uroporphyrin iii profile

Uroporphyrin III is a porphyrin precursor to heme, a molecule essential for red blood cells. It is characterized by four carboxyl groups attached to the propionic acid side chains. Uroporphyrinogen III is synthesized in the body through a series of enzymatic reactions involving the incorporation of succinyl CoA and glycine. The compound accumulates in the body due to defects in the biosynthesis of heme, leading to a condition known as porphyria. Elevated levels of uroporphyrin III can cause a range of symptoms, including photosensitivity, abdominal pain, and neurological issues. The compound is a strong photosensitizer, meaning it can absorb light energy and transfer it to surrounding molecules, leading to the generation of reactive oxygen species that can damage cells and tissues. Research on uroporphyrin III focuses on understanding its role in porphyria, developing treatments for the condition, and exploring its potential applications in photodynamic therapy for cancer. '

ID Source	ID
PubMed CID	72423
CHEMBL ID	406782
CHEBI ID	15436
SCHEMBL ID	521478
MeSH ID	M0077908

Synonym
3-[(1z,4z,9z,15z)-8,13,18-tris(2-carboxyethyl)-3,7,12,17-tetrakis(carboxymethyl)-21,23-dihydroporphyrin-2-yl]propanoic acid
3,8,13,17-tetrakis(carboxymethyl)-21h,23h-porphine-2,7,12,18-tetrapropanoic acid
uroprophyrin iii
3-[(5z,10z,14z,19z)-7,12,18-tris(2-carboxyethyl)-3,8,13,17-tetrakis(carboxymethyl)-21,23-dihydroporphyrin-2-yl]propanoic acid
2,7,12,18-porphinetetrapropionic acid, 3,8,13,17-tetrakis(carboxymethyl)- (8ci)
uroporphyrin iii (6ci)
21h,23h-porphine-2,7,12,18-tetrapropanoic acid, 3,8,13,17-tetrakis(carboxymethyl)- (9ci)
2,7,12,18-porphinetetrapropionic acid, 3,8,13,17-tetrakis(carboxymethyl)-
3,8,13,17-tetrakis(carboxymethyl)porphyrin-2,7,12,18-tetrapropionic acid
CHEBI:15436
3,8,13,17-tetrakis(carboxymethyl)porphyrin-2,7,12,18-tetrapropanoic acid
uroporphyrin iii
18273-06-8
C02469
CHEMBL406782
unii-qgr6x13t96
SCHEMBL521478
3,8,13,17-tetramethyl-2,7,12,18-porphinetetrapropionic acid
3,8,13,17-tetramethyl-2,7,12,18-porphinetetrapropionate
3,8,13,17-tetrakis(carboxymethyl)porphyrin-2,7,12,18-tetrapropanoate
DTXSID70896977
3-[7,12,18-tris(2-carboxyethyl)-3,8,13,17-tetrakis(carboxymethyl)-21,24-dihydroporphyrin-2-yl]propanoic acid
DTXSID00864821

Pathway	Proteins	Compounds
Biochemical pathways: part I	0	466

Assay ID	Title	Year	Journal	Article
AID106898	Inhibition of HIV-1 P24 production.	1994	Journal of medicinal chemistry, Apr-15, Volume: 37, Issue:8	Three-dimensional structure-activity analysis of a series of porphyrin derivatives with anti-HIV-1 activity targeted to the V3 loop of the gp120 envelope glycoprotein of the human immunodeficiency virus type 1.
AID104239	Inhibition of HIV-1 P24 production.	1994	Journal of medicinal chemistry, Apr-15, Volume: 37, Issue:8	Three-dimensional structure-activity analysis of a series of porphyrin derivatives with anti-HIV-1 activity targeted to the V3 loop of the gp120 envelope glycoprotein of the human immunodeficiency virus type 1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	15 (53.57)	18.7374
1990's	5 (17.86)	18.2507
2000's	4 (14.29)	29.6817
2010's	4 (14.29)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.33%)	6.00%
Case Studies	3 (10.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	26 (86.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
aminolevulinic acid Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.. 5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.	2.11	1	4-oxo monocarboxylic acid; amino acid zwitterion; delta-amino acid	antineoplastic agent; dermatologic drug; Escherichia coli metabolite; human metabolite; mouse metabolite; photosensitizing agent; plant metabolite; prodrug; Saccharomyces cerevisiae metabolite
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	1.96	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
porphobilinogen [no description available]	2.64	3	aralkylamino compound; dicarboxylic acid; pyrroles	Escherichia coli metabolite; metabolite; mouse metabolite
uroporphyrinogen iii Uroporphyrinogens: Porphyrinogens which are intermediates in heme biosynthesis. They have four acetic acid and four propionic acid side chains attached to the pyrrole rings. Uroporphyrinogen I and III are formed from polypyrryl methane in the presence of uroporphyrinogen III cosynthetase and uroporphyrin I synthetase, respectively. They can yield uroporphyrins by autooxidation or coproporphyrinogens by decarboxylation.	1.96	1	uroporphyrinogen	Escherichia coli metabolite; mouse metabolite
aurintricarboxylic acid Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.. aurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.	1.98	1	monohydroxybenzoic acid; quinomethanes; tricarboxylic acid	fluorochrome; histological dye; insulin-like growth factor receptor 1 antagonist
protoporphyrin ix protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685. protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.	3.06	5
histidine Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.	7.1	1	amino acid zwitterion; histidine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
hexachlorobenzene Hexachlorobenzene: An agricultural fungicide and seed treatment agent.. hexachlorobenzene : A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.	1.99	1	aromatic fungicide; chlorobenzenes	antifungal agrochemical; carcinogenic agent; persistent organic pollutant
coproporphyrin i coproporphyrin I: RN given refers to cpd with specified locants; see also record for coproporphyrin III; zinc coproporphyrin I is fluorescent and a characteristic component of meconium	2.42	2
mesoporphyrin ix mesoporphyrin IX: RN given refers to parent cpd; mesoheme is the iron salt of mesoporphyrin IX. mesoporphyrin IX : A member of the class of mesoporphyrins obtained by formal hydrogenation of the two vinyl groups in protoporphyrin.	1.98	1
uroporphyrin i uroporphyrin I: RN given refers to parent cpd	3.24	6
zinc coproporphyrin iii coproporphyrin III: RN given refers to unlabeled parent cpd; see also record for coproporphyrin I	3.28	6
arsenic Arsenic: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)	2.03	1	metalloid atom; pnictogen	micronutrient
chlorophyll a Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.	1.96	1	chlorophyll; methyl ester	cofactor
heme Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.	7.51	2
heme d1 heme d1: extractable heme from Pseudomonas nitrite reductase. ferroheme d1 : A ferroheme having four carboxy groups and oxo groups on two of the pyrrole rings.	2.1	1
siroheme [no description available]	7.1	1

Condition	Relationship Strength	Studies
Acute Porphyria [description not available]	7.37	2
Porphyria, Acute Intermittent An autosomal dominant porphyria that is due to a deficiency of HYDROXYMETHYLBILANE SYNTHASE in the LIVER, the third enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features are recurrent and life-threatening neurologic disturbances, ABDOMINAL PAIN, and elevated level of AMINOLEVULINIC ACID and PORPHOBILINOGEN in the urine.	2.37	2
Remission, Spontaneous A spontaneous diminution or abatement of a disease over time, without formal treatment.	2.01	1
Porphyria Cutanea Tarda An autosomal dominant or acquired porphyria due to a deficiency of UROPORPHYRINOGEN DECARBOXYLASE in the LIVER. It is characterized by photosensitivity and cutaneous lesions with little or no neurologic symptoms. Type I is the acquired form and is strongly associated with liver diseases and hepatic toxicities caused by alcohol or estrogenic steroids. Type II is the familial form.	2.42	2
Porphyria [description not available]	6.93	1
Porphyrias A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.	1.93	1
Facial Dermatoses Skin diseases involving the FACE.	2.03	1
Actinic Reticuloid Syndrome [description not available]	2.03	1
Nail Fungus [description not available]	2.03	1
HIV Coinfection [description not available]	2.03	1
Hand Dermatosis [description not available]	2.03	1
Foot Dermatoses Skin diseases of the foot, general or unspecified.	2.03	1
Hand Dermatoses Skin diseases involving the HANDS.	2.03	1
Onychomycosis A fungal infection of the nail, usually caused by DERMATOPHYTES; YEASTS; or nondermatophyte MOLDS.	2.03	1
HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).	2.03	1
Arsenic Encephalopathy [description not available]	2.03	1
Experimental Mammary Neoplasms [description not available]	1.96	1
Chronic Kidney Failure [description not available]	1.95	1
Bullous Dermatoses [description not available]	1.95	1
Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.	1.95	1
Uremia A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.	1.95	1
Hepatic Porphyria [description not available]	1.99	1
Porphyrias, Hepatic A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.	1.99	1

uroporphyrin iii

Cross-References

Synonyms (23)

Pathways (1)

Bioassays (2)

Research

Studies (28)

Market Indicators

Research Demand Index: 29.19

Study Types