Keratoderma, Palmoplantar, Diffuse

An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present.

Synonym
Keratosis Palmaris et Plantaris Familiaris
Tylosis
Unna-Thost Syndrome
Thost-Unna Syndrome
Keratoderma, Palmoplantar, Diffuse

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	12 (25.00)	23.3326
1990's	20 (41.67)	12.5806
2000's	9 (18.75)	18.1394
2010's	5 (10.42)	28.8240
2020's	2 (4.17)	9.53

Drug	Relationship Strength	Studies
glycine	low	1
methanol	low	1
urea	low	1
fluorouracil	low	2
prednisolone	low	1
lysine	low	1
cyclohexanol	low	1
thorium	low	1
venlafaxine hydrochloride	low	1
biotin	low	2
retinol	low	4
melphalan	low	1
bromochloroacetic acid	low	17
etretinate	low	2
acitretin	low	2
arsenic	low	2
pepstatin	low	1
involucrin	low	1
epidermal growth factor	low	1

Protein Targets (283)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Luciferase	2	0	0	2
USP1 protein, partial	5	0	0	5
TDP1 protein	6	0	0	6
Microtubule-associated protein tau	4	0	0	4
AR protein	10	0	0	10
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
glucocorticoid receptor [Homo sapiens]	6	0	0	6
estrogen nuclear receptor alpha	9	0	0	9
peroxisome proliferator activated receptor gamma	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
vitamin D3 receptor isoform VDRA	4	0	0	4
thyroid hormone receptor beta isoform 2	6	0	0	6
flap endonuclease 1	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
geminin	9	0	0	9
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	3	0	0	3
histone acetyltransferase KAT2A isoform 1	2	0	0	2
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	6
Bile salt export pump	0	1	0	1
Bile salt export pump	0	6	0	6
Rap guanine nucleotide exchange factor 3	2	0	0	2
Cellular tumor antigen p53	7	0	0	7
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
RAR-related orphan receptor gamma	8	0	0	8
apical membrane antigen 1, AMA1	1	0	0	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
thyroid stimulating hormone receptor	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	8	0	0	8
Nuclear receptor ROR-gamma	3	0	0	3
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Vitamin D3 receptor	0	0	1	1
PPM1D protein	1	0	0	1
thioredoxin glutathione reductase	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Interferon beta	4	0	0	4
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	0	0	1
Cytochrome P450 3A4	0	2	0	3
Androgen receptor	0	3	0	3
Cytochrome P450 2D6	0	1	0	1
Vitamin D3 receptor	0	1	2	4
Cytochrome P450 2C9	0	2	0	3
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Cytochrome P450 2C19	0	1	0	1
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	5	0	5
Vitamin D3 receptor A	0	0	2	2
GLI family zinc finger 3	9	0	0	9
retinoid X nuclear receptor alpha	8	0	0	8
pregnane X nuclear receptor	9	0	0	9
aryl hydrocarbon receptor	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
estrogen receptor 2 (ER beta)	4	0	0	4
progesterone receptor	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
estrogen-related nuclear receptor alpha	6	0	0	6
farnesoid X nuclear receptor	3	0	0	3
G	2	0	0	2
cytochrome P450 2D6	2	0	0	2
peroxisome proliferator-activated receptor delta	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
activating transcription factor 6	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
heat shock protein beta-1	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Glutamate receptor 2	4	0	0	4
Inositol hexakisphosphate kinase 1	2	0	0	2
cytochrome P450 2C9, partial	2	0	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
interleukin 8	2	0	0	2
endonuclease IV	1	0	0	1
acetylcholinesterase	2	0	0	2
glp-1 receptor, partial	3	0	0	3
Skn7p	0	0	0	1
thioredoxin reductase	3	0	0	3
pregnane X receptor	2	0	0	2
ATAD5 protein, partial	1	0	0	1
Thrombopoietin	1	0	0	1
thyroid stimulating hormone receptor	4	0	0	4
EWS/FLI fusion protein	3	0	0	3
nonstructural protein 1	1	0	0	1
67.9K protein	1	0	0	1
arylsulfatase A	1	0	0	1
IDH1	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Histone H2A.x	3	0	0	3
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
chromobox protein homolog 1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
huntingtin isoform 2	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Vpr	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
lamin isoform A-delta10	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Amyloid-beta precursor protein	1	1	0	2
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	3	0	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
ATP-dependent phosphofructokinase	2	0	0	2
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	3
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	3
Glutamate receptor ionotropic, NMDA 2B	0	2	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	1	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	1	3
Proton-coupled amino acid transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	1	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Glutamate receptor ionotropic, NMDA 3A	0	2	1	3
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
Glutathione reductase, mitochondrial	0	2	0	2
Cationic amino acid transporter 3	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
15-lipoxygenase, partial	2	0	0	2
phosphopantetheinyl transferase	2	0	0	2
Fumarate hydratase	1	0	0	1
GLS protein	1	0	0	1
Smad3	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
polyprotein	1	0	0	1
glucocerebrosidase	1	0	0	1
caspase-3	2	0	0	2
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Spike glycoprotein	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
TAR DNA-binding protein 43	2	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
GABA theta subunit	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Chain A, CATHEPSIN D	0	1	0	1
Chain B, CATHEPSIN D	0	1	0	1
Chain A, PLASMEPSIN II	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain E, ENDOTHIAPEPSIN	0	1	0	1
Chain A, Cruzipain	2	0	0	2
Chain E, RHIZOPUSPEPSIN	0	1	0	1
Chain E, ENDOTHIAPEPSIN	0	1	0	1
Chain E, ENDOTHIAPEPSIN	0	1	0	1
Chain E, RHIZOPUSPEPSIN	0	1	0	1
Chain E, RHIZOPUSPEPSIN	0	1	0	1
regulator of G-protein signaling 4	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Pepsin A	0	2	0	2
Renin	0	2	0	2
Cathepsin D	0	2	0	3
Procathepsin L	0	1	0	1
Cathepsin B	0	1	0	1
Pro-cathepsin H	0	1	0	1
Candidapepsin-2	0	1	0	1
Pepsin A-5	0	1	0	1
Gag-Pro polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Cathepsin E	0	1	0	1
Plasmepsin-1	0	1	0	1
Plasmepsin-2	0	1	0	1
Cathepsin D	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 9	0	1	0	1
Plasmepsin 4	0	1	0	1
Protease	0	1	0	1
Cysteine protease	0	1	0	1
Chymotrypsin-C	0	1	0	1
Transporter	0	1	0	1
Protease	0	2	0	2
luciferase	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	1	8
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
Estrogen receptor beta	0	2	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Alpha-synuclein	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
Integrin beta-3	1	0	0	1
Integrin alpha-IIb	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Keratoderma, Palmoplantar, Diffuse

Synonyms(5)

Research

Studies (48)

Protein Targets (283)

Keratoderma, Palmoplantar, Diffuse

Synonyms(5)

Research

Studies (48)

Drugs Studied (24)

Protein Targets (283)