Page last updated: 2024-11-13

i-antigen

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

I-antigen: used as a marker for well-differentiated leukemia cells; carbohydrate structure of immunodominant epitope is Galbeta1-4GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-3R which is very similar to that of sialyl SSEA-1 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	73427349
CHEBI ID	61610
MeSH ID	M0211517

Synonyms (10)

Synonym
i-antigen
beta-d-galactosyl-(1->4)-n-acetyl-beta-d-glucosaminyl-(1->3)-beta-d-galactosyl-(1->4)-n-acetyl-beta-d-glucosaminyl-(1->3)-(1->3)-beta-d-galactosyl-(1->4)-beta-d-glucosyl-(1<->1')-ceramide
CHEBI:61610 ,
galbeta1-4glcnacbeta1-3galbeta1-4glcnacbeta1-3galbeta1-4glcbeta1-1cer
lacto-n-norhexaosylceramide
(gal)3 (glc)1 (glcnac)2 (cer)1
nlc6cer
EPITOPE ID:149545
beta-d-galp-(1->4)-beta-d-glcpnac-(1->3)-beta-d-galp-(1->4)-beta-d-glcpnac-(1->3)-beta-d-galp-(1->4)-beta-d-glcp-(1<->1')-cer
Q28529700

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (36)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	21 (58.33)	18.7374
1990's	3 (8.33)	18.2507
2000's	4 (11.11)	29.6817
2010's	7 (19.44)	24.3611
2020's	1 (2.78)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	31.87 (24.57)
Research Supply Index	3.74 (2.92)
Research Growth Index	4.56 (4.65)
Search Engine Demand Index	42.09 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (31.87)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (2.50%)	5.53%
Reviews	1 (2.50%)	6.00%
Case Studies	1 (2.50%)	4.05%
Observational	0 (0.00%)	0.25%
Other	37 (92.50%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
serine Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.	2.01	1	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	2.01	1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.08	1	dialdehyde	biomarker
acetylglucosamine Acetylglucosamine: The N-acetyl derivative of glucosamine.. N-acetyl-beta-D-glucosamine : An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.	2.07	1	N-acetyl-D-glucosamine	epitope
d,d-t80-prallethrin d,d-T80-prallethrin: structure given in first source	2.08	1
n-acetyllactosamine N-acetyllactosamine: RN given refers to D-isomer. N-acetyllactosamine : A beta-D-galactopyranosyl-(1->4)-N-acetyl-D-glucosamine having beta-configuration at the reducing end anomeric centre.	2.07	1	beta-D-Galp-(1->4)-D-GlcpNAc
arsenic Arsenic: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)	2.25	1	metalloid atom; pnictogen	micronutrient
pyrethrins [no description available]	2.08	1
lewis x antigen Lewis X Antigen: A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, Lewis X antigen is a stage-specific embryonic antigen.	1.98	1
concanavalin a Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.	1.98	1

Condition	Relationship Strength	Studies	Trials
Disease Exacerbation [description not available]	2.21	1	0
Auricular Fibrillation [description not available]	2.21	1	0
Atrial Fibrillation Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.	2.21	1	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.53	2	0
Acrania [description not available]	2.05	1	0
Neural Tube Defects Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)	2.05	1	0
Aneuploid [description not available]	2.07	1	0
Abnormalities, Autosome [description not available]	2.07	1	0
47,XX,+21 [description not available]	2.07	1	0
Chromosomal Triplication [description not available]	2.07	1	0
Down Syndrome A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)	2.07	1	0
Cataract, Membranous [description not available]	2.98	1	0
Cataract Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)	2.98	1	0
Great Pox [description not available]	2.33	2	0
Syphilis A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.	2.33	2	0
B Virus Infection [description not available]	1.93	1	0
Blood Diseases [description not available]	1.93	1	0
Hematologic Diseases Disorders of the blood and blood forming tissues.	1.93	1	0
Endometrioma An enlarged area of ENDOMETRIOSIS that resembles a tumor. It is usually found in the OVARY. When it is filled with old blood, it is known as a chocolate cyst.	1.93	1	0
Endometriosis A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.	1.93	1	0
Hepatitis, Infectious [description not available]	1.93	1	0
Hepatitis INFLAMMATION of the LIVER.	1.93	1	0
Hepatitis A INFLAMMATION of the LIVER in humans caused by a member of the HEPATOVIRUS genus, HUMAN HEPATITIS A VIRUS. It can be transmitted through fecal contamination of food or water.	1.93	1	0
Ciliophora Infections Infections with protozoa of the phylum CILIOPHORA.	3.42	1	1
Fish Diseases Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).	3.42	1	1
Leukemia, Lymphocytic [description not available]	1.98	1	0
Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.	1.98	1	0
Acquired Autoimmune Hemolytic Anemia [description not available]	1.99	1	0
Anemia, Hemolytic, Autoimmune Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.	1.99	1	0

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