Page last updated: 2024-08-26

arsenic and darinaparsin

arsenic has been researched along with darinaparsin in 30 studies

Research

Studies (30)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (33.33)	29.6817
2010's	16 (53.33)	24.3611
2020's	4 (13.33)	2.80

Authors

Authors	Studies
Hirano, S; Kobayashi, Y	1
Himeno, S; Hirano, S; Kobayashi, Y; Kojima, C; Sakurai, MH; Sakurai, T; Waalkes, MP	1
Feldmann, J; Jaspars, M; Meharg, AA; Raab, A; Wright, SH	1
Colombo, M; Diaz, Z; Komarnitsky, PB; Kourelis, M; Mann, KK; Marcoux, S; Miller, WH	1
Kanaki, K; Pergantis, SA	1
Chen, YW; Freireich, E; Kantarjian, H; Quintás-Cardama, A; Verstovsek, S; Zingaro, R	1
Aguirre, V; Arriagada, S; Bertoglio, JC; Burgos, RA; Cáceres, DD; Calvo, M; Hancke, JL	1
Boise, LH; Cai, Y; Croutch, C; Gutman, D; Lee, KP; Matulis, SM; Morales, AA; Yehiayan, L	1
Abbadessa, G; Blaszkowsky, LS; Chen, H; Costa, M; Feun, L; Gold, P; Henderson, C; Hochster, H; Lewis, J; Muggia, F; Nierodzik, M; Rosenzweig, B; Ryan, T; Van Veldhuizen, P; Wu, J; Zheng, H; Zhu, AX	1
Camacho, LH; Daring, S; Gutierrez, C; Hong, DS; Komarnitsky, PB; Kurzrock, R; Ng, C; Schwartz, B; Stevens, J; Tsimberidou, AM; Uehara, CK; Verstovsek, S	1
Lossos, IS; Mann, KK; Miller, WH; Wallner, B	1
Boccia, RV; Craig, MD; Hamilton, BL; Hosein, PJ; Lewis, JJ; Lossos, IS; Tallman, MS	1
Chiang, C; Goldenring, JR; Kolobova, E; Liu, J; Mason, TA; Roland, JT	1
Knox, SJ; Li, X; Nolley, R; Peehl, DM; Reese, SW; Tian, J; Young, SR; Zhao, H	1
del Rincon, SV; Diaz, Z; Garnier, N; Gupta, A; Kourelis, M; Kwan, S; Mann, KK; Miller, WH; Molina, MF; Petruccelli, LA; Schipper, HM	1
Doi, H; Knox, SJ; Li, X; Peehl, DM; Saar, M; Santos, J; Tian, J	1
Bohle, DS; Conklin, DS; Dahabieh, MS; del Rincon, SV; Garnier, N; Gu, Y; Mann, KK; Miller, WH; Nichol, JN; Redstone, GG; Sun, Y	1
Boise, LH; Cai, Y; Liu, G; Matulis, S; Stice, S; Yehiayan, L	1
Bhalla, S; Crombie, J; Evens, AM; Gartenhaus, RB; Kandela, I; Mazar, A; Ravi, D; Sharma, J	1
Bansal, N; Bertino, JR; Farley, NJ; Lewis, J; Wu, L; Youssoufian, H	1
Chang, SL; DiRocco, DP; Fabian, SL; Fleig, SV; Heckl, D; Humphreys, BD; Ikeda, Y; Kramann, R; Maarouf, O; Rennke, HG; Schneider, RK; Waikar, SS; Wongboonsin, J	1
Boise, LH; Cai, Y; Liu, G; Matulis, S; Stice, S	1
Hirano, S; Kato, A; Kobayashi, Y; Udagawa, O	1
Cai, Y; McCord, B; McGoron, AJ; Mebel, A; Sun, Y; Yang, M; Zhang, X	1
Bae, H; Ito, I; Kubota, K; Nagahama, F; Okamoto, T; Sonehara, Y; Tateishi, U; Tsuchiya, J	1
Guan, X; Hu, X; Li, H; Sun, H; Toy, PH; Wang, H; Xu, X; Zhang, Y	1
Chowdhury, T; Mandal, SM; Roymahapatra, G	1
Ishizawa, K; Kim, WS; Nagahama, F; Nagai, H; Ogura, M; Sonehara, Y; Suehiro, Y; Tobinai, K; Uchida, T; Uike, N	1
Ando, K; Fukuhara, N; Izutsu, K; Kang, HJ; Kim, WS; Ko, PS; Kwong, YL; Nagahama, F; Nagai, H; Nakajima, H; Negoro, E; Sonehara, Y; Suehiro, Y; Terui, Y; Tien, HF; Tobinai, K; Uchida, T; Yamamoto, K; Yoon, DH	1
Nagahama, F; Sonehara, Y; Yao, K	1

Reviews

1 review(s) available for arsenic and darinaparsin

Article	Year
Darinaparsin: a novel organic arsenical with promising anticancer activity. Expert opinion on investigational drugs, 2009, Volume: 18, Issue:11 Topics: Animals; Antineoplastic Agents; Arsenicals; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Glutathione; Humans; Neoplasms; Signal Transduction	2009

Trials

8 trial(s) available for arsenic and darinaparsin

Article	Year
Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clinical rheumatology, 2009, Volume: 28, Issue:8 Topics: Adolescent; Adult; Aged; Andrographis; Arsenicals; Arthralgia; Arthritis, Rheumatoid; Chloroquine; Double-Blind Method; Drug Therapy, Combination; Female; Glutathione; Humans; Methotrexate; Middle Aged; Phytotherapy; Placebos; Plant Extracts; Plant Leaves; Prednisone; Prospective Studies; Radiography; Severity of Illness Index; Young Adult	2009
Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma. Investigational new drugs, 2010, Volume: 28, Issue:5 Topics: Adult; Aged; Antineoplastic Agents; Arsenicals; Carcinoma, Hepatocellular; Disease-Free Survival; Female; Glutathione; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Treatment Outcome	2010
A phase I clinical trial of darinaparsin in patients with refractory solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Jul-15, Volume: 15, Issue:14 Topics: Area Under Curve; Arsenicals; Ataxia; Dizziness; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Glutathione; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Nausea; Neoplasms; Nervous System Diseases; Treatment Outcome	2009
A multicenter phase II study of darinaparsin in relapsed or refractory Hodgkin's and non-Hodgkin's lymphoma. American journal of hematology, 2012, Volume: 87, Issue:1 Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Arsenicals; Female; Glutathione; Hodgkin Disease; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Recurrence; Treatment Outcome	2012
Standardization of [F-18]FDG PET/CT for response evaluation by the Radiologic Society of North America-Quantitative Imaging Biomarker Alliance (RSNA-QIBA) profile: preliminary results from the Japan-QIBA (J-QIBA) activities for Asian international multice Japanese journal of radiology, 2018, Volume: 36, Issue:11 Topics: Aged; Arsenicals; Asia; Biomarkers; Female; Fluorodeoxyglucose F18; Glutathione; Humans; Internationality; Japan; Lymphoma, T-Cell, Peripheral; Male; Middle Aged; North America; Phantoms, Imaging; Positron Emission Tomography Computed Tomography; Radiology; Radiopharmaceuticals; Reference Standards; Societies, Medical; Treatment Outcome	2018
Phase I studies of darinaparsin in patients with relapsed or refractory peripheral T-cell lymphoma: a pooled analysis of two phase I studies conducted in Japan and Korea. Japanese journal of clinical oncology, 2021, Feb-08, Volume: 51, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Arsenicals; Female; Glutathione; Humans; Japan; Lymphoma, T-Cell, Peripheral; Male; Middle Aged; Neoplasm Recurrence, Local; Republic of Korea; Time Factors; Treatment Outcome; Young Adult	2021
Darinaparsin in patients with relapsed or refractory peripheral T-cell lymphoma: results of an Asian phase 2 study. Blood advances, 2023, 09-12, Volume: 7, Issue:17 Topics: Arsenicals; Glutathione; Humans; Lymphoma, T-Cell, Peripheral; Neutropenia	2023
[Pharmacological profile and clinical study results of darinaparsin (DARVIAS Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2023, Volume: 158, Issue:5 Topics: Arsenic; Arsenicals; Cystine; Glutathione; Humans; Lymphoma, T-Cell, Peripheral	2023

Other Studies

21 other study(ies) available for arsenic and darinaparsin

Article	Year
Cytotoxic effects of S-(dimethylarsino)-glutathione: a putative intermediate metabolite of inorganic arsenicals. Toxicology, 2006, Oct-03, Volume: 227, Issue:1-2 Topics: Animals; Arsenicals; Arsenites; Cell Culture Techniques; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endothelial Cells; Gas Chromatography-Mass Spectrometry; Glutathione; HL-60 Cells; Humans; Rats; Sodium Compounds	2006
Toxicity of a trivalent organic arsenic compound, dimethylarsinous glutathione in a rat liver cell line (TRL 1215). British journal of pharmacology, 2006, Volume: 149, Issue:7 Topics: Animals; Antineoplastic Agents; Arsenic Poisoning; Arsenicals; Arsenites; Cacodylic Acid; Cell Line; Cell Survival; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Erythrocytes; Glutathione; Hepatocytes; Humans; Inhibitory Concentration 50; Methylation; Rats; Rats, Inbred F344; Serum Albumin; Time Factors	2006
Pentavalent arsenic can bind to biomolecules. Angewandte Chemie (International ed. in English), 2007, Volume: 46, Issue:15 Topics: Arsenic; Arsenicals; Binding Sites; Biopolymers; Brassica; Chromatography, High Pressure Liquid; Glutathione; Mass Spectrometry; Peptides; Sulfur	2007
A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines. Leukemia, 2008, Volume: 22, Issue:10 Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Drug Resistance, Neoplasm; Glutathione; Hematologic Neoplasms; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mice; Multidrug Resistance-Associated Proteins; Oncogene Proteins, Fusion; Oxidative Stress; Oxides	2008
Development of mass spectrometric methods for detecting arsenic-glutathione complexes. Journal of the American Society for Mass Spectrometry, 2008, Volume: 19, Issue:10 Topics: Arsenicals; Arsenites; Cacodylic Acid; Chromatography, High Pressure Liquid; Glutathione; Sodium Compounds; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2008
Chemical and clinical development of darinaparsin, a novel organic arsenic derivative. Anti-cancer agents in medicinal chemistry, 2008, Volume: 8, Issue:8 Topics: Animals; Antineoplastic Agents; Arsenicals; Drug Screening Assays, Antitumor; Glutathione; Humans; Leukemia, Myeloid, Acute; Mice	2008
Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Molecular cancer therapeutics, 2009, Volume: 8, Issue:5 Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Buthionine Sulfoximine; Cell Line, Tumor; Cell Survival; Cysteine; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Multiple Myeloma; Oxides	2009
Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. PloS one, 2011, Volume: 6, Issue:11 Topics: Animals; Antineoplastic Agents; Arsenicals; Arsenites; Cilia; Glutathione; Hedgehog Proteins; HeLa Cells; Humans; Mice; Microtubules; NIH 3T3 Cells; Polymerization; Signal Transduction; Sodium Compounds; Stress, Physiological	2011
Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Jun-15, Volume: 18, Issue:12 Topics: Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Bone Marrow; Cell Hypoxia; Glutathione; Humans; Intestines; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Oxides; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); Radiation-Sensitizing Agents; Reactive Oxygen Species; Xenograft Model Antitumor Assays	2012
The novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cells. Leukemia, 2013, Volume: 27, Issue:11 Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Blast Crisis; Blotting, Western; Cell Cycle; Cell Proliferation; Chromatin Immunoprecipitation; Cytoprotection; DNA Helicases; Flow Cytometry; Glutathione; Heme Oxygenase-1; Humans; Leukemia, Promyelocytic, Acute; NF-E2-Related Factor 2; Nuclear Proteins; Oxides; Phosphorylation; Promoter Regions, Genetic; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured	2013
Radioprotection and cell cycle arrest of intestinal epithelial cells by darinaparsin, a tumor radiosensitizer. International journal of radiation oncology, biology, physics, 2013, Dec-01, Volume: 87, Issue:5 Topics: Animals; Apoptosis; Arsenicals; Cell Cycle Checkpoints; DNA Damage; DNA Repair; Duodenum; Epithelial Cells; Female; Gastrointestinal Tract; Glutathione; Heterografts; Humans; Male; Mice; Prostatic Neoplasms; Radiation Injuries, Experimental; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Syndrome	2013
The novel arsenical darinaparsin is transported by cystine importing systems. Molecular pharmacology, 2014, Volume: 85, Issue:4 Topics: Amino Acid Transport System y+; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Biological Transport; Cell Line, Tumor; Cysteine; gamma-Glutamyltransferase; Glutathione; Humans; Oxides; Sulfhydryl Compounds	2014
Dimethylarsinothioyl glutathione as a metabolite in human multiple myeloma cell lines upon exposure to Darinaparsin. Chemical research in toxicology, 2014, May-19, Volume: 27, Issue:5 Topics: Antineoplastic Agents; Apoptosis; Arsenicals; Cell Line, Tumor; Glutathione; Humans; Multiple Myeloma	2014
The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Dec-01, Volume: 20, Issue:23 Topics: Animals; Apoptosis; Arsenic; Arsenicals; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Glutathione; Hodgkin Disease; Humans; Intracellular Space; Lymphoma, T-Cell; Mice; Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays	2014
Darinaparsin inhibits prostate tumor-initiating cells and Du145 xenografts and is an inhibitor of hedgehog signaling. Molecular cancer therapeutics, 2015, Volume: 14, Issue:1 Topics: Animals; Antineoplastic Agents; Arsenicals; Cell Cycle; Cell Line, Tumor; Docetaxel; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Neoplastic; Glutathione; Hedgehog Proteins; Humans; Kruppel-Like Transcription Factors; Male; Mice; Neoplastic Stem Cells; Nuclear Proteins; Prostatic Neoplasms; Signal Transduction; Taxoids; Xenograft Model Antitumor Assays; Zinc Finger Protein Gli2	2015
Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis. The Journal of clinical investigation, 2015, Aug-03, Volume: 125, Issue:8 Topics: Animals; Arsenicals; Cell Cycle Checkpoints; Cell Line; Fibrosis; Glutathione; Humans; Kidney; Kidney Diseases; Kruppel-Like Transcription Factors; Mice; Mice, Knockout; Myofibroblasts; Pyridines; Pyrimidines; Zinc Finger Protein GLI1; Zinc Finger Protein Gli2	2015
Determination of multiple human arsenic metabolites employing high performance liquid chromatography inductively coupled plasma mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Jan-15, Volume: 1009-1010 Topics: Arsenicals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Glutathione; Humans; Limit of Detection; Mass Spectrometry; Neoplasms; Sulfur	2016
Pharmacodynamics of S-dimethylarsino-glutathione, a putative metabolic intermediate of inorganic arsenic, in mice. Biochemical pharmacology, 2017, Feb-15, Volume: 126 Topics: Animals; Antineoplastic Agents; Arsenicals; Arsenites; Glutathione; Injections, Intravenous; Male; Mice, Inbred C57BL; Protein Binding; Serum Albumin; Sodium Compounds; Tissue Distribution	2017
Raman spectra of thiolated arsenicals with biological importance. Talanta, 2018, Mar-01, Volume: 179 Topics: Arsenicals; Cacodylic Acid; Glutathione; Organometallic Compounds; Quantum Theory; Solutions; Spectrum Analysis, Raman; Vibration; Water	2018
S-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells. Chemical communications (Cambridge, England), 2019, Oct-29, Volume: 55, Issue:87 Topics: Antineoplastic Agents; Apoptosis; Arsenicals; Cell Line, Tumor; Drug Screening Assays, Antitumor; Glutathione; Histones; Humans; Leukemia, Promyelocytic, Acute; Molecular Structure; TNF-Related Apoptosis-Inducing Ligand	2019
In Silico Identification of a Potent Arsenic Based Approved Drug Darinaparsin against SARS-CoV-2: Inhibitor of RNA Dependent RNA polymerase (RdRp) and Essential Proteases. Infectious disorders drug targets, 2021, Volume: 21, Issue:4 Topics: Antiviral Agents; Arsenicals; Computer Simulation; COVID-19; Glutathione; Humans; Molecular Docking Simulation; Peptide Hydrolases; Protease Inhibitors; RNA-Dependent RNA Polymerase; SARS-CoV-2	2021