Phthalonic acid is a dicarboxylic acid with the formula C8H6O5. It is a white solid that is soluble in water. Phthalonic acid is a precursor to phthalic anhydride, which is used in the production of plastics, resins, and other materials. Phthalonic acid is also used in the synthesis of pharmaceuticals and other chemicals. The importance of studying phthalonic acid lies in its potential applications in various industrial processes and its role as an intermediate in the synthesis of other important compounds. Its unique structural features and reactivity make it a valuable molecule for research in organic chemistry and related fields.'
phthalonic acid: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 10710 |
| CHEMBL ID | 300586 |
| SCHEMBL ID | 240838 |
| MeSH ID | M0059554 |
| Synonym |
|---|
| BB 0241847 |
| 2-carboxy-alpha-oxobenzeneacetic acid |
| 528-46-1 |
| 2-oxalobenzoic acid |
| phthalonic acid |
| STK505512 |
| 2-(carboxycarbonyl)benzoic acid |
| AKOS000321457 |
| CHEMBL300586 , |
| 2-oxalyl-benzoic acid |
| bdbm50102181 |
| FT-0657455 |
| A829278 |
| SCHEMBL240838 |
| DTXSID10200776 |
| mfcd00090830 |
| phthalonsaure |
| 2-oxalo-benzoic acid |
| D85948 |
| SY276744 |
| WS-01222 |
| 2-(carboxycarbonyl)benzoicacid |
| CS-0322976 |
Phthalonic acid is a powerful inhibitor of alpha-oxoglutarate transport in mitochondria.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Phthalonic acid is a powerful inhibitor of alpha-oxoglutarate transport in mitochondria. " | ( Phthalonic acid, an inhibitor of alpha-oxoglutarate transport in mitochondria. Eggelte, TA; Meijer, AJ; von Woerkom, GM, 1976) | 3.14 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 (µMol) | 1,500.0000 | 0.0005 | 3.4984 | 9.7600 | AID164985 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID164985 | Inhibitory activity against Yersinia Protein-tyrosine phosphatase 1B | 2001 | Bioorganic & medicinal chemistry letters, Jul-23, Volume: 11, Issue:14 | alpha-Ketocarboxylic acid-based inhibitors of protein tyrosine phosphatases. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (27.02) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||