Page last updated: 2024-09-27

Arachnodactyly

An abnormal bone development that is characterized by extra long and slender hands and fingers, such that the clenched thumb extends beyond the ulnar side of the hand. Arachnodactyly can include feet and toes. Arachnodactyly has been associated with several gene mutations and syndromes.

Synonyms(1)

Synonym
Arachnodactyly

Research

Studies (50)

TimeframeStudies, This Condition (%)All Conditions %
pre-199032 (64.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's12 (24.00)28.8240
2020's6 (12.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
bupropion0low10
glycine0low10
fentanyl0low10
halothane0low10
2-propanol0low60
phenobarbital0low10
phenylbutazone0low10
prednisolone0low10
hydroxyproline0low30
serine0low20
cyanides0low10
threonine0low10
ephedrine0low10
trolamine salicylate0low10
4-methoxyamphetamine0low20
propiconazole0low10
fluorodeoxyglucose f180low10
proline0low20
inositol 3-phosphate0low20
pancuronium0low10
keratan sulfate0low10
cystine0low10
iridal0low10
arsenic0low10
chondroitin0low40
transforming growth factor beta0low80
hyaluronoglucosaminidase0low10
vitamin b 120low10
thromboplastin0low10
eye0low70

Protein Targets (301)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma5005
GLI family zinc finger 35005
AR protein8008
aldehyde dehydrogenase 1 family, member A14004
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha5005
estrogen nuclear receptor alpha8008
peroxisome proliferator-activated receptor delta3003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x1001
thyroid hormone receptor beta isoform a3003
heat shock protein beta-11001
nuclear factor erythroid 2-related factor 2 isoform 14004
lamin isoform A-delta105005
Voltage-dependent calcium channel gamma-2 subunit5005
Glutamate receptor 25005
5-hydroxytryptamine receptor 2C0112
5-hydroxytryptamine receptor 2A0112
5-hydroxytryptamine receptor 1A0112
5-hydroxytryptamine receptor 1B0112
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0112
5-hydroxytryptamine receptor 60011
Sodium-dependent serotonin transporter0213
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0011
thioredoxin reductase4004
USP1 protein, partial3003
Microtubule-associated protein tau3003
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Bile salt export pump0606
Canalicular multispecific organic anion transporter 10303
GLS protein3003
D(1A) dopamine receptor2002
histone acetyltransferase KAT2A isoform 12002
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Integrin alpha-50101
Acetylcholine receptor subunit beta0101
UDP-glucuronosyltransferase 2B70101
Neuronal acetylcholine receptor subunit beta-20102
UDP-glucuronosyltransferase 1-60101
Cytochrome P450 2B60002
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0101
Neuronal acetylcholine receptor subunit beta-40102
Neuronal acetylcholine receptor subunit alpha-30101
Cytochrome P450 2C190101
UDP-glucuronosyltransferase 2B10 0101
Neuronal acetylcholine receptor subunit alpha-70101
Neuronal acetylcholine receptor subunit alpha-40102
Sodium-dependent dopamine transporter 0202
Acetylcholine receptor subunit delta0101
ATP-dependent phosphofructokinase2002
Carbonic anhydrase 10303
Carbonic anhydrase 20303
Carbonic anhydrase 40202
Carbonic anhydrase0101
Carbonic anhydrase 150202
Chain A, Beta-lactamase2002
Chain A, Cruzipain2002
acetylcholinesterase1001
SMAD family member 22002
ATAD5 protein, partial1001
SMAD family member 32002
TDP1 protein5005
STAT3, partial0101
Smad31001
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor3003
glucocorticoid receptor [Homo sapiens]4004
estrogen-related nuclear receptor alpha4004
farnesoid X nuclear receptor2002
pregnane X nuclear receptor5005
67.9K protein2002
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
IDH11001
thyroid stimulating hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
nuclear receptor subfamily 1, group I, member 22002
NPC intracellular cholesterol transporter 1 precursor1001
nuclear factor erythroid 2-related factor 2 isoform 22002
potassium voltage-gated channel subfamily H member 2 isoform d2002
thyroid hormone receptor beta isoform 22002
ras-related protein Rab-9A1001
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
nuclear receptor ROR-gamma isoform 12002
geminin4004
Interferon beta3003
Cellular tumor antigen p535005
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit beta-10101
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10101
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Luciferase2002
cytochrome P450 family 3 subfamily A polypeptide 43003
euchromatic histone-lysine N-methyltransferase 22002
Solute carrier family 22 member 1 0101
Nuclear receptor subfamily 1 group I member 20011
ATP-dependent translocase ABCB10101
D(2) dopamine receptor0101
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0202
Mu-type opioid receptor0213
Kappa-type opioid receptor0101
Histamine H1 receptor0101
Mu-type opioid receptor0213
D(3) dopamine receptor0101
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
Kappa-type opioid receptor0202
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Potassium voltage-gated channel subfamily H member 20202
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10101
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Glutamate receptor ionotropic, NMDA 1 0314
Sodium- and chloride-dependent glycine transporter 10101
Glutamate receptor ionotropic, NMDA 2A 0213
Glutamate receptor ionotropic, NMDA 2B0213
Glutamate receptor ionotropic, NMDA 2C0213
Large neutral amino acids transporter small subunit 10101
Glutamate receptor ionotropic, NMDA 2D0213
Proton-coupled amino acid transporter 10404
Glutamate receptor ionotropic, NMDA 3B0213
Serine racemase0101
Olfactory receptor 51E20011
Glutamate receptor ionotropic, NMDA 3A0213
Sodium- and chloride-dependent glycine transporter 20101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Albumin0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Neutral amino acid transporter A0303
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0303
Amino acid transporter0303
arylsulfatase A1001
serine/threonine-protein kinase mTOR isoform 11001
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
pregnane X receptor2002
phosphopantetheinyl transferase3003
Estrogen receptor 10101
regulator of G-protein signaling 41001
nonstructural protein 12002
G1001
Parkin1001
Bloom syndrome protein isoform 11001
cytochrome P450 2C9 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
vitamin D3 receptor isoform VDRA2002
chromobox protein homolog 12002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
fMet-Leu-Phe receptor0101
mitogen-activated protein kinase 11001
DNA polymerase iota isoform a (long)2002
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 11001
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi1001
HLA class I histocompatibility antigen, B alpha chain 1001
Prostaglandin G/H synthase 10101
Cytochrome P450 2C9 0202
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Prostaglandin G/H synthase 20303
Prostaglandin G/H synthase 2 0101
Histamine H2 receptor2002
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
TAR DNA-binding protein 432002
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0202
Cyclooxygenase-2 0101
Solute carrier family 22 member 80202
GABA theta subunit1001
Inositol hexakisphosphate kinase 11001
Gamma-aminobutyric acid receptor subunit epsilon1001
cytochrome P450 2C9, partial1001
luciferase0001
aryl hydrocarbon receptor2002
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
lethal factor (plasmid)2002
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Chain A, Ferritin light chain1001
glp-1 receptor, partial1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Cytochrome P450 3A40101
Guanine nucleotide-binding protein G1001
heat shock protein 90, putative0001
Chain A, 2-oxoglutarate Oxygenase2002
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
DNA polymerase kappa isoform 11001
muscarinic acetylcholine receptor M11001
Acetylcholinesterase0101
Pyruvate kinase PKM0011
Cholinesterase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]