anion transporter family member 1A40103
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50002
Rap guanine nucleotide exchange factor 31001
Transthyretin0103
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0246
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, Nuclear Receptor ROR-beta0101
thyrotropin-releasing hormone receptor1001
Ornithine decarboxylase0001
Cytochrome P450 1A20112
Retinoic acid receptor alpha0227
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Alpha-1D adrenergic receptor0101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2C190112
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
Chain A, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)0101
Chain B, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)0101
Chain A, Histone deacetylase 7a0101
Chain A, Histone deacetylase 7a0101
Histone deacetylase 80101
Histone deacetylase 0101
Lysine-specific demethylase 4E0101
unnamed protein product0001
Histone deacetylase 10202
5-hydroxytryptamine receptor 3A0101
Histone deacetylase 30101
Plasma kallikrein0101
Leukotriene A-4 hydrolase0101
Vitamin D3 receptor0101
Adenosine receptor A10101
Histone deacetylase 20101
Splicing factor 3B subunit 30101
Histone deacetylase 10101
Adenosine receptor A10101
Histone deacetylase 0101
Histone deacetylase 40101
Polyamine deacetylase HDAC100101
Histone deacetylase 30101
Histone deacetylase-like amidohydrolase0202
Histone deacetylase 70101
NAD-dependent protein deacetylase sirtuin-60112
Histone deacetylase 80101
Histone deacetylase 110101
HD2 type histone deacetylase HDA106 0202
Histone deacetylase 90101
Histone deacetylase 70101
Histone deacetylase 6 0101
Histone deacetylase 40101
Histone deacetylase 0101
Nuclear receptor corepressor 20202
Histone deacetylase 60101
Histone deacetylase 50101
Histone deacetylase 0101
Thyroid hormone receptor beta0101
Sigma non-opioid intracellular receptor 10011
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Chain A, Uracil-DNA Glycosylase0101
Protein cereblon0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]